Amino acid dipepetide frequency for Knoellia flava TL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.818AlaAla: 18.818 ± 0.187
0.867AlaCys: 0.867 ± 0.032
8.091AlaAsp: 8.091 ± 0.107
7.523AlaGlu: 7.523 ± 0.092
3.568AlaPhe: 3.568 ± 0.063
12.111AlaGly: 12.111 ± 0.121
2.624AlaHis: 2.624 ± 0.054
4.163AlaIle: 4.163 ± 0.07
2.888AlaLys: 2.888 ± 0.072
13.343AlaLeu: 13.343 ± 0.148
2.802AlaMet: 2.802 ± 0.048
2.086AlaAsn: 2.086 ± 0.047
6.268AlaPro: 6.268 ± 0.103
3.462AlaGln: 3.462 ± 0.058
9.436AlaArg: 9.436 ± 0.109
7.014AlaSer: 7.014 ± 0.084
8.189AlaThr: 8.189 ± 0.123
11.945AlaVal: 11.945 ± 0.127
1.996AlaTrp: 1.996 ± 0.047
2.711AlaTyr: 2.711 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.809CysAla: 0.809 ± 0.028
0.065CysCys: 0.065 ± 0.009
0.464CysAsp: 0.464 ± 0.025
0.322CysGlu: 0.322 ± 0.019
0.216CysPhe: 0.216 ± 0.016
0.761CysGly: 0.761 ± 0.028
0.158CysHis: 0.158 ± 0.013
0.196CysIle: 0.196 ± 0.014
0.101CysLys: 0.101 ± 0.011
0.57CysLeu: 0.57 ± 0.024
0.104CysMet: 0.104 ± 0.01
0.122CysAsn: 0.122 ± 0.011
0.411CysPro: 0.411 ± 0.019
0.136CysGln: 0.136 ± 0.013
0.519CysArg: 0.519 ± 0.022
0.4CysSer: 0.4 ± 0.019
0.452CysThr: 0.452 ± 0.022
0.587CysVal: 0.587 ± 0.022
0.094CysTrp: 0.094 ± 0.01
0.113CysTyr: 0.113 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
8.162AspAla: 8.162 ± 0.111
0.35AspCys: 0.35 ± 0.021
4.785AspAsp: 4.785 ± 0.08
4.807AspGlu: 4.807 ± 0.077
1.588AspPhe: 1.588 ± 0.043
6.52AspGly: 6.52 ± 0.091
1.511AspHis: 1.511 ± 0.039
2.094AspIle: 2.094 ± 0.043
1.146AspLys: 1.146 ± 0.039
7.147AspLeu: 7.147 ± 0.091
0.869AspMet: 0.869 ± 0.026
1.033AspAsn: 1.033 ± 0.034
4.344AspPro: 4.344 ± 0.061
1.39AspGln: 1.39 ± 0.039
4.695AspArg: 4.695 ± 0.067
2.672AspSer: 2.672 ± 0.059
3.151AspThr: 3.151 ± 0.056
6.472AspVal: 6.472 ± 0.096
0.922AspTrp: 0.922 ± 0.028
1.183AspTyr: 1.183 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
7.302GluAla: 7.302 ± 0.097
0.352GluCys: 0.352 ± 0.018
3.191GluAsp: 3.191 ± 0.061
3.29GluGlu: 3.29 ± 0.063
1.508GluPhe: 1.508 ± 0.042
4.806GluGly: 4.806 ± 0.073
1.633GluHis: 1.633 ± 0.041
2.202GluIle: 2.202 ± 0.049
1.372GluLys: 1.372 ± 0.04
6.013GluLeu: 6.013 ± 0.078
0.972GluMet: 0.972 ± 0.032
0.914GluAsn: 0.914 ± 0.031
3.19GluPro: 3.19 ± 0.06
2.208GluGln: 2.208 ± 0.05
5.455GluArg: 5.455 ± 0.085
3.027GluSer: 3.027 ± 0.046
3.05GluThr: 3.05 ± 0.056
5.869GluVal: 5.869 ± 0.088
0.851GluTrp: 0.851 ± 0.029
0.801GluTyr: 0.801 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.553PheAla: 3.553 ± 0.062
0.216PheCys: 0.216 ± 0.014
2.045PheAsp: 2.045 ± 0.047
1.538PheGlu: 1.538 ± 0.037
0.883PhePhe: 0.883 ± 0.034
3.074PheGly: 3.074 ± 0.055
0.566PheHis: 0.566 ± 0.022
0.799PheIle: 0.799 ± 0.03
0.468PheLys: 0.468 ± 0.023
2.506PheLeu: 2.506 ± 0.063
0.436PheMet: 0.436 ± 0.017
0.548PheAsn: 0.548 ± 0.022
1.27PhePro: 1.27 ± 0.033
0.53PheGln: 0.53 ± 0.021
1.666PheArg: 1.666 ± 0.044
1.476PheSer: 1.476 ± 0.037
1.806PheThr: 1.806 ± 0.042
2.77PheVal: 2.77 ± 0.056
0.429PheTrp: 0.429 ± 0.021
0.587PheTyr: 0.587 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
10.739GlyAla: 10.739 ± 0.118
0.721GlyCys: 0.721 ± 0.032
5.682GlyAsp: 5.682 ± 0.076
5.381GlyGlu: 5.381 ± 0.074
2.984GlyPhe: 2.984 ± 0.061
8.491GlyGly: 8.491 ± 0.128
2.195GlyHis: 2.195 ± 0.048
3.806GlyIle: 3.806 ± 0.062
2.199GlyLys: 2.199 ± 0.056
9.485GlyLeu: 9.485 ± 0.126
2.023GlyMet: 2.023 ± 0.043
1.648GlyAsn: 1.648 ± 0.047
4.597GlyPro: 4.597 ± 0.064
2.529GlyGln: 2.529 ± 0.048
7.372GlyArg: 7.372 ± 0.093
6.099GlySer: 6.099 ± 0.097
5.992GlyThr: 5.992 ± 0.09
8.241GlyVal: 8.241 ± 0.1
1.811GlyTrp: 1.811 ± 0.047
1.998GlyTyr: 1.998 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.467HisAla: 2.467 ± 0.053
0.167HisCys: 0.167 ± 0.012
1.689HisAsp: 1.689 ± 0.042
1.378HisGlu: 1.378 ± 0.034
0.531HisPhe: 0.531 ± 0.023
2.213HisGly: 2.213 ± 0.047
0.685HisHis: 0.685 ± 0.03
0.564HisIle: 0.564 ± 0.024
0.308HisLys: 0.308 ± 0.017
2.435HisLeu: 2.435 ± 0.054
0.293HisMet: 0.293 ± 0.017
0.356HisAsn: 0.356 ± 0.02
1.578HisPro: 1.578 ± 0.042
0.543HisGln: 0.543 ± 0.024
1.78HisArg: 1.78 ± 0.042
0.929HisSer: 0.929 ± 0.031
1.135HisThr: 1.135 ± 0.034
2.217HisVal: 2.217 ± 0.041
0.353HisTrp: 0.353 ± 0.02
0.422HisTyr: 0.422 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.799IleAla: 4.799 ± 0.086
0.252IleCys: 0.252 ± 0.016
2.531IleAsp: 2.531 ± 0.049
2.188IleGlu: 2.188 ± 0.046
0.822IlePhe: 0.822 ± 0.032
3.596IleGly: 3.596 ± 0.069
0.618IleHis: 0.618 ± 0.027
1.018IleIle: 1.018 ± 0.036
0.732IleLys: 0.732 ± 0.031
2.721IleLeu: 2.721 ± 0.051
0.429IleMet: 0.429 ± 0.02
0.712IleAsn: 0.712 ± 0.031
1.844IlePro: 1.844 ± 0.044
0.733IleGln: 0.733 ± 0.027
2.182IleArg: 2.182 ± 0.048
1.735IleSer: 1.735 ± 0.039
2.252IleThr: 2.252 ± 0.048
3.222IleVal: 3.222 ± 0.071
0.385IleTrp: 0.385 ± 0.019
0.572IleTyr: 0.572 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
2.908LysAla: 2.908 ± 0.074
0.081LysCys: 0.081 ± 0.009
1.362LysAsp: 1.362 ± 0.039
1.095LysGlu: 1.095 ± 0.036
0.438LysPhe: 0.438 ± 0.022
1.908LysGly: 1.908 ± 0.05
0.42LysHis: 0.42 ± 0.018
0.713LysIle: 0.713 ± 0.031
0.776LysLys: 0.776 ± 0.045
1.458LysLeu: 1.458 ± 0.043
0.349LysMet: 0.349 ± 0.018
0.481LysAsn: 0.481 ± 0.023
1.167LysPro: 1.167 ± 0.037
0.674LysGln: 0.674 ± 0.029
1.356LysArg: 1.356 ± 0.042
1.108LysSer: 1.108 ± 0.038
1.182LysThr: 1.182 ± 0.041
2.165LysVal: 2.165 ± 0.048
0.24LysTrp: 0.24 ± 0.013
0.408LysTyr: 0.408 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.371LeuAla: 14.371 ± 0.164
0.591LeuCys: 0.591 ± 0.023
7.127LeuAsp: 7.127 ± 0.108
5.291LeuGlu: 5.291 ± 0.07
2.319LeuPhe: 2.319 ± 0.06
9.751LeuGly: 9.751 ± 0.109
1.989LeuHis: 1.989 ± 0.049
2.693LeuIle: 2.693 ± 0.059
1.636LeuLys: 1.636 ± 0.05
10.282LeuLeu: 10.282 ± 0.135
1.617LeuMet: 1.617 ± 0.038
1.427LeuAsn: 1.427 ± 0.039
5.5LeuPro: 5.5 ± 0.083
2.131LeuGln: 2.131 ± 0.046
7.757LeuArg: 7.757 ± 0.101
5.298LeuSer: 5.298 ± 0.076
6.538LeuThr: 6.538 ± 0.081
10.641LeuVal: 10.641 ± 0.128
1.256LeuTrp: 1.256 ± 0.037
1.356LeuTyr: 1.356 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
2.374MetAla: 2.374 ± 0.044
0.125MetCys: 0.125 ± 0.011
0.899MetAsp: 0.899 ± 0.028
0.775MetGlu: 0.775 ± 0.027
0.489MetPhe: 0.489 ± 0.023
1.531MetGly: 1.531 ± 0.044
0.357MetHis: 0.357 ± 0.02
0.581MetIle: 0.581 ± 0.023
0.403MetLys: 0.403 ± 0.02
1.77MetLeu: 1.77 ± 0.036
0.279MetMet: 0.279 ± 0.017
0.416MetAsn: 0.416 ± 0.02
1.218MetPro: 1.218 ± 0.034
0.442MetGln: 0.442 ± 0.023
1.559MetArg: 1.559 ± 0.042
1.58MetSer: 1.58 ± 0.04
1.719MetThr: 1.719 ± 0.039
1.447MetVal: 1.447 ± 0.037
0.251MetTrp: 0.251 ± 0.015
0.266MetTyr: 0.266 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.229AsnAla: 2.229 ± 0.049
0.138AsnCys: 0.138 ± 0.014
1.024AsnAsp: 1.024 ± 0.031
0.842AsnGlu: 0.842 ± 0.029
0.512AsnPhe: 0.512 ± 0.024
1.657AsnGly: 1.657 ± 0.046
0.382AsnHis: 0.382 ± 0.018
0.645AsnIle: 0.645 ± 0.025
0.377AsnLys: 0.377 ± 0.021
1.726AsnLeu: 1.726 ± 0.047
0.244AsnMet: 0.244 ± 0.015
0.385AsnAsn: 0.385 ± 0.021
1.443AsnPro: 1.443 ± 0.041
0.475AsnGln: 0.475 ± 0.023
1.162AsnArg: 1.162 ± 0.034
0.819AsnSer: 0.819 ± 0.03
1.001AsnThr: 1.001 ± 0.032
1.52AsnVal: 1.52 ± 0.037
0.239AsnTrp: 0.239 ± 0.016
0.389AsnTyr: 0.389 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.869ProAla: 6.869 ± 0.095
0.273ProCys: 0.273 ± 0.016
4.205ProAsp: 4.205 ± 0.066
4.026ProGlu: 4.026 ± 0.051
1.513ProPhe: 1.513 ± 0.037
5.656ProGly: 5.656 ± 0.083
1.219ProHis: 1.219 ± 0.036
1.519ProIle: 1.519 ± 0.041
1.133ProLys: 1.133 ± 0.04
4.729ProLeu: 4.729 ± 0.074
1.106ProMet: 1.106 ± 0.033
0.886ProAsn: 0.886 ± 0.031
2.74ProPro: 2.74 ± 0.068
1.509ProGln: 1.509 ± 0.048
3.655ProArg: 3.655 ± 0.061
3.564ProSer: 3.564 ± 0.075
3.892ProThr: 3.892 ± 0.079
5.31ProVal: 5.31 ± 0.084
0.987ProTrp: 0.987 ± 0.034
0.926ProTyr: 0.926 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.149GlnAla: 3.149 ± 0.057
0.172GlnCys: 0.172 ± 0.013
1.202GlnAsp: 1.202 ± 0.035
1.212GlnGlu: 1.212 ± 0.033
0.684GlnPhe: 0.684 ± 0.029
2.168GlnGly: 2.168 ± 0.047
0.618GlnHis: 0.618 ± 0.024
0.985GlnIle: 0.985 ± 0.033
0.562GlnLys: 0.562 ± 0.023
2.597GlnLeu: 2.597 ± 0.055
0.56GlnMet: 0.56 ± 0.023
0.462GlnAsn: 0.462 ± 0.023
1.531GlnPro: 1.531 ± 0.041
1.029GlnGln: 1.029 ± 0.043
2.416GlnArg: 2.416 ± 0.055
1.345GlnSer: 1.345 ± 0.035
1.365GlnThr: 1.365 ± 0.043
2.662GlnVal: 2.662 ± 0.054
0.505GlnTrp: 0.505 ± 0.023
0.448GlnTyr: 0.448 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
8.922ArgAla: 8.922 ± 0.104
0.454ArgCys: 0.454 ± 0.021
4.768ArgAsp: 4.768 ± 0.084
4.759ArgGlu: 4.759 ± 0.067
2.186ArgPhe: 2.186 ± 0.048
6.021ArgGly: 6.021 ± 0.087
1.944ArgHis: 1.944 ± 0.046
3.028ArgIle: 3.028 ± 0.063
1.368ArgLys: 1.368 ± 0.044
7.968ArgLeu: 7.968 ± 0.118
1.715ArgMet: 1.715 ± 0.042
1.244ArgAsn: 1.244 ± 0.035
4.228ArgPro: 4.228 ± 0.072
1.945ArgGln: 1.945 ± 0.046
7.295ArgArg: 7.295 ± 0.113
4.446ArgSer: 4.446 ± 0.078
4.886ArgThr: 4.886 ± 0.063
6.423ArgVal: 6.423 ± 0.083
1.443ArgTrp: 1.443 ± 0.039
1.375ArgTyr: 1.375 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.044SerAla: 7.044 ± 0.094
0.366SerCys: 0.366 ± 0.022
3.219SerAsp: 3.219 ± 0.06
2.785SerGlu: 2.785 ± 0.052
1.53SerPhe: 1.53 ± 0.037
6.245SerGly: 6.245 ± 0.089
1.131SerHis: 1.131 ± 0.039
1.906SerIle: 1.906 ± 0.049
1.063SerLys: 1.063 ± 0.034
5.152SerLeu: 5.152 ± 0.069
1.332SerMet: 1.332 ± 0.035
0.979SerAsn: 0.979 ± 0.03
3.317SerPro: 3.317 ± 0.061
1.404SerGln: 1.404 ± 0.042
4.2SerArg: 4.2 ± 0.071
3.553SerSer: 3.553 ± 0.081
3.912SerThr: 3.912 ± 0.064
5.028SerVal: 5.028 ± 0.066
0.996SerTrp: 0.996 ± 0.03
1.056SerTyr: 1.056 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.006ThrAla: 8.006 ± 0.131
0.459ThrCys: 0.459 ± 0.022
3.766ThrAsp: 3.766 ± 0.062
3.166ThrGlu: 3.166 ± 0.056
1.943ThrPhe: 1.943 ± 0.048
6.222ThrGly: 6.222 ± 0.09
1.313ThrHis: 1.313 ± 0.034
2.261ThrIle: 2.261 ± 0.05
1.376ThrLys: 1.376 ± 0.05
5.781ThrLeu: 5.781 ± 0.078
1.195ThrMet: 1.195 ± 0.038
1.151ThrAsn: 1.151 ± 0.032
4.218ThrPro: 4.218 ± 0.076
1.408ThrGln: 1.408 ± 0.037
4.12ThrArg: 4.12 ± 0.062
4.097ThrSer: 4.097 ± 0.072
4.73ThrThr: 4.73 ± 0.093
6.212ThrVal: 6.212 ± 0.086
1.077ThrTrp: 1.077 ± 0.033
1.291ThrTyr: 1.291 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
12.913ValAla: 12.913 ± 0.122
0.693ValCys: 0.693 ± 0.029
6.588ValAsp: 6.588 ± 0.088
5.927ValGlu: 5.927 ± 0.076
2.334ValPhe: 2.334 ± 0.059
8.414ValGly: 8.414 ± 0.114
2.027ValHis: 2.027 ± 0.046
3.257ValIle: 3.257 ± 0.058
1.744ValLys: 1.744 ± 0.042
10.279ValLeu: 10.279 ± 0.125
1.62ValMet: 1.62 ± 0.041
1.649ValAsn: 1.649 ± 0.04
5.155ValPro: 5.155 ± 0.079
2.157ValGln: 2.157 ± 0.042
7.023ValArg: 7.023 ± 0.09
5.119ValSer: 5.119 ± 0.077
6.594ValThr: 6.594 ± 0.092
11.314ValVal: 11.314 ± 0.135
1.22ValTrp: 1.22 ± 0.039
1.202ValTyr: 1.202 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.689TrpAla: 1.689 ± 0.042
0.133TrpCys: 0.133 ± 0.01
0.92TrpAsp: 0.92 ± 0.032
0.681TrpGlu: 0.681 ± 0.024
0.563TrpPhe: 0.563 ± 0.023
1.169TrpGly: 1.169 ± 0.034
0.353TrpHis: 0.353 ± 0.019
0.458TrpIle: 0.458 ± 0.024
0.323TrpLys: 0.323 ± 0.02
1.778TrpLeu: 1.778 ± 0.048
0.338TrpMet: 0.338 ± 0.017
0.372TrpAsn: 0.372 ± 0.018
0.785TrpPro: 0.785 ± 0.027
0.509TrpGln: 0.509 ± 0.024
1.343TrpArg: 1.343 ± 0.037
1.086TrpSer: 1.086 ± 0.033
1.025TrpThr: 1.025 ± 0.033
1.508TrpVal: 1.508 ± 0.035
0.422TrpTrp: 0.422 ± 0.021
0.274TrpTyr: 0.274 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.782TyrAla: 2.782 ± 0.05
0.126TyrCys: 0.126 ± 0.012
1.284TyrAsp: 1.284 ± 0.037
1.021TyrGlu: 1.021 ± 0.035
0.555TyrPhe: 0.555 ± 0.024
1.678TyrGly: 1.678 ± 0.045
0.301TyrHis: 0.301 ± 0.018
0.457TyrIle: 0.457 ± 0.024
0.311TyrLys: 0.311 ± 0.019
1.831TyrLeu: 1.831 ± 0.046
0.199TyrMet: 0.199 ± 0.016
0.339TyrAsn: 0.339 ± 0.019
0.915TyrPro: 0.915 ± 0.034
0.456TyrGln: 0.456 ± 0.021
1.425TyrArg: 1.425 ± 0.04
0.848TyrSer: 0.848 ± 0.03
0.923TyrThr: 0.923 ± 0.034
1.677TyrVal: 1.677 ± 0.036
0.248TyrTrp: 0.248 ± 0.017
0.393TyrTyr: 0.393 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3373 proteins (1069445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski