Amino acid dipepetide frequency for Actinopolymorpha singaporensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.381AlaAla: 19.381 ± 0.143	1.02AlaCys: 1.02 ± 0.027	8.68AlaAsp: 8.68 ± 0.067	8.275AlaGlu: 8.275 ± 0.075	3.666AlaPhe: 3.666 ± 0.05	13.946AlaGly: 13.946 ± 0.105	2.546AlaHis: 2.546 ± 0.042	3.695AlaIle: 3.695 ± 0.048	2.486AlaLys: 2.486 ± 0.045	12.612AlaLeu: 12.612 ± 0.104	2.49AlaMet: 2.49 ± 0.039	2.151AlaAsn: 2.151 ± 0.032	6.221AlaPro: 6.221 ± 0.065	3.568AlaGln: 3.568 ± 0.045	10.655AlaArg: 10.655 ± 0.102	5.781AlaSer: 5.781 ± 0.068	7.288AlaThr: 7.288 ± 0.074	11.763AlaVal: 11.763 ± 0.099	1.952AlaTrp: 1.952 ± 0.033	2.836AlaTyr: 2.836 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.947CysAla: 0.947 ± 0.025	0.094CysCys: 0.094 ± 0.007	0.48CysAsp: 0.48 ± 0.015	0.419CysGlu: 0.419 ± 0.016	0.223CysPhe: 0.223 ± 0.011	0.896CysGly: 0.896 ± 0.022	0.241CysHis: 0.241 ± 0.012	0.145CysIle: 0.145 ± 0.009	0.087CysLys: 0.087 ± 0.007	0.722CysLeu: 0.722 ± 0.019	0.116CysMet: 0.116 ± 0.007	0.122CysAsn: 0.122 ± 0.009	0.523CysPro: 0.523 ± 0.017	0.175CysGln: 0.175 ± 0.009	0.647CysArg: 0.647 ± 0.022	0.391CysSer: 0.391 ± 0.015	0.463CysThr: 0.463 ± 0.017	0.73CysVal: 0.73 ± 0.023	0.146CysTrp: 0.146 ± 0.01	0.191CysTyr: 0.191 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.312AspAla: 7.312 ± 0.062	0.391AspCys: 0.391 ± 0.015	3.922AspAsp: 3.922 ± 0.065	3.861AspGlu: 3.861 ± 0.065	1.685AspPhe: 1.685 ± 0.033	6.139AspGly: 6.139 ± 0.065	1.534AspHis: 1.534 ± 0.032	1.628AspIle: 1.628 ± 0.033	1.013AspLys: 1.013 ± 0.028	7.171AspLeu: 7.171 ± 0.068	0.715AspMet: 0.715 ± 0.02	0.997AspAsn: 0.997 ± 0.029	4.837AspPro: 4.837 ± 0.053	1.956AspGln: 1.956 ± 0.035	5.51AspArg: 5.51 ± 0.058	2.532AspSer: 2.532 ± 0.038	2.865AspThr: 2.865 ± 0.045	5.7AspVal: 5.7 ± 0.058	1.014AspTrp: 1.014 ± 0.023	1.229AspTyr: 1.229 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.433GluAla: 6.433 ± 0.069	0.328GluCys: 0.328 ± 0.014	2.678GluAsp: 2.678 ± 0.048	3.219GluGlu: 3.219 ± 0.054	1.602GluPhe: 1.602 ± 0.03	3.842GluGly: 3.842 ± 0.049	1.508GluHis: 1.508 ± 0.033	2.061GluIle: 2.061 ± 0.035	1.141GluLys: 1.141 ± 0.031	6.233GluLeu: 6.233 ± 0.063	0.776GluMet: 0.776 ± 0.02	0.884GluAsn: 0.884 ± 0.027	3.691GluPro: 3.691 ± 0.045	2.157GluGln: 2.157 ± 0.034	5.695GluArg: 5.695 ± 0.067	2.511GluSer: 2.511 ± 0.039	2.585GluThr: 2.585 ± 0.04	5.026GluVal: 5.026 ± 0.057	0.829GluTrp: 0.829 ± 0.024	1.168GluTyr: 1.168 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.799PheAla: 3.799 ± 0.053	0.285PheCys: 0.285 ± 0.013	2.105PheAsp: 2.105 ± 0.036	1.445PheGlu: 1.445 ± 0.029	0.945PhePhe: 0.945 ± 0.028	3.23PheGly: 3.23 ± 0.05	0.646PheHis: 0.646 ± 0.017	0.58PheIle: 0.58 ± 0.019	0.376PheLys: 0.376 ± 0.016	2.701PheLeu: 2.701 ± 0.047	0.373PheMet: 0.373 ± 0.016	0.561PheAsn: 0.561 ± 0.017	1.405PhePro: 1.405 ± 0.028	0.682PheGln: 0.682 ± 0.02	2.016PheArg: 2.016 ± 0.039	1.31PheSer: 1.31 ± 0.027	1.907PheThr: 1.907 ± 0.036	2.817PheVal: 2.817 ± 0.041	0.493PheTrp: 0.493 ± 0.016	0.647PheTyr: 0.647 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.468GlyAla: 10.468 ± 0.086	0.877GlyCys: 0.877 ± 0.022	5.206GlyAsp: 5.206 ± 0.057	5.09GlyGlu: 5.09 ± 0.062	2.897GlyPhe: 2.897 ± 0.04	8.651GlyGly: 8.651 ± 0.087	2.264GlyHis: 2.264 ± 0.04	3.284GlyIle: 3.284 ± 0.049	2.161GlyLys: 2.161 ± 0.043	9.272GlyLeu: 9.272 ± 0.083	1.961GlyMet: 1.961 ± 0.034	1.754GlyAsn: 1.754 ± 0.03	5.286GlyPro: 5.286 ± 0.048	2.785GlyGln: 2.785 ± 0.041	8.385GlyArg: 8.385 ± 0.079	5.585GlySer: 5.585 ± 0.065	5.944GlyThr: 5.944 ± 0.059	7.983GlyVal: 7.983 ± 0.072	1.923GlyTrp: 1.923 ± 0.034	2.321GlyTyr: 2.321 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.575HisAla: 2.575 ± 0.042	0.208HisCys: 0.208 ± 0.009	1.43HisAsp: 1.43 ± 0.027	1.177HisGlu: 1.177 ± 0.027	0.617HisPhe: 0.617 ± 0.018	2.224HisGly: 2.224 ± 0.035	0.735HisHis: 0.735 ± 0.022	0.547HisIle: 0.547 ± 0.018	0.322HisLys: 0.322 ± 0.014	2.597HisLeu: 2.597 ± 0.042	0.272HisMet: 0.272 ± 0.012	0.422HisAsn: 0.422 ± 0.016	1.786HisPro: 1.786 ± 0.038	0.71HisGln: 0.71 ± 0.022	2.057HisArg: 2.057 ± 0.033	0.942HisSer: 0.942 ± 0.023	1.16HisThr: 1.16 ± 0.024	1.966HisVal: 1.966 ± 0.035	0.385HisTrp: 0.385 ± 0.016	0.496HisTyr: 0.496 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.206IleAla: 4.206 ± 0.054	0.294IleCys: 0.294 ± 0.012	2.131IleAsp: 2.131 ± 0.031	1.804IleGlu: 1.804 ± 0.035	0.827IlePhe: 0.827 ± 0.023	3.279IleGly: 3.279 ± 0.053	0.611IleHis: 0.611 ± 0.018	0.848IleIle: 0.848 ± 0.026	0.523IleLys: 0.523 ± 0.017	2.616IleLeu: 2.616 ± 0.045	0.395IleMet: 0.395 ± 0.016	0.621IleAsn: 0.621 ± 0.021	1.814IlePro: 1.814 ± 0.035	0.7IleGln: 0.7 ± 0.019	2.408IleArg: 2.408 ± 0.029	1.568IleSer: 1.568 ± 0.029	1.747IleThr: 1.747 ± 0.028	2.866IleVal: 2.866 ± 0.046	0.379IleTrp: 0.379 ± 0.015	0.627IleTyr: 0.627 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.306LysAla: 2.306 ± 0.047	0.094LysCys: 0.094 ± 0.007	0.985LysAsp: 0.985 ± 0.027	0.894LysGlu: 0.894 ± 0.025	0.46LysPhe: 0.46 ± 0.016	1.45LysGly: 1.45 ± 0.038	0.373LysHis: 0.373 ± 0.016	0.673LysIle: 0.673 ± 0.022	0.587LysLys: 0.587 ± 0.034	1.83LysLeu: 1.83 ± 0.037	0.304LysMet: 0.304 ± 0.013	0.419LysAsn: 0.419 ± 0.018	1.3LysPro: 1.3 ± 0.034	0.612LysGln: 0.612 ± 0.02	1.241LysArg: 1.241 ± 0.03	0.94LysSer: 0.94 ± 0.025	0.983LysThr: 0.983 ± 0.026	1.81LysVal: 1.81 ± 0.035	0.239LysTrp: 0.239 ± 0.012	0.473LysTyr: 0.473 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.755LeuAla: 15.755 ± 0.128	0.786LeuCys: 0.786 ± 0.022	6.793LeuAsp: 6.793 ± 0.062	4.471LeuGlu: 4.471 ± 0.054	2.47LeuPhe: 2.47 ± 0.045	9.442LeuGly: 9.442 ± 0.08	2.162LeuHis: 2.162 ± 0.035	2.668LeuIle: 2.668 ± 0.044	1.346LeuLys: 1.346 ± 0.035	10.698LeuLeu: 10.698 ± 0.108	1.414LeuMet: 1.414 ± 0.025	1.594LeuAsn: 1.594 ± 0.036	6.236LeuPro: 6.236 ± 0.06	2.086LeuGln: 2.086 ± 0.033	8.894LeuArg: 8.894 ± 0.084	5.088LeuSer: 5.088 ± 0.052	6.479LeuThr: 6.479 ± 0.062	10.093LeuVal: 10.093 ± 0.097	1.313LeuTrp: 1.313 ± 0.027	1.737LeuTyr: 1.737 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.097MetAla: 2.097 ± 0.031	0.135MetCys: 0.135 ± 0.009	0.789MetAsp: 0.789 ± 0.02	0.616MetGlu: 0.616 ± 0.019	0.506MetPhe: 0.506 ± 0.016	1.215MetGly: 1.215 ± 0.027	0.31MetHis: 0.31 ± 0.013	0.608MetIle: 0.608 ± 0.02	0.336MetLys: 0.336 ± 0.013	1.722MetLeu: 1.722 ± 0.029	0.265MetMet: 0.265 ± 0.012	0.414MetAsn: 0.414 ± 0.015	1.128MetPro: 1.128 ± 0.022	0.392MetGln: 0.392 ± 0.015	1.52MetArg: 1.52 ± 0.032	1.339MetSer: 1.339 ± 0.025	1.431MetThr: 1.431 ± 0.027	1.424MetVal: 1.424 ± 0.025	0.221MetTrp: 0.221 ± 0.01	0.351MetTyr: 0.351 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.265AsnAla: 2.265 ± 0.036	0.14AsnCys: 0.14 ± 0.009	1.031AsnAsp: 1.031 ± 0.026	0.759AsnGlu: 0.759 ± 0.021	0.53AsnPhe: 0.53 ± 0.021	1.79AsnGly: 1.79 ± 0.03	0.431AsnHis: 0.431 ± 0.016	0.572AsnIle: 0.572 ± 0.021	0.354AsnLys: 0.354 ± 0.018	1.854AsnLeu: 1.854 ± 0.035	0.24AsnMet: 0.24 ± 0.012	0.388AsnAsn: 0.388 ± 0.015	1.492AsnPro: 1.492 ± 0.034	0.546AsnGln: 0.546 ± 0.018	1.328AsnArg: 1.328 ± 0.028	0.871AsnSer: 0.871 ± 0.022	1.002AsnThr: 1.002 ± 0.025	1.501AsnVal: 1.501 ± 0.028	0.313AsnTrp: 0.313 ± 0.015	0.458AsnTyr: 0.458 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.512ProAla: 8.512 ± 0.08	0.328ProCys: 0.328 ± 0.015	4.963ProAsp: 4.963 ± 0.061	4.065ProGlu: 4.065 ± 0.054	1.567ProPhe: 1.567 ± 0.028	6.639ProGly: 6.639 ± 0.064	1.387ProHis: 1.387 ± 0.032	1.561ProIle: 1.561 ± 0.029	1.133ProLys: 1.133 ± 0.029	5.07ProLeu: 5.07 ± 0.061	1.043ProMet: 1.043 ± 0.025	1.162ProAsn: 1.162 ± 0.026	3.71ProPro: 3.71 ± 0.065	1.437ProGln: 1.437 ± 0.026	4.365ProArg: 4.365 ± 0.049	3.269ProSer: 3.269 ± 0.045	3.85ProThr: 3.85 ± 0.055	5.45ProVal: 5.45 ± 0.06	0.984ProTrp: 0.984 ± 0.023	1.391ProTyr: 1.391 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.813GlnAla: 3.813 ± 0.047	0.169GlnCys: 0.169 ± 0.009	1.258GlnAsp: 1.258 ± 0.029	1.295GlnGlu: 1.295 ± 0.028	0.675GlnPhe: 0.675 ± 0.019	2.038GlnGly: 2.038 ± 0.034	0.643GlnHis: 0.643 ± 0.02	1.066GlnIle: 1.066 ± 0.027	0.537GlnLys: 0.537 ± 0.018	2.988GlnLeu: 2.988 ± 0.041	0.47GlnMet: 0.47 ± 0.016	0.499GlnAsn: 0.499 ± 0.018	1.835GlnPro: 1.835 ± 0.037	1.031GlnGln: 1.031 ± 0.029	2.45GlnArg: 2.45 ± 0.039	1.182GlnSer: 1.182 ± 0.024	1.447GlnThr: 1.447 ± 0.026	2.878GlnVal: 2.878 ± 0.039	0.466GlnTrp: 0.466 ± 0.017	0.574GlnTyr: 0.574 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.079ArgAla: 10.079 ± 0.097	0.679ArgCys: 0.679 ± 0.02	4.74ArgAsp: 4.74 ± 0.06	4.652ArgGlu: 4.652 ± 0.065	2.479ArgPhe: 2.479 ± 0.04	6.189ArgGly: 6.189 ± 0.059	2.103ArgHis: 2.103 ± 0.037	3.323ArgIle: 3.323 ± 0.041	1.472ArgLys: 1.472 ± 0.033	9.264ArgLeu: 9.264 ± 0.097	1.937ArgMet: 1.937 ± 0.031	1.429ArgAsn: 1.429 ± 0.027	5.519ArgPro: 5.519 ± 0.065	2.609ArgGln: 2.609 ± 0.036	9.056ArgArg: 9.056 ± 0.098	4.709ArgSer: 4.709 ± 0.059	5.369ArgThr: 5.369 ± 0.056	6.594ArgVal: 6.594 ± 0.073	1.675ArgTrp: 1.675 ± 0.03	1.925ArgTyr: 1.925 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.678SerAla: 6.678 ± 0.072	0.344SerCys: 0.344 ± 0.014	2.624SerAsp: 2.624 ± 0.045	2.329SerGlu: 2.329 ± 0.036	1.559SerPhe: 1.559 ± 0.029	5.842SerGly: 5.842 ± 0.062	1.03SerHis: 1.03 ± 0.021	1.472SerIle: 1.472 ± 0.032	0.868SerLys: 0.868 ± 0.027	4.625SerLeu: 4.625 ± 0.053	1.105SerMet: 1.105 ± 0.026	0.904SerAsn: 0.904 ± 0.021	3.4SerPro: 3.4 ± 0.046	1.298SerGln: 1.298 ± 0.03	4.026SerArg: 4.026 ± 0.044	2.883SerSer: 2.883 ± 0.044	3.264SerThr: 3.264 ± 0.043	4.387SerVal: 4.387 ± 0.05	0.99SerTrp: 0.99 ± 0.025	1.287SerTyr: 1.287 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.528ThrAla: 7.528 ± 0.068	0.49ThrCys: 0.49 ± 0.016	3.565ThrAsp: 3.565 ± 0.05	2.94ThrGlu: 2.94 ± 0.036	1.836ThrPhe: 1.836 ± 0.032	6.227ThrGly: 6.227 ± 0.063	1.207ThrHis: 1.207 ± 0.027	1.837ThrIle: 1.837 ± 0.032	1.108ThrLys: 1.108 ± 0.029	5.537ThrLeu: 5.537 ± 0.058	1.052ThrMet: 1.052 ± 0.025	1.108ThrAsn: 1.108 ± 0.025	4.155ThrPro: 4.155 ± 0.052	1.345ThrGln: 1.345 ± 0.027	4.139ThrArg: 4.139 ± 0.047	3.418ThrSer: 3.418 ± 0.051	3.923ThrThr: 3.923 ± 0.052	5.613ThrVal: 5.613 ± 0.06	1.054ThrTrp: 1.054 ± 0.026	1.432ThrTyr: 1.432 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	12.132ValAla: 12.132 ± 0.088	0.777ValCys: 0.777 ± 0.019	6.008ValAsp: 6.008 ± 0.064	5.184ValGlu: 5.184 ± 0.061	2.524ValPhe: 2.524 ± 0.038	7.857ValGly: 7.857 ± 0.07	2.022ValHis: 2.022 ± 0.036	2.663ValIle: 2.663 ± 0.042	1.413ValLys: 1.413 ± 0.032	9.82ValLeu: 9.82 ± 0.085	1.351ValMet: 1.351 ± 0.027	1.612ValAsn: 1.612 ± 0.03	5.482ValPro: 5.482 ± 0.057	1.946ValGln: 1.946 ± 0.032	8.104ValArg: 8.104 ± 0.073	4.544ValSer: 4.544 ± 0.051	5.674ValThr: 5.674 ± 0.063	9.9ValVal: 9.9 ± 0.097	1.216ValTrp: 1.216 ± 0.028	1.574ValTyr: 1.574 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.738TrpAla: 1.738 ± 0.033	0.152TrpCys: 0.152 ± 0.009	0.873TrpAsp: 0.873 ± 0.022	0.75TrpGlu: 0.75 ± 0.022	0.539TrpPhe: 0.539 ± 0.017	1.087TrpGly: 1.087 ± 0.026	0.422TrpHis: 0.422 ± 0.015	0.564TrpIle: 0.564 ± 0.02	0.386TrpLys: 0.386 ± 0.017	1.932TrpLeu: 1.932 ± 0.034	0.314TrpMet: 0.314 ± 0.014	0.428TrpAsn: 0.428 ± 0.017	0.912TrpPro: 0.912 ± 0.024	0.632TrpGln: 0.632 ± 0.017	1.498TrpArg: 1.498 ± 0.029	1.083TrpSer: 1.083 ± 0.024	1.049TrpThr: 1.049 ± 0.024	1.243TrpVal: 1.243 ± 0.027	0.455TrpTrp: 0.455 ± 0.016	0.401TrpTyr: 0.401 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.989TyrAla: 2.989 ± 0.037	0.166TyrCys: 0.166 ± 0.009	1.752TyrAsp: 1.752 ± 0.032	1.122TyrGlu: 1.122 ± 0.027	0.717TyrPhe: 0.717 ± 0.02	2.116TyrGly: 2.116 ± 0.034	0.456TyrHis: 0.456 ± 0.016	0.469TyrIle: 0.469 ± 0.015	0.322TyrLys: 0.322 ± 0.014	2.263TyrLeu: 2.263 ± 0.035	0.223TyrMet: 0.223 ± 0.011	0.395TyrAsn: 0.395 ± 0.017	1.153TyrPro: 1.153 ± 0.028	0.646TyrGln: 0.646 ± 0.019	1.808TyrArg: 1.808 ± 0.031	0.968TyrSer: 0.968 ± 0.024	1.086TyrThr: 1.086 ± 0.025	2.058TyrVal: 2.058 ± 0.037	0.411TyrTrp: 0.411 ± 0.014	0.537TyrTyr: 0.537 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5596 proteins (1865002 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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