Amino acid dipepetide frequency for Streptomyces roseochromogenus subsp. oscitans DS 12.976

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.654AlaAla: 20.654 ± 0.133	1.189AlaCys: 1.189 ± 0.021	8.266AlaAsp: 8.266 ± 0.061	8.727AlaGlu: 8.727 ± 0.075	3.593AlaPhe: 3.593 ± 0.04	12.72AlaGly: 12.72 ± 0.092	3.096AlaHis: 3.096 ± 0.034	3.509AlaIle: 3.509 ± 0.036	2.886AlaLys: 2.886 ± 0.044	14.569AlaLeu: 14.569 ± 0.1	2.47AlaMet: 2.47 ± 0.034	1.967AlaAsn: 1.967 ± 0.029	6.809AlaPro: 6.809 ± 0.058	4.006AlaGln: 4.006 ± 0.053	10.301AlaArg: 10.301 ± 0.071	5.9AlaSer: 5.9 ± 0.059	7.001AlaThr: 7.001 ± 0.06	12.172AlaVal: 12.172 ± 0.077	1.88AlaTrp: 1.88 ± 0.028	2.876AlaTyr: 2.876 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.19CysAla: 1.19 ± 0.024	0.109CysCys: 0.109 ± 0.006	0.5CysAsp: 0.5 ± 0.014	0.396CysGlu: 0.396 ± 0.013	0.232CysPhe: 0.232 ± 0.01	1.018CysGly: 1.018 ± 0.021	0.205CysHis: 0.205 ± 0.009	0.187CysIle: 0.187 ± 0.008	0.125CysLys: 0.125 ± 0.008	0.83CysLeu: 0.83 ± 0.019	0.137CysMet: 0.137 ± 0.007	0.155CysAsn: 0.155 ± 0.007	0.532CysPro: 0.532 ± 0.015	0.193CysGln: 0.193 ± 0.009	0.669CysArg: 0.669 ± 0.016	0.473CysSer: 0.473 ± 0.014	0.58CysThr: 0.58 ± 0.015	0.71CysVal: 0.71 ± 0.016	0.155CysTrp: 0.155 ± 0.008	0.165CysTyr: 0.165 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.455AspAla: 7.455 ± 0.055	0.452AspCys: 0.452 ± 0.013	3.422AspAsp: 3.422 ± 0.043	3.604AspGlu: 3.604 ± 0.035	1.682AspPhe: 1.682 ± 0.027	6.202AspGly: 6.202 ± 0.05	1.52AspHis: 1.52 ± 0.024	1.943AspIle: 1.943 ± 0.029	1.237AspLys: 1.237 ± 0.026	6.179AspLeu: 6.179 ± 0.054	0.837AspMet: 0.837 ± 0.016	0.995AspAsn: 0.995 ± 0.02	4.423AspPro: 4.423 ± 0.051	1.655AspGln: 1.655 ± 0.03	4.803AspArg: 4.803 ± 0.046	2.595AspSer: 2.595 ± 0.034	3.324AspThr: 3.324 ± 0.036	4.567AspVal: 4.567 ± 0.041	1.031AspTrp: 1.031 ± 0.021	1.164AspTyr: 1.164 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.228GluAla: 7.228 ± 0.069	0.368GluCys: 0.368 ± 0.012	2.804GluAsp: 2.804 ± 0.036	3.485GluGlu: 3.485 ± 0.046	1.442GluPhe: 1.442 ± 0.025	4.051GluGly: 4.051 ± 0.044	1.542GluHis: 1.542 ± 0.022	2.232GluIle: 2.232 ± 0.036	1.386GluLys: 1.386 ± 0.024	6.699GluLeu: 6.699 ± 0.058	0.862GluMet: 0.862 ± 0.017	1.005GluAsn: 1.005 ± 0.019	3.298GluPro: 3.298 ± 0.042	2.293GluGln: 2.293 ± 0.03	5.401GluArg: 5.401 ± 0.055	2.438GluSer: 2.438 ± 0.031	2.912GluThr: 2.912 ± 0.039	4.297GluVal: 4.297 ± 0.047	0.746GluTrp: 0.746 ± 0.015	1.084GluTyr: 1.084 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.73PheAla: 3.73 ± 0.044	0.272PheCys: 0.272 ± 0.01	1.905PheAsp: 1.905 ± 0.03	1.402PheGlu: 1.402 ± 0.026	0.913PhePhe: 0.913 ± 0.022	3.0PheGly: 3.0 ± 0.037	0.664PheHis: 0.664 ± 0.018	0.725PheIle: 0.725 ± 0.018	0.538PheLys: 0.538 ± 0.013	2.629PheLeu: 2.629 ± 0.037	0.386PheMet: 0.386 ± 0.011	0.567PheAsn: 0.567 ± 0.016	1.438PhePro: 1.438 ± 0.024	0.723PheGln: 0.723 ± 0.017	1.823PheArg: 1.823 ± 0.029	1.498PheSer: 1.498 ± 0.026	2.056PheThr: 2.056 ± 0.027	2.174PheVal: 2.174 ± 0.029	0.412PheTrp: 0.412 ± 0.012	0.585PheTyr: 0.585 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.613GlyAla: 10.613 ± 0.075	0.921GlyCys: 0.921 ± 0.02	5.008GlyAsp: 5.008 ± 0.042	4.846GlyGlu: 4.846 ± 0.048	2.862GlyPhe: 2.862 ± 0.038	8.435GlyGly: 8.435 ± 0.078	2.503GlyHis: 2.503 ± 0.034	3.499GlyIle: 3.499 ± 0.037	2.495GlyLys: 2.495 ± 0.033	9.461GlyLeu: 9.461 ± 0.072	1.968GlyMet: 1.968 ± 0.027	1.782GlyAsn: 1.782 ± 0.035	4.936GlyPro: 4.936 ± 0.046	2.78GlyGln: 2.78 ± 0.032	7.566GlyArg: 7.566 ± 0.051	5.331GlySer: 5.331 ± 0.06	6.539GlyThr: 6.539 ± 0.057	7.351GlyVal: 7.351 ± 0.058	1.714GlyTrp: 1.714 ± 0.029	2.367GlyTyr: 2.367 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.854HisAla: 2.854 ± 0.035	0.228HisCys: 0.228 ± 0.009	1.434HisAsp: 1.434 ± 0.025	1.254HisGlu: 1.254 ± 0.023	0.677HisPhe: 0.677 ± 0.016	2.579HisGly: 2.579 ± 0.033	0.796HisHis: 0.796 ± 0.024	0.77HisIle: 0.77 ± 0.015	0.412HisLys: 0.412 ± 0.013	2.558HisLeu: 2.558 ± 0.035	0.364HisMet: 0.364 ± 0.012	0.396HisAsn: 0.396 ± 0.013	1.899HisPro: 1.899 ± 0.027	0.7HisGln: 0.7 ± 0.018	2.234HisArg: 2.234 ± 0.028	1.126HisSer: 1.126 ± 0.022	1.535HisThr: 1.535 ± 0.024	1.749HisVal: 1.749 ± 0.024	0.406HisTrp: 0.406 ± 0.014	0.522HisTyr: 0.522 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.895IleAla: 4.895 ± 0.05	0.296IleCys: 0.296 ± 0.012	2.205IleAsp: 2.205 ± 0.031	2.014IleGlu: 2.014 ± 0.032	0.69IlePhe: 0.69 ± 0.018	3.592IleGly: 3.592 ± 0.043	0.644IleHis: 0.644 ± 0.016	0.889IleIle: 0.889 ± 0.021	0.78IleLys: 0.78 ± 0.02	2.461IleLeu: 2.461 ± 0.034	0.454IleMet: 0.454 ± 0.012	0.707IleAsn: 0.707 ± 0.017	1.856IlePro: 1.856 ± 0.027	0.795IleGln: 0.795 ± 0.02	2.375IleArg: 2.375 ± 0.032	1.732IleSer: 1.732 ± 0.026	2.348IleThr: 2.348 ± 0.036	2.712IleVal: 2.712 ± 0.03	0.409IleTrp: 0.409 ± 0.014	0.537IleTyr: 0.537 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.029LysAla: 3.029 ± 0.044	0.131LysCys: 0.131 ± 0.008	1.416LysAsp: 1.416 ± 0.029	1.178LysGlu: 1.178 ± 0.024	0.468LysPhe: 0.468 ± 0.016	1.894LysGly: 1.894 ± 0.034	0.468LysHis: 0.468 ± 0.014	0.887LysIle: 0.887 ± 0.02	0.882LysLys: 0.882 ± 0.027	2.052LysLeu: 2.052 ± 0.031	0.392LysMet: 0.392 ± 0.013	0.547LysAsn: 0.547 ± 0.018	1.407LysPro: 1.407 ± 0.029	0.732LysGln: 0.732 ± 0.018	1.455LysArg: 1.455 ± 0.024	1.145LysSer: 1.145 ± 0.025	1.364LysThr: 1.364 ± 0.025	1.931LysVal: 1.931 ± 0.032	0.274LysTrp: 0.274 ± 0.01	0.487LysTyr: 0.487 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.223LeuAla: 15.223 ± 0.1	0.907LeuCys: 0.907 ± 0.019	6.596LeuAsp: 6.596 ± 0.056	4.634LeuGlu: 4.634 ± 0.048	2.638LeuPhe: 2.638 ± 0.038	9.213LeuGly: 9.213 ± 0.068	2.45LeuHis: 2.45 ± 0.031	3.427LeuIle: 3.427 ± 0.04	2.18LeuLys: 2.18 ± 0.034	11.433LeuLeu: 11.433 ± 0.093	1.662LeuMet: 1.662 ± 0.027	1.741LeuAsn: 1.741 ± 0.026	6.664LeuPro: 6.664 ± 0.056	2.362LeuGln: 2.362 ± 0.03	8.719LeuArg: 8.719 ± 0.076	5.286LeuSer: 5.286 ± 0.048	7.049LeuThr: 7.049 ± 0.057	8.641LeuVal: 8.641 ± 0.07	1.355LeuTrp: 1.355 ± 0.024	1.975LeuTyr: 1.975 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.263MetAla: 2.263 ± 0.033	0.149MetCys: 0.149 ± 0.008	0.888MetAsp: 0.888 ± 0.017	0.754MetGlu: 0.754 ± 0.017	0.465MetPhe: 0.465 ± 0.014	1.306MetGly: 1.306 ± 0.021	0.375MetHis: 0.375 ± 0.012	0.672MetIle: 0.672 ± 0.017	0.417MetLys: 0.417 ± 0.014	1.72MetLeu: 1.72 ± 0.028	0.284MetMet: 0.284 ± 0.009	0.438MetAsn: 0.438 ± 0.012	1.122MetPro: 1.122 ± 0.022	0.474MetGln: 0.474 ± 0.014	1.402MetArg: 1.402 ± 0.022	1.264MetSer: 1.264 ± 0.024	1.576MetThr: 1.576 ± 0.024	1.282MetVal: 1.282 ± 0.023	0.213MetTrp: 0.213 ± 0.01	0.34MetTyr: 0.34 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.25AsnAla: 2.25 ± 0.029	0.187AsnCys: 0.187 ± 0.01	0.998AsnAsp: 0.998 ± 0.02	0.778AsnGlu: 0.778 ± 0.02	0.474AsnPhe: 0.474 ± 0.015	1.928AsnGly: 1.928 ± 0.027	0.421AsnHis: 0.421 ± 0.012	0.654AsnIle: 0.654 ± 0.018	0.417AsnLys: 0.417 ± 0.014	1.658AsnLeu: 1.658 ± 0.028	0.308AsnMet: 0.308 ± 0.01	0.449AsnAsn: 0.449 ± 0.015	1.424AsnPro: 1.424 ± 0.024	0.561AsnGln: 0.561 ± 0.017	1.251AsnArg: 1.251 ± 0.02	0.998AsnSer: 0.998 ± 0.02	1.135AsnThr: 1.135 ± 0.023	1.367AsnVal: 1.367 ± 0.023	0.303AsnTrp: 0.303 ± 0.011	0.415AsnTyr: 0.415 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.615ProAla: 8.615 ± 0.066	0.39ProCys: 0.39 ± 0.013	4.45ProAsp: 4.45 ± 0.049	4.321ProGlu: 4.321 ± 0.05	1.547ProPhe: 1.547 ± 0.024	6.498ProGly: 6.498 ± 0.048	1.518ProHis: 1.518 ± 0.027	1.293ProIle: 1.293 ± 0.024	1.242ProLys: 1.242 ± 0.026	5.49ProLeu: 5.49 ± 0.051	1.007ProMet: 1.007 ± 0.021	0.926ProAsn: 0.926 ± 0.019	3.376ProPro: 3.376 ± 0.051	1.86ProGln: 1.86 ± 0.033	3.841ProArg: 3.841 ± 0.042	3.133ProSer: 3.133 ± 0.034	3.136ProThr: 3.136 ± 0.036	5.517ProVal: 5.517 ± 0.047	0.903ProTrp: 0.903 ± 0.018	1.495ProTyr: 1.495 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.977GlnAla: 3.977 ± 0.048	0.21GlnCys: 0.21 ± 0.01	1.468GlnAsp: 1.468 ± 0.026	1.459GlnGlu: 1.459 ± 0.024	0.713GlnPhe: 0.713 ± 0.016	2.372GlnGly: 2.372 ± 0.033	0.773GlnHis: 0.773 ± 0.016	1.15GlnIle: 1.15 ± 0.025	0.668GlnLys: 0.668 ± 0.02	3.272GlnLeu: 3.272 ± 0.036	0.519GlnMet: 0.519 ± 0.014	0.549GlnAsn: 0.549 ± 0.015	1.833GlnPro: 1.833 ± 0.03	1.352GlnGln: 1.352 ± 0.035	2.482GlnArg: 2.482 ± 0.032	1.354GlnSer: 1.354 ± 0.023	1.494GlnThr: 1.494 ± 0.026	2.435GlnVal: 2.435 ± 0.031	0.478GlnTrp: 0.478 ± 0.013	0.661GlnTyr: 0.661 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.758ArgAla: 9.758 ± 0.067	0.63ArgCys: 0.63 ± 0.017	4.174ArgAsp: 4.174 ± 0.039	4.698ArgGlu: 4.698 ± 0.052	2.324ArgPhe: 2.324 ± 0.027	5.636ArgGly: 5.636 ± 0.048	2.242ArgHis: 2.242 ± 0.035	3.344ArgIle: 3.344 ± 0.038	1.636ArgLys: 1.636 ± 0.027	9.024ArgLeu: 9.024 ± 0.078	1.719ArgMet: 1.719 ± 0.022	1.305ArgAsn: 1.305 ± 0.024	4.986ArgPro: 4.986 ± 0.046	2.479ArgGln: 2.479 ± 0.035	7.657ArgArg: 7.657 ± 0.069	3.947ArgSer: 3.947 ± 0.042	5.387ArgThr: 5.387 ± 0.049	5.646ArgVal: 5.646 ± 0.048	1.381ArgTrp: 1.381 ± 0.021	1.865ArgTyr: 1.865 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.798SerAla: 6.798 ± 0.064	0.459SerCys: 0.459 ± 0.014	2.608SerAsp: 2.608 ± 0.029	2.285SerGlu: 2.285 ± 0.03	1.504SerPhe: 1.504 ± 0.022	6.05SerGly: 6.05 ± 0.059	1.041SerHis: 1.041 ± 0.022	1.441SerIle: 1.441 ± 0.024	1.066SerLys: 1.066 ± 0.021	4.94SerLeu: 4.94 ± 0.046	1.102SerMet: 1.102 ± 0.021	0.883SerAsn: 0.883 ± 0.021	3.188SerPro: 3.188 ± 0.035	1.292SerGln: 1.292 ± 0.022	3.615SerArg: 3.615 ± 0.035	2.879SerSer: 2.879 ± 0.043	3.084SerThr: 3.084 ± 0.042	4.171SerVal: 4.171 ± 0.041	0.923SerTrp: 0.923 ± 0.02	1.317SerTyr: 1.317 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.13ThrAla: 9.13 ± 0.07	0.474ThrCys: 0.474 ± 0.015	3.686ThrAsp: 3.686 ± 0.04	3.326ThrGlu: 3.326 ± 0.039	1.613ThrPhe: 1.613 ± 0.027	6.792ThrGly: 6.792 ± 0.051	1.352ThrHis: 1.352 ± 0.023	1.795ThrIle: 1.795 ± 0.026	1.181ThrLys: 1.181 ± 0.023	5.91ThrLeu: 5.91 ± 0.051	0.952ThrMet: 0.952 ± 0.018	1.045ThrAsn: 1.045 ± 0.018	4.167ThrPro: 4.167 ± 0.038	1.449ThrGln: 1.449 ± 0.028	3.984ThrArg: 3.984 ± 0.04	3.268ThrSer: 3.268 ± 0.042	3.924ThrThr: 3.924 ± 0.053	6.121ThrVal: 6.121 ± 0.053	0.96ThrTrp: 0.96 ± 0.024	1.413ThrTyr: 1.413 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.338ValAla: 10.338 ± 0.068	0.836ValCys: 0.836 ± 0.018	4.754ValAsp: 4.754 ± 0.045	4.417ValGlu: 4.417 ± 0.043	2.437ValPhe: 2.437 ± 0.031	6.242ValGly: 6.242 ± 0.055	2.054ValHis: 2.054 ± 0.03	2.892ValIle: 2.892 ± 0.032	1.757ValLys: 1.757 ± 0.031	9.336ValLeu: 9.336 ± 0.067	1.421ValMet: 1.421 ± 0.025	1.674ValAsn: 1.674 ± 0.024	5.249ValPro: 5.249 ± 0.048	2.169ValGln: 2.169 ± 0.027	7.065ValArg: 7.065 ± 0.059	4.319ValSer: 4.319 ± 0.041	5.701ValThr: 5.701 ± 0.045	7.648ValVal: 7.648 ± 0.061	1.179ValTrp: 1.179 ± 0.026	1.665ValTyr: 1.665 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.67TrpAla: 1.67 ± 0.028	0.163TrpCys: 0.163 ± 0.009	0.823TrpAsp: 0.823 ± 0.019	0.716TrpGlu: 0.716 ± 0.018	0.509TrpPhe: 0.509 ± 0.014	1.026TrpGly: 1.026 ± 0.02	0.421TrpHis: 0.421 ± 0.014	0.576TrpIle: 0.576 ± 0.015	0.391TrpLys: 0.391 ± 0.012	1.825TrpLeu: 1.825 ± 0.031	0.288TrpMet: 0.288 ± 0.012	0.417TrpAsn: 0.417 ± 0.014	0.818TrpPro: 0.818 ± 0.018	0.672TrpGln: 0.672 ± 0.018	1.342TrpArg: 1.342 ± 0.028	0.967TrpSer: 0.967 ± 0.02	1.092TrpThr: 1.092 ± 0.021	0.984TrpVal: 0.984 ± 0.02	0.36TrpTrp: 0.36 ± 0.014	0.391TrpTyr: 0.391 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.92TyrAla: 2.92 ± 0.034	0.191TyrCys: 0.191 ± 0.008	1.683TyrAsp: 1.683 ± 0.034	1.281TyrGlu: 1.281 ± 0.024	0.658TyrPhe: 0.658 ± 0.018	2.423TyrGly: 2.423 ± 0.035	0.41TyrHis: 0.41 ± 0.013	0.507TyrIle: 0.507 ± 0.015	0.445TyrLys: 0.445 ± 0.013	2.106TyrLeu: 2.106 ± 0.029	0.273TyrMet: 0.273 ± 0.011	0.424TyrAsn: 0.424 ± 0.015	1.135TyrPro: 1.135 ± 0.026	0.67TyrGln: 0.67 ± 0.016	1.852TyrArg: 1.852 ± 0.028	0.996TyrSer: 0.996 ± 0.021	1.307TyrThr: 1.307 ± 0.028	1.679TyrVal: 1.679 ± 0.025	0.364TyrTrp: 0.364 ± 0.012	0.479TyrTyr: 0.479 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8885 proteins (2650407 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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