Amino acid dipepetide frequency for Prevotella sp. CAG:1092

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.697AlaAla: 5.697 ± 0.107	0.993AlaCys: 0.993 ± 0.039	4.809AlaAsp: 4.809 ± 0.083	4.719AlaGlu: 4.719 ± 0.086	3.069AlaPhe: 3.069 ± 0.06	4.527AlaGly: 4.527 ± 0.083	1.333AlaHis: 1.333 ± 0.039	5.311AlaIle: 5.311 ± 0.08	5.345AlaLys: 5.345 ± 0.097	6.345AlaLeu: 6.345 ± 0.104	2.302AlaMet: 2.302 ± 0.055	4.108AlaAsn: 4.108 ± 0.078	2.101AlaPro: 2.101 ± 0.054	2.751AlaGln: 2.751 ± 0.067	2.734AlaArg: 2.734 ± 0.067	4.302AlaSer: 4.302 ± 0.074	4.644AlaThr: 4.644 ± 0.094	4.419AlaVal: 4.419 ± 0.088	0.84AlaTrp: 0.84 ± 0.033	2.923AlaTyr: 2.923 ± 0.064	0.006AlaXaa: 0.006 ± 0.002
Cys	0.881CysAla: 0.881 ± 0.035	0.27CysCys: 0.27 ± 0.02	0.846CysAsp: 0.846 ± 0.035	0.743CysGlu: 0.743 ± 0.03	0.623CysPhe: 0.623 ± 0.036	1.201CysGly: 1.201 ± 0.042	0.402CysHis: 0.402 ± 0.025	0.973CysIle: 0.973 ± 0.038	0.857CysLys: 0.857 ± 0.035	1.138CysLeu: 1.138 ± 0.036	0.382CysMet: 0.382 ± 0.022	0.726CysAsn: 0.726 ± 0.027	0.571CysPro: 0.571 ± 0.029	0.432CysGln: 0.432 ± 0.021	0.632CysArg: 0.632 ± 0.031	0.839CysSer: 0.839 ± 0.038	0.667CysThr: 0.667 ± 0.032	0.796CysVal: 0.796 ± 0.029	0.174CysTrp: 0.174 ± 0.014	0.67CysTyr: 0.67 ± 0.03	0.001CysXaa: 0.001 ± 0.001
Asp	4.483AspAla: 4.483 ± 0.084	0.76AspCys: 0.76 ± 0.032	3.628AspAsp: 3.628 ± 0.08	4.244AspGlu: 4.244 ± 0.093	3.081AspPhe: 3.081 ± 0.057	4.673AspGly: 4.673 ± 0.097	0.976AspHis: 0.976 ± 0.033	4.765AspIle: 4.765 ± 0.102	4.599AspLys: 4.599 ± 0.087	4.248AspLeu: 4.248 ± 0.077	1.815AspMet: 1.815 ± 0.049	3.663AspAsn: 3.663 ± 0.073	1.683AspPro: 1.683 ± 0.055	1.249AspGln: 1.249 ± 0.035	2.219AspArg: 2.219 ± 0.048	3.396AspSer: 3.396 ± 0.069	2.975AspThr: 2.975 ± 0.061	4.028AspVal: 4.028 ± 0.071	0.789AspTrp: 0.789 ± 0.035	3.039AspTyr: 3.039 ± 0.059	0.001AspXaa: 0.001 ± 0.001
Glu	4.674GluAla: 4.674 ± 0.079	0.771GluCys: 0.771 ± 0.032	3.403GluAsp: 3.403 ± 0.069	4.357GluGlu: 4.357 ± 0.095	2.354GluPhe: 2.354 ± 0.056	4.089GluGly: 4.089 ± 0.078	1.2GluHis: 1.2 ± 0.041	4.358GluIle: 4.358 ± 0.083	4.637GluLys: 4.637 ± 0.086	5.292GluLeu: 5.292 ± 0.093	2.113GluMet: 2.113 ± 0.046	3.517GluAsn: 3.517 ± 0.065	1.704GluPro: 1.704 ± 0.045	2.404GluGln: 2.404 ± 0.05	2.869GluArg: 2.869 ± 0.054	2.921GluSer: 2.921 ± 0.065	3.125GluThr: 3.125 ± 0.058	3.911GluVal: 3.911 ± 0.07	0.832GluTrp: 0.832 ± 0.032	2.844GluTyr: 2.844 ± 0.062	0.001GluXaa: 0.001 ± 0.001
Phe	3.287PheAla: 3.287 ± 0.068	0.75PheCys: 0.75 ± 0.029	2.977PheAsp: 2.977 ± 0.052	2.363PheGlu: 2.363 ± 0.052	1.861PhePhe: 1.861 ± 0.058	3.182PheGly: 3.182 ± 0.069	0.87PheHis: 0.87 ± 0.034	2.842PheIle: 2.842 ± 0.068	2.57PheLys: 2.57 ± 0.064	3.317PheLeu: 3.317 ± 0.071	1.227PheMet: 1.227 ± 0.039	2.442PheAsn: 2.442 ± 0.054	1.418PhePro: 1.418 ± 0.04	1.093PheGln: 1.093 ± 0.035	1.729PheArg: 1.729 ± 0.041	3.12PheSer: 3.12 ± 0.061	2.642PheThr: 2.642 ± 0.055	2.975PheVal: 2.975 ± 0.063	0.465PheTrp: 0.465 ± 0.025	1.755PheTyr: 1.755 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.35GlyAla: 4.35 ± 0.087	1.064GlyCys: 1.064 ± 0.043	3.799GlyAsp: 3.799 ± 0.074	3.98GlyGlu: 3.98 ± 0.075	2.952GlyPhe: 2.952 ± 0.062	4.725GlyGly: 4.725 ± 0.127	1.244GlyHis: 1.244 ± 0.041	5.286GlyIle: 5.286 ± 0.085	5.688GlyLys: 5.688 ± 0.085	5.344GlyLeu: 5.344 ± 0.081	2.13GlyMet: 2.13 ± 0.059	3.969GlyAsn: 3.969 ± 0.096	1.227GlyPro: 1.227 ± 0.047	1.962GlyGln: 1.962 ± 0.056	2.686GlyArg: 2.686 ± 0.058	4.019GlySer: 4.019 ± 0.092	4.103GlyThr: 4.103 ± 0.09	4.652GlyVal: 4.652 ± 0.082	0.981GlyTrp: 0.981 ± 0.04	3.324GlyTyr: 3.324 ± 0.073	0.005GlyXaa: 0.005 ± 0.002
His	1.229HisAla: 1.229 ± 0.041	0.307HisCys: 0.307 ± 0.02	1.198HisAsp: 1.198 ± 0.045	1.077HisGlu: 1.077 ± 0.039	0.952HisPhe: 0.952 ± 0.033	1.387HisGly: 1.387 ± 0.042	0.551HisHis: 0.551 ± 0.031	1.471HisIle: 1.471 ± 0.045	1.17HisLys: 1.17 ± 0.039	1.668HisLeu: 1.668 ± 0.051	0.38HisMet: 0.38 ± 0.023	1.099HisAsn: 1.099 ± 0.034	0.912HisPro: 0.912 ± 0.027	0.636HisGln: 0.636 ± 0.028	0.856HisArg: 0.856 ± 0.033	1.168HisSer: 1.168 ± 0.045	1.074HisThr: 1.074 ± 0.035	1.144HisVal: 1.144 ± 0.034	0.236HisTrp: 0.236 ± 0.017	0.899HisTyr: 0.899 ± 0.035	0.001HisXaa: 0.001 ± 0.001
Ile	5.464IleAla: 5.464 ± 0.095	1.057IleCys: 1.057 ± 0.041	5.003IleAsp: 5.003 ± 0.08	4.55IleGlu: 4.55 ± 0.078	2.738IlePhe: 2.738 ± 0.072	4.52IleGly: 4.52 ± 0.076	1.273IleHis: 1.273 ± 0.037	4.782IleIle: 4.782 ± 0.101	4.84IleLys: 4.84 ± 0.077	5.315IleLeu: 5.315 ± 0.097	1.757IleMet: 1.757 ± 0.047	3.988IleAsn: 3.988 ± 0.078	2.884IlePro: 2.884 ± 0.067	1.94IleGln: 1.94 ± 0.053	2.873IleArg: 2.873 ± 0.066	4.681IleSer: 4.681 ± 0.079	4.219IleThr: 4.219 ± 0.066	4.824IleVal: 4.824 ± 0.088	0.681IleTrp: 0.681 ± 0.032	2.765IleTyr: 2.765 ± 0.054	0.002IleXaa: 0.002 ± 0.001
Lys	5.6LysAla: 5.6 ± 0.093	0.729LysCys: 0.729 ± 0.03	4.2LysAsp: 4.2 ± 0.077	5.053LysGlu: 5.053 ± 0.098	2.469LysPhe: 2.469 ± 0.062	4.517LysGly: 4.517 ± 0.082	1.317LysHis: 1.317 ± 0.043	4.495LysIle: 4.495 ± 0.084	5.553LysLys: 5.553 ± 0.09	5.78LysLeu: 5.78 ± 0.082	2.448LysMet: 2.448 ± 0.061	4.008LysAsn: 4.008 ± 0.074	2.425LysPro: 2.425 ± 0.057	2.702LysGln: 2.702 ± 0.059	3.139LysArg: 3.139 ± 0.069	3.821LysSer: 3.821 ± 0.069	4.031LysThr: 4.031 ± 0.076	4.678LysVal: 4.678 ± 0.075	0.886LysTrp: 0.886 ± 0.033	3.267LysTyr: 3.267 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	6.352LeuAla: 6.352 ± 0.091	1.331LeuCys: 1.331 ± 0.042	4.667LeuAsp: 4.667 ± 0.077	4.301LeuGlu: 4.301 ± 0.079	3.731LeuPhe: 3.731 ± 0.079	5.387LeuGly: 5.387 ± 0.089	1.793LeuHis: 1.793 ± 0.04	4.764LeuIle: 4.764 ± 0.099	5.958LeuLys: 5.958 ± 0.095	7.502LeuLeu: 7.502 ± 0.13	2.664LeuMet: 2.664 ± 0.057	4.543LeuAsn: 4.543 ± 0.081	3.393LeuPro: 3.393 ± 0.064	3.045LeuGln: 3.045 ± 0.061	3.911LeuArg: 3.911 ± 0.077	6.097LeuSer: 6.097 ± 0.098	4.927LeuThr: 4.927 ± 0.079	5.05LeuVal: 5.05 ± 0.094	0.933LeuTrp: 0.933 ± 0.034	3.498LeuTyr: 3.498 ± 0.067	0.005LeuXaa: 0.005 ± 0.002
Met	2.629MetAla: 2.629 ± 0.057	0.324MetCys: 0.324 ± 0.02	1.498MetAsp: 1.498 ± 0.041	1.863MetGlu: 1.863 ± 0.052	1.119MetPhe: 1.119 ± 0.041	1.906MetGly: 1.906 ± 0.045	0.563MetHis: 0.563 ± 0.025	1.699MetIle: 1.699 ± 0.045	2.561MetLys: 2.561 ± 0.06	2.818MetLeu: 2.818 ± 0.062	1.07MetMet: 1.07 ± 0.043	1.577MetAsn: 1.577 ± 0.043	1.442MetPro: 1.442 ± 0.046	1.229MetGln: 1.229 ± 0.039	1.324MetArg: 1.324 ± 0.036	1.724MetSer: 1.724 ± 0.048	1.64MetThr: 1.64 ± 0.044	1.893MetVal: 1.893 ± 0.049	0.27MetTrp: 0.27 ± 0.019	0.889MetTyr: 0.889 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.921AsnAla: 3.921 ± 0.069	0.66AsnCys: 0.66 ± 0.03	3.451AsnAsp: 3.451 ± 0.069	3.09AsnGlu: 3.09 ± 0.065	2.257AsnPhe: 2.257 ± 0.055	4.688AsnGly: 4.688 ± 0.09	1.073AsnHis: 1.073 ± 0.035	4.652AsnIle: 4.652 ± 0.082	3.851AsnLys: 3.851 ± 0.077	4.344AsnLeu: 4.344 ± 0.079	1.544AsnMet: 1.544 ± 0.05	3.531AsnAsn: 3.531 ± 0.09	2.29AsnPro: 2.29 ± 0.058	1.523AsnGln: 1.523 ± 0.039	2.277AsnArg: 2.277 ± 0.056	3.129AsnSer: 3.129 ± 0.073	3.157AsnThr: 3.157 ± 0.074	3.653AsnVal: 3.653 ± 0.076	0.675AsnTrp: 0.675 ± 0.033	2.517AsnTyr: 2.517 ± 0.069	0.002AsnXaa: 0.002 ± 0.002
Pro	2.43ProAla: 2.43 ± 0.067	0.438ProCys: 0.438 ± 0.023	2.186ProAsp: 2.186 ± 0.057	2.658ProGlu: 2.658 ± 0.054	1.602ProPhe: 1.602 ± 0.05	2.036ProGly: 2.036 ± 0.055	0.661ProHis: 0.661 ± 0.03	2.252ProIle: 2.252 ± 0.051	2.168ProLys: 2.168 ± 0.052	2.801ProLeu: 2.801 ± 0.059	1.017ProMet: 1.017 ± 0.037	1.795ProAsn: 1.795 ± 0.053	0.576ProPro: 0.576 ± 0.028	1.331ProGln: 1.331 ± 0.043	1.192ProArg: 1.192 ± 0.044	2.274ProSer: 2.274 ± 0.056	2.22ProThr: 2.22 ± 0.054	2.45ProVal: 2.45 ± 0.051	0.386ProTrp: 0.386 ± 0.021	1.651ProTyr: 1.651 ± 0.051	0.001ProXaa: 0.001 ± 0.001
Gln	2.343GlnAla: 2.343 ± 0.063	0.39GlnCys: 0.39 ± 0.024	1.57GlnAsp: 1.57 ± 0.046	2.012GlnGlu: 2.012 ± 0.054	1.305GlnPhe: 1.305 ± 0.036	2.048GlnGly: 2.048 ± 0.053	0.713GlnHis: 0.713 ± 0.033	2.283GlnIle: 2.283 ± 0.056	2.439GlnLys: 2.439 ± 0.059	3.263GlnLeu: 3.263 ± 0.067	1.183GlnMet: 1.183 ± 0.04	1.738GlnAsn: 1.738 ± 0.05	1.211GlnPro: 1.211 ± 0.044	1.843GlnGln: 1.843 ± 0.063	1.613GlnArg: 1.613 ± 0.043	1.794GlnSer: 1.794 ± 0.049	1.951GlnThr: 1.951 ± 0.049	1.881GlnVal: 1.881 ± 0.049	0.471GlnTrp: 0.471 ± 0.023	1.521GlnTyr: 1.521 ± 0.046	0.001GlnXaa: 0.001 ± 0.001
Arg	2.476ArgAla: 2.476 ± 0.063	0.527ArgCys: 0.527 ± 0.026	2.118ArgAsp: 2.118 ± 0.044	2.543ArgGlu: 2.543 ± 0.07	1.909ArgPhe: 1.909 ± 0.05	2.455ArgGly: 2.455 ± 0.059	0.985ArgHis: 0.985 ± 0.042	3.244ArgIle: 3.244 ± 0.069	3.161ArgLys: 3.161 ± 0.062	4.038ArgLeu: 4.038 ± 0.074	1.469ArgMet: 1.469 ± 0.042	2.48ArgAsn: 2.48 ± 0.054	1.426ArgPro: 1.426 ± 0.052	1.911ArgGln: 1.911 ± 0.052	2.049ArgArg: 2.049 ± 0.048	2.107ArgSer: 2.107 ± 0.054	2.121ArgThr: 2.121 ± 0.054	2.336ArgVal: 2.336 ± 0.053	0.588ArgTrp: 0.588 ± 0.026	2.045ArgTyr: 2.045 ± 0.044	0.001ArgXaa: 0.001 ± 0.001
Ser	4.392SerAla: 4.392 ± 0.075	0.879SerCys: 0.879 ± 0.036	3.553SerAsp: 3.553 ± 0.064	3.387SerGlu: 3.387 ± 0.066	3.006SerPhe: 3.006 ± 0.065	3.912SerGly: 3.912 ± 0.069	1.252SerHis: 1.252 ± 0.04	4.436SerIle: 4.436 ± 0.085	3.88SerLys: 3.88 ± 0.069	5.732SerLeu: 5.732 ± 0.091	1.659SerMet: 1.659 ± 0.047	3.198SerAsn: 3.198 ± 0.071	2.093SerPro: 2.093 ± 0.049	2.057SerGln: 2.057 ± 0.056	2.387SerArg: 2.387 ± 0.06	4.026SerSer: 4.026 ± 0.096	3.483SerThr: 3.483 ± 0.07	3.908SerVal: 3.908 ± 0.07	0.774SerTrp: 0.774 ± 0.031	2.812SerTyr: 2.812 ± 0.064	0.002SerXaa: 0.002 ± 0.002
Thr	4.09ThrAla: 4.09 ± 0.094	0.723ThrCys: 0.723 ± 0.028	3.521ThrAsp: 3.521 ± 0.073	3.169ThrGlu: 3.169 ± 0.071	2.663ThrPhe: 2.663 ± 0.059	3.928ThrGly: 3.928 ± 0.086	0.995ThrHis: 0.995 ± 0.033	4.842ThrIle: 4.842 ± 0.088	3.621ThrLys: 3.621 ± 0.067	5.128ThrLeu: 5.128 ± 0.084	1.525ThrMet: 1.525 ± 0.04	2.887ThrAsn: 2.887 ± 0.064	2.625ThrPro: 2.625 ± 0.065	1.637ThrGln: 1.637 ± 0.044	2.075ThrArg: 2.075 ± 0.046	3.7ThrSer: 3.7 ± 0.075	3.907ThrThr: 3.907 ± 0.079	3.563ThrVal: 3.563 ± 0.069	0.73ThrTrp: 0.73 ± 0.029	2.611ThrTyr: 2.611 ± 0.059	0.004ThrXaa: 0.004 ± 0.002
Val	5.242ValAla: 5.242 ± 0.083	1.056ValCys: 1.056 ± 0.035	4.309ValAsp: 4.309 ± 0.074	4.239ValGlu: 4.239 ± 0.074	2.656ValPhe: 2.656 ± 0.057	4.383ValGly: 4.383 ± 0.077	0.964ValHis: 0.964 ± 0.036	4.019ValIle: 4.019 ± 0.077	4.563ValLys: 4.563 ± 0.082	5.071ValLeu: 5.071 ± 0.083	1.815ValMet: 1.815 ± 0.045	3.373ValAsn: 3.373 ± 0.065	2.261ValPro: 2.261 ± 0.057	1.731ValGln: 1.731 ± 0.046	2.724ValArg: 2.724 ± 0.052	4.169ValSer: 4.169 ± 0.066	3.58ValThr: 3.58 ± 0.083	5.119ValVal: 5.119 ± 0.108	0.727ValTrp: 0.727 ± 0.026	2.661ValTyr: 2.661 ± 0.056	0.004ValXaa: 0.004 ± 0.002
Trp	0.801TrpAla: 0.801 ± 0.03	0.195TrpCys: 0.195 ± 0.017	0.706TrpAsp: 0.706 ± 0.034	0.62TrpGlu: 0.62 ± 0.029	0.549TrpPhe: 0.549 ± 0.026	0.871TrpGly: 0.871 ± 0.034	0.324TrpHis: 0.324 ± 0.018	0.692TrpIle: 0.692 ± 0.029	0.845TrpLys: 0.845 ± 0.031	1.144TrpLeu: 1.144 ± 0.043	0.41TrpMet: 0.41 ± 0.024	0.81TrpAsn: 0.81 ± 0.031	0.265TrpPro: 0.265 ± 0.018	0.549TrpGln: 0.549 ± 0.026	0.577TrpArg: 0.577 ± 0.03	0.671TrpSer: 0.671 ± 0.029	0.735TrpThr: 0.735 ± 0.036	0.677TrpVal: 0.677 ± 0.032	0.214TrpTrp: 0.214 ± 0.017	0.543TrpTyr: 0.543 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.936TyrAla: 2.936 ± 0.069	0.602TyrCys: 0.602 ± 0.025	2.87TyrAsp: 2.87 ± 0.075	2.406TyrGlu: 2.406 ± 0.06	1.987TyrPhe: 1.987 ± 0.05	3.055TyrGly: 3.055 ± 0.079	0.921TyrHis: 0.921 ± 0.032	2.992TyrIle: 2.992 ± 0.06	2.812TyrLys: 2.812 ± 0.059	3.562TyrLeu: 3.562 ± 0.073	1.124TyrMet: 1.124 ± 0.04	2.834TyrAsn: 2.834 ± 0.077	1.612TyrPro: 1.612 ± 0.05	1.549TyrGln: 1.549 ± 0.047	2.123TyrArg: 2.123 ± 0.052	2.863TyrSer: 2.863 ± 0.057	2.738TyrThr: 2.738 ± 0.067	2.705TyrVal: 2.705 ± 0.063	0.543TyrTrp: 0.543 ± 0.03	2.32TyrTyr: 2.32 ± 0.051	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.004XaaHis: 0.004 ± 0.002	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.005XaaPro: 0.005 ± 0.002	0.002XaaGln: 0.002 ± 0.002	0.001XaaArg: 0.001 ± 0.001	0.005XaaSer: 0.005 ± 0.003	0.005XaaThr: 0.005 ± 0.002	0.002XaaVal: 0.002 ± 0.002	0.002XaaTrp: 0.002 ± 0.002	0.001XaaTyr: 0.001 ± 0.001	0.052XaaXaa: 0.052 ± 0.01

Statistics based on 2513 proteins (840019 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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