Amino acid dipepetide frequency for Pseudohalocynthiibacter aestuariivivens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.033AlaAla: 16.033 ± 0.155	1.172AlaCys: 1.172 ± 0.031	7.113AlaAsp: 7.113 ± 0.093	7.674AlaGlu: 7.674 ± 0.104	4.053AlaPhe: 4.053 ± 0.056	10.139AlaGly: 10.139 ± 0.11	2.445AlaHis: 2.445 ± 0.049	6.04AlaIle: 6.04 ± 0.073	3.739AlaLys: 3.739 ± 0.057	13.357AlaLeu: 13.357 ± 0.131	3.74AlaMet: 3.74 ± 0.063	2.828AlaAsn: 2.828 ± 0.044	5.611AlaPro: 5.611 ± 0.092	4.584AlaGln: 4.584 ± 0.067	8.601AlaArg: 8.601 ± 0.086	5.63AlaSer: 5.63 ± 0.063	6.066AlaThr: 6.066 ± 0.084	8.071AlaVal: 8.071 ± 0.079	1.353AlaTrp: 1.353 ± 0.034	2.61AlaTyr: 2.61 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.199CysAla: 1.199 ± 0.038	0.131CysCys: 0.131 ± 0.009	0.679CysAsp: 0.679 ± 0.025	0.456CysGlu: 0.456 ± 0.02	0.372CysPhe: 0.372 ± 0.017	1.049CysGly: 1.049 ± 0.03	0.293CysHis: 0.293 ± 0.016	0.47CysIle: 0.47 ± 0.02	0.24CysLys: 0.24 ± 0.012	0.886CysLeu: 0.886 ± 0.027	0.192CysMet: 0.192 ± 0.014	0.262CysAsn: 0.262 ± 0.014	0.542CysPro: 0.542 ± 0.02	0.286CysGln: 0.286 ± 0.015	0.608CysArg: 0.608 ± 0.024	0.443CysSer: 0.443 ± 0.017	0.531CysThr: 0.531 ± 0.023	0.69CysVal: 0.69 ± 0.024	0.14CysTrp: 0.14 ± 0.01	0.244CysTyr: 0.244 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.779AspAla: 7.779 ± 0.089	0.561AspCys: 0.561 ± 0.022	3.788AspAsp: 3.788 ± 0.076	3.545AspGlu: 3.545 ± 0.061	2.246AspPhe: 2.246 ± 0.043	5.684AspGly: 5.684 ± 0.105	1.375AspHis: 1.375 ± 0.03	3.455AspIle: 3.455 ± 0.063	1.704AspLys: 1.704 ± 0.038	6.357AspLeu: 6.357 ± 0.067	1.871AspMet: 1.871 ± 0.042	1.378AspAsn: 1.378 ± 0.033	3.534AspPro: 3.534 ± 0.064	2.01AspGln: 2.01 ± 0.031	4.246AspArg: 4.246 ± 0.061	2.29AspSer: 2.29 ± 0.047	3.313AspThr: 3.313 ± 0.062	4.662AspVal: 4.662 ± 0.068	1.156AspTrp: 1.156 ± 0.032	1.516AspTyr: 1.516 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.531GluAla: 7.531 ± 0.09	0.442GluCys: 0.442 ± 0.021	3.247GluAsp: 3.247 ± 0.047	3.228GluGlu: 3.228 ± 0.066	1.932GluPhe: 1.932 ± 0.043	4.388GluGly: 4.388 ± 0.067	1.173GluHis: 1.173 ± 0.032	3.676GluIle: 3.676 ± 0.053	2.085GluLys: 2.085 ± 0.046	4.827GluLeu: 4.827 ± 0.067	1.993GluMet: 1.993 ± 0.042	1.762GluAsn: 1.762 ± 0.035	2.39GluPro: 2.39 ± 0.048	1.91GluGln: 1.91 ± 0.037	4.023GluArg: 4.023 ± 0.07	2.118GluSer: 2.118 ± 0.043	3.785GluThr: 3.785 ± 0.054	4.29GluVal: 4.29 ± 0.056	0.744GluTrp: 0.744 ± 0.025	1.12GluTyr: 1.12 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.313PheAla: 4.313 ± 0.063	0.449PheCys: 0.449 ± 0.018	2.927PheAsp: 2.927 ± 0.046	2.148PheGlu: 2.148 ± 0.042	1.396PhePhe: 1.396 ± 0.043	3.731PheGly: 3.731 ± 0.058	0.753PheHis: 0.753 ± 0.023	1.581PheIle: 1.581 ± 0.04	0.91PheLys: 0.91 ± 0.027	3.279PheLeu: 3.279 ± 0.062	0.847PheMet: 0.847 ± 0.028	1.004PheAsn: 1.004 ± 0.032	1.443PhePro: 1.443 ± 0.041	1.067PheGln: 1.067 ± 0.03	2.085PheArg: 2.085 ± 0.041	2.21PheSer: 2.21 ± 0.043	2.013PheThr: 2.013 ± 0.043	2.616PheVal: 2.616 ± 0.049	0.536PheTrp: 0.536 ± 0.022	0.967PheTyr: 0.967 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.871GlyAla: 9.871 ± 0.116	0.923GlyCys: 0.923 ± 0.03	5.016GlyAsp: 5.016 ± 0.087	4.26GlyGlu: 4.26 ± 0.065	3.579GlyPhe: 3.579 ± 0.057	7.507GlyGly: 7.507 ± 0.153	2.056GlyHis: 2.056 ± 0.048	4.628GlyIle: 4.628 ± 0.059	3.071GlyLys: 3.071 ± 0.06	8.796GlyLeu: 8.796 ± 0.099	2.721GlyMet: 2.721 ± 0.055	2.196GlyAsn: 2.196 ± 0.058	3.6GlyPro: 3.6 ± 0.055	3.26GlyGln: 3.26 ± 0.056	5.563GlyArg: 5.563 ± 0.073	4.41GlySer: 4.41 ± 0.099	4.989GlyThr: 4.989 ± 0.103	6.31GlyVal: 6.31 ± 0.07	1.436GlyTrp: 1.436 ± 0.034	2.406GlyTyr: 2.406 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.497HisAla: 2.497 ± 0.057	0.276HisCys: 0.276 ± 0.014	1.381HisAsp: 1.381 ± 0.036	1.097HisGlu: 1.097 ± 0.028	0.879HisPhe: 0.879 ± 0.027	1.954HisGly: 1.954 ± 0.044	0.62HisHis: 0.62 ± 0.027	1.062HisIle: 1.062 ± 0.029	0.521HisLys: 0.521 ± 0.021	2.188HisLeu: 2.188 ± 0.045	0.61HisMet: 0.61 ± 0.021	0.482HisAsn: 0.482 ± 0.021	1.415HisPro: 1.415 ± 0.038	0.597HisGln: 0.597 ± 0.023	1.384HisArg: 1.384 ± 0.038	1.056HisSer: 1.056 ± 0.032	0.962HisThr: 0.962 ± 0.027	1.613HisVal: 1.613 ± 0.035	0.37HisTrp: 0.37 ± 0.017	0.59HisTyr: 0.59 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.321IleAla: 7.321 ± 0.073	0.707IleCys: 0.707 ± 0.024	3.724IleAsp: 3.724 ± 0.051	3.66IleGlu: 3.66 ± 0.051	1.791IlePhe: 1.791 ± 0.04	5.078IleGly: 5.078 ± 0.067	0.971IleHis: 0.971 ± 0.03	2.636IleIle: 2.636 ± 0.047	1.532IleLys: 1.532 ± 0.033	4.714IleLeu: 4.714 ± 0.066	1.166IleMet: 1.166 ± 0.036	1.503IleAsn: 1.503 ± 0.033	2.411IlePro: 2.411 ± 0.044	1.245IleGln: 1.245 ± 0.033	3.208IleArg: 3.208 ± 0.046	3.173IleSer: 3.173 ± 0.056	3.23IleThr: 3.23 ± 0.056	3.959IleVal: 3.959 ± 0.065	0.732IleTrp: 0.732 ± 0.025	1.33IleTyr: 1.33 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.566LysAla: 3.566 ± 0.064	0.221LysCys: 0.221 ± 0.013	1.716LysAsp: 1.716 ± 0.039	1.508LysGlu: 1.508 ± 0.038	0.95LysPhe: 0.95 ± 0.029	2.658LysGly: 2.658 ± 0.062	0.645LysHis: 0.645 ± 0.026	1.611LysIle: 1.611 ± 0.044	1.161LysLys: 1.161 ± 0.036	2.964LysLeu: 2.964 ± 0.047	0.895LysMet: 0.895 ± 0.024	0.84LysAsn: 0.84 ± 0.026	1.77LysPro: 1.77 ± 0.041	0.942LysGln: 0.942 ± 0.026	2.261LysArg: 2.261 ± 0.051	2.012LysSer: 2.012 ± 0.041	1.961LysThr: 1.961 ± 0.036	2.196LysVal: 2.196 ± 0.047	0.418LysTrp: 0.418 ± 0.018	0.681LysTyr: 0.681 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.835LeuAla: 11.835 ± 0.12	1.038LeuCys: 1.038 ± 0.031	5.971LeuAsp: 5.971 ± 0.074	5.211LeuGlu: 5.211 ± 0.069	3.36LeuPhe: 3.36 ± 0.057	8.272LeuGly: 8.272 ± 0.098	1.994LeuHis: 1.994 ± 0.046	5.511LeuIle: 5.511 ± 0.073	3.136LeuLys: 3.136 ± 0.049	8.749LeuLeu: 8.749 ± 0.11	2.741LeuMet: 2.741 ± 0.053	2.831LeuAsn: 2.831 ± 0.048	5.353LeuPro: 5.353 ± 0.073	2.659LeuGln: 2.659 ± 0.046	7.048LeuArg: 7.048 ± 0.072	6.598LeuSer: 6.598 ± 0.075	6.119LeuThr: 6.119 ± 0.08	6.469LeuVal: 6.469 ± 0.081	1.32LeuTrp: 1.32 ± 0.03	1.995LeuTyr: 1.995 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.475MetAla: 3.475 ± 0.055	0.223MetCys: 0.223 ± 0.014	1.512MetAsp: 1.512 ± 0.039	1.315MetGlu: 1.315 ± 0.036	0.817MetPhe: 0.817 ± 0.027	2.323MetGly: 2.323 ± 0.047	0.541MetHis: 0.541 ± 0.02	1.7MetIle: 1.7 ± 0.035	1.07MetLys: 1.07 ± 0.03	2.665MetLeu: 2.665 ± 0.05	0.849MetMet: 0.849 ± 0.028	0.919MetAsn: 0.919 ± 0.03	1.626MetPro: 1.626 ± 0.042	1.165MetGln: 1.165 ± 0.033	2.016MetArg: 2.016 ± 0.041	1.852MetSer: 1.852 ± 0.037	2.145MetThr: 2.145 ± 0.037	1.994MetVal: 1.994 ± 0.042	0.258MetTrp: 0.258 ± 0.014	0.362MetTyr: 0.362 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.395AsnAla: 3.395 ± 0.051	0.283AsnCys: 0.283 ± 0.014	1.544AsnAsp: 1.544 ± 0.035	1.254AsnGlu: 1.254 ± 0.031	1.001AsnPhe: 1.001 ± 0.027	2.496AsnGly: 2.496 ± 0.054	0.533AsnHis: 0.533 ± 0.023	1.448AsnIle: 1.448 ± 0.043	0.686AsnLys: 0.686 ± 0.027	2.529AsnLeu: 2.529 ± 0.045	0.725AsnMet: 0.725 ± 0.024	0.732AsnAsn: 0.732 ± 0.033	1.831AsnPro: 1.831 ± 0.045	0.778AsnGln: 0.778 ± 0.024	1.726AsnArg: 1.726 ± 0.041	1.23AsnSer: 1.23 ± 0.036	1.54AsnThr: 1.54 ± 0.037	1.983AsnVal: 1.983 ± 0.043	0.485AsnTrp: 0.485 ± 0.02	0.679AsnTyr: 0.679 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.176ProAla: 5.176 ± 0.075	0.361ProCys: 0.361 ± 0.015	4.075ProAsp: 4.075 ± 0.059	3.879ProGlu: 3.879 ± 0.062	1.933ProPhe: 1.933 ± 0.039	4.446ProGly: 4.446 ± 0.06	1.141ProHis: 1.141 ± 0.034	2.372ProIle: 2.372 ± 0.048	1.636ProLys: 1.636 ± 0.038	4.609ProLeu: 4.609 ± 0.073	1.319ProMet: 1.319 ± 0.036	1.393ProAsn: 1.393 ± 0.032	2.193ProPro: 2.193 ± 0.042	1.638ProGln: 1.638 ± 0.037	2.712ProArg: 2.712 ± 0.049	2.492ProSer: 2.492 ± 0.047	2.511ProThr: 2.511 ± 0.042	4.045ProVal: 4.045 ± 0.058	0.63ProTrp: 0.63 ± 0.023	1.198ProTyr: 1.198 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.913GlnAla: 3.913 ± 0.064	0.236GlnCys: 0.236 ± 0.014	1.731GlnAsp: 1.731 ± 0.038	1.572GlnGlu: 1.572 ± 0.037	1.091GlnPhe: 1.091 ± 0.034	2.511GlnGly: 2.511 ± 0.049	0.678GlnHis: 0.678 ± 0.024	2.257GlnIle: 2.257 ± 0.041	1.05GlnLys: 1.05 ± 0.034	2.92GlnLeu: 2.92 ± 0.05	1.245GlnMet: 1.245 ± 0.03	1.061GlnAsn: 1.061 ± 0.028	1.557GlnPro: 1.557 ± 0.036	1.171GlnGln: 1.171 ± 0.033	2.221GlnArg: 2.221 ± 0.047	1.97GlnSer: 1.97 ± 0.038	2.015GlnThr: 2.015 ± 0.036	2.361GlnVal: 2.361 ± 0.044	0.42GlnTrp: 0.42 ± 0.016	0.633GlnTyr: 0.633 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.21ArgAla: 8.21 ± 0.092	0.531ArgCys: 0.531 ± 0.022	4.308ArgAsp: 4.308 ± 0.055	3.644ArgGlu: 3.644 ± 0.06	2.515ArgPhe: 2.515 ± 0.042	4.671ArgGly: 4.671 ± 0.058	1.55ArgHis: 1.55 ± 0.037	3.943ArgIle: 3.943 ± 0.053	2.284ArgLys: 2.284 ± 0.046	6.921ArgLeu: 6.921 ± 0.08	1.97ArgMet: 1.97 ± 0.041	1.85ArgAsn: 1.85 ± 0.043	3.081ArgPro: 3.081 ± 0.055	2.332ArgGln: 2.332 ± 0.041	4.905ArgArg: 4.905 ± 0.075	3.262ArgSer: 3.262 ± 0.054	3.238ArgThr: 3.238 ± 0.053	4.652ArgVal: 4.652 ± 0.061	0.895ArgTrp: 0.895 ± 0.026	1.668ArgTyr: 1.668 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.096SerAla: 6.096 ± 0.068	0.474SerCys: 0.474 ± 0.019	3.612SerAsp: 3.612 ± 0.055	2.933SerGlu: 2.933 ± 0.052	2.205SerPhe: 2.205 ± 0.047	5.533SerGly: 5.533 ± 0.1	1.134SerHis: 1.134 ± 0.028	2.663SerIle: 2.663 ± 0.047	1.538SerLys: 1.538 ± 0.037	4.964SerLeu: 4.964 ± 0.061	1.324SerMet: 1.324 ± 0.031	1.453SerAsn: 1.453 ± 0.034	2.446SerPro: 2.446 ± 0.043	1.653SerGln: 1.653 ± 0.036	3.188SerArg: 3.188 ± 0.05	2.67SerSer: 2.67 ± 0.054	2.643SerThr: 2.643 ± 0.051	3.884SerVal: 3.884 ± 0.06	0.735SerTrp: 0.735 ± 0.024	1.433SerTyr: 1.433 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.309ThrAla: 6.309 ± 0.093	0.552ThrCys: 0.552 ± 0.024	3.465ThrAsp: 3.465 ± 0.078	3.132ThrGlu: 3.132 ± 0.052	1.982ThrPhe: 1.982 ± 0.039	5.587ThrGly: 5.587 ± 0.074	1.23ThrHis: 1.23 ± 0.033	2.883ThrIle: 2.883 ± 0.047	1.562ThrLys: 1.562 ± 0.047	6.191ThrLeu: 6.191 ± 0.068	1.436ThrMet: 1.436 ± 0.035	1.405ThrAsn: 1.405 ± 0.035	3.486ThrPro: 3.486 ± 0.06	1.781ThrGln: 1.781 ± 0.042	3.612ThrArg: 3.612 ± 0.052	2.904ThrSer: 2.904 ± 0.053	2.951ThrThr: 2.951 ± 0.057	4.145ThrVal: 4.145 ± 0.068	0.663ThrTrp: 0.663 ± 0.027	1.404ThrTyr: 1.404 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.341ValAla: 8.341 ± 0.081	0.714ValCys: 0.714 ± 0.023	4.174ValAsp: 4.174 ± 0.057	4.209ValGlu: 4.209 ± 0.055	2.746ValPhe: 2.746 ± 0.051	5.33ValGly: 5.33 ± 0.069	1.437ValHis: 1.437 ± 0.034	4.374ValIle: 4.374 ± 0.066	2.033ValLys: 2.033 ± 0.047	7.324ValLeu: 7.324 ± 0.084	2.178ValMet: 2.178 ± 0.045	1.977ValAsn: 1.977 ± 0.041	3.624ValPro: 3.624 ± 0.061	2.198ValGln: 2.198 ± 0.041	4.37ValArg: 4.37 ± 0.058	4.272ValSer: 4.272 ± 0.055	4.671ValThr: 4.671 ± 0.084	5.41ValVal: 5.41 ± 0.065	0.937ValTrp: 0.937 ± 0.025	1.47ValTyr: 1.47 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.346TrpAla: 1.346 ± 0.033	0.155TrpCys: 0.155 ± 0.01	0.776TrpAsp: 0.776 ± 0.023	0.664TrpGlu: 0.664 ± 0.025	0.539TrpPhe: 0.539 ± 0.021	1.04TrpGly: 1.04 ± 0.03	0.369TrpHis: 0.369 ± 0.017	0.71TrpIle: 0.71 ± 0.024	0.425TrpLys: 0.425 ± 0.019	1.616TrpLeu: 1.616 ± 0.037	0.448TrpMet: 0.448 ± 0.018	0.409TrpAsn: 0.409 ± 0.016	0.689TrpPro: 0.689 ± 0.025	0.644TrpGln: 0.644 ± 0.022	1.055TrpArg: 1.055 ± 0.031	0.765TrpSer: 0.765 ± 0.026	0.774TrpThr: 0.774 ± 0.03	0.88TrpVal: 0.88 ± 0.028	0.231TrpTrp: 0.231 ± 0.013	0.286TrpTyr: 0.286 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.652TyrAla: 2.652 ± 0.047	0.266TyrCys: 0.266 ± 0.015	1.712TyrAsp: 1.712 ± 0.039	1.273TyrGlu: 1.273 ± 0.03	0.889TyrPhe: 0.889 ± 0.027	2.203TyrGly: 2.203 ± 0.038	0.616TyrHis: 0.616 ± 0.025	1.068TyrIle: 1.068 ± 0.027	0.59TyrLys: 0.59 ± 0.021	2.356TyrLeu: 2.356 ± 0.044	0.56TyrMet: 0.56 ± 0.023	0.59TyrAsn: 0.59 ± 0.021	1.159TyrPro: 1.159 ± 0.032	0.693TyrGln: 0.693 ± 0.023	1.6TyrArg: 1.6 ± 0.034	1.218TyrSer: 1.218 ± 0.034	1.225TyrThr: 1.225 ± 0.033	1.556TyrVal: 1.556 ± 0.033	0.363TyrTrp: 0.363 ± 0.017	0.611TyrTyr: 0.611 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4194 proteins (1331213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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