Amino acid dipepetide frequency for Coprobacillus sp. CAG:605

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.416AlaAla: 2.416 ± 0.109
0.691AlaCys: 0.691 ± 0.05
2.073AlaAsp: 2.073 ± 0.087
2.222AlaGlu: 2.222 ± 0.099
1.952AlaPhe: 1.952 ± 0.077
2.753AlaGly: 2.753 ± 0.12
0.714AlaHis: 0.714 ± 0.045
4.506AlaIle: 4.506 ± 0.139
4.649AlaLys: 4.649 ± 0.135
4.857AlaLeu: 4.857 ± 0.123
1.343AlaMet: 1.343 ± 0.063
3.02AlaAsn: 3.02 ± 0.102
1.082AlaPro: 1.082 ± 0.057
1.188AlaGln: 1.188 ± 0.063
1.834AlaArg: 1.834 ± 0.083
3.745AlaSer: 3.745 ± 0.121
3.031AlaThr: 3.031 ± 0.114
2.537AlaVal: 2.537 ± 0.074
0.287AlaTrp: 0.287 ± 0.031
2.216AlaTyr: 2.216 ± 0.085
0.003AlaXaa: 0.003 ± 0.003
Cys
0.537CysAla: 0.537 ± 0.037
0.149CysCys: 0.149 ± 0.026
0.764CysAsp: 0.764 ± 0.051
0.688CysGlu: 0.688 ± 0.044
0.452CysPhe: 0.452 ± 0.033
0.961CysGly: 0.961 ± 0.061
0.281CysHis: 0.281 ± 0.029
0.885CysIle: 0.885 ± 0.049
0.82CysLys: 0.82 ± 0.052
1.076CysLeu: 1.076 ± 0.059
0.247CysMet: 0.247 ± 0.025
0.736CysAsn: 0.736 ± 0.045
0.449CysPro: 0.449 ± 0.048
0.337CysGln: 0.337 ± 0.036
0.264CysArg: 0.264 ± 0.024
0.817CysSer: 0.817 ± 0.056
0.551CysThr: 0.551 ± 0.048
0.694CysVal: 0.694 ± 0.052
0.042CysTrp: 0.042 ± 0.012
0.615CysTyr: 0.615 ± 0.047
0.0CysXaa: 0.0 ± 0.0
Asp
2.77AspAla: 2.77 ± 0.102
0.663AspCys: 0.663 ± 0.043
3.315AspAsp: 3.315 ± 0.11
4.202AspGlu: 4.202 ± 0.127
2.896AspPhe: 2.896 ± 0.1
2.969AspGly: 2.969 ± 0.134
0.612AspHis: 0.612 ± 0.042
6.512AspIle: 6.512 ± 0.141
5.837AspLys: 5.837 ± 0.148
5.615AspLeu: 5.615 ± 0.14
1.576AspMet: 1.576 ± 0.062
4.983AspAsn: 4.983 ± 0.137
1.281AspPro: 1.281 ± 0.061
0.73AspGln: 0.73 ± 0.044
1.528AspArg: 1.528 ± 0.065
3.34AspSer: 3.34 ± 0.102
3.823AspThr: 3.823 ± 0.098
3.672AspVal: 3.672 ± 0.118
0.281AspTrp: 0.281 ± 0.031
4.059AspTyr: 4.059 ± 0.108
0.0AspXaa: 0.0 ± 0.0
Glu
3.458GluAla: 3.458 ± 0.107
0.699GluCys: 0.699 ± 0.043
4.405GluAsp: 4.405 ± 0.111
6.211GluGlu: 6.211 ± 0.171
2.677GluPhe: 2.677 ± 0.093
2.801GluGly: 2.801 ± 0.098
0.935GluHis: 0.935 ± 0.06
6.455GluIle: 6.455 ± 0.163
5.874GluLys: 5.874 ± 0.146
7.166GluLeu: 7.166 ± 0.177
1.688GluMet: 1.688 ± 0.07
4.891GluAsn: 4.891 ± 0.112
1.464GluPro: 1.464 ± 0.07
1.862GluGln: 1.862 ± 0.075
2.267GluArg: 2.267 ± 0.09
3.436GluSer: 3.436 ± 0.111
3.582GluThr: 3.582 ± 0.113
4.309GluVal: 4.309 ± 0.136
0.382GluTrp: 0.382 ± 0.037
3.955GluTyr: 3.955 ± 0.105
0.0GluXaa: 0.0 ± 0.0
Phe
1.702PheAla: 1.702 ± 0.087
0.48PheCys: 0.48 ± 0.041
2.702PheAsp: 2.702 ± 0.094
2.326PheGlu: 2.326 ± 0.088
1.7PhePhe: 1.7 ± 0.088
2.295PheGly: 2.295 ± 0.088
0.503PheHis: 0.503 ± 0.041
4.048PheIle: 4.048 ± 0.128
3.804PheLys: 3.804 ± 0.114
4.121PheLeu: 4.121 ± 0.151
1.051PheMet: 1.051 ± 0.053
3.329PheAsn: 3.329 ± 0.119
0.899PhePro: 0.899 ± 0.045
0.916PheGln: 0.916 ± 0.046
1.138PheArg: 1.138 ± 0.055
2.511PheSer: 2.511 ± 0.096
2.236PheThr: 2.236 ± 0.088
2.247PheVal: 2.247 ± 0.087
0.222PheTrp: 0.222 ± 0.026
2.059PheTyr: 2.059 ± 0.093
0.0PheXaa: 0.0 ± 0.0
Gly
2.851GlyAla: 2.851 ± 0.112
0.806GlyCys: 0.806 ± 0.055
2.629GlyAsp: 2.629 ± 0.094
2.902GlyGlu: 2.902 ± 0.095
2.514GlyPhe: 2.514 ± 0.096
3.565GlyGly: 3.565 ± 0.28
0.997GlyHis: 0.997 ± 0.062
5.096GlyIle: 5.096 ± 0.126
4.399GlyLys: 4.399 ± 0.12
4.835GlyLeu: 4.835 ± 0.139
1.309GlyMet: 1.309 ± 0.061
3.267GlyAsn: 3.267 ± 0.116
0.913GlyPro: 0.913 ± 0.053
1.216GlyGln: 1.216 ± 0.064
1.702GlyArg: 1.702 ± 0.09
3.514GlySer: 3.514 ± 0.131
3.298GlyThr: 3.298 ± 0.108
3.756GlyVal: 3.756 ± 0.112
0.303GlyTrp: 0.303 ± 0.027
3.379GlyTyr: 3.379 ± 0.127
0.0GlyXaa: 0.0 ± 0.0
His
0.652HisAla: 0.652 ± 0.049
0.197HisCys: 0.197 ± 0.024
0.896HisAsp: 0.896 ± 0.051
0.966HisGlu: 0.966 ± 0.052
0.601HisPhe: 0.601 ± 0.038
0.77HisGly: 0.77 ± 0.047
0.312HisHis: 0.312 ± 0.032
1.247HisIle: 1.247 ± 0.063
1.087HisLys: 1.087 ± 0.063
1.177HisLeu: 1.177 ± 0.066
0.374HisMet: 0.374 ± 0.034
0.978HisAsn: 0.978 ± 0.061
0.525HisPro: 0.525 ± 0.037
0.379HisGln: 0.379 ± 0.032
0.469HisArg: 0.469 ± 0.037
0.778HisSer: 0.778 ± 0.045
0.694HisThr: 0.694 ± 0.042
0.792HisVal: 0.792 ± 0.05
0.073HisTrp: 0.073 ± 0.015
0.728HisTyr: 0.728 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
4.669IleAla: 4.669 ± 0.121
1.073IleCys: 1.073 ± 0.055
6.138IleAsp: 6.138 ± 0.141
5.868IleGlu: 5.868 ± 0.132
3.947IlePhe: 3.947 ± 0.132
4.545IleGly: 4.545 ± 0.129
1.152IleHis: 1.152 ± 0.066
9.523IleIle: 9.523 ± 0.249
9.152IleLys: 9.152 ± 0.196
9.61IleLeu: 9.61 ± 0.197
2.284IleMet: 2.284 ± 0.078
7.194IleAsn: 7.194 ± 0.165
2.795IlePro: 2.795 ± 0.093
1.492IleGln: 1.492 ± 0.06
2.773IleArg: 2.773 ± 0.074
6.447IleSer: 6.447 ± 0.161
5.455IleThr: 5.455 ± 0.133
5.829IleVal: 5.829 ± 0.144
0.447IleTrp: 0.447 ± 0.04
4.444IleTyr: 4.444 ± 0.114
0.0IleXaa: 0.0 ± 0.0
Lys
3.961LysAla: 3.961 ± 0.119
0.876LysCys: 0.876 ± 0.056
6.658LysAsp: 6.658 ± 0.129
8.972LysGlu: 8.972 ± 0.194
2.93LysPhe: 2.93 ± 0.088
3.716LysGly: 3.716 ± 0.128
1.02LysHis: 1.02 ± 0.054
8.436LysIle: 8.436 ± 0.184
9.804LysLys: 9.804 ± 0.213
8.043LysLeu: 8.043 ± 0.164
2.582LysMet: 2.582 ± 0.09
7.787LysAsn: 7.787 ± 0.167
1.966LysPro: 1.966 ± 0.074
2.245LysGln: 2.245 ± 0.089
3.166LysArg: 3.166 ± 0.108
5.329LysSer: 5.329 ± 0.134
4.964LysThr: 4.964 ± 0.105
5.871LysVal: 5.871 ± 0.131
0.534LysTrp: 0.534 ± 0.041
6.166LysTyr: 6.166 ± 0.143
0.0LysXaa: 0.0 ± 0.0
Leu
4.82LeuAla: 4.82 ± 0.138
1.017LeuCys: 1.017 ± 0.061
6.568LeuAsp: 6.568 ± 0.146
7.756LeuGlu: 7.756 ± 0.186
3.705LeuPhe: 3.705 ± 0.125
5.5LeuGly: 5.5 ± 0.137
1.101LeuHis: 1.101 ± 0.063
8.36LeuIle: 8.36 ± 0.203
9.408LeuLys: 9.408 ± 0.186
7.84LeuLeu: 7.84 ± 0.176
2.093LeuMet: 2.093 ± 0.064
7.144LeuAsn: 7.144 ± 0.175
2.438LeuPro: 2.438 ± 0.083
1.888LeuGln: 1.888 ± 0.072
2.902LeuArg: 2.902 ± 0.092
6.613LeuSer: 6.613 ± 0.153
5.332LeuThr: 5.332 ± 0.126
5.944LeuVal: 5.944 ± 0.137
0.466LeuTrp: 0.466 ± 0.041
4.152LeuTyr: 4.152 ± 0.126
0.0LeuXaa: 0.0 ± 0.0
Met
1.607MetAla: 1.607 ± 0.059
0.244MetCys: 0.244 ± 0.029
1.537MetAsp: 1.537 ± 0.068
1.41MetGlu: 1.41 ± 0.068
1.008MetPhe: 1.008 ± 0.055
1.424MetGly: 1.424 ± 0.056
0.317MetHis: 0.317 ± 0.033
2.068MetIle: 2.068 ± 0.081
2.528MetLys: 2.528 ± 0.082
2.115MetLeu: 2.115 ± 0.081
0.635MetMet: 0.635 ± 0.04
1.921MetAsn: 1.921 ± 0.07
0.809MetPro: 0.809 ± 0.048
0.685MetGln: 0.685 ± 0.041
0.767MetArg: 0.767 ± 0.054
1.466MetSer: 1.466 ± 0.062
1.185MetThr: 1.185 ± 0.063
1.5MetVal: 1.5 ± 0.069
0.118MetTrp: 0.118 ± 0.018
1.098MetTyr: 1.098 ± 0.058
0.0MetXaa: 0.0 ± 0.0
Asn
3.261AsnAla: 3.261 ± 0.102
0.84AsnCys: 0.84 ± 0.058
4.565AsnAsp: 4.565 ± 0.116
5.099AsnGlu: 5.099 ± 0.125
2.68AsnPhe: 2.68 ± 0.087
3.896AsnGly: 3.896 ± 0.115
1.07AsnHis: 1.07 ± 0.06
7.686AsnIle: 7.686 ± 0.146
7.484AsnLys: 7.484 ± 0.151
6.84AsnLeu: 6.84 ± 0.158
1.972AsnMet: 1.972 ± 0.073
6.447AsnAsn: 6.447 ± 0.167
2.171AsnPro: 2.171 ± 0.088
1.885AsnGln: 1.885 ± 0.078
2.07AsnArg: 2.07 ± 0.076
4.205AsnSer: 4.205 ± 0.132
4.231AsnThr: 4.231 ± 0.116
4.135AsnVal: 4.135 ± 0.114
0.36AsnTrp: 0.36 ± 0.042
4.497AsnTyr: 4.497 ± 0.126
0.0AsnXaa: 0.0 ± 0.0
Pro
1.051ProAla: 1.051 ± 0.059
0.197ProCys: 0.197 ± 0.025
1.486ProAsp: 1.486 ± 0.073
1.862ProGlu: 1.862 ± 0.079
1.107ProPhe: 1.107 ± 0.062
1.25ProGly: 1.25 ± 0.068
0.343ProHis: 0.343 ± 0.034
2.413ProIle: 2.413 ± 0.074
2.346ProLys: 2.346 ± 0.086
2.135ProLeu: 2.135 ± 0.087
0.514ProMet: 0.514 ± 0.039
1.84ProAsn: 1.84 ± 0.074
0.388ProPro: 0.388 ± 0.033
0.584ProGln: 0.584 ± 0.041
0.812ProArg: 0.812 ± 0.048
1.767ProSer: 1.767 ± 0.073
1.551ProThr: 1.551 ± 0.073
1.694ProVal: 1.694 ± 0.079
0.194ProTrp: 0.194 ± 0.024
1.393ProTyr: 1.393 ± 0.069
0.0ProXaa: 0.0 ± 0.0
Gln
1.222GlnAla: 1.222 ± 0.065
0.132GlnCys: 0.132 ± 0.02
1.537GlnAsp: 1.537 ± 0.062
2.239GlnGlu: 2.239 ± 0.088
0.719GlnPhe: 0.719 ± 0.047
1.149GlnGly: 1.149 ± 0.053
0.258GlnHis: 0.258 ± 0.028
2.09GlnIle: 2.09 ± 0.074
2.073GlnLys: 2.073 ± 0.082
1.573GlnLeu: 1.573 ± 0.073
0.567GlnMet: 0.567 ± 0.043
1.832GlnAsn: 1.832 ± 0.077
0.435GlnPro: 0.435 ± 0.037
0.556GlnGln: 0.556 ± 0.065
0.832GlnArg: 0.832 ± 0.045
1.416GlnSer: 1.416 ± 0.073
1.292GlnThr: 1.292 ± 0.056
1.562GlnVal: 1.562 ± 0.062
0.132GlnTrp: 0.132 ± 0.021
1.042GlnTyr: 1.042 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
1.374ArgAla: 1.374 ± 0.064
0.334ArgCys: 0.334 ± 0.032
1.767ArgAsp: 1.767 ± 0.079
2.076ArgGlu: 2.076 ± 0.082
1.261ArgPhe: 1.261 ± 0.052
1.641ArgGly: 1.641 ± 0.077
0.539ArgHis: 0.539 ± 0.039
2.848ArgIle: 2.848 ± 0.1
3.208ArgLys: 3.208 ± 0.106
3.127ArgLeu: 3.127 ± 0.093
0.885ArgMet: 0.885 ± 0.055
2.096ArgAsn: 2.096 ± 0.076
0.846ArgPro: 0.846 ± 0.045
0.722ArgGln: 0.722 ± 0.05
1.475ArgArg: 1.475 ± 0.075
1.655ArgSer: 1.655 ± 0.071
1.598ArgThr: 1.598 ± 0.073
2.034ArgVal: 2.034 ± 0.08
0.157ArgTrp: 0.157 ± 0.024
1.739ArgTyr: 1.739 ± 0.075
0.0ArgXaa: 0.0 ± 0.0
Ser
2.545SerAla: 2.545 ± 0.099
0.705SerCys: 0.705 ± 0.059
3.18SerAsp: 3.18 ± 0.103
3.247SerGlu: 3.247 ± 0.097
2.764SerPhe: 2.764 ± 0.093
3.972SerGly: 3.972 ± 0.143
0.868SerHis: 0.868 ± 0.052
6.073SerIle: 6.073 ± 0.143
6.489SerLys: 6.489 ± 0.142
6.489SerLeu: 6.489 ± 0.142
1.424SerMet: 1.424 ± 0.065
5.129SerAsn: 5.129 ± 0.127
1.256SerPro: 1.256 ± 0.06
1.455SerGln: 1.455 ± 0.061
2.017SerArg: 2.017 ± 0.074
4.818SerSer: 4.818 ± 0.15
3.655SerThr: 3.655 ± 0.118
3.615SerVal: 3.615 ± 0.117
0.438SerTrp: 0.438 ± 0.037
3.702SerTyr: 3.702 ± 0.109
0.0SerXaa: 0.0 ± 0.0
Thr
2.343ThrAla: 2.343 ± 0.101
0.736ThrCys: 0.736 ± 0.051
3.068ThrAsp: 3.068 ± 0.111
3.014ThrGlu: 3.014 ± 0.097
2.312ThrPhe: 2.312 ± 0.082
3.267ThrGly: 3.267 ± 0.109
0.896ThrHis: 0.896 ± 0.054
5.745ThrIle: 5.745 ± 0.131
5.812ThrLys: 5.812 ± 0.128
6.017ThrLeu: 6.017 ± 0.125
1.222ThrMet: 1.222 ± 0.065
3.95ThrAsn: 3.95 ± 0.112
1.921ThrPro: 1.921 ± 0.092
1.197ThrGln: 1.197 ± 0.06
1.601ThrArg: 1.601 ± 0.059
3.975ThrSer: 3.975 ± 0.126
3.68ThrThr: 3.68 ± 0.113
2.646ThrVal: 2.646 ± 0.094
0.413ThrTrp: 0.413 ± 0.035
2.95ThrTyr: 2.95 ± 0.112
0.003ThrXaa: 0.003 ± 0.003
Val
3.242ValAla: 3.242 ± 0.1
0.86ValCys: 0.86 ± 0.049
3.641ValAsp: 3.641 ± 0.102
3.511ValGlu: 3.511 ± 0.109
2.357ValPhe: 2.357 ± 0.086
3.545ValGly: 3.545 ± 0.12
0.742ValHis: 0.742 ± 0.046
5.717ValIle: 5.717 ± 0.129
5.402ValLys: 5.402 ± 0.142
5.924ValLeu: 5.924 ± 0.128
1.424ValMet: 1.424 ± 0.061
4.062ValAsn: 4.062 ± 0.104
1.671ValPro: 1.671 ± 0.073
1.082ValGln: 1.082 ± 0.057
2.068ValArg: 2.068 ± 0.087
4.455ValSer: 4.455 ± 0.12
3.393ValThr: 3.393 ± 0.114
4.379ValVal: 4.379 ± 0.116
0.351ValTrp: 0.351 ± 0.035
2.736ValTyr: 2.736 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.244TrpAla: 0.244 ± 0.028
0.084TrpCys: 0.084 ± 0.017
0.354TrpAsp: 0.354 ± 0.029
0.272TrpGlu: 0.272 ± 0.032
0.272TrpPhe: 0.272 ± 0.029
0.334TrpGly: 0.334 ± 0.033
0.112TrpHis: 0.112 ± 0.018
0.396TrpIle: 0.396 ± 0.034
0.334TrpLys: 0.334 ± 0.03
0.587TrpLeu: 0.587 ± 0.044
0.126TrpMet: 0.126 ± 0.018
0.396TrpAsn: 0.396 ± 0.031
0.126TrpPro: 0.126 ± 0.018
0.211TrpGln: 0.211 ± 0.022
0.146TrpArg: 0.146 ± 0.018
0.379TrpSer: 0.379 ± 0.036
0.317TrpThr: 0.317 ± 0.037
0.334TrpVal: 0.334 ± 0.032
0.104TrpTrp: 0.104 ± 0.018
0.385TrpTyr: 0.385 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.393TyrAla: 2.393 ± 0.082
0.581TyrCys: 0.581 ± 0.04
3.385TyrAsp: 3.385 ± 0.112
3.672TyrGlu: 3.672 ± 0.105
2.433TyrPhe: 2.433 ± 0.087
2.899TyrGly: 2.899 ± 0.094
0.921TyrHis: 0.921 ± 0.062
4.733TyrIle: 4.733 ± 0.112
4.514TyrLys: 4.514 ± 0.12
5.899TyrLeu: 5.899 ± 0.155
1.124TyrMet: 1.124 ± 0.051
4.393TyrAsn: 4.393 ± 0.128
1.489TyrPro: 1.489 ± 0.064
2.028TyrGln: 2.028 ± 0.081
1.551TyrArg: 1.551 ± 0.06
3.177TyrSer: 3.177 ± 0.101
2.899TyrThr: 2.899 ± 0.1
3.011TyrVal: 3.011 ± 0.096
0.213TyrTrp: 0.213 ± 0.024
3.36TyrTyr: 3.36 ± 0.118
0.003TyrXaa: 0.003 ± 0.003
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.003XaaLys: 0.003 ± 0.003
0.0XaaLeu: 0.0 ± 0.0
0.003XaaMet: 0.003 ± 0.003
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.003XaaTyr: 0.003 ± 0.003
0.006XaaXaa: 0.006 ± 0.007
Statistics based on 1211 proteins (355982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski