Amino acid dipepetide frequency for Dialister sp. CAG:486

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.196AlaAla: 10.196 ± 0.202	1.194AlaCys: 1.194 ± 0.048	5.276AlaAsp: 5.276 ± 0.088	6.369AlaGlu: 6.369 ± 0.14	3.628AlaPhe: 3.628 ± 0.095	7.564AlaGly: 7.564 ± 0.141	1.819AlaHis: 1.819 ± 0.059	5.79AlaIle: 5.79 ± 0.107	5.768AlaLys: 5.768 ± 0.107	9.289AlaLeu: 9.289 ± 0.155	3.041AlaMet: 3.041 ± 0.074	2.405AlaAsn: 2.405 ± 0.083	2.943AlaPro: 2.943 ± 0.088	2.391AlaGln: 2.391 ± 0.069	4.079AlaArg: 4.079 ± 0.109	5.1AlaSer: 5.1 ± 0.11	3.328AlaThr: 3.328 ± 0.078	6.823AlaVal: 6.823 ± 0.125	0.82AlaTrp: 0.82 ± 0.04	2.88AlaTyr: 2.88 ± 0.081	0.002AlaXaa: 0.002 ± 0.002
Cys	1.022CysAla: 1.022 ± 0.046	0.225CysCys: 0.225 ± 0.023	0.706CysAsp: 0.706 ± 0.039	0.75CysGlu: 0.75 ± 0.04	0.599CysPhe: 0.599 ± 0.036	1.288CysGly: 1.288 ± 0.057	0.428CysHis: 0.428 ± 0.037	0.799CysIle: 0.799 ± 0.041	0.509CysLys: 0.509 ± 0.03	1.222CysLeu: 1.222 ± 0.048	0.309CysMet: 0.309 ± 0.021	0.306CysAsn: 0.306 ± 0.024	0.592CysPro: 0.592 ± 0.044	0.365CysGln: 0.365 ± 0.023	0.755CysArg: 0.755 ± 0.041	0.648CysSer: 0.648 ± 0.032	0.622CysThr: 0.622 ± 0.032	0.802CysVal: 0.802 ± 0.038	0.117CysTrp: 0.117 ± 0.014	0.447CysTyr: 0.447 ± 0.032	0.0CysXaa: 0.0 ± 0.0
Asp	5.02AspAla: 5.02 ± 0.104	0.655AspCys: 0.655 ± 0.04	2.912AspAsp: 2.912 ± 0.085	3.849AspGlu: 3.849 ± 0.085	2.803AspPhe: 2.803 ± 0.076	4.544AspGly: 4.544 ± 0.105	1.251AspHis: 1.251 ± 0.056	4.292AspIle: 4.292 ± 0.088	2.987AspLys: 2.987 ± 0.084	5.17AspLeu: 5.17 ± 0.102	2.146AspMet: 2.146 ± 0.069	1.543AspAsn: 1.543 ± 0.058	2.48AspPro: 2.48 ± 0.063	1.507AspGln: 1.507 ± 0.05	3.01AspArg: 3.01 ± 0.07	2.443AspSer: 2.443 ± 0.066	3.19AspThr: 3.19 ± 0.086	4.092AspVal: 4.092 ± 0.09	0.673AspTrp: 0.673 ± 0.039	2.206AspTyr: 2.206 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	7.019GluAla: 7.019 ± 0.131	0.615GluCys: 0.615 ± 0.033	4.079GluAsp: 4.079 ± 0.095	6.753GluGlu: 6.753 ± 0.152	1.828GluPhe: 1.828 ± 0.064	5.077GluGly: 5.077 ± 0.108	1.278GluHis: 1.278 ± 0.047	4.729GluIle: 4.729 ± 0.088	6.514GluLys: 6.514 ± 0.131	5.423GluLeu: 5.423 ± 0.116	2.478GluMet: 2.478 ± 0.062	2.765GluAsn: 2.765 ± 0.077	1.788GluPro: 1.788 ± 0.059	1.914GluGln: 1.914 ± 0.06	3.604GluArg: 3.604 ± 0.092	3.011GluSer: 3.011 ± 0.066	3.627GluThr: 3.627 ± 0.09	4.174GluVal: 4.174 ± 0.101	0.655GluTrp: 0.655 ± 0.033	1.959GluTyr: 1.959 ± 0.063	0.002GluXaa: 0.002 ± 0.002
Phe	3.261PheAla: 3.261 ± 0.08	0.634PheCys: 0.634 ± 0.029	2.407PheAsp: 2.407 ± 0.072	2.094PheGlu: 2.094 ± 0.052	2.038PhePhe: 2.038 ± 0.076	3.134PheGly: 3.134 ± 0.082	1.147PheHis: 1.147 ± 0.042	2.664PheIle: 2.664 ± 0.087	1.736PheLys: 1.736 ± 0.057	4.534PheLeu: 4.534 ± 0.116	1.185PheMet: 1.185 ± 0.048	1.136PheAsn: 1.136 ± 0.044	1.676PhePro: 1.676 ± 0.059	1.113PheGln: 1.113 ± 0.051	1.942PheArg: 1.942 ± 0.057	2.699PheSer: 2.699 ± 0.063	2.424PheThr: 2.424 ± 0.073	2.438PheVal: 2.438 ± 0.079	0.503PheTrp: 0.503 ± 0.037	1.437PheTyr: 1.437 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	6.295GlyAla: 6.295 ± 0.125	1.169GlyCys: 1.169 ± 0.051	4.17GlyAsp: 4.17 ± 0.103	5.009GlyGlu: 5.009 ± 0.107	3.078GlyPhe: 3.078 ± 0.08	5.633GlyGly: 5.633 ± 0.139	1.853GlyHis: 1.853 ± 0.065	6.005GlyIle: 6.005 ± 0.12	5.656GlyLys: 5.656 ± 0.11	6.881GlyLeu: 6.881 ± 0.124	2.742GlyMet: 2.742 ± 0.083	2.756GlyAsn: 2.756 ± 0.089	1.744GlyPro: 1.744 ± 0.051	2.08GlyGln: 2.08 ± 0.062	3.967GlyArg: 3.967 ± 0.097	4.427GlySer: 4.427 ± 0.098	4.355GlyThr: 4.355 ± 0.096	5.294GlyVal: 5.294 ± 0.099	0.87GlyTrp: 0.87 ± 0.039	2.655GlyTyr: 2.655 ± 0.071	0.003GlyXaa: 0.003 ± 0.002
His	1.84HisAla: 1.84 ± 0.057	0.327HisCys: 0.327 ± 0.031	1.159HisAsp: 1.159 ± 0.055	1.358HisGlu: 1.358 ± 0.067	1.202HisPhe: 1.202 ± 0.053	1.765HisGly: 1.765 ± 0.065	0.704HisHis: 0.704 ± 0.039	1.646HisIle: 1.646 ± 0.058	1.017HisLys: 1.017 ± 0.043	2.232HisLeu: 2.232 ± 0.061	0.739HisMet: 0.739 ± 0.034	0.641HisAsn: 0.641 ± 0.035	1.299HisPro: 1.299 ± 0.053	0.753HisGln: 0.753 ± 0.035	1.169HisArg: 1.169 ± 0.047	1.01HisSer: 1.01 ± 0.044	1.192HisThr: 1.192 ± 0.048	1.736HisVal: 1.736 ± 0.054	0.245HisTrp: 0.245 ± 0.023	0.778HisTyr: 0.778 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	6.056IleAla: 6.056 ± 0.117	0.987IleCys: 0.987 ± 0.046	4.029IleAsp: 4.029 ± 0.095	4.158IleGlu: 4.158 ± 0.1	2.602IlePhe: 2.602 ± 0.083	5.149IleGly: 5.149 ± 0.113	1.805IleHis: 1.805 ± 0.052	4.008IleIle: 4.008 ± 0.099	2.767IleLys: 2.767 ± 0.078	6.621IleLeu: 6.621 ± 0.116	1.708IleMet: 1.708 ± 0.055	1.846IleAsn: 1.846 ± 0.062	3.368IlePro: 3.368 ± 0.089	1.916IleGln: 1.916 ± 0.066	3.731IleArg: 3.731 ± 0.082	4.719IleSer: 4.719 ± 0.095	3.676IleThr: 3.676 ± 0.097	4.453IleVal: 4.453 ± 0.083	0.561IleTrp: 0.561 ± 0.03	2.207IleTyr: 2.207 ± 0.063	0.002IleXaa: 0.002 ± 0.002
Lys	6.175LysAla: 6.175 ± 0.112	0.486LysCys: 0.486 ± 0.043	4.251LysAsp: 4.251 ± 0.103	6.357LysGlu: 6.357 ± 0.139	1.325LysPhe: 1.325 ± 0.056	4.583LysGly: 4.583 ± 0.093	1.019LysHis: 1.019 ± 0.043	3.462LysIle: 3.462 ± 0.094	5.778LysLys: 5.778 ± 0.13	4.693LysLeu: 4.693 ± 0.104	2.227LysMet: 2.227 ± 0.065	2.671LysAsn: 2.671 ± 0.082	2.062LysPro: 2.062 ± 0.066	1.909LysGln: 1.909 ± 0.056	3.08LysArg: 3.08 ± 0.066	3.135LysSer: 3.135 ± 0.083	3.59LysThr: 3.59 ± 0.073	4.098LysVal: 4.098 ± 0.097	0.657LysTrp: 0.657 ± 0.034	2.048LysTyr: 2.048 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	9.34LeuAla: 9.34 ± 0.152	1.232LeuCys: 1.232 ± 0.045	4.752LeuAsp: 4.752 ± 0.09	5.138LeuGlu: 5.138 ± 0.112	4.16LeuPhe: 4.16 ± 0.109	6.682LeuGly: 6.682 ± 0.123	2.101LeuHis: 2.101 ± 0.063	5.523LeuIle: 5.523 ± 0.118	5.339LeuLys: 5.339 ± 0.107	9.595LeuLeu: 9.595 ± 0.2	2.76LeuMet: 2.76 ± 0.072	2.578LeuAsn: 2.578 ± 0.073	4.537LeuPro: 4.537 ± 0.107	2.545LeuGln: 2.545 ± 0.069	4.418LeuArg: 4.418 ± 0.1	7.55LeuSer: 7.55 ± 0.149	5.715LeuThr: 5.715 ± 0.107	5.713LeuVal: 5.713 ± 0.111	0.932LeuTrp: 0.932 ± 0.045	3.125LeuTyr: 3.125 ± 0.085	0.0LeuXaa: 0.0 ± 0.0
Met	3.373MetAla: 3.373 ± 0.062	0.295MetCys: 0.295 ± 0.024	2.02MetAsp: 2.02 ± 0.062	2.352MetGlu: 2.352 ± 0.065	0.767MetPhe: 0.767 ± 0.037	2.463MetGly: 2.463 ± 0.079	0.598MetHis: 0.598 ± 0.029	1.966MetIle: 1.966 ± 0.064	2.803MetLys: 2.803 ± 0.071	2.613MetLeu: 2.613 ± 0.068	1.047MetMet: 1.047 ± 0.045	1.442MetAsn: 1.442 ± 0.054	1.335MetPro: 1.335 ± 0.042	1.136MetGln: 1.136 ± 0.047	1.576MetArg: 1.576 ± 0.056	1.676MetSer: 1.676 ± 0.06	2.129MetThr: 2.129 ± 0.065	1.935MetVal: 1.935 ± 0.057	0.208MetTrp: 0.208 ± 0.018	0.94MetTyr: 0.94 ± 0.042	0.0MetXaa: 0.0 ± 0.0
Asn	2.807AsnAla: 2.807 ± 0.08	0.36AsnCys: 0.36 ± 0.029	1.83AsnAsp: 1.83 ± 0.071	2.059AsnGlu: 2.059 ± 0.065	1.232AsnPhe: 1.232 ± 0.05	2.868AsnGly: 2.868 ± 0.092	0.821AsnHis: 0.821 ± 0.041	2.279AsnIle: 2.279 ± 0.071	1.674AsnLys: 1.674 ± 0.06	2.77AsnLeu: 2.77 ± 0.084	1.084AsnMet: 1.084 ± 0.037	1.024AsnAsn: 1.024 ± 0.054	1.777AsnPro: 1.777 ± 0.056	1.197AsnGln: 1.197 ± 0.06	1.573AsnArg: 1.573 ± 0.061	1.529AsnSer: 1.529 ± 0.06	1.692AsnThr: 1.692 ± 0.072	2.323AsnVal: 2.323 ± 0.065	0.383AsnTrp: 0.383 ± 0.028	1.281AsnTyr: 1.281 ± 0.055	0.002AsnXaa: 0.002 ± 0.002
Pro	3.371ProAla: 3.371 ± 0.089	0.453ProCys: 0.453 ± 0.032	2.3ProAsp: 2.3 ± 0.07	3.406ProGlu: 3.406 ± 0.083	1.933ProPhe: 1.933 ± 0.066	2.721ProGly: 2.721 ± 0.069	0.86ProHis: 0.86 ± 0.046	2.471ProIle: 2.471 ± 0.079	2.277ProLys: 2.277 ± 0.061	3.637ProLeu: 3.637 ± 0.089	1.213ProMet: 1.213 ± 0.043	1.138ProAsn: 1.138 ± 0.05	1.248ProPro: 1.248 ± 0.049	1.15ProGln: 1.15 ± 0.047	1.48ProArg: 1.48 ± 0.057	2.307ProSer: 2.307 ± 0.07	1.823ProThr: 1.823 ± 0.057	3.391ProVal: 3.391 ± 0.083	0.437ProTrp: 0.437 ± 0.031	1.48ProTyr: 1.48 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	2.643GlnAla: 2.643 ± 0.084	0.306GlnCys: 0.306 ± 0.023	1.508GlnAsp: 1.508 ± 0.053	2.169GlnGlu: 2.169 ± 0.067	0.994GlnPhe: 0.994 ± 0.042	2.015GlnGly: 2.015 ± 0.055	0.587GlnHis: 0.587 ± 0.03	1.886GlnIle: 1.886 ± 0.057	2.438GlnLys: 2.438 ± 0.07	2.599GlnLeu: 2.599 ± 0.07	1.14GlnMet: 1.14 ± 0.049	1.127GlnAsn: 1.127 ± 0.048	1.026GlnPro: 1.026 ± 0.044	1.152GlnGln: 1.152 ± 0.05	1.484GlnArg: 1.484 ± 0.05	1.482GlnSer: 1.482 ± 0.054	1.472GlnThr: 1.472 ± 0.051	1.987GlnVal: 1.987 ± 0.056	0.327GlnTrp: 0.327 ± 0.025	1.061GlnTyr: 1.061 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.716ArgAla: 3.716 ± 0.087	0.589ArgCys: 0.589 ± 0.034	2.595ArgAsp: 2.595 ± 0.079	3.898ArgGlu: 3.898 ± 0.098	2.258ArgPhe: 2.258 ± 0.068	3.233ArgGly: 3.233 ± 0.069	1.206ArgHis: 1.206 ± 0.056	3.515ArgIle: 3.515 ± 0.088	3.475ArgLys: 3.475 ± 0.094	4.784ArgLeu: 4.784 ± 0.097	1.77ArgMet: 1.77 ± 0.056	1.86ArgAsn: 1.86 ± 0.068	1.842ArgPro: 1.842 ± 0.069	1.826ArgGln: 1.826 ± 0.061	3.135ArgArg: 3.135 ± 0.105	2.74ArgSer: 2.74 ± 0.068	2.356ArgThr: 2.356 ± 0.065	2.957ArgVal: 2.957 ± 0.078	0.572ArgTrp: 0.572 ± 0.036	1.854ArgTyr: 1.854 ± 0.061	0.002ArgXaa: 0.002 ± 0.002
Ser	5.037SerAla: 5.037 ± 0.11	0.788SerCys: 0.788 ± 0.035	3.261SerAsp: 3.261 ± 0.077	3.309SerGlu: 3.309 ± 0.075	2.658SerPhe: 2.658 ± 0.067	4.871SerGly: 4.871 ± 0.099	1.449SerHis: 1.449 ± 0.053	3.786SerIle: 3.786 ± 0.079	2.786SerLys: 2.786 ± 0.079	5.846SerLeu: 5.846 ± 0.112	1.851SerMet: 1.851 ± 0.061	1.496SerAsn: 1.496 ± 0.053	2.183SerPro: 2.183 ± 0.068	1.743SerGln: 1.743 ± 0.06	3.071SerArg: 3.071 ± 0.084	3.359SerSer: 3.359 ± 0.098	2.714SerThr: 2.714 ± 0.077	4.037SerVal: 4.037 ± 0.108	0.722SerTrp: 0.722 ± 0.037	2.344SerTyr: 2.344 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	5.023ThrAla: 5.023 ± 0.123	0.636ThrCys: 0.636 ± 0.035	2.889ThrAsp: 2.889 ± 0.075	3.44ThrGlu: 3.44 ± 0.08	2.178ThrPhe: 2.178 ± 0.066	4.745ThrGly: 4.745 ± 0.099	1.171ThrHis: 1.171 ± 0.045	3.85ThrIle: 3.85 ± 0.09	2.961ThrLys: 2.961 ± 0.076	5.163ThrLeu: 5.163 ± 0.105	1.627ThrMet: 1.627 ± 0.055	1.676ThrAsn: 1.676 ± 0.07	2.517ThrPro: 2.517 ± 0.058	1.202ThrGln: 1.202 ± 0.043	2.344ThrArg: 2.344 ± 0.063	2.772ThrSer: 2.772 ± 0.071	2.672ThrThr: 2.672 ± 0.091	4.016ThrVal: 4.016 ± 0.082	0.53ThrTrp: 0.53 ± 0.033	1.923ThrTyr: 1.923 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	5.074ValAla: 5.074 ± 0.112	0.972ValCys: 0.972 ± 0.044	3.698ValAsp: 3.698 ± 0.084	3.962ValGlu: 3.962 ± 0.086	2.856ValPhe: 2.856 ± 0.08	4.611ValGly: 4.611 ± 0.1	1.461ValHis: 1.461 ± 0.054	4.836ValIle: 4.836 ± 0.111	4.558ValLys: 4.558 ± 0.08	6.524ValLeu: 6.524 ± 0.113	2.207ValMet: 2.207 ± 0.072	2.541ValAsn: 2.541 ± 0.073	2.912ValPro: 2.912 ± 0.075	1.777ValGln: 1.777 ± 0.06	3.298ValArg: 3.298 ± 0.082	4.49ValSer: 4.49 ± 0.092	4.317ValThr: 4.317 ± 0.095	4.654ValVal: 4.654 ± 0.116	0.633ValTrp: 0.633 ± 0.037	2.387ValTyr: 2.387 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.725TrpAla: 0.725 ± 0.034	0.143TrpCys: 0.143 ± 0.017	0.575TrpAsp: 0.575 ± 0.033	0.668TrpGlu: 0.668 ± 0.039	0.386TrpPhe: 0.386 ± 0.025	0.743TrpGly: 0.743 ± 0.04	0.287TrpHis: 0.287 ± 0.023	0.701TrpIle: 0.701 ± 0.037	0.8TrpLys: 0.8 ± 0.042	0.97TrpLeu: 0.97 ± 0.042	0.421TrpMet: 0.421 ± 0.026	0.507TrpAsn: 0.507 ± 0.03	0.304TrpPro: 0.304 ± 0.024	0.544TrpGln: 0.544 ± 0.032	0.512TrpArg: 0.512 ± 0.029	0.528TrpSer: 0.528 ± 0.034	0.488TrpThr: 0.488 ± 0.032	0.544TrpVal: 0.544 ± 0.028	0.152TrpTrp: 0.152 ± 0.017	0.36TrpTyr: 0.36 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.711TyrAla: 2.711 ± 0.064	0.444TyrCys: 0.444 ± 0.027	2.354TyrAsp: 2.354 ± 0.07	2.197TyrGlu: 2.197 ± 0.064	1.673TyrPhe: 1.673 ± 0.063	2.954TyrGly: 2.954 ± 0.08	0.968TyrHis: 0.968 ± 0.04	2.158TyrIle: 2.158 ± 0.068	1.762TyrLys: 1.762 ± 0.06	3.17TyrLeu: 3.17 ± 0.082	0.98TyrMet: 0.98 ± 0.037	1.108TyrAsn: 1.108 ± 0.052	1.463TyrPro: 1.463 ± 0.054	1.183TyrGln: 1.183 ± 0.044	1.952TyrArg: 1.952 ± 0.065	1.681TyrSer: 1.681 ± 0.053	1.952TyrThr: 1.952 ± 0.065	2.302TyrVal: 2.302 ± 0.065	0.36TyrTrp: 0.36 ± 0.026	1.244TyrTyr: 1.244 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.002XaaCys: 0.002 ± 0.002	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.002XaaSer: 0.002 ± 0.002	0.002XaaThr: 0.002 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.002XaaTrp: 0.002 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.019XaaXaa: 0.019 ± 0.008

Statistics based on 1926 proteins (572162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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