Amino acid dipepetide frequency for Apis mellifera associated microvirus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.087AlaAla: 7.087 ± 3.484
1.417AlaCys: 1.417 ± 1.709
4.961AlaAsp: 4.961 ± 0.924
4.961AlaGlu: 4.961 ± 2.248
2.835AlaPhe: 2.835 ± 1.071
6.378AlaGly: 6.378 ± 1.161
1.417AlaHis: 1.417 ± 1.039
6.378AlaIle: 6.378 ± 1.85
1.417AlaLys: 1.417 ± 0.978
7.087AlaLeu: 7.087 ± 1.912
1.417AlaMet: 1.417 ± 0.539
2.126AlaAsn: 2.126 ± 1.094
4.252AlaPro: 4.252 ± 1.539
6.378AlaGln: 6.378 ± 2.635
7.087AlaArg: 7.087 ± 2.243
9.213AlaSer: 9.213 ± 3.544
9.922AlaThr: 9.922 ± 2.057
7.796AlaVal: 7.796 ± 1.954
1.417AlaTrp: 1.417 ± 0.777
4.252AlaTyr: 4.252 ± 1.965
0.0AlaXaa: 0.0 ± 0.0
Cys
0.709CysAla: 0.709 ± 0.854
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.709CysGlu: 0.709 ± 0.52
0.709CysPhe: 0.709 ± 0.54
0.709CysGly: 0.709 ± 0.54
0.709CysHis: 0.709 ± 0.854
0.0CysIle: 0.0 ± 0.0
1.417CysLys: 1.417 ± 1.271
0.709CysLeu: 0.709 ± 0.52
0.709CysMet: 0.709 ± 0.54
0.0CysAsn: 0.0 ± 0.0
0.709CysPro: 0.709 ± 0.54
0.0CysGln: 0.0 ± 0.0
1.417CysArg: 1.417 ± 0.978
2.126CysSer: 2.126 ± 1.442
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.961AspAla: 4.961 ± 1.491
0.709AspCys: 0.709 ± 0.854
4.252AspAsp: 4.252 ± 1.866
2.835AspGlu: 2.835 ± 1.315
7.796AspPhe: 7.796 ± 1.399
0.709AspGly: 0.709 ± 0.52
1.417AspHis: 1.417 ± 0.539
2.126AspIle: 2.126 ± 0.802
0.709AspLys: 0.709 ± 0.54
7.087AspLeu: 7.087 ± 2.531
2.126AspMet: 2.126 ± 1.01
2.835AspAsn: 2.835 ± 0.895
3.544AspPro: 3.544 ± 2.812
1.417AspGln: 1.417 ± 1.039
3.544AspArg: 3.544 ± 1.383
3.544AspSer: 3.544 ± 1.378
3.544AspThr: 3.544 ± 1.795
2.835AspVal: 2.835 ± 1.051
0.0AspTrp: 0.0 ± 0.0
2.835AspTyr: 2.835 ± 1.381
0.0AspXaa: 0.0 ± 0.0
Glu
4.252GluAla: 4.252 ± 2.608
1.417GluCys: 1.417 ± 0.978
2.126GluAsp: 2.126 ± 1.36
1.417GluGlu: 1.417 ± 1.039
2.835GluPhe: 2.835 ± 1.057
0.0GluGly: 0.0 ± 0.0
0.709GluHis: 0.709 ± 0.52
2.835GluIle: 2.835 ± 1.652
0.0GluLys: 0.0 ± 0.0
4.252GluLeu: 4.252 ± 0.883
2.126GluMet: 2.126 ± 0.945
2.835GluAsn: 2.835 ± 0.854
0.0GluPro: 0.0 ± 0.0
2.835GluGln: 2.835 ± 1.148
4.961GluArg: 4.961 ± 2.716
2.835GluSer: 2.835 ± 0.929
0.709GluThr: 0.709 ± 0.622
4.252GluVal: 4.252 ± 0.969
1.417GluTrp: 1.417 ± 0.539
2.126GluTyr: 2.126 ± 0.523
0.0GluXaa: 0.0 ± 0.0
Phe
3.544PheAla: 3.544 ± 1.227
0.0PheCys: 0.0 ± 0.0
3.544PheAsp: 3.544 ± 1.787
2.835PheGlu: 2.835 ± 0.919
4.252PhePhe: 4.252 ± 1.739
4.961PheGly: 4.961 ± 2.281
1.417PheHis: 1.417 ± 1.08
0.709PheIle: 0.709 ± 0.52
3.544PheLys: 3.544 ± 2.01
5.67PheLeu: 5.67 ± 1.633
3.544PheMet: 3.544 ± 0.981
1.417PheAsn: 1.417 ± 0.772
2.126PhePro: 2.126 ± 0.945
2.126PheGln: 2.126 ± 0.802
7.087PheArg: 7.087 ± 1.73
2.126PheSer: 2.126 ± 1.603
2.835PheThr: 2.835 ± 2.079
3.544PheVal: 3.544 ± 1.861
0.0PheTrp: 0.0 ± 0.0
0.709PheTyr: 0.709 ± 0.52
0.0PheXaa: 0.0 ± 0.0
Gly
9.922GlyAla: 9.922 ± 3.386
0.0GlyCys: 0.0 ± 0.0
5.67GlyAsp: 5.67 ± 1.093
5.67GlyGlu: 5.67 ± 1.834
1.417GlyPhe: 1.417 ± 0.574
9.922GlyGly: 9.922 ± 4.017
1.417GlyHis: 1.417 ± 0.539
1.417GlyIle: 1.417 ± 1.08
3.544GlyLys: 3.544 ± 1.188
9.922GlyLeu: 9.922 ± 2.116
0.709GlyMet: 0.709 ± 0.622
4.252GlyAsn: 4.252 ± 1.457
3.544GlyPro: 3.544 ± 0.956
5.67GlyGln: 5.67 ± 1.073
0.709GlyArg: 0.709 ± 0.622
8.505GlySer: 8.505 ± 2.21
3.544GlyThr: 3.544 ± 2.599
4.961GlyVal: 4.961 ± 1.529
0.709GlyTrp: 0.709 ± 0.622
2.126GlyTyr: 2.126 ± 1.559
0.0GlyXaa: 0.0 ± 0.0
His
2.126HisAla: 2.126 ± 0.748
0.0HisCys: 0.0 ± 0.0
3.544HisAsp: 3.544 ± 1.317
1.417HisGlu: 1.417 ± 1.08
2.126HisPhe: 2.126 ± 0.91
2.126HisGly: 2.126 ± 0.945
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.709HisLys: 0.709 ± 0.52
1.417HisLeu: 1.417 ± 1.039
0.0HisMet: 0.0 ± 0.0
1.417HisAsn: 1.417 ± 0.539
1.417HisPro: 1.417 ± 0.539
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.709HisThr: 0.709 ± 0.54
1.417HisVal: 1.417 ± 1.08
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.67IleAla: 5.67 ± 2.311
0.709IleCys: 0.709 ± 0.54
2.835IleAsp: 2.835 ± 1.016
2.126IleGlu: 2.126 ± 1.078
0.709IlePhe: 0.709 ± 0.52
4.252IleGly: 4.252 ± 1.046
0.0IleHis: 0.0 ± 0.0
1.417IleIle: 1.417 ± 1.039
2.126IleLys: 2.126 ± 1.867
1.417IleLeu: 1.417 ± 0.574
1.417IleMet: 1.417 ± 0.944
4.252IleAsn: 4.252 ± 2.344
0.709IlePro: 0.709 ± 0.52
1.417IleGln: 1.417 ± 1.025
2.835IleArg: 2.835 ± 0.895
3.544IleSer: 3.544 ± 1.843
4.252IleThr: 4.252 ± 1.256
0.709IleVal: 0.709 ± 0.52
0.709IleTrp: 0.709 ± 0.52
2.835IleTyr: 2.835 ± 1.471
0.0IleXaa: 0.0 ± 0.0
Lys
4.252LysAla: 4.252 ± 2.184
0.709LysCys: 0.709 ± 0.54
3.544LysAsp: 3.544 ± 2.267
2.126LysGlu: 2.126 ± 0.945
2.126LysPhe: 2.126 ± 0.802
0.709LysGly: 0.709 ± 0.52
0.0LysHis: 0.0 ± 0.0
0.709LysIle: 0.709 ± 0.622
1.417LysLys: 1.417 ± 1.08
0.709LysLeu: 0.709 ± 0.52
0.0LysMet: 0.0 ± 0.0
2.835LysAsn: 2.835 ± 1.051
0.709LysPro: 0.709 ± 0.941
2.835LysGln: 2.835 ± 1.665
3.544LysArg: 3.544 ± 1.383
2.835LysSer: 2.835 ± 2.044
1.417LysThr: 1.417 ± 0.539
3.544LysVal: 3.544 ± 1.706
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
6.378LeuAla: 6.378 ± 0.844
0.709LeuCys: 0.709 ± 0.854
2.835LeuAsp: 2.835 ± 0.696
4.961LeuGlu: 4.961 ± 3.612
6.378LeuPhe: 6.378 ± 1.51
7.087LeuGly: 7.087 ± 3.515
0.709LeuHis: 0.709 ± 0.54
3.544LeuIle: 3.544 ± 1.843
2.835LeuLys: 2.835 ± 1.553
4.252LeuLeu: 4.252 ± 1.521
2.126LeuMet: 2.126 ± 0.883
2.835LeuAsn: 2.835 ± 1.148
8.505LeuPro: 8.505 ± 2.098
2.126LeuGln: 2.126 ± 0.883
6.378LeuArg: 6.378 ± 2.037
4.961LeuSer: 4.961 ± 2.123
4.252LeuThr: 4.252 ± 1.256
7.796LeuVal: 7.796 ± 1.687
0.709LeuTrp: 0.709 ± 0.54
0.709LeuTyr: 0.709 ± 0.52
0.0LeuXaa: 0.0 ± 0.0
Met
3.544MetAla: 3.544 ± 1.178
0.709MetCys: 0.709 ± 0.54
2.126MetAsp: 2.126 ± 0.748
2.126MetGlu: 2.126 ± 1.442
0.0MetPhe: 0.0 ± 0.0
2.835MetGly: 2.835 ± 1.016
1.417MetHis: 1.417 ± 0.539
2.126MetIle: 2.126 ± 1.559
2.835MetLys: 2.835 ± 1.225
2.126MetLeu: 2.126 ± 1.078
0.709MetMet: 0.709 ± 0.52
0.0MetAsn: 0.0 ± 0.0
1.417MetPro: 1.417 ± 1.233
0.709MetGln: 0.709 ± 0.622
2.126MetArg: 2.126 ± 1.094
3.544MetSer: 3.544 ± 1.766
0.709MetThr: 0.709 ± 0.622
0.709MetVal: 0.709 ± 0.54
0.709MetTrp: 0.709 ± 0.52
1.417MetTyr: 1.417 ± 0.818
0.0MetXaa: 0.0 ± 0.0
Asn
3.544AsnAla: 3.544 ± 1.164
0.709AsnCys: 0.709 ± 0.54
2.126AsnAsp: 2.126 ± 0.748
1.417AsnGlu: 1.417 ± 0.574
0.0AsnPhe: 0.0 ± 0.0
2.126AsnGly: 2.126 ± 1.072
0.0AsnHis: 0.0 ± 0.0
0.709AsnIle: 0.709 ± 0.54
0.709AsnLys: 0.709 ± 0.52
8.505AsnLeu: 8.505 ± 2.948
1.417AsnMet: 1.417 ± 0.777
0.709AsnAsn: 0.709 ± 0.85
3.544AsnPro: 3.544 ± 0.83
2.126AsnGln: 2.126 ± 0.901
2.126AsnArg: 2.126 ± 0.802
1.417AsnSer: 1.417 ± 1.039
2.126AsnThr: 2.126 ± 0.901
3.544AsnVal: 3.544 ± 1.86
1.417AsnTrp: 1.417 ± 0.574
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.67ProAla: 5.67 ± 2.844
0.0ProCys: 0.0 ± 0.0
2.126ProAsp: 2.126 ± 0.91
2.126ProGlu: 2.126 ± 0.831
2.126ProPhe: 2.126 ± 0.831
4.961ProGly: 4.961 ± 2.241
1.417ProHis: 1.417 ± 1.08
3.544ProIle: 3.544 ± 1.843
0.0ProLys: 0.0 ± 0.0
3.544ProLeu: 3.544 ± 1.403
2.126ProMet: 2.126 ± 0.523
1.417ProAsn: 1.417 ± 0.539
1.417ProPro: 1.417 ± 1.039
4.961ProGln: 4.961 ± 2.366
2.126ProArg: 2.126 ± 0.91
4.252ProSer: 4.252 ± 2.187
4.961ProThr: 4.961 ± 1.19
4.961ProVal: 4.961 ± 1.04
0.709ProTrp: 0.709 ± 0.52
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
4.961GlnAla: 4.961 ± 1.947
0.709GlnCys: 0.709 ± 0.54
1.417GlnAsp: 1.417 ± 0.978
2.126GlnGlu: 2.126 ± 1.078
2.126GlnPhe: 2.126 ± 1.005
4.252GlnGly: 4.252 ± 2.207
0.709GlnHis: 0.709 ± 0.85
4.252GlnIle: 4.252 ± 1.811
3.544GlnLys: 3.544 ± 0.956
3.544GlnLeu: 3.544 ± 1.134
3.544GlnMet: 3.544 ± 1.345
2.835GlnAsn: 2.835 ± 1.429
0.0GlnPro: 0.0 ± 0.0
4.252GlnGln: 4.252 ± 2.214
2.835GlnArg: 2.835 ± 1.354
0.709GlnSer: 0.709 ± 0.85
2.835GlnThr: 2.835 ± 1.354
3.544GlnVal: 3.544 ± 1.195
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
7.796ArgAla: 7.796 ± 2.693
0.0ArgCys: 0.0 ± 0.0
7.087ArgAsp: 7.087 ± 1.942
2.126ArgGlu: 2.126 ± 1.165
2.835ArgPhe: 2.835 ± 1.545
7.087ArgGly: 7.087 ± 1.236
1.417ArgHis: 1.417 ± 0.539
3.544ArgIle: 3.544 ± 1.864
0.709ArgLys: 0.709 ± 0.54
6.378ArgLeu: 6.378 ± 1.975
2.835ArgMet: 2.835 ± 1.142
0.709ArgAsn: 0.709 ± 0.52
2.835ArgPro: 2.835 ± 0.838
1.417ArgGln: 1.417 ± 1.271
5.67ArgArg: 5.67 ± 1.315
4.252ArgSer: 4.252 ± 1.087
1.417ArgThr: 1.417 ± 0.539
2.835ArgVal: 2.835 ± 1.086
0.0ArgTrp: 0.0 ± 0.0
4.961ArgTyr: 4.961 ± 1.92
0.0ArgXaa: 0.0 ± 0.0
Ser
8.505SerAla: 8.505 ± 1.013
0.709SerCys: 0.709 ± 0.52
3.544SerAsp: 3.544 ± 2.01
0.0SerGlu: 0.0 ± 0.0
4.252SerPhe: 4.252 ± 1.856
4.961SerGly: 4.961 ± 1.631
1.417SerHis: 1.417 ± 1.039
2.126SerIle: 2.126 ± 0.901
0.709SerLys: 0.709 ± 0.85
4.252SerLeu: 4.252 ± 2.571
2.835SerMet: 2.835 ± 1.19
2.835SerAsn: 2.835 ± 1.665
2.835SerPro: 2.835 ± 1.051
2.126SerGln: 2.126 ± 1.01
4.961SerArg: 4.961 ± 1.864
5.67SerSer: 5.67 ± 2.077
6.378SerThr: 6.378 ± 3.137
8.505SerVal: 8.505 ± 3.258
0.0SerTrp: 0.0 ± 0.0
1.417SerTyr: 1.417 ± 0.978
0.0SerXaa: 0.0 ± 0.0
Thr
6.378ThrAla: 6.378 ± 2.418
0.0ThrCys: 0.0 ± 0.0
0.709ThrAsp: 0.709 ± 0.85
2.835ThrGlu: 2.835 ± 1.148
5.67ThrPhe: 5.67 ± 1.431
11.339ThrGly: 11.339 ± 3.028
2.126ThrHis: 2.126 ± 0.945
2.126ThrIle: 2.126 ± 0.523
2.835ThrLys: 2.835 ± 1.662
3.544ThrLeu: 3.544 ± 1.317
1.417ThrMet: 1.417 ± 0.574
1.417ThrAsn: 1.417 ± 0.818
4.961ThrPro: 4.961 ± 2.189
1.417ThrGln: 1.417 ± 1.245
2.126ThrArg: 2.126 ± 1.094
1.417ThrSer: 1.417 ± 1.039
2.126ThrThr: 2.126 ± 1.559
4.252ThrVal: 4.252 ± 1.143
0.709ThrTrp: 0.709 ± 0.54
1.417ThrTyr: 1.417 ± 0.539
0.0ThrXaa: 0.0 ± 0.0
Val
4.961ValAla: 4.961 ± 2.176
1.417ValCys: 1.417 ± 1.037
3.544ValAsp: 3.544 ± 1.734
1.417ValGlu: 1.417 ± 0.777
3.544ValPhe: 3.544 ± 1.037
7.087ValGly: 7.087 ± 2.061
0.709ValHis: 0.709 ± 0.54
3.544ValIle: 3.544 ± 1.615
4.252ValLys: 4.252 ± 1.258
4.961ValLeu: 4.961 ± 2.098
2.126ValMet: 2.126 ± 1.031
1.417ValAsn: 1.417 ± 0.777
8.505ValPro: 8.505 ± 3.929
2.835ValGln: 2.835 ± 1.057
4.961ValArg: 4.961 ± 2.523
4.252ValSer: 4.252 ± 1.087
6.378ValThr: 6.378 ± 2.496
2.835ValVal: 2.835 ± 1.402
1.417ValTrp: 1.417 ± 0.539
1.417ValTyr: 1.417 ± 0.777
0.0ValXaa: 0.0 ± 0.0
Trp
0.709TrpAla: 0.709 ± 0.54
0.0TrpCys: 0.0 ± 0.0
0.709TrpAsp: 0.709 ± 0.52
0.709TrpGlu: 0.709 ± 0.622
1.417TrpPhe: 1.417 ± 0.539
0.0TrpGly: 0.0 ± 0.0
0.709TrpHis: 0.709 ± 0.52
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.709TrpAsn: 0.709 ± 0.622
0.709TrpPro: 0.709 ± 0.52
1.417TrpGln: 1.417 ± 0.777
0.0TrpArg: 0.0 ± 0.0
1.417TrpSer: 1.417 ± 0.539
0.0TrpThr: 0.0 ± 0.0
1.417TrpVal: 1.417 ± 0.539
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.835TyrAla: 2.835 ± 1.381
0.709TyrCys: 0.709 ± 0.52
2.126TyrAsp: 2.126 ± 0.91
0.0TyrGlu: 0.0 ± 0.0
2.835TyrPhe: 2.835 ± 1.381
2.126TyrGly: 2.126 ± 0.748
0.709TyrHis: 0.709 ± 0.52
2.835TyrIle: 2.835 ± 1.077
0.709TyrLys: 0.709 ± 0.54
0.709TyrLeu: 0.709 ± 0.941
0.0TyrMet: 0.0 ± 0.0
1.417TyrAsn: 1.417 ± 1.039
0.709TyrPro: 0.709 ± 0.622
2.126TyrGln: 2.126 ± 0.901
1.417TyrArg: 1.417 ± 1.055
2.126TyrSer: 2.126 ± 1.358
0.709TyrThr: 0.709 ± 0.52
2.126TyrVal: 2.126 ± 0.883
0.0TyrTrp: 0.0 ± 0.0
1.417TyrTyr: 1.417 ± 1.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski