Amino acid dipepetide frequency for Streptococcus phage P5641

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.857AlaAla: 2.857 ± 0.894
0.173AlaCys: 0.173 ± 0.125
4.242AlaAsp: 4.242 ± 0.963
4.588AlaGlu: 4.588 ± 0.636
2.51AlaPhe: 2.51 ± 0.626
3.895AlaGly: 3.895 ± 0.705
0.779AlaHis: 0.779 ± 0.255
4.761AlaIle: 4.761 ± 0.684
6.319AlaLys: 6.319 ± 1.163
5.367AlaLeu: 5.367 ± 0.621
1.472AlaMet: 1.472 ± 0.469
4.501AlaAsn: 4.501 ± 0.841
1.212AlaPro: 1.212 ± 0.313
3.289AlaGln: 3.289 ± 0.578
2.424AlaArg: 2.424 ± 0.462
4.242AlaSer: 4.242 ± 0.683
3.982AlaThr: 3.982 ± 0.879
4.155AlaVal: 4.155 ± 0.79
1.039AlaTrp: 1.039 ± 0.281
2.943AlaTyr: 2.943 ± 0.657
0.0AlaXaa: 0.0 ± 0.0
Cys
0.173CysAla: 0.173 ± 0.148
0.0CysCys: 0.0 ± 0.0
0.519CysAsp: 0.519 ± 0.239
0.433CysGlu: 0.433 ± 0.236
0.346CysPhe: 0.346 ± 0.216
0.173CysGly: 0.173 ± 0.138
0.087CysHis: 0.087 ± 0.096
0.173CysIle: 0.173 ± 0.153
0.606CysLys: 0.606 ± 0.326
0.519CysLeu: 0.519 ± 0.269
0.087CysMet: 0.087 ± 0.095
0.26CysAsn: 0.26 ± 0.147
0.087CysPro: 0.087 ± 0.095
0.173CysGln: 0.173 ± 0.149
0.173CysArg: 0.173 ± 0.191
0.519CysSer: 0.519 ± 0.288
0.346CysThr: 0.346 ± 0.18
0.173CysVal: 0.173 ± 0.117
0.087CysTrp: 0.087 ± 0.099
0.087CysTyr: 0.087 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
3.636AspAla: 3.636 ± 0.642
0.346AspCys: 0.346 ± 0.233
4.934AspAsp: 4.934 ± 0.697
3.636AspGlu: 3.636 ± 0.783
4.069AspPhe: 4.069 ± 0.627
5.886AspGly: 5.886 ± 1.363
0.866AspHis: 0.866 ± 0.229
4.848AspIle: 4.848 ± 0.587
5.454AspLys: 5.454 ± 0.775
4.155AspLeu: 4.155 ± 0.728
2.078AspMet: 2.078 ± 0.497
4.501AspAsn: 4.501 ± 0.805
1.991AspPro: 1.991 ± 0.45
1.212AspGln: 1.212 ± 0.262
2.597AspArg: 2.597 ± 0.469
3.809AspSer: 3.809 ± 0.579
3.982AspThr: 3.982 ± 0.516
3.289AspVal: 3.289 ± 0.597
0.779AspTrp: 0.779 ± 0.285
2.857AspTyr: 2.857 ± 0.552
0.0AspXaa: 0.0 ± 0.0
Glu
4.588GluAla: 4.588 ± 0.416
0.173GluCys: 0.173 ± 0.104
4.155GluAsp: 4.155 ± 0.781
4.761GluGlu: 4.761 ± 1.042
2.078GluPhe: 2.078 ± 0.429
2.943GluGly: 2.943 ± 0.514
1.212GluHis: 1.212 ± 0.392
6.146GluIle: 6.146 ± 0.897
4.588GluLys: 4.588 ± 1.11
6.146GluLeu: 6.146 ± 1.027
2.164GluMet: 2.164 ± 0.486
4.242GluAsn: 4.242 ± 0.676
1.558GluPro: 1.558 ± 0.399
3.289GluGln: 3.289 ± 0.72
3.289GluArg: 3.289 ± 0.621
3.722GluSer: 3.722 ± 0.486
3.549GluThr: 3.549 ± 0.679
4.675GluVal: 4.675 ± 0.816
1.212GluTrp: 1.212 ± 0.304
3.116GluTyr: 3.116 ± 0.472
0.0GluXaa: 0.0 ± 0.0
Phe
2.77PheAla: 2.77 ± 0.51
0.0PheCys: 0.0 ± 0.0
3.03PheAsp: 3.03 ± 0.483
2.684PheGlu: 2.684 ± 0.703
1.385PhePhe: 1.385 ± 0.314
3.203PheGly: 3.203 ± 0.637
0.433PheHis: 0.433 ± 0.173
2.857PheIle: 2.857 ± 0.561
4.069PheLys: 4.069 ± 0.744
2.77PheLeu: 2.77 ± 0.566
0.606PheMet: 0.606 ± 0.275
3.636PheAsn: 3.636 ± 0.617
0.606PhePro: 0.606 ± 0.214
1.558PheGln: 1.558 ± 0.307
1.472PheArg: 1.472 ± 0.385
2.51PheSer: 2.51 ± 0.533
2.51PheThr: 2.51 ± 0.442
2.684PheVal: 2.684 ± 0.433
0.866PheTrp: 0.866 ± 0.227
1.818PheTyr: 1.818 ± 0.348
0.0PheXaa: 0.0 ± 0.0
Gly
3.03GlyAla: 3.03 ± 0.669
0.346GlyCys: 0.346 ± 0.195
4.328GlyAsp: 4.328 ± 0.637
3.549GlyGlu: 3.549 ± 0.585
3.03GlyPhe: 3.03 ± 0.422
3.895GlyGly: 3.895 ± 0.84
0.866GlyHis: 0.866 ± 0.247
5.54GlyIle: 5.54 ± 0.812
5.627GlyLys: 5.627 ± 0.742
6.146GlyLeu: 6.146 ± 0.796
1.212GlyMet: 1.212 ± 0.314
3.722GlyAsn: 3.722 ± 0.645
1.818GlyPro: 1.818 ± 0.519
3.289GlyGln: 3.289 ± 0.537
3.116GlyArg: 3.116 ± 0.524
4.242GlySer: 4.242 ± 0.754
4.588GlyThr: 4.588 ± 0.841
3.203GlyVal: 3.203 ± 0.637
1.298GlyTrp: 1.298 ± 0.395
3.809GlyTyr: 3.809 ± 0.63
0.0GlyXaa: 0.0 ± 0.0
His
0.606HisAla: 0.606 ± 0.247
0.087HisCys: 0.087 ± 0.092
0.779HisAsp: 0.779 ± 0.3
0.433HisGlu: 0.433 ± 0.274
0.693HisPhe: 0.693 ± 0.246
0.952HisGly: 0.952 ± 0.272
0.433HisHis: 0.433 ± 0.203
1.039HisIle: 1.039 ± 0.313
1.212HisLys: 1.212 ± 0.286
1.298HisLeu: 1.298 ± 0.259
0.26HisMet: 0.26 ± 0.17
0.779HisAsn: 0.779 ± 0.277
0.693HisPro: 0.693 ± 0.196
0.346HisGln: 0.346 ± 0.226
0.693HisArg: 0.693 ± 0.237
1.212HisSer: 1.212 ± 0.26
0.606HisThr: 0.606 ± 0.184
0.952HisVal: 0.952 ± 0.214
0.0HisTrp: 0.0 ± 0.0
0.779HisTyr: 0.779 ± 0.338
0.0HisXaa: 0.0 ± 0.0
Ile
5.107IleAla: 5.107 ± 0.944
0.519IleCys: 0.519 ± 0.228
4.675IleAsp: 4.675 ± 0.685
5.107IleGlu: 5.107 ± 0.702
1.212IlePhe: 1.212 ± 0.26
4.934IleGly: 4.934 ± 0.702
0.693IleHis: 0.693 ± 0.262
2.943IleIle: 2.943 ± 0.557
6.839IleLys: 6.839 ± 0.833
3.895IleLeu: 3.895 ± 0.654
1.645IleMet: 1.645 ± 0.488
4.242IleAsn: 4.242 ± 0.509
2.857IlePro: 2.857 ± 0.567
2.943IleGln: 2.943 ± 0.564
2.684IleArg: 2.684 ± 0.53
4.501IleSer: 4.501 ± 0.581
3.463IleThr: 3.463 ± 0.452
3.549IleVal: 3.549 ± 0.603
1.212IleTrp: 1.212 ± 0.317
1.991IleTyr: 1.991 ± 0.436
0.0IleXaa: 0.0 ± 0.0
Lys
6.146LysAla: 6.146 ± 0.735
0.26LysCys: 0.26 ± 0.211
4.242LysAsp: 4.242 ± 0.741
7.445LysGlu: 7.445 ± 1.124
3.895LysPhe: 3.895 ± 0.731
5.886LysGly: 5.886 ± 0.692
1.298LysHis: 1.298 ± 0.428
4.934LysIle: 4.934 ± 0.547
6.839LysLys: 6.839 ± 1.251
7.358LysLeu: 7.358 ± 0.878
2.684LysMet: 2.684 ± 0.61
6.06LysAsn: 6.06 ± 1.013
3.203LysPro: 3.203 ± 0.626
4.155LysGln: 4.155 ± 0.53
3.549LysArg: 3.549 ± 0.509
4.069LysSer: 4.069 ± 0.494
5.454LysThr: 5.454 ± 0.783
4.761LysVal: 4.761 ± 0.791
1.125LysTrp: 1.125 ± 0.24
3.376LysTyr: 3.376 ± 0.705
0.0LysXaa: 0.0 ± 0.0
Leu
6.146LeuAla: 6.146 ± 0.81
0.433LeuCys: 0.433 ± 0.227
5.021LeuAsp: 5.021 ± 0.62
7.185LeuGlu: 7.185 ± 0.913
2.51LeuPhe: 2.51 ± 0.388
6.06LeuGly: 6.06 ± 0.864
0.779LeuHis: 0.779 ± 0.26
3.809LeuIle: 3.809 ± 0.561
6.925LeuLys: 6.925 ± 0.682
6.06LeuLeu: 6.06 ± 0.681
2.424LeuMet: 2.424 ± 0.564
5.454LeuAsn: 5.454 ± 0.665
2.251LeuPro: 2.251 ± 0.406
2.078LeuGln: 2.078 ± 0.393
3.463LeuArg: 3.463 ± 0.731
5.454LeuSer: 5.454 ± 0.761
5.886LeuThr: 5.886 ± 0.929
4.069LeuVal: 4.069 ± 0.643
0.693LeuTrp: 0.693 ± 0.201
2.597LeuTyr: 2.597 ± 0.457
0.0LeuXaa: 0.0 ± 0.0
Met
1.645MetAla: 1.645 ± 0.337
0.0MetCys: 0.0 ± 0.0
1.385MetAsp: 1.385 ± 0.474
1.298MetGlu: 1.298 ± 0.376
1.125MetPhe: 1.125 ± 0.241
1.125MetGly: 1.125 ± 0.384
0.26MetHis: 0.26 ± 0.157
1.904MetIle: 1.904 ± 0.42
3.289MetLys: 3.289 ± 0.594
2.164MetLeu: 2.164 ± 0.393
0.693MetMet: 0.693 ± 0.298
1.039MetAsn: 1.039 ± 0.253
0.952MetPro: 0.952 ± 0.254
1.125MetGln: 1.125 ± 0.347
0.866MetArg: 0.866 ± 0.252
1.558MetSer: 1.558 ± 0.359
1.904MetThr: 1.904 ± 0.418
1.385MetVal: 1.385 ± 0.375
0.173MetTrp: 0.173 ± 0.114
1.298MetTyr: 1.298 ± 0.363
0.0MetXaa: 0.0 ± 0.0
Asn
5.021AsnAla: 5.021 ± 1.04
0.433AsnCys: 0.433 ± 0.214
3.636AsnAsp: 3.636 ± 0.569
3.549AsnGlu: 3.549 ± 0.703
3.116AsnPhe: 3.116 ± 0.508
6.146AsnGly: 6.146 ± 1.19
0.779AsnHis: 0.779 ± 0.212
3.549AsnIle: 3.549 ± 0.634
5.28AsnLys: 5.28 ± 0.782
5.367AsnLeu: 5.367 ± 0.489
1.385AsnMet: 1.385 ± 0.37
4.675AsnAsn: 4.675 ± 0.822
3.03AsnPro: 3.03 ± 0.714
2.424AsnGln: 2.424 ± 0.403
2.51AsnArg: 2.51 ± 0.524
4.588AsnSer: 4.588 ± 0.533
3.289AsnThr: 3.289 ± 0.575
4.069AsnVal: 4.069 ± 0.625
0.693AsnTrp: 0.693 ± 0.245
2.251AsnTyr: 2.251 ± 0.4
0.0AsnXaa: 0.0 ± 0.0
Pro
1.731ProAla: 1.731 ± 0.315
0.087ProCys: 0.087 ± 0.094
1.731ProAsp: 1.731 ± 0.529
1.904ProGlu: 1.904 ± 0.433
1.298ProPhe: 1.298 ± 0.311
1.298ProGly: 1.298 ± 0.578
0.346ProHis: 0.346 ± 0.162
1.558ProIle: 1.558 ± 0.298
3.895ProLys: 3.895 ± 0.459
2.251ProLeu: 2.251 ± 0.379
0.26ProMet: 0.26 ± 0.163
2.77ProAsn: 2.77 ± 0.46
0.433ProPro: 0.433 ± 0.207
1.385ProGln: 1.385 ± 0.248
0.952ProArg: 0.952 ± 0.312
2.597ProSer: 2.597 ± 0.521
1.991ProThr: 1.991 ± 0.397
0.866ProVal: 0.866 ± 0.328
0.606ProTrp: 0.606 ± 0.208
1.385ProTyr: 1.385 ± 0.39
0.0ProXaa: 0.0 ± 0.0
Gln
3.722GlnAla: 3.722 ± 0.627
0.087GlnCys: 0.087 ± 0.08
2.597GlnAsp: 2.597 ± 0.551
3.03GlnGlu: 3.03 ± 0.773
1.818GlnPhe: 1.818 ± 0.507
3.116GlnGly: 3.116 ± 0.686
0.346GlnHis: 0.346 ± 0.199
1.645GlnIle: 1.645 ± 0.349
3.376GlnLys: 3.376 ± 0.585
3.549GlnLeu: 3.549 ± 0.461
1.731GlnMet: 1.731 ± 0.341
2.77GlnAsn: 2.77 ± 0.517
0.433GlnPro: 0.433 ± 0.223
3.116GlnGln: 3.116 ± 0.64
1.731GlnArg: 1.731 ± 0.401
1.731GlnSer: 1.731 ± 0.405
3.116GlnThr: 3.116 ± 0.473
1.818GlnVal: 1.818 ± 0.396
0.693GlnTrp: 0.693 ± 0.292
2.251GlnTyr: 2.251 ± 0.35
0.0GlnXaa: 0.0 ± 0.0
Arg
2.251ArgAla: 2.251 ± 0.39
0.087ArgCys: 0.087 ± 0.096
2.337ArgAsp: 2.337 ± 0.45
2.77ArgGlu: 2.77 ± 0.557
2.251ArgPhe: 2.251 ± 0.475
2.337ArgGly: 2.337 ± 0.42
0.519ArgHis: 0.519 ± 0.191
2.51ArgIle: 2.51 ± 0.463
3.116ArgLys: 3.116 ± 0.711
3.722ArgLeu: 3.722 ± 0.564
1.212ArgMet: 1.212 ± 0.331
2.424ArgAsn: 2.424 ± 0.377
1.125ArgPro: 1.125 ± 0.316
2.078ArgGln: 2.078 ± 0.415
1.385ArgArg: 1.385 ± 0.375
2.078ArgSer: 2.078 ± 0.439
2.857ArgThr: 2.857 ± 0.669
2.684ArgVal: 2.684 ± 0.474
1.039ArgTrp: 1.039 ± 0.315
2.164ArgTyr: 2.164 ± 0.511
0.0ArgXaa: 0.0 ± 0.0
Ser
3.376SerAla: 3.376 ± 0.688
0.433SerCys: 0.433 ± 0.204
5.28SerAsp: 5.28 ± 0.541
4.242SerGlu: 4.242 ± 0.589
2.424SerPhe: 2.424 ± 0.491
4.155SerGly: 4.155 ± 0.485
0.866SerHis: 0.866 ± 0.331
4.848SerIle: 4.848 ± 0.515
5.367SerLys: 5.367 ± 0.863
4.501SerLeu: 4.501 ± 0.675
1.991SerMet: 1.991 ± 0.311
4.242SerAsn: 4.242 ± 0.555
1.731SerPro: 1.731 ± 0.321
2.597SerGln: 2.597 ± 0.602
3.376SerArg: 3.376 ± 0.607
3.116SerSer: 3.116 ± 0.702
4.155SerThr: 4.155 ± 0.645
4.069SerVal: 4.069 ± 0.522
0.519SerTrp: 0.519 ± 0.264
2.424SerTyr: 2.424 ± 0.434
0.0SerXaa: 0.0 ± 0.0
Thr
4.675ThrAla: 4.675 ± 0.726
0.26ThrCys: 0.26 ± 0.149
3.895ThrAsp: 3.895 ± 0.614
3.636ThrGlu: 3.636 ± 0.543
2.251ThrPhe: 2.251 ± 0.485
4.069ThrGly: 4.069 ± 0.556
1.212ThrHis: 1.212 ± 0.344
4.588ThrIle: 4.588 ± 1.005
4.761ThrLys: 4.761 ± 0.649
6.579ThrLeu: 6.579 ± 0.78
0.519ThrMet: 0.519 ± 0.219
4.848ThrAsn: 4.848 ± 0.655
1.558ThrPro: 1.558 ± 0.387
2.77ThrGln: 2.77 ± 0.663
2.078ThrArg: 2.078 ± 0.39
4.501ThrSer: 4.501 ± 0.498
2.684ThrThr: 2.684 ± 0.494
3.809ThrVal: 3.809 ± 0.666
0.952ThrTrp: 0.952 ± 0.273
2.943ThrTyr: 2.943 ± 0.557
0.0ThrXaa: 0.0 ± 0.0
Val
3.895ValAla: 3.895 ± 0.742
0.433ValCys: 0.433 ± 0.256
4.069ValAsp: 4.069 ± 0.459
3.809ValGlu: 3.809 ± 0.633
2.857ValPhe: 2.857 ± 0.518
3.376ValGly: 3.376 ± 0.534
0.606ValHis: 0.606 ± 0.201
3.463ValIle: 3.463 ± 0.466
4.848ValLys: 4.848 ± 0.668
3.116ValLeu: 3.116 ± 0.732
1.125ValMet: 1.125 ± 0.314
3.376ValAsn: 3.376 ± 0.496
1.818ValPro: 1.818 ± 0.429
1.904ValGln: 1.904 ± 0.537
1.991ValArg: 1.991 ± 0.526
4.848ValSer: 4.848 ± 0.748
4.934ValThr: 4.934 ± 0.784
3.636ValVal: 3.636 ± 0.649
1.039ValTrp: 1.039 ± 0.239
2.251ValTyr: 2.251 ± 0.526
0.0ValXaa: 0.0 ± 0.0
Trp
0.606TrpAla: 0.606 ± 0.232
0.0TrpCys: 0.0 ± 0.0
0.952TrpAsp: 0.952 ± 0.355
1.039TrpGlu: 1.039 ± 0.337
0.433TrpPhe: 0.433 ± 0.182
0.606TrpGly: 0.606 ± 0.323
0.173TrpHis: 0.173 ± 0.121
0.952TrpIle: 0.952 ± 0.262
1.039TrpLys: 1.039 ± 0.329
1.298TrpLeu: 1.298 ± 0.308
0.173TrpMet: 0.173 ± 0.101
0.693TrpAsn: 0.693 ± 0.275
0.173TrpPro: 0.173 ± 0.145
0.519TrpGln: 0.519 ± 0.199
0.866TrpArg: 0.866 ± 0.273
1.904TrpSer: 1.904 ± 0.485
1.039TrpThr: 1.039 ± 0.283
1.212TrpVal: 1.212 ± 0.293
0.433TrpTrp: 0.433 ± 0.219
0.433TrpTyr: 0.433 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.77TyrAla: 2.77 ± 0.59
0.866TyrCys: 0.866 ± 0.345
3.116TyrAsp: 3.116 ± 0.612
2.597TyrGlu: 2.597 ± 0.529
2.164TyrPhe: 2.164 ± 0.416
2.597TyrGly: 2.597 ± 0.645
1.298TyrHis: 1.298 ± 0.336
2.943TyrIle: 2.943 ± 0.569
3.289TyrLys: 3.289 ± 0.43
3.03TyrLeu: 3.03 ± 0.396
1.385TyrMet: 1.385 ± 0.442
1.558TyrAsn: 1.558 ± 0.335
1.818TyrPro: 1.818 ± 0.506
2.424TyrGln: 2.424 ± 0.353
1.731TyrArg: 1.731 ± 0.333
2.51TyrSer: 2.51 ± 0.56
2.251TyrThr: 2.251 ± 0.667
2.337TyrVal: 2.337 ± 0.427
0.087TyrTrp: 0.087 ± 0.095
1.731TyrTyr: 1.731 ± 0.394
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski