Amino acid dipepetide frequency for Lolium perenne-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.135AlaAla: 3.135 ± 2.11
0.0AlaCys: 0.0 ± 0.0
4.702AlaAsp: 4.702 ± 3.488
1.567AlaGlu: 1.567 ± 1.163
3.135AlaPhe: 3.135 ± 2.326
3.135AlaGly: 3.135 ± 2.11
1.567AlaHis: 1.567 ± 1.163
10.972AlaIle: 10.972 ± 1.486
1.567AlaLys: 1.567 ± 1.055
3.135AlaLeu: 3.135 ± 2.11
0.0AlaMet: 0.0 ± 0.0
4.702AlaAsn: 4.702 ± 0.947
1.567AlaPro: 1.567 ± 1.055
4.702AlaGln: 4.702 ± 1.271
3.135AlaArg: 3.135 ± 2.326
6.27AlaSer: 6.27 ± 2.002
4.702AlaThr: 4.702 ± 0.947
4.702AlaVal: 4.702 ± 0.947
3.135AlaTrp: 3.135 ± 0.108
1.567AlaTyr: 1.567 ± 1.163
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.567CysGlu: 1.567 ± 1.163
0.0CysPhe: 0.0 ± 0.0
1.567CysGly: 1.567 ± 1.163
0.0CysHis: 0.0 ± 0.0
3.135CysIle: 3.135 ± 2.326
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.567CysPro: 1.567 ± 1.163
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.567CysVal: 1.567 ± 1.055
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
12.539AspAla: 12.539 ± 2.649
0.0AspCys: 0.0 ± 0.0
1.567AspAsp: 1.567 ± 1.163
3.135AspGlu: 3.135 ± 0.108
3.135AspPhe: 3.135 ± 2.326
4.702AspGly: 4.702 ± 1.271
1.567AspHis: 1.567 ± 1.163
1.567AspIle: 1.567 ± 1.055
1.567AspLys: 1.567 ± 1.163
3.135AspLeu: 3.135 ± 2.326
0.0AspMet: 0.0 ± 0.0
3.135AspAsn: 3.135 ± 0.108
4.702AspPro: 4.702 ± 3.488
0.0AspGln: 0.0 ± 0.0
3.135AspArg: 3.135 ± 2.326
1.567AspSer: 1.567 ± 1.055
3.135AspThr: 3.135 ± 2.11
3.135AspVal: 3.135 ± 2.11
1.567AspTrp: 1.567 ± 1.163
3.135AspTyr: 3.135 ± 2.326
0.0AspXaa: 0.0 ± 0.0
Glu
3.135GluAla: 3.135 ± 2.326
3.135GluCys: 3.135 ± 2.326
1.567GluAsp: 1.567 ± 1.055
0.0GluGlu: 0.0 ± 0.0
1.567GluPhe: 1.567 ± 1.163
1.567GluGly: 1.567 ± 1.055
3.135GluHis: 3.135 ± 2.11
1.567GluIle: 1.567 ± 1.163
1.567GluLys: 1.567 ± 1.163
1.567GluLeu: 1.567 ± 1.163
3.135GluMet: 3.135 ± 0.108
1.567GluAsn: 1.567 ± 1.163
0.0GluPro: 0.0 ± 0.0
1.567GluGln: 1.567 ± 1.055
1.567GluArg: 1.567 ± 1.163
3.135GluSer: 3.135 ± 0.108
1.567GluThr: 1.567 ± 1.163
4.702GluVal: 4.702 ± 3.165
1.567GluTrp: 1.567 ± 1.163
3.135GluTyr: 3.135 ± 0.108
0.0GluXaa: 0.0 ± 0.0
Phe
3.135PheAla: 3.135 ± 2.326
0.0PheCys: 0.0 ± 0.0
9.404PheAsp: 9.404 ± 4.759
1.567PheGlu: 1.567 ± 1.163
0.0PhePhe: 0.0 ± 0.0
1.567PheGly: 1.567 ± 1.055
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
6.27PheLys: 6.27 ± 0.216
1.567PheLeu: 1.567 ± 1.163
1.567PheMet: 1.567 ± 1.163
1.567PheAsn: 1.567 ± 1.163
1.567PhePro: 1.567 ± 1.163
1.567PheGln: 1.567 ± 1.163
7.837PheArg: 7.837 ± 3.057
1.567PheSer: 1.567 ± 1.055
3.135PheThr: 3.135 ± 0.108
1.567PheVal: 1.567 ± 1.163
0.0PheTrp: 0.0 ± 0.0
1.567PheTyr: 1.567 ± 1.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.702GlyAla: 4.702 ± 1.271
0.0GlyCys: 0.0 ± 0.0
0.0GlyAsp: 0.0 ± 0.0
3.135GlyGlu: 3.135 ± 0.108
3.135GlyPhe: 3.135 ± 2.11
4.702GlyGly: 4.702 ± 3.165
4.702GlyHis: 4.702 ± 0.947
0.0GlyIle: 0.0 ± 0.0
7.837GlyLys: 7.837 ± 3.596
3.135GlyLeu: 3.135 ± 0.108
4.702GlyMet: 4.702 ± 3.165
1.567GlyAsn: 1.567 ± 1.055
3.135GlyPro: 3.135 ± 0.108
0.0GlyGln: 0.0 ± 0.0
6.27GlyArg: 6.27 ± 0.216
3.135GlySer: 3.135 ± 2.11
1.567GlyThr: 1.567 ± 1.055
9.404GlyVal: 9.404 ± 4.112
0.0GlyTrp: 0.0 ± 0.0
3.135GlyTyr: 3.135 ± 2.11
0.0GlyXaa: 0.0 ± 0.0
His
3.135HisAla: 3.135 ± 0.108
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
4.702HisGlu: 4.702 ± 1.271
3.135HisPhe: 3.135 ± 2.326
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
6.27HisIle: 6.27 ± 2.002
1.567HisLys: 1.567 ± 1.055
1.567HisLeu: 1.567 ± 1.055
1.567HisMet: 1.567 ± 1.163
0.0HisAsn: 0.0 ± 0.0
1.567HisPro: 1.567 ± 1.163
1.567HisGln: 1.567 ± 1.163
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
1.567HisThr: 1.567 ± 1.163
0.0HisVal: 0.0 ± 0.0
1.567HisTrp: 1.567 ± 1.055
1.567HisTyr: 1.567 ± 1.163
0.0HisXaa: 0.0 ± 0.0
Ile
1.567IleAla: 1.567 ± 1.055
0.0IleCys: 0.0 ± 0.0
3.135IleAsp: 3.135 ± 2.326
4.702IleGlu: 4.702 ± 0.947
6.27IlePhe: 6.27 ± 4.651
0.0IleGly: 0.0 ± 0.0
1.567IleHis: 1.567 ± 1.163
6.27IleIle: 6.27 ± 2.002
7.837IleLys: 7.837 ± 3.596
6.27IleLeu: 6.27 ± 2.433
1.567IleMet: 1.567 ± 1.055
3.135IleAsn: 3.135 ± 0.108
6.27IlePro: 6.27 ± 0.216
3.135IleGln: 3.135 ± 2.11
4.702IleArg: 4.702 ± 1.271
1.567IleSer: 1.567 ± 1.055
1.567IleThr: 1.567 ± 1.055
6.27IleVal: 6.27 ± 2.002
1.567IleTrp: 1.567 ± 1.055
3.135IleTyr: 3.135 ± 0.108
0.0IleXaa: 0.0 ± 0.0
Lys
1.567LysAla: 1.567 ± 1.055
0.0LysCys: 0.0 ± 0.0
3.135LysAsp: 3.135 ± 2.326
3.135LysGlu: 3.135 ± 2.326
4.702LysPhe: 4.702 ± 0.947
4.702LysGly: 4.702 ± 3.165
0.0LysHis: 0.0 ± 0.0
4.702LysIle: 4.702 ± 0.947
7.837LysLys: 7.837 ± 0.84
7.837LysLeu: 7.837 ± 3.057
0.0LysMet: 0.0 ± 0.0
1.567LysAsn: 1.567 ± 1.163
1.567LysPro: 1.567 ± 1.163
6.27LysGln: 6.27 ± 4.651
4.702LysArg: 4.702 ± 0.947
3.135LysSer: 3.135 ± 0.108
7.837LysThr: 7.837 ± 1.378
6.27LysVal: 6.27 ± 4.22
3.135LysTrp: 3.135 ± 2.326
4.702LysTyr: 4.702 ± 1.271
0.0LysXaa: 0.0 ± 0.0
Leu
3.135LeuAla: 3.135 ± 2.11
0.0LeuCys: 0.0 ± 0.0
1.567LeuAsp: 1.567 ± 1.055
1.567LeuGlu: 1.567 ± 1.163
3.135LeuPhe: 3.135 ± 2.326
4.702LeuGly: 4.702 ± 1.271
0.0LeuHis: 0.0 ± 0.0
4.702LeuIle: 4.702 ± 1.271
4.702LeuLys: 4.702 ± 0.947
6.27LeuLeu: 6.27 ± 0.216
1.567LeuMet: 1.567 ± 1.055
3.135LeuAsn: 3.135 ± 2.11
3.135LeuPro: 3.135 ± 2.11
3.135LeuGln: 3.135 ± 0.108
0.0LeuArg: 0.0 ± 0.0
9.404LeuSer: 9.404 ± 4.759
6.27LeuThr: 6.27 ± 2.433
3.135LeuVal: 3.135 ± 2.11
1.567LeuTrp: 1.567 ± 1.163
3.135LeuTyr: 3.135 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
3.135MetAla: 3.135 ± 2.11
0.0MetCys: 0.0 ± 0.0
6.27MetAsp: 6.27 ± 0.216
1.567MetGlu: 1.567 ± 1.163
0.0MetPhe: 0.0 ± 0.0
1.567MetGly: 1.567 ± 1.055
0.0MetHis: 0.0 ± 0.0
1.567MetIle: 1.567 ± 1.163
1.567MetLys: 1.567 ± 1.163
0.0MetLeu: 0.0 ± 0.0
1.567MetMet: 1.567 ± 1.163
1.567MetAsn: 1.567 ± 1.055
0.0MetPro: 0.0 ± 0.0
1.567MetGln: 1.567 ± 1.055
0.0MetArg: 0.0 ± 0.0
3.135MetSer: 3.135 ± 0.108
4.702MetThr: 4.702 ± 3.165
1.567MetVal: 1.567 ± 1.055
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.567AsnAla: 1.567 ± 1.163
0.0AsnCys: 0.0 ± 0.0
4.702AsnAsp: 4.702 ± 0.947
0.0AsnGlu: 0.0 ± 0.0
0.0AsnPhe: 0.0 ± 0.0
3.135AsnGly: 3.135 ± 0.108
0.0AsnHis: 0.0 ± 0.0
6.27AsnIle: 6.27 ± 0.216
6.27AsnLys: 6.27 ± 0.216
1.567AsnLeu: 1.567 ± 1.163
3.135AsnMet: 3.135 ± 2.11
0.0AsnAsn: 0.0 ± 0.0
4.702AsnPro: 4.702 ± 0.947
3.135AsnGln: 3.135 ± 0.108
1.567AsnArg: 1.567 ± 1.055
0.0AsnSer: 0.0 ± 0.0
3.135AsnThr: 3.135 ± 0.108
1.567AsnVal: 1.567 ± 1.055
0.0AsnTrp: 0.0 ± 0.0
6.27AsnTyr: 6.27 ± 2.002
0.0AsnXaa: 0.0 ± 0.0
Pro
3.135ProAla: 3.135 ± 2.11
1.567ProCys: 1.567 ± 1.163
4.702ProAsp: 4.702 ± 3.488
1.567ProGlu: 1.567 ± 1.055
1.567ProPhe: 1.567 ± 1.055
6.27ProGly: 6.27 ± 2.002
0.0ProHis: 0.0 ± 0.0
4.702ProIle: 4.702 ± 0.947
1.567ProLys: 1.567 ± 1.163
3.135ProLeu: 3.135 ± 2.326
1.567ProMet: 1.567 ± 1.055
1.567ProAsn: 1.567 ± 1.163
1.567ProPro: 1.567 ± 1.055
3.135ProGln: 3.135 ± 2.326
3.135ProArg: 3.135 ± 0.108
3.135ProSer: 3.135 ± 0.108
1.567ProThr: 1.567 ± 1.055
0.0ProVal: 0.0 ± 0.0
0.0ProTrp: 0.0 ± 0.0
1.567ProTyr: 1.567 ± 1.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.135GlnAla: 3.135 ± 0.108
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
1.567GlnGlu: 1.567 ± 1.163
4.702GlnPhe: 4.702 ± 0.947
0.0GlnGly: 0.0 ± 0.0
3.135GlnHis: 3.135 ± 2.326
1.567GlnIle: 1.567 ± 1.163
1.567GlnLys: 1.567 ± 1.055
1.567GlnLeu: 1.567 ± 1.055
1.567GlnMet: 1.567 ± 1.163
6.27GlnAsn: 6.27 ± 0.216
4.702GlnPro: 4.702 ± 1.271
1.567GlnGln: 1.567 ± 1.163
3.135GlnArg: 3.135 ± 0.108
4.702GlnSer: 4.702 ± 0.947
0.0GlnThr: 0.0 ± 0.0
1.567GlnVal: 1.567 ± 1.055
1.567GlnTrp: 1.567 ± 1.163
4.702GlnTyr: 4.702 ± 3.488
0.0GlnXaa: 0.0 ± 0.0
Arg
3.135ArgAla: 3.135 ± 0.108
0.0ArgCys: 0.0 ± 0.0
4.702ArgAsp: 4.702 ± 0.947
1.567ArgGlu: 1.567 ± 1.055
1.567ArgPhe: 1.567 ± 1.163
3.135ArgGly: 3.135 ± 2.11
4.702ArgHis: 4.702 ± 3.488
1.567ArgIle: 1.567 ± 1.163
6.27ArgLys: 6.27 ± 2.002
3.135ArgLeu: 3.135 ± 2.326
0.0ArgMet: 0.0 ± 0.0
3.135ArgAsn: 3.135 ± 2.11
1.567ArgPro: 1.567 ± 1.163
3.135ArgGln: 3.135 ± 0.108
3.135ArgArg: 3.135 ± 2.11
1.567ArgSer: 1.567 ± 1.163
4.702ArgThr: 4.702 ± 0.947
6.27ArgVal: 6.27 ± 0.216
0.0ArgTrp: 0.0 ± 0.0
1.567ArgTyr: 1.567 ± 1.163
0.0ArgXaa: 0.0 ± 0.0
Ser
3.135SerAla: 3.135 ± 0.108
0.0SerCys: 0.0 ± 0.0
1.567SerAsp: 1.567 ± 1.163
1.567SerGlu: 1.567 ± 1.055
6.27SerPhe: 6.27 ± 2.002
9.404SerGly: 9.404 ± 4.112
0.0SerHis: 0.0 ± 0.0
3.135SerIle: 3.135 ± 2.326
3.135SerLys: 3.135 ± 0.108
6.27SerLeu: 6.27 ± 0.216
0.0SerMet: 0.0 ± 0.0
4.702SerAsn: 4.702 ± 0.947
1.567SerPro: 1.567 ± 1.055
4.702SerGln: 4.702 ± 1.271
6.27SerArg: 6.27 ± 2.433
6.27SerSer: 6.27 ± 2.002
0.0SerThr: 0.0 ± 0.0
6.27SerVal: 6.27 ± 4.22
0.0SerTrp: 0.0 ± 0.0
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
1.567ThrAla: 1.567 ± 1.163
1.567ThrCys: 1.567 ± 1.055
3.135ThrAsp: 3.135 ± 2.326
0.0ThrGlu: 0.0 ± 0.0
1.567ThrPhe: 1.567 ± 1.055
4.702ThrGly: 4.702 ± 1.271
4.702ThrHis: 4.702 ± 0.947
3.135ThrIle: 3.135 ± 0.108
6.27ThrLys: 6.27 ± 0.216
3.135ThrLeu: 3.135 ± 2.11
0.0ThrMet: 0.0 ± 0.0
4.702ThrAsn: 4.702 ± 3.165
4.702ThrPro: 4.702 ± 3.165
1.567ThrGln: 1.567 ± 1.163
1.567ThrArg: 1.567 ± 1.055
4.702ThrSer: 4.702 ± 3.165
6.27ThrThr: 6.27 ± 0.216
3.135ThrVal: 3.135 ± 2.11
1.567ThrTrp: 1.567 ± 1.163
1.567ThrTyr: 1.567 ± 1.163
0.0ThrXaa: 0.0 ± 0.0
Val
6.27ValAla: 6.27 ± 2.002
1.567ValCys: 1.567 ± 1.163
3.135ValAsp: 3.135 ± 2.11
4.702ValGlu: 4.702 ± 3.165
0.0ValPhe: 0.0 ± 0.0
6.27ValGly: 6.27 ± 2.002
3.135ValHis: 3.135 ± 2.11
1.567ValIle: 1.567 ± 1.055
6.27ValLys: 6.27 ± 4.22
3.135ValLeu: 3.135 ± 2.11
3.135ValMet: 3.135 ± 1.678
0.0ValAsn: 0.0 ± 0.0
0.0ValPro: 0.0 ± 0.0
6.27ValGln: 6.27 ± 2.002
4.702ValArg: 4.702 ± 0.947
6.27ValSer: 6.27 ± 0.216
6.27ValThr: 6.27 ± 4.22
3.135ValVal: 3.135 ± 2.11
0.0ValTrp: 0.0 ± 0.0
1.567ValTyr: 1.567 ± 1.055
0.0ValXaa: 0.0 ± 0.0
Trp
1.567TrpAla: 1.567 ± 1.163
0.0TrpCys: 0.0 ± 0.0
1.567TrpAsp: 1.567 ± 1.163
1.567TrpGlu: 1.567 ± 1.163
0.0TrpPhe: 0.0 ± 0.0
1.567TrpGly: 1.567 ± 1.163
0.0TrpHis: 0.0 ± 0.0
3.135TrpIle: 3.135 ± 0.108
1.567TrpLys: 1.567 ± 1.055
3.135TrpLeu: 3.135 ± 2.326
0.0TrpMet: 0.0 ± 0.0
3.135TrpAsn: 3.135 ± 2.326
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
1.567TrpThr: 1.567 ± 1.055
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.702TyrAla: 4.702 ± 1.271
1.567TyrCys: 1.567 ± 1.163
1.567TyrAsp: 1.567 ± 1.055
1.567TyrGlu: 1.567 ± 1.163
1.567TyrPhe: 1.567 ± 1.163
1.567TyrGly: 1.567 ± 1.163
1.567TyrHis: 1.567 ± 1.163
4.702TyrIle: 4.702 ± 0.947
1.567TyrLys: 1.567 ± 1.163
4.702TyrLeu: 4.702 ± 0.947
3.135TyrMet: 3.135 ± 0.883
1.567TyrAsn: 1.567 ± 1.055
1.567TyrPro: 1.567 ± 1.055
0.0TyrGln: 0.0 ± 0.0
0.0TyrArg: 0.0 ± 0.0
4.702TyrSer: 4.702 ± 0.947
0.0TyrThr: 0.0 ± 0.0
3.135TyrVal: 3.135 ± 0.108
1.567TyrTrp: 1.567 ± 1.163
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (639 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski