Amino acid dipepetide frequency for Pelosinus sp. UFO1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.614AlaAla: 7.614 ± 0.112	0.918AlaCys: 0.918 ± 0.03	3.827AlaAsp: 3.827 ± 0.055	4.866AlaGlu: 4.866 ± 0.067	3.085AlaPhe: 3.085 ± 0.053	6.37AlaGly: 6.37 ± 0.081	1.297AlaHis: 1.297 ± 0.029	6.685AlaIle: 6.685 ± 0.077	5.12AlaLys: 5.12 ± 0.072	7.773AlaLeu: 7.773 ± 0.093	2.473AlaMet: 2.473 ± 0.043	3.252AlaAsn: 3.252 ± 0.051	2.194AlaPro: 2.194 ± 0.04	2.755AlaGln: 2.755 ± 0.047	3.035AlaArg: 3.035 ± 0.052	4.506AlaSer: 4.506 ± 0.068	4.329AlaThr: 4.329 ± 0.063	6.47AlaVal: 6.47 ± 0.092	0.645AlaTrp: 0.645 ± 0.023	2.378AlaTyr: 2.378 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.793CysAla: 0.793 ± 0.026	0.214CysCys: 0.214 ± 0.014	0.522CysAsp: 0.522 ± 0.019	0.602CysGlu: 0.602 ± 0.021	0.436CysPhe: 0.436 ± 0.019	1.145CysGly: 1.145 ± 0.033	0.267CysHis: 0.267 ± 0.014	0.912CysIle: 0.912 ± 0.024	0.637CysLys: 0.637 ± 0.019	1.061CysLeu: 1.061 ± 0.028	0.328CysMet: 0.328 ± 0.014	0.51CysAsn: 0.51 ± 0.018	0.606CysPro: 0.606 ± 0.026	0.442CysGln: 0.442 ± 0.02	0.512CysArg: 0.512 ± 0.022	0.795CysSer: 0.795 ± 0.021	0.622CysThr: 0.622 ± 0.02	0.661CysVal: 0.661 ± 0.023	0.121CysTrp: 0.121 ± 0.01	0.365CysTyr: 0.365 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.444AspAla: 3.444 ± 0.053	0.602AspCys: 0.602 ± 0.023	2.154AspAsp: 2.154 ± 0.045	3.236AspGlu: 3.236 ± 0.051	2.22AspPhe: 2.22 ± 0.037	3.342AspGly: 3.342 ± 0.058	0.854AspHis: 0.854 ± 0.028	4.499AspIle: 4.499 ± 0.059	3.402AspLys: 3.402 ± 0.052	4.417AspLeu: 4.417 ± 0.059	1.417AspMet: 1.417 ± 0.035	2.128AspAsn: 2.128 ± 0.057	1.75AspPro: 1.75 ± 0.036	1.484AspGln: 1.484 ± 0.031	1.989AspArg: 1.989 ± 0.04	2.649AspSer: 2.649 ± 0.047	2.705AspThr: 2.705 ± 0.081	3.744AspVal: 3.744 ± 0.058	0.555AspTrp: 0.555 ± 0.02	1.933AspTyr: 1.933 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.663GluAla: 4.663 ± 0.063	0.625GluCys: 0.625 ± 0.023	2.837GluAsp: 2.837 ± 0.043	4.939GluGlu: 4.939 ± 0.064	2.368GluPhe: 2.368 ± 0.04	3.716GluGly: 3.716 ± 0.062	1.209GluHis: 1.209 ± 0.032	5.564GluIle: 5.564 ± 0.072	5.405GluLys: 5.405 ± 0.069	6.298GluLeu: 6.298 ± 0.069	2.026GluMet: 2.026 ± 0.037	3.254GluAsn: 3.254 ± 0.063	1.632GluPro: 1.632 ± 0.035	2.935GluGln: 2.935 ± 0.062	2.967GluArg: 2.967 ± 0.052	2.906GluSer: 2.906 ± 0.044	2.99GluThr: 2.99 ± 0.044	4.672GluVal: 4.672 ± 0.069	0.587GluTrp: 0.587 ± 0.024	2.209GluTyr: 2.209 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.203PheAla: 3.203 ± 0.05	0.528PheCys: 0.528 ± 0.021	2.155PheAsp: 2.155 ± 0.045	2.034PheGlu: 2.034 ± 0.04	1.914PhePhe: 1.914 ± 0.044	3.304PheGly: 3.304 ± 0.086	0.771PheHis: 0.771 ± 0.022	3.48PheIle: 3.48 ± 0.053	2.103PheLys: 2.103 ± 0.039	3.947PheLeu: 3.947 ± 0.065	1.169PheMet: 1.169 ± 0.032	1.77PheAsn: 1.77 ± 0.035	1.5PhePro: 1.5 ± 0.035	1.218PheGln: 1.218 ± 0.028	1.457PheArg: 1.457 ± 0.036	2.989PheSer: 2.989 ± 0.042	2.465PheThr: 2.465 ± 0.042	2.816PheVal: 2.816 ± 0.044	0.435PheTrp: 0.435 ± 0.021	1.416PheTyr: 1.416 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.744GlyAla: 5.744 ± 0.115	1.035GlyCys: 1.035 ± 0.031	3.206GlyAsp: 3.206 ± 0.06	4.144GlyGlu: 4.144 ± 0.064	3.261GlyPhe: 3.261 ± 0.055	5.357GlyGly: 5.357 ± 0.111	1.457GlyHis: 1.457 ± 0.037	6.838GlyIle: 6.838 ± 0.085	5.085GlyLys: 5.085 ± 0.059	6.936GlyLeu: 6.936 ± 0.091	2.37GlyMet: 2.37 ± 0.045	3.24GlyAsn: 3.24 ± 0.116	1.871GlyPro: 1.871 ± 0.04	2.558GlyGln: 2.558 ± 0.044	2.977GlyArg: 2.977 ± 0.041	4.165GlySer: 4.165 ± 0.062	4.266GlyThr: 4.266 ± 0.069	5.641GlyVal: 5.641 ± 0.073	0.757GlyTrp: 0.757 ± 0.024	2.819GlyTyr: 2.819 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.304HisAla: 1.304 ± 0.033	0.322HisCys: 0.322 ± 0.015	0.893HisAsp: 0.893 ± 0.027	1.064HisGlu: 1.064 ± 0.03	0.854HisPhe: 0.854 ± 0.028	1.431HisGly: 1.431 ± 0.034	0.553HisHis: 0.553 ± 0.021	1.518HisIle: 1.518 ± 0.034	1.047HisLys: 1.047 ± 0.028	1.828HisLeu: 1.828 ± 0.039	0.541HisMet: 0.541 ± 0.021	0.866HisAsn: 0.866 ± 0.027	0.998HisPro: 0.998 ± 0.029	0.65HisGln: 0.65 ± 0.023	0.802HisArg: 0.802 ± 0.028	1.128HisSer: 1.128 ± 0.028	1.006HisThr: 1.006 ± 0.027	1.186HisVal: 1.186 ± 0.028	0.212HisTrp: 0.212 ± 0.013	0.68HisTyr: 0.68 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.185IleAla: 7.185 ± 0.079	0.966IleCys: 0.966 ± 0.031	4.354IleAsp: 4.354 ± 0.069	5.113IleGlu: 5.113 ± 0.067	3.076IlePhe: 3.076 ± 0.048	6.5IleGly: 6.5 ± 0.069	1.558IleHis: 1.558 ± 0.038	6.637IleIle: 6.637 ± 0.09	5.067IleLys: 5.067 ± 0.054	7.605IleLeu: 7.605 ± 0.086	2.236IleMet: 2.236 ± 0.043	3.699IleAsn: 3.699 ± 0.055	3.613IlePro: 3.613 ± 0.054	2.548IleGln: 2.548 ± 0.043	3.2IleArg: 3.2 ± 0.056	5.353IleSer: 5.353 ± 0.072	5.03IleThr: 5.03 ± 0.068	6.167IleVal: 6.167 ± 0.079	0.642IleTrp: 0.642 ± 0.023	2.277IleTyr: 2.277 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.841LysAla: 4.841 ± 0.063	0.555LysCys: 0.555 ± 0.023	3.308LysAsp: 3.308 ± 0.052	5.258LysGlu: 5.258 ± 0.073	2.013LysPhe: 2.013 ± 0.035	3.937LysGly: 3.937 ± 0.056	1.031LysHis: 1.031 ± 0.025	5.337LysIle: 5.337 ± 0.066	4.708LysLys: 4.708 ± 0.061	5.664LysLeu: 5.664 ± 0.069	2.177LysMet: 2.177 ± 0.041	3.276LysAsn: 3.276 ± 0.05	2.119LysPro: 2.119 ± 0.039	2.519LysGln: 2.519 ± 0.047	2.541LysArg: 2.541 ± 0.041	3.371LysSer: 3.371 ± 0.05	3.41LysThr: 3.41 ± 0.05	4.95LysVal: 4.95 ± 0.067	0.616LysTrp: 0.616 ± 0.022	2.156LysTyr: 2.156 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	8.509LeuAla: 8.509 ± 0.088	1.073LeuCys: 1.073 ± 0.028	4.715LeuAsp: 4.715 ± 0.063	5.909LeuGlu: 5.909 ± 0.068	4.037LeuPhe: 4.037 ± 0.061	7.256LeuGly: 7.256 ± 0.089	1.829LeuHis: 1.829 ± 0.037	6.935LeuIle: 6.935 ± 0.085	5.73LeuLys: 5.73 ± 0.074	10.05LeuLeu: 10.05 ± 0.127	2.548LeuMet: 2.548 ± 0.044	3.924LeuAsn: 3.924 ± 0.062	4.121LeuPro: 4.121 ± 0.061	3.459LeuGln: 3.459 ± 0.07	3.859LeuArg: 3.859 ± 0.062	6.518LeuSer: 6.518 ± 0.079	5.727LeuThr: 5.727 ± 0.088	6.929LeuVal: 6.929 ± 0.084	0.879LeuTrp: 0.879 ± 0.027	2.841LeuTyr: 2.841 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.465MetAla: 2.465 ± 0.046	0.25MetCys: 0.25 ± 0.015	1.446MetAsp: 1.446 ± 0.033	1.855MetGlu: 1.855 ± 0.041	0.988MetPhe: 0.988 ± 0.026	2.248MetGly: 2.248 ± 0.044	0.469MetHis: 0.469 ± 0.019	2.263MetIle: 2.263 ± 0.041	1.981MetLys: 1.981 ± 0.032	2.903MetLeu: 2.903 ± 0.047	0.844MetMet: 0.844 ± 0.026	1.421MetAsn: 1.421 ± 0.032	1.184MetPro: 1.184 ± 0.027	1.132MetGln: 1.132 ± 0.035	1.132MetArg: 1.132 ± 0.027	1.845MetSer: 1.845 ± 0.035	1.579MetThr: 1.579 ± 0.034	2.164MetVal: 2.164 ± 0.039	0.214MetTrp: 0.214 ± 0.014	0.77MetTyr: 0.77 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.08AsnAla: 3.08 ± 0.054	0.529AsnCys: 0.529 ± 0.022	2.025AsnAsp: 2.025 ± 0.054	2.578AsnGlu: 2.578 ± 0.048	1.801AsnPhe: 1.801 ± 0.035	3.04AsnGly: 3.04 ± 0.06	0.88AsnHis: 0.88 ± 0.027	4.0AsnIle: 4.0 ± 0.063	2.899AsnLys: 2.899 ± 0.045	4.371AsnLeu: 4.371 ± 0.057	1.266AsnMet: 1.266 ± 0.027	2.123AsnAsn: 2.123 ± 0.058	2.154AsnPro: 2.154 ± 0.046	1.787AsnGln: 1.787 ± 0.036	1.795AsnArg: 1.795 ± 0.04	2.637AsnSer: 2.637 ± 0.054	2.463AsnThr: 2.463 ± 0.046	3.19AsnVal: 3.19 ± 0.064	0.52AsnTrp: 0.52 ± 0.018	1.591AsnTyr: 1.591 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.643ProAla: 2.643 ± 0.049	0.402ProCys: 0.402 ± 0.018	1.949ProAsp: 1.949 ± 0.039	2.787ProGlu: 2.787 ± 0.044	1.632ProPhe: 1.632 ± 0.032	2.709ProGly: 2.709 ± 0.046	0.799ProHis: 0.799 ± 0.027	3.027ProIle: 3.027 ± 0.05	1.928ProLys: 1.928 ± 0.04	3.504ProLeu: 3.504 ± 0.054	0.96ProMet: 0.96 ± 0.024	1.602ProAsn: 1.602 ± 0.034	1.16ProPro: 1.16 ± 0.033	1.334ProGln: 1.334 ± 0.041	1.28ProArg: 1.28 ± 0.035	2.058ProSer: 2.058 ± 0.038	2.07ProThr: 2.07 ± 0.039	2.969ProVal: 2.969 ± 0.052	0.394ProTrp: 0.394 ± 0.018	1.304ProTyr: 1.304 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.099GlnAla: 3.099 ± 0.055	0.377GlnCys: 0.377 ± 0.018	1.786GlnAsp: 1.786 ± 0.043	2.793GlnGlu: 2.793 ± 0.05	1.24GlnPhe: 1.24 ± 0.028	2.554GlnGly: 2.554 ± 0.042	0.68GlnHis: 0.68 ± 0.023	2.764GlnIle: 2.764 ± 0.052	2.35GlnLys: 2.35 ± 0.039	3.498GlnLeu: 3.498 ± 0.071	1.051GlnMet: 1.051 ± 0.025	1.568GlnAsn: 1.568 ± 0.035	1.224GlnPro: 1.224 ± 0.031	1.743GlnGln: 1.743 ± 0.044	1.542GlnArg: 1.542 ± 0.035	2.077GlnSer: 2.077 ± 0.044	1.753GlnThr: 1.753 ± 0.039	2.694GlnVal: 2.694 ± 0.042	0.355GlnTrp: 0.355 ± 0.016	1.287GlnTyr: 1.287 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.578ArgAla: 2.578 ± 0.046	0.435ArgCys: 0.435 ± 0.02	1.973ArgAsp: 1.973 ± 0.036	3.026ArgGlu: 3.026 ± 0.052	1.638ArgPhe: 1.638 ± 0.033	2.642ArgGly: 2.642 ± 0.048	0.834ArgHis: 0.834 ± 0.021	3.337ArgIle: 3.337 ± 0.054	2.685ArgLys: 2.685 ± 0.052	3.916ArgLeu: 3.916 ± 0.052	1.266ArgMet: 1.266 ± 0.032	1.831ArgAsn: 1.831 ± 0.038	1.39ArgPro: 1.39 ± 0.033	1.806ArgGln: 1.806 ± 0.038	1.977ArgArg: 1.977 ± 0.044	2.14ArgSer: 2.14 ± 0.04	2.008ArgThr: 2.008 ± 0.043	2.837ArgVal: 2.837 ± 0.044	0.398ArgTrp: 0.398 ± 0.016	1.476ArgTyr: 1.476 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.279SerAla: 4.279 ± 0.067	0.687SerCys: 0.687 ± 0.028	2.672SerAsp: 2.672 ± 0.043	3.393SerGlu: 3.393 ± 0.053	2.727SerPhe: 2.727 ± 0.04	4.718SerGly: 4.718 ± 0.067	1.178SerHis: 1.178 ± 0.031	5.106SerIle: 5.106 ± 0.059	3.617SerLys: 3.617 ± 0.052	6.045SerLeu: 6.045 ± 0.076	1.795SerMet: 1.795 ± 0.035	2.642SerAsn: 2.642 ± 0.041	2.187SerPro: 2.187 ± 0.04	2.241SerGln: 2.241 ± 0.042	2.376SerArg: 2.376 ± 0.04	4.014SerSer: 4.014 ± 0.064	3.266SerThr: 3.266 ± 0.062	4.102SerVal: 4.102 ± 0.052	0.625SerTrp: 0.625 ± 0.022	2.098SerTyr: 2.098 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.722ThrAla: 4.722 ± 0.061	0.608ThrCys: 0.608 ± 0.023	2.521ThrAsp: 2.521 ± 0.051	3.019ThrGlu: 3.019 ± 0.047	2.327ThrPhe: 2.327 ± 0.084	4.752ThrGly: 4.752 ± 0.086	0.967ThrHis: 0.967 ± 0.028	4.733ThrIle: 4.733 ± 0.069	3.175ThrLys: 3.175 ± 0.055	5.477ThrLeu: 5.477 ± 0.075	1.52ThrMet: 1.52 ± 0.035	2.402ThrAsn: 2.402 ± 0.045	2.424ThrPro: 2.424 ± 0.042	1.697ThrGln: 1.697 ± 0.038	1.96ThrArg: 1.96 ± 0.035	3.256ThrSer: 3.256 ± 0.053	3.365ThrThr: 3.365 ± 0.063	4.496ThrVal: 4.496 ± 0.059	0.52ThrTrp: 0.52 ± 0.019	1.784ThrTyr: 1.784 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.455ValAla: 6.455 ± 0.075	0.878ValCys: 0.878 ± 0.026	3.926ValAsp: 3.926 ± 0.061	4.717ValGlu: 4.717 ± 0.068	3.101ValPhe: 3.101 ± 0.048	5.464ValGly: 5.464 ± 0.068	1.286ValHis: 1.286 ± 0.033	6.05ValIle: 6.05 ± 0.065	4.384ValLys: 4.384 ± 0.056	7.181ValLeu: 7.181 ± 0.079	2.096ValMet: 2.096 ± 0.039	3.223ValAsn: 3.223 ± 0.051	2.731ValPro: 2.731 ± 0.042	2.191ValGln: 2.191 ± 0.038	2.797ValArg: 2.797 ± 0.043	4.708ValSer: 4.708 ± 0.059	4.445ValThr: 4.445 ± 0.091	6.076ValVal: 6.076 ± 0.083	0.609ValTrp: 0.609 ± 0.022	2.164ValTyr: 2.164 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.667TrpAla: 0.667 ± 0.025	0.114TrpCys: 0.114 ± 0.009	0.501TrpAsp: 0.501 ± 0.019	0.538TrpGlu: 0.538 ± 0.021	0.443TrpPhe: 0.443 ± 0.02	0.701TrpGly: 0.701 ± 0.023	0.214TrpHis: 0.214 ± 0.014	0.676TrpIle: 0.676 ± 0.025	0.526TrpLys: 0.526 ± 0.018	1.085TrpLeu: 1.085 ± 0.031	0.296TrpMet: 0.296 ± 0.014	0.431TrpAsn: 0.431 ± 0.017	0.319TrpPro: 0.319 ± 0.017	0.547TrpGln: 0.547 ± 0.023	0.456TrpArg: 0.456 ± 0.019	0.579TrpSer: 0.579 ± 0.021	0.42TrpThr: 0.42 ± 0.019	0.611TrpVal: 0.611 ± 0.021	0.168TrpTrp: 0.168 ± 0.013	0.336TrpTyr: 0.336 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.305TyrAla: 2.305 ± 0.042	0.434TyrCys: 0.434 ± 0.019	1.755TyrAsp: 1.755 ± 0.04	1.928TyrGlu: 1.928 ± 0.04	1.516TyrPhe: 1.516 ± 0.033	2.539TyrGly: 2.539 ± 0.052	0.749TyrHis: 0.749 ± 0.025	2.464TyrIle: 2.464 ± 0.05	1.937TyrLys: 1.937 ± 0.045	3.289TyrLeu: 3.289 ± 0.054	0.776TyrMet: 0.776 ± 0.025	1.565TyrAsn: 1.565 ± 0.038	1.336TyrPro: 1.336 ± 0.03	1.388TyrGln: 1.388 ± 0.038	1.537TyrArg: 1.537 ± 0.029	2.075TyrSer: 2.075 ± 0.04	1.806TyrThr: 1.806 ± 0.038	2.107TyrVal: 2.107 ± 0.038	0.375TyrTrp: 0.375 ± 0.016	1.287TyrTyr: 1.287 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4754 proteins (1424518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---