Amino acid dipepetide frequency for Glaciihabitans tibetensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.588AlaAla: 19.588 ± 0.187	0.571AlaCys: 0.571 ± 0.025	7.584AlaAsp: 7.584 ± 0.089	7.545AlaGlu: 7.545 ± 0.1	3.743AlaPhe: 3.743 ± 0.059	11.846AlaGly: 11.846 ± 0.13	2.209AlaHis: 2.209 ± 0.05	6.247AlaIle: 6.247 ± 0.089	2.711AlaLys: 2.711 ± 0.076	13.951AlaLeu: 13.951 ± 0.14	2.582AlaMet: 2.582 ± 0.048	2.772AlaAsn: 2.772 ± 0.052	6.386AlaPro: 6.386 ± 0.1	3.792AlaGln: 3.792 ± 0.063	8.096AlaArg: 8.096 ± 0.104	8.361AlaSer: 8.361 ± 0.095	8.272AlaThr: 8.272 ± 0.104	11.337AlaVal: 11.337 ± 0.106	1.617AlaTrp: 1.617 ± 0.036	2.223AlaTyr: 2.223 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.616CysAla: 0.616 ± 0.028	0.041CysCys: 0.041 ± 0.007	0.289CysAsp: 0.289 ± 0.018	0.252CysGlu: 0.252 ± 0.018	0.159CysPhe: 0.159 ± 0.012	0.571CysGly: 0.571 ± 0.027	0.097CysHis: 0.097 ± 0.009	0.189CysIle: 0.189 ± 0.013	0.069CysLys: 0.069 ± 0.008	0.449CysLeu: 0.449 ± 0.022	0.071CysMet: 0.071 ± 0.008	0.103CysAsn: 0.103 ± 0.01	0.252CysPro: 0.252 ± 0.015	0.094CysGln: 0.094 ± 0.01	0.278CysArg: 0.278 ± 0.016	0.358CysSer: 0.358 ± 0.017	0.303CysThr: 0.303 ± 0.016	0.456CysVal: 0.456 ± 0.019	0.083CysTrp: 0.083 ± 0.015	0.111CysTyr: 0.111 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.817AspAla: 7.817 ± 0.09	0.249AspCys: 0.249 ± 0.014	3.77AspAsp: 3.77 ± 0.08	3.81AspGlu: 3.81 ± 0.063	1.876AspPhe: 1.876 ± 0.045	5.403AspGly: 5.403 ± 0.073	1.142AspHis: 1.142 ± 0.033	2.622AspIle: 2.622 ± 0.049	1.038AspLys: 1.038 ± 0.035	5.91AspLeu: 5.91 ± 0.072	0.737AspMet: 0.737 ± 0.028	1.277AspAsn: 1.277 ± 0.034	3.81AspPro: 3.81 ± 0.058	1.607AspGln: 1.607 ± 0.041	4.07AspArg: 4.07 ± 0.069	3.401AspSer: 3.401 ± 0.063	3.131AspThr: 3.131 ± 0.063	5.152AspVal: 5.152 ± 0.072	0.862AspTrp: 0.862 ± 0.034	1.333AspTyr: 1.333 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.458GluAla: 6.458 ± 0.089	0.232GluCys: 0.232 ± 0.013	2.564GluAsp: 2.564 ± 0.057	2.789GluGlu: 2.789 ± 0.054	1.906GluPhe: 1.906 ± 0.04	3.678GluGly: 3.678 ± 0.061	1.303GluHis: 1.303 ± 0.036	2.789GluIle: 2.789 ± 0.056	1.443GluLys: 1.443 ± 0.039	6.557GluLeu: 6.557 ± 0.087	1.044GluMet: 1.044 ± 0.032	1.455GluAsn: 1.455 ± 0.043	2.87GluPro: 2.87 ± 0.06	2.094GluGln: 2.094 ± 0.039	4.277GluArg: 4.277 ± 0.071	3.366GluSer: 3.366 ± 0.059	3.101GluThr: 3.101 ± 0.059	4.354GluVal: 4.354 ± 0.075	0.797GluTrp: 0.797 ± 0.028	1.202GluTyr: 1.202 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.428PheAla: 4.428 ± 0.065	0.19PheCys: 0.19 ± 0.014	2.368PheAsp: 2.368 ± 0.043	1.85PheGlu: 1.85 ± 0.043	1.133PhePhe: 1.133 ± 0.037	3.551PheGly: 3.551 ± 0.058	0.546PheHis: 0.546 ± 0.021	1.296PheIle: 1.296 ± 0.032	0.473PheLys: 0.473 ± 0.024	2.85PheLeu: 2.85 ± 0.056	0.465PheMet: 0.465 ± 0.019	0.733PheAsn: 0.733 ± 0.03	1.444PhePro: 1.444 ± 0.037	0.767PheGln: 0.767 ± 0.023	1.73PheArg: 1.73 ± 0.037	2.145PheSer: 2.145 ± 0.042	2.26PheThr: 2.26 ± 0.047	3.038PheVal: 3.038 ± 0.049	0.49PheTrp: 0.49 ± 0.02	0.753PheTyr: 0.753 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.28GlyAla: 10.28 ± 0.114	0.561GlyCys: 0.561 ± 0.022	4.753GlyAsp: 4.753 ± 0.079	4.642GlyGlu: 4.642 ± 0.076	3.282GlyPhe: 3.282 ± 0.062	7.246GlyGly: 7.246 ± 0.098	1.71GlyHis: 1.71 ± 0.041	4.828GlyIle: 4.828 ± 0.066	2.17GlyLys: 2.17 ± 0.057	8.52GlyLeu: 8.52 ± 0.103	1.785GlyMet: 1.785 ± 0.044	2.046GlyAsn: 2.046 ± 0.056	3.494GlyPro: 3.494 ± 0.063	2.502GlyGln: 2.502 ± 0.052	5.438GlyArg: 5.438 ± 0.073	6.208GlySer: 6.208 ± 0.1	5.901GlyThr: 5.901 ± 0.094	7.571GlyVal: 7.571 ± 0.092	1.493GlyTrp: 1.493 ± 0.043	2.27GlyTyr: 2.27 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.047HisAla: 2.047 ± 0.051	0.109HisCys: 0.109 ± 0.009	1.108HisAsp: 1.108 ± 0.032	0.939HisGlu: 0.939 ± 0.033	0.585HisPhe: 0.585 ± 0.022	1.792HisGly: 1.792 ± 0.042	0.518HisHis: 0.518 ± 0.021	0.77HisIle: 0.77 ± 0.027	0.307HisLys: 0.307 ± 0.018	1.915HisLeu: 1.915 ± 0.05	0.304HisMet: 0.304 ± 0.02	0.492HisAsn: 0.492 ± 0.021	1.368HisPro: 1.368 ± 0.04	0.539HisGln: 0.539 ± 0.027	1.42HisArg: 1.42 ± 0.037	1.207HisSer: 1.207 ± 0.032	1.088HisThr: 1.088 ± 0.034	1.446HisVal: 1.446 ± 0.037	0.266HisTrp: 0.266 ± 0.016	0.426HisTyr: 0.426 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	7.213IleAla: 7.213 ± 0.093	0.265IleCys: 0.265 ± 0.017	3.352IleAsp: 3.352 ± 0.058	2.908IleGlu: 2.908 ± 0.054	1.42IlePhe: 1.42 ± 0.036	4.45IleGly: 4.45 ± 0.068	0.744IleHis: 0.744 ± 0.025	2.068IleIle: 2.068 ± 0.053	0.872IleLys: 0.872 ± 0.032	4.122IleLeu: 4.122 ± 0.072	0.618IleMet: 0.618 ± 0.024	1.182IleAsn: 1.182 ± 0.033	2.716IlePro: 2.716 ± 0.052	1.044IleGln: 1.044 ± 0.03	2.653IleArg: 2.653 ± 0.053	2.93IleSer: 2.93 ± 0.054	3.311IleThr: 3.311 ± 0.062	4.783IleVal: 4.783 ± 0.067	0.553IleTrp: 0.553 ± 0.027	0.881IleTyr: 0.881 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.386LysAla: 2.386 ± 0.054	0.053LysCys: 0.053 ± 0.006	1.103LysAsp: 1.103 ± 0.039	0.946LysGlu: 0.946 ± 0.038	0.618LysPhe: 0.618 ± 0.025	1.424LysGly: 1.424 ± 0.045	0.461LysHis: 0.461 ± 0.021	1.042LysIle: 1.042 ± 0.039	0.804LysLys: 0.804 ± 0.032	2.056LysLeu: 2.056 ± 0.05	0.438LysMet: 0.438 ± 0.02	0.691LysAsn: 0.691 ± 0.025	1.202LysPro: 1.202 ± 0.037	0.699LysGln: 0.699 ± 0.027	1.58LysArg: 1.58 ± 0.043	1.369LysSer: 1.369 ± 0.042	1.401LysThr: 1.401 ± 0.042	1.686LysVal: 1.686 ± 0.041	0.243LysTrp: 0.243 ± 0.014	0.539LysTyr: 0.539 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.386LeuAla: 14.386 ± 0.132	0.482LeuCys: 0.482 ± 0.021	6.334LeuAsp: 6.334 ± 0.088	5.151LeuGlu: 5.151 ± 0.08	3.1LeuPhe: 3.1 ± 0.061	9.235LeuGly: 9.235 ± 0.099	1.784LeuHis: 1.784 ± 0.04	4.673LeuIle: 4.673 ± 0.07	1.933LeuLys: 1.933 ± 0.051	10.401LeuLeu: 10.401 ± 0.156	1.61LeuMet: 1.61 ± 0.038	2.121LeuAsn: 2.121 ± 0.043	5.51LeuPro: 5.51 ± 0.083	2.484LeuGln: 2.484 ± 0.045	6.89LeuArg: 6.89 ± 0.102	6.528LeuSer: 6.528 ± 0.09	6.465LeuThr: 6.465 ± 0.073	9.377LeuVal: 9.377 ± 0.106	1.207LeuTrp: 1.207 ± 0.032	1.723LeuTyr: 1.723 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.088MetAla: 2.088 ± 0.046	0.098MetCys: 0.098 ± 0.01	0.806MetAsp: 0.806 ± 0.022	0.664MetGlu: 0.664 ± 0.024	0.53MetPhe: 0.53 ± 0.021	1.213MetGly: 1.213 ± 0.034	0.333MetHis: 0.333 ± 0.018	0.868MetIle: 0.868 ± 0.026	0.466MetLys: 0.466 ± 0.021	1.801MetLeu: 1.801 ± 0.042	0.311MetMet: 0.311 ± 0.018	0.576MetAsn: 0.576 ± 0.026	1.06MetPro: 1.06 ± 0.032	0.518MetGln: 0.518 ± 0.024	1.232MetArg: 1.232 ± 0.032	1.503MetSer: 1.503 ± 0.036	1.653MetThr: 1.653 ± 0.041	1.495MetVal: 1.495 ± 0.038	0.183MetTrp: 0.183 ± 0.014	0.283MetTyr: 0.283 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.908AsnAla: 2.908 ± 0.06	0.13AsnCys: 0.13 ± 0.011	1.405AsnAsp: 1.405 ± 0.04	1.227AsnGlu: 1.227 ± 0.036	0.885AsnPhe: 0.885 ± 0.036	2.24AsnGly: 2.24 ± 0.065	0.443AsnHis: 0.443 ± 0.022	1.016AsnIle: 1.016 ± 0.032	0.5AsnLys: 0.5 ± 0.02	2.253AsnLeu: 2.253 ± 0.045	0.376AsnMet: 0.376 ± 0.02	0.63AsnAsn: 0.63 ± 0.028	1.808AsnPro: 1.808 ± 0.046	0.648AsnGln: 0.648 ± 0.032	1.446AsnArg: 1.446 ± 0.04	1.429AsnSer: 1.429 ± 0.037	1.408AsnThr: 1.408 ± 0.043	1.889AsnVal: 1.889 ± 0.042	0.368AsnTrp: 0.368 ± 0.02	0.609AsnTyr: 0.609 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.25ProAla: 7.25 ± 0.109	0.162ProCys: 0.162 ± 0.013	3.516ProAsp: 3.516 ± 0.056	3.589ProGlu: 3.589 ± 0.068	1.699ProPhe: 1.699 ± 0.036	4.797ProGly: 4.797 ± 0.067	1.019ProHis: 1.019 ± 0.033	2.299ProIle: 2.299 ± 0.046	1.017ProLys: 1.017 ± 0.032	4.81ProLeu: 4.81 ± 0.067	0.875ProMet: 0.875 ± 0.029	1.232ProAsn: 1.232 ± 0.032	2.386ProPro: 2.386 ± 0.071	1.534ProGln: 1.534 ± 0.04	3.165ProArg: 3.165 ± 0.064	3.519ProSer: 3.519 ± 0.061	3.926ProThr: 3.926 ± 0.07	4.774ProVal: 4.774 ± 0.073	0.757ProTrp: 0.757 ± 0.027	1.041ProTyr: 1.041 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.203GlnAla: 3.203 ± 0.065	0.128GlnCys: 0.128 ± 0.012	1.23GlnAsp: 1.23 ± 0.034	1.167GlnGlu: 1.167 ± 0.029	0.98GlnPhe: 0.98 ± 0.032	1.832GlnGly: 1.832 ± 0.043	0.631GlnHis: 0.631 ± 0.022	1.53GlnIle: 1.53 ± 0.036	0.744GlnLys: 0.744 ± 0.028	3.456GlnLeu: 3.456 ± 0.061	0.556GlnMet: 0.556 ± 0.021	0.743GlnAsn: 0.743 ± 0.035	1.517GlnPro: 1.517 ± 0.038	1.154GlnGln: 1.154 ± 0.037	2.225GlnArg: 2.225 ± 0.051	1.765GlnSer: 1.765 ± 0.046	1.582GlnThr: 1.582 ± 0.037	2.319GlnVal: 2.319 ± 0.052	0.48GlnTrp: 0.48 ± 0.021	0.68GlnTyr: 0.68 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.927ArgAla: 7.927 ± 0.094	0.264ArgCys: 0.264 ± 0.015	3.843ArgAsp: 3.843 ± 0.064	3.774ArgGlu: 3.774 ± 0.067	2.278ArgPhe: 2.278 ± 0.052	4.864ArgGly: 4.864 ± 0.073	1.285ArgHis: 1.285 ± 0.039	3.367ArgIle: 3.367 ± 0.052	1.393ArgLys: 1.393 ± 0.04	6.59ArgLeu: 6.59 ± 0.093	1.53ArgMet: 1.53 ± 0.038	1.459ArgAsn: 1.459 ± 0.039	3.223ArgPro: 3.223 ± 0.063	2.0ArgGln: 2.0 ± 0.05	5.272ArgArg: 5.272 ± 0.083	4.325ArgSer: 4.325 ± 0.07	3.924ArgThr: 3.924 ± 0.063	5.689ArgVal: 5.689 ± 0.083	1.035ArgTrp: 1.035 ± 0.035	1.545ArgTyr: 1.545 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	8.77SerAla: 8.77 ± 0.102	0.305SerCys: 0.305 ± 0.017	3.759SerAsp: 3.759 ± 0.065	3.244SerGlu: 3.244 ± 0.049	2.168SerPhe: 2.168 ± 0.049	6.377SerGly: 6.377 ± 0.089	1.121SerHis: 1.121 ± 0.033	3.102SerIle: 3.102 ± 0.059	1.243SerLys: 1.243 ± 0.038	6.096SerLeu: 6.096 ± 0.084	1.203SerMet: 1.203 ± 0.035	1.493SerAsn: 1.493 ± 0.043	3.603SerPro: 3.603 ± 0.065	1.622SerGln: 1.622 ± 0.038	4.082SerArg: 4.082 ± 0.067	4.48SerSer: 4.48 ± 0.072	4.491SerThr: 4.491 ± 0.071	5.76SerVal: 5.76 ± 0.085	1.007SerTrp: 1.007 ± 0.033	1.405SerTyr: 1.405 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	8.361ThrAla: 8.361 ± 0.119	0.295ThrCys: 0.295 ± 0.019	3.736ThrAsp: 3.736 ± 0.068	3.429ThrGlu: 3.429 ± 0.054	2.014ThrPhe: 2.014 ± 0.045	5.906ThrGly: 5.906 ± 0.098	1.141ThrHis: 1.141 ± 0.037	3.245ThrIle: 3.245 ± 0.053	1.251ThrLys: 1.251 ± 0.041	6.348ThrLeu: 6.348 ± 0.069	1.041ThrMet: 1.041 ± 0.031	1.54ThrAsn: 1.54 ± 0.038	4.311ThrPro: 4.311 ± 0.076	1.567ThrGln: 1.567 ± 0.034	3.81ThrArg: 3.81 ± 0.056	4.254ThrSer: 4.254 ± 0.072	4.581ThrThr: 4.581 ± 0.084	6.28ThrVal: 6.28 ± 0.099	0.836ThrTrp: 0.836 ± 0.028	1.216ThrTyr: 1.216 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	11.79ValAla: 11.79 ± 0.114	0.474ValCys: 0.474 ± 0.022	5.532ValAsp: 5.532 ± 0.079	4.593ValGlu: 4.593 ± 0.067	2.829ValPhe: 2.829 ± 0.056	7.401ValGly: 7.401 ± 0.084	1.587ValHis: 1.587 ± 0.045	4.613ValIle: 4.613 ± 0.074	1.597ValLys: 1.597 ± 0.04	9.347ValLeu: 9.347 ± 0.111	1.542ValMet: 1.542 ± 0.038	2.021ValAsn: 2.021 ± 0.049	4.634ValPro: 4.634 ± 0.072	2.147ValGln: 2.147 ± 0.044	5.423ValArg: 5.423 ± 0.079	5.82ValSer: 5.82 ± 0.086	6.154ValThr: 6.154 ± 0.096	8.96ValVal: 8.96 ± 0.121	1.063ValTrp: 1.063 ± 0.032	1.58ValTyr: 1.58 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.541TrpAla: 1.541 ± 0.038	0.087TrpCys: 0.087 ± 0.008	0.742TrpAsp: 0.742 ± 0.026	0.64TrpGlu: 0.64 ± 0.025	0.513TrpPhe: 0.513 ± 0.022	1.009TrpGly: 1.009 ± 0.033	0.271TrpHis: 0.271 ± 0.014	0.732TrpIle: 0.732 ± 0.025	0.348TrpLys: 0.348 ± 0.017	1.627TrpLeu: 1.627 ± 0.046	0.328TrpMet: 0.328 ± 0.018	0.465TrpAsn: 0.465 ± 0.022	0.649TrpPro: 0.649 ± 0.026	0.521TrpGln: 0.521 ± 0.024	1.031TrpArg: 1.031 ± 0.032	0.921TrpSer: 0.921 ± 0.032	0.884TrpThr: 0.884 ± 0.03	1.1TrpVal: 1.1 ± 0.028	0.327TrpTrp: 0.327 ± 0.019	0.264TrpTyr: 0.264 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.372TyrAla: 2.372 ± 0.048	0.146TyrCys: 0.146 ± 0.013	1.225TyrAsp: 1.225 ± 0.04	1.117TyrGlu: 1.117 ± 0.032	0.794TyrPhe: 0.794 ± 0.024	1.866TyrGly: 1.866 ± 0.046	0.298TyrHis: 0.298 ± 0.018	0.789TyrIle: 0.789 ± 0.026	0.365TyrLys: 0.365 ± 0.021	2.336TyrLeu: 2.336 ± 0.052	0.263TyrMet: 0.263 ± 0.016	0.589TyrAsn: 0.589 ± 0.029	1.124TyrPro: 1.124 ± 0.032	0.588TyrGln: 0.588 ± 0.026	1.469TyrArg: 1.469 ± 0.038	1.444TyrSer: 1.444 ± 0.041	1.326TyrThr: 1.326 ± 0.039	1.642TyrVal: 1.642 ± 0.042	0.333TyrTrp: 0.333 ± 0.019	0.502TyrTyr: 0.502 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3456 proteins (1121382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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