Amino acid dipepetide frequency for Staphylococcus virus 53

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.697AlaAla: 1.697 ± 0.525
0.354AlaCys: 0.354 ± 0.158
2.758AlaAsp: 2.758 ± 0.396
3.748AlaGlu: 3.748 ± 0.478
2.688AlaPhe: 2.688 ± 0.486
3.466AlaGly: 3.466 ± 0.632
1.273AlaHis: 1.273 ± 0.298
4.809AlaIle: 4.809 ± 1.088
4.88AlaLys: 4.88 ± 0.736
4.173AlaLeu: 4.173 ± 0.616
1.697AlaMet: 1.697 ± 0.41
3.748AlaAsn: 3.748 ± 0.59
1.556AlaPro: 1.556 ± 0.379
2.051AlaGln: 2.051 ± 0.406
2.405AlaArg: 2.405 ± 0.411
3.678AlaSer: 3.678 ± 0.578
3.89AlaThr: 3.89 ± 0.575
3.607AlaVal: 3.607 ± 0.605
0.849AlaTrp: 0.849 ± 0.26
2.475AlaTyr: 2.475 ± 0.354
0.0AlaXaa: 0.0 ± 0.0
Cys
0.141CysAla: 0.141 ± 0.102
0.0CysCys: 0.0 ± 0.0
0.212CysAsp: 0.212 ± 0.158
0.354CysGlu: 0.354 ± 0.161
0.424CysPhe: 0.424 ± 0.211
0.283CysGly: 0.283 ± 0.138
0.0CysHis: 0.0 ± 0.0
0.566CysIle: 0.566 ± 0.175
0.637CysLys: 0.637 ± 0.237
0.495CysLeu: 0.495 ± 0.203
0.141CysMet: 0.141 ± 0.101
0.424CysAsn: 0.424 ± 0.218
0.212CysPro: 0.212 ± 0.12
0.283CysGln: 0.283 ± 0.135
0.283CysArg: 0.283 ± 0.152
0.495CysSer: 0.495 ± 0.227
0.495CysThr: 0.495 ± 0.181
0.283CysVal: 0.283 ± 0.161
0.071CysTrp: 0.071 ± 0.054
0.283CysTyr: 0.283 ± 0.152
0.0CysXaa: 0.0 ± 0.0
Asp
3.253AspAla: 3.253 ± 0.557
0.424AspCys: 0.424 ± 0.177
4.597AspAsp: 4.597 ± 0.924
5.587AspGlu: 5.587 ± 0.918
3.607AspPhe: 3.607 ± 0.546
3.395AspGly: 3.395 ± 0.555
0.495AspHis: 0.495 ± 0.218
5.446AspIle: 5.446 ± 0.685
5.658AspLys: 5.658 ± 0.711
4.809AspLeu: 4.809 ± 0.674
2.051AspMet: 2.051 ± 0.481
4.102AspAsn: 4.102 ± 0.517
1.273AspPro: 1.273 ± 0.324
0.99AspGln: 0.99 ± 0.25
2.334AspArg: 2.334 ± 0.402
3.748AspSer: 3.748 ± 0.517
3.466AspThr: 3.466 ± 0.578
3.466AspVal: 3.466 ± 0.506
0.778AspTrp: 0.778 ± 0.199
2.263AspTyr: 2.263 ± 0.473
0.0AspXaa: 0.0 ± 0.0
Glu
5.092GluAla: 5.092 ± 0.702
0.566GluCys: 0.566 ± 0.202
3.395GluAsp: 3.395 ± 0.63
5.375GluGlu: 5.375 ± 0.834
3.466GluPhe: 3.466 ± 0.567
3.041GluGly: 3.041 ± 0.509
0.99GluHis: 0.99 ± 0.244
6.082GluIle: 6.082 ± 0.985
5.941GluLys: 5.941 ± 1.005
6.436GluLeu: 6.436 ± 0.723
2.263GluMet: 2.263 ± 0.437
4.88GluAsn: 4.88 ± 0.565
2.051GluPro: 2.051 ± 0.346
3.748GluGln: 3.748 ± 0.546
3.748GluArg: 3.748 ± 0.583
3.466GluSer: 3.466 ± 0.602
2.971GluThr: 2.971 ± 0.453
4.951GluVal: 4.951 ± 0.733
0.566GluTrp: 0.566 ± 0.194
5.092GluTyr: 5.092 ± 0.646
0.0GluXaa: 0.0 ± 0.0
Phe
1.91PheAla: 1.91 ± 0.283
0.354PheCys: 0.354 ± 0.145
3.183PheAsp: 3.183 ± 0.438
3.607PheGlu: 3.607 ± 0.514
1.556PhePhe: 1.556 ± 0.308
2.617PheGly: 2.617 ± 0.453
0.495PheHis: 0.495 ± 0.185
3.183PheIle: 3.183 ± 0.426
4.031PheLys: 4.031 ± 0.534
2.971PheLeu: 2.971 ± 0.372
1.132PheMet: 1.132 ± 0.248
3.466PheAsn: 3.466 ± 0.463
0.919PhePro: 0.919 ± 0.283
0.99PheGln: 0.99 ± 0.375
1.627PheArg: 1.627 ± 0.352
3.183PheSer: 3.183 ± 0.513
3.112PheThr: 3.112 ± 0.417
2.9PheVal: 2.9 ± 0.481
0.141PheTrp: 0.141 ± 0.093
1.98PheTyr: 1.98 ± 0.323
0.0PheXaa: 0.0 ± 0.0
Gly
2.829GlyAla: 2.829 ± 0.482
0.283GlyCys: 0.283 ± 0.143
3.536GlyAsp: 3.536 ± 0.428
3.466GlyGlu: 3.466 ± 0.528
2.122GlyPhe: 2.122 ± 0.453
2.829GlyGly: 2.829 ± 0.561
1.485GlyHis: 1.485 ± 0.442
4.244GlyIle: 4.244 ± 0.515
4.597GlyLys: 4.597 ± 0.577
5.304GlyLeu: 5.304 ± 0.607
1.485GlyMet: 1.485 ± 0.332
3.395GlyAsn: 3.395 ± 0.556
0.707GlyPro: 0.707 ± 0.311
1.768GlyGln: 1.768 ± 0.362
2.122GlyArg: 2.122 ± 0.361
2.475GlySer: 2.475 ± 0.483
3.395GlyThr: 3.395 ± 0.521
4.314GlyVal: 4.314 ± 0.556
0.919GlyTrp: 0.919 ± 0.318
2.829GlyTyr: 2.829 ± 0.485
0.0GlyXaa: 0.0 ± 0.0
His
1.273HisAla: 1.273 ± 0.325
0.141HisCys: 0.141 ± 0.096
0.99HisAsp: 0.99 ± 0.241
1.273HisGlu: 1.273 ± 0.364
0.849HisPhe: 0.849 ± 0.216
1.344HisGly: 1.344 ± 0.314
0.354HisHis: 0.354 ± 0.146
0.99HisIle: 0.99 ± 0.237
0.919HisLys: 0.919 ± 0.289
1.202HisLeu: 1.202 ± 0.286
0.424HisMet: 0.424 ± 0.195
0.99HisAsn: 0.99 ± 0.268
0.566HisPro: 0.566 ± 0.154
0.849HisGln: 0.849 ± 0.295
0.283HisArg: 0.283 ± 0.149
1.132HisSer: 1.132 ± 0.242
0.707HisThr: 0.707 ± 0.247
1.273HisVal: 1.273 ± 0.32
0.0HisTrp: 0.0 ± 0.0
0.707HisTyr: 0.707 ± 0.263
0.0HisXaa: 0.0 ± 0.0
Ile
5.092IleAla: 5.092 ± 0.75
0.141IleCys: 0.141 ± 0.087
5.8IleAsp: 5.8 ± 0.558
6.082IleGlu: 6.082 ± 0.746
2.475IlePhe: 2.475 ± 0.441
3.678IleGly: 3.678 ± 0.53
1.344IleHis: 1.344 ± 0.321
4.668IleIle: 4.668 ± 0.509
8.416IleLys: 8.416 ± 0.778
5.446IleLeu: 5.446 ± 0.587
1.98IleMet: 1.98 ± 0.402
4.809IleAsn: 4.809 ± 0.551
2.193IlePro: 2.193 ± 0.327
2.405IleGln: 2.405 ± 0.477
2.829IleArg: 2.829 ± 0.519
4.668IleSer: 4.668 ± 0.511
5.375IleThr: 5.375 ± 0.787
3.961IleVal: 3.961 ± 0.562
1.273IleTrp: 1.273 ± 0.605
3.678IleTyr: 3.678 ± 0.533
0.0IleXaa: 0.0 ± 0.0
Lys
5.8LysAla: 5.8 ± 0.545
0.495LysCys: 0.495 ± 0.204
5.87LysAsp: 5.87 ± 0.782
8.063LysGlu: 8.063 ± 0.912
3.324LysPhe: 3.324 ± 0.508
5.234LysGly: 5.234 ± 0.709
1.91LysHis: 1.91 ± 0.445
6.86LysIle: 6.86 ± 0.844
8.841LysLys: 8.841 ± 0.859
7.356LysLeu: 7.356 ± 0.688
1.91LysMet: 1.91 ± 0.329
6.295LysAsn: 6.295 ± 0.929
2.263LysPro: 2.263 ± 0.46
4.597LysGln: 4.597 ± 0.567
3.819LysArg: 3.819 ± 0.553
5.022LysSer: 5.022 ± 0.556
5.517LysThr: 5.517 ± 0.602
6.224LysVal: 6.224 ± 0.615
0.566LysTrp: 0.566 ± 0.178
4.739LysTyr: 4.739 ± 0.762
0.0LysXaa: 0.0 ± 0.0
Leu
3.324LeuAla: 3.324 ± 0.513
0.495LeuCys: 0.495 ± 0.238
4.173LeuAsp: 4.173 ± 0.641
5.234LeuGlu: 5.234 ± 0.667
3.466LeuPhe: 3.466 ± 0.545
4.031LeuGly: 4.031 ± 0.503
0.849LeuHis: 0.849 ± 0.25
4.88LeuIle: 4.88 ± 0.583
8.275LeuLys: 8.275 ± 0.722
5.658LeuLeu: 5.658 ± 0.695
1.839LeuMet: 1.839 ± 0.307
6.012LeuAsn: 6.012 ± 0.522
2.334LeuPro: 2.334 ± 0.423
3.324LeuGln: 3.324 ± 0.535
3.89LeuArg: 3.89 ± 0.794
5.092LeuSer: 5.092 ± 0.575
4.597LeuThr: 4.597 ± 0.502
5.022LeuVal: 5.022 ± 0.812
0.637LeuTrp: 0.637 ± 0.239
3.819LeuTyr: 3.819 ± 0.557
0.0LeuXaa: 0.0 ± 0.0
Met
1.485MetAla: 1.485 ± 0.289
0.141MetCys: 0.141 ± 0.097
1.273MetAsp: 1.273 ± 0.246
1.697MetGlu: 1.697 ± 0.35
0.849MetPhe: 0.849 ± 0.263
1.061MetGly: 1.061 ± 0.273
0.424MetHis: 0.424 ± 0.199
1.415MetIle: 1.415 ± 0.265
1.839MetLys: 1.839 ± 0.327
2.9MetLeu: 2.9 ± 0.438
0.778MetMet: 0.778 ± 0.226
2.122MetAsn: 2.122 ± 0.426
1.202MetPro: 1.202 ± 0.278
1.485MetGln: 1.485 ± 0.32
1.202MetArg: 1.202 ± 0.372
1.344MetSer: 1.344 ± 0.346
2.475MetThr: 2.475 ± 0.502
1.061MetVal: 1.061 ± 0.204
0.354MetTrp: 0.354 ± 0.164
1.202MetTyr: 1.202 ± 0.275
0.0MetXaa: 0.0 ± 0.0
Asn
4.739AsnAla: 4.739 ± 0.849
0.566AsnCys: 0.566 ± 0.267
4.951AsnAsp: 4.951 ± 0.519
4.739AsnGlu: 4.739 ± 0.585
2.617AsnPhe: 2.617 ± 0.519
4.526AsnGly: 4.526 ± 0.663
1.061AsnHis: 1.061 ± 0.255
4.456AsnIle: 4.456 ± 0.455
7.285AsnLys: 7.285 ± 0.732
4.951AsnLeu: 4.951 ± 0.587
1.697AsnMet: 1.697 ± 0.31
4.244AsnAsn: 4.244 ± 0.717
2.546AsnPro: 2.546 ± 0.416
2.475AsnGln: 2.475 ± 0.364
2.9AsnArg: 2.9 ± 0.396
3.112AsnSer: 3.112 ± 0.423
4.173AsnThr: 4.173 ± 0.563
4.526AsnVal: 4.526 ± 0.63
0.707AsnTrp: 0.707 ± 0.188
2.971AsnTyr: 2.971 ± 0.503
0.0AsnXaa: 0.0 ± 0.0
Pro
1.485ProAla: 1.485 ± 0.318
0.354ProCys: 0.354 ± 0.188
1.485ProAsp: 1.485 ± 0.263
2.051ProGlu: 2.051 ± 0.304
1.344ProPhe: 1.344 ± 0.327
1.485ProGly: 1.485 ± 0.377
0.354ProHis: 0.354 ± 0.147
2.263ProIle: 2.263 ± 0.387
2.688ProLys: 2.688 ± 0.467
1.202ProLeu: 1.202 ± 0.282
0.99ProMet: 0.99 ± 0.244
2.475ProAsn: 2.475 ± 0.346
0.637ProPro: 0.637 ± 0.225
1.415ProGln: 1.415 ± 0.341
0.919ProArg: 0.919 ± 0.309
1.485ProSer: 1.485 ± 0.35
1.98ProThr: 1.98 ± 0.413
1.91ProVal: 1.91 ± 0.412
0.141ProTrp: 0.141 ± 0.102
1.202ProTyr: 1.202 ± 0.296
0.0ProXaa: 0.0 ± 0.0
Gln
2.263GlnAla: 2.263 ± 0.479
0.424GlnCys: 0.424 ± 0.176
2.193GlnAsp: 2.193 ± 0.42
2.334GlnGlu: 2.334 ± 0.451
2.051GlnPhe: 2.051 ± 0.367
2.475GlnGly: 2.475 ± 0.336
0.495GlnHis: 0.495 ± 0.158
2.405GlnIle: 2.405 ± 0.316
3.324GlnLys: 3.324 ± 0.546
2.829GlnLeu: 2.829 ± 0.479
1.415GlnMet: 1.415 ± 0.289
2.051GlnAsn: 2.051 ± 0.347
1.415GlnPro: 1.415 ± 0.269
1.768GlnGln: 1.768 ± 0.455
1.768GlnArg: 1.768 ± 0.372
2.263GlnSer: 2.263 ± 0.4
2.263GlnThr: 2.263 ± 0.436
2.122GlnVal: 2.122 ± 0.342
0.424GlnTrp: 0.424 ± 0.191
1.132GlnTyr: 1.132 ± 0.308
0.0GlnXaa: 0.0 ± 0.0
Arg
1.485ArgAla: 1.485 ± 0.36
0.495ArgCys: 0.495 ± 0.193
1.98ArgAsp: 1.98 ± 0.487
2.688ArgGlu: 2.688 ± 0.427
1.91ArgPhe: 1.91 ± 0.402
2.051ArgGly: 2.051 ± 0.431
0.99ArgHis: 0.99 ± 0.253
3.607ArgIle: 3.607 ± 0.549
4.314ArgLys: 4.314 ± 0.748
4.031ArgLeu: 4.031 ± 0.444
0.637ArgMet: 0.637 ± 0.233
3.112ArgAsn: 3.112 ± 0.487
0.99ArgPro: 0.99 ± 0.273
1.415ArgGln: 1.415 ± 0.302
1.485ArgArg: 1.485 ± 0.394
2.122ArgSer: 2.122 ± 0.371
2.334ArgThr: 2.334 ± 0.434
2.334ArgVal: 2.334 ± 0.451
0.637ArgTrp: 0.637 ± 0.244
1.91ArgTyr: 1.91 ± 0.421
0.0ArgXaa: 0.0 ± 0.0
Ser
4.173SerAla: 4.173 ± 0.68
0.071SerCys: 0.071 ± 0.073
4.102SerAsp: 4.102 ± 0.727
2.971SerGlu: 2.971 ± 0.339
2.829SerPhe: 2.829 ± 0.459
3.607SerGly: 3.607 ± 0.669
0.919SerHis: 0.919 ± 0.273
5.446SerIle: 5.446 ± 0.684
5.375SerLys: 5.375 ± 0.489
4.031SerLeu: 4.031 ± 0.449
1.344SerMet: 1.344 ± 0.332
3.961SerAsn: 3.961 ± 0.503
1.485SerPro: 1.485 ± 0.349
1.91SerGln: 1.91 ± 0.415
2.475SerArg: 2.475 ± 0.368
3.324SerSer: 3.324 ± 0.489
3.89SerThr: 3.89 ± 0.411
2.971SerVal: 2.971 ± 0.447
0.212SerTrp: 0.212 ± 0.124
2.475SerTyr: 2.475 ± 0.405
0.0SerXaa: 0.0 ± 0.0
Thr
3.536ThrAla: 3.536 ± 0.688
0.141ThrCys: 0.141 ± 0.099
3.466ThrAsp: 3.466 ± 0.527
4.88ThrGlu: 4.88 ± 0.797
3.112ThrPhe: 3.112 ± 0.536
3.607ThrGly: 3.607 ± 0.558
0.849ThrHis: 0.849 ± 0.209
5.304ThrIle: 5.304 ± 1.114
5.8ThrLys: 5.8 ± 0.624
4.668ThrLeu: 4.668 ± 0.465
1.061ThrMet: 1.061 ± 0.345
4.173ThrAsn: 4.173 ± 0.571
2.051ThrPro: 2.051 ± 0.375
2.617ThrGln: 2.617 ± 0.505
2.263ThrArg: 2.263 ± 0.319
4.031ThrSer: 4.031 ± 0.705
3.89ThrThr: 3.89 ± 0.755
4.668ThrVal: 4.668 ± 0.64
0.495ThrTrp: 0.495 ± 0.197
1.91ThrTyr: 1.91 ± 0.293
0.0ThrXaa: 0.0 ± 0.0
Val
3.607ValAla: 3.607 ± 0.993
0.283ValCys: 0.283 ± 0.138
4.809ValAsp: 4.809 ± 0.725
5.587ValGlu: 5.587 ± 0.654
2.475ValPhe: 2.475 ± 0.437
2.263ValGly: 2.263 ± 0.422
0.99ValHis: 0.99 ± 0.268
5.446ValIle: 5.446 ± 0.631
6.224ValLys: 6.224 ± 0.537
4.597ValLeu: 4.597 ± 0.645
2.122ValMet: 2.122 ± 0.451
4.668ValAsn: 4.668 ± 0.621
2.122ValPro: 2.122 ± 0.429
1.273ValGln: 1.273 ± 0.29
1.91ValArg: 1.91 ± 0.43
3.536ValSer: 3.536 ± 0.59
3.678ValThr: 3.678 ± 0.531
3.819ValVal: 3.819 ± 0.656
1.061ValTrp: 1.061 ± 0.358
2.334ValTyr: 2.334 ± 0.501
0.0ValXaa: 0.0 ± 0.0
Trp
0.849TrpAla: 0.849 ± 0.283
0.071TrpCys: 0.071 ± 0.054
0.354TrpAsp: 0.354 ± 0.168
0.566TrpGlu: 0.566 ± 0.202
0.283TrpPhe: 0.283 ± 0.13
0.424TrpGly: 0.424 ± 0.25
0.141TrpHis: 0.141 ± 0.094
0.707TrpIle: 0.707 ± 0.249
0.637TrpLys: 0.637 ± 0.229
0.637TrpLeu: 0.637 ± 0.221
0.212TrpMet: 0.212 ± 0.127
1.697TrpAsn: 1.697 ± 0.995
0.141TrpPro: 0.141 ± 0.094
0.495TrpGln: 0.495 ± 0.211
0.212TrpArg: 0.212 ± 0.119
0.919TrpSer: 0.919 ± 0.31
1.132TrpThr: 1.132 ± 0.297
0.707TrpVal: 0.707 ± 0.251
0.0TrpTrp: 0.0 ± 0.0
0.566TrpTyr: 0.566 ± 0.214
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.768TyrAla: 1.768 ± 0.353
0.283TyrCys: 0.283 ± 0.139
2.617TyrAsp: 2.617 ± 0.55
3.819TyrGlu: 3.819 ± 0.613
1.91TyrPhe: 1.91 ± 0.388
2.688TyrGly: 2.688 ± 0.579
0.849TyrHis: 0.849 ± 0.269
3.536TyrIle: 3.536 ± 0.516
5.022TyrLys: 5.022 ± 0.742
3.253TyrLeu: 3.253 ± 0.512
1.061TyrMet: 1.061 ± 0.244
2.617TyrAsn: 2.617 ± 0.322
1.202TyrPro: 1.202 ± 0.306
1.556TyrGln: 1.556 ± 0.317
2.051TyrArg: 2.051 ± 0.444
2.546TyrSer: 2.546 ± 0.468
3.183TyrThr: 3.183 ± 0.406
2.688TyrVal: 2.688 ± 0.396
0.919TyrTrp: 0.919 ± 0.239
1.98TyrTyr: 1.98 ± 0.366
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (14140 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski