Amino acid dipepetide frequency for Rhodopirellula maiorica SM1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.54AlaAla: 11.54 ± 0.097
1.048AlaCys: 1.048 ± 0.021
6.29AlaAsp: 6.29 ± 0.055
6.417AlaGlu: 6.417 ± 0.064
3.312AlaPhe: 3.312 ± 0.037
7.206AlaGly: 7.206 ± 0.067
1.482AlaHis: 1.482 ± 0.027
6.112AlaIle: 6.112 ± 0.056
4.278AlaLys: 4.278 ± 0.054
7.282AlaLeu: 7.282 ± 0.062
2.818AlaMet: 2.818 ± 0.036
3.553AlaAsn: 3.553 ± 0.04
3.522AlaPro: 3.522 ± 0.038
2.84AlaGln: 2.84 ± 0.035
4.979AlaArg: 4.979 ± 0.049
6.908AlaSer: 6.908 ± 0.053
6.144AlaThr: 6.144 ± 0.06
6.869AlaVal: 6.869 ± 0.062
1.263AlaTrp: 1.263 ± 0.023
2.017AlaTyr: 2.017 ± 0.029
0.0AlaXaa: 0.0 ± 0.0
Cys
0.702CysAla: 0.702 ± 0.017
0.214CysCys: 0.214 ± 0.01
0.786CysAsp: 0.786 ± 0.019
0.7CysGlu: 0.7 ± 0.018
0.47CysPhe: 0.47 ± 0.014
1.021CysGly: 1.021 ± 0.024
0.464CysHis: 0.464 ± 0.018
0.502CysIle: 0.502 ± 0.014
0.332CysLys: 0.332 ± 0.012
1.031CysLeu: 1.031 ± 0.023
0.223CysMet: 0.223 ± 0.009
0.361CysAsn: 0.361 ± 0.013
0.557CysPro: 0.557 ± 0.019
0.422CysGln: 0.422 ± 0.014
0.766CysArg: 0.766 ± 0.02
0.76CysSer: 0.76 ± 0.016
0.51CysThr: 0.51 ± 0.015
0.865CysVal: 0.865 ± 0.021
0.167CysTrp: 0.167 ± 0.007
0.289CysTyr: 0.289 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.978AspAla: 6.978 ± 0.056
0.649AspCys: 0.649 ± 0.019
4.582AspAsp: 4.582 ± 0.064
4.379AspGlu: 4.379 ± 0.05
2.461AspPhe: 2.461 ± 0.034
5.466AspGly: 5.466 ± 0.071
1.558AspHis: 1.558 ± 0.027
2.617AspIle: 2.617 ± 0.034
1.845AspLys: 1.845 ± 0.034
5.71AspLeu: 5.71 ± 0.05
1.049AspMet: 1.049 ± 0.022
1.866AspAsn: 1.866 ± 0.031
3.856AspPro: 3.856 ± 0.043
2.708AspGln: 2.708 ± 0.033
4.4AspArg: 4.4 ± 0.044
4.288AspSer: 4.288 ± 0.048
2.955AspThr: 2.955 ± 0.049
4.63AspVal: 4.63 ± 0.058
1.111AspTrp: 1.111 ± 0.023
1.621AspTyr: 1.621 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
5.418GluAla: 5.418 ± 0.057
0.502GluCys: 0.502 ± 0.015
2.839GluAsp: 2.839 ± 0.038
2.967GluGlu: 2.967 ± 0.053
2.275GluPhe: 2.275 ± 0.033
3.454GluGly: 3.454 ± 0.041
1.396GluHis: 1.396 ± 0.024
3.609GluIle: 3.609 ± 0.04
2.578GluLys: 2.578 ± 0.042
6.385GluLeu: 6.385 ± 0.058
1.648GluMet: 1.648 ± 0.029
2.239GluAsn: 2.239 ± 0.031
2.624GluPro: 2.624 ± 0.04
2.965GluGln: 2.965 ± 0.039
3.794GluArg: 3.794 ± 0.042
4.778GluSer: 4.778 ± 0.044
3.905GluThr: 3.905 ± 0.038
3.982GluVal: 3.982 ± 0.045
0.67GluTrp: 0.67 ± 0.015
1.326GluTyr: 1.326 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
4.022PheAla: 4.022 ± 0.043
0.516PheCys: 0.516 ± 0.014
3.005PheAsp: 3.005 ± 0.042
2.178PheGlu: 2.178 ± 0.032
1.473PhePhe: 1.473 ± 0.028
3.203PheGly: 3.203 ± 0.039
0.829PheHis: 0.829 ± 0.019
1.461PheIle: 1.461 ± 0.026
1.011PheLys: 1.011 ± 0.02
3.23PheLeu: 3.23 ± 0.042
0.677PheMet: 0.677 ± 0.018
1.188PheAsn: 1.188 ± 0.022
1.629PhePro: 1.629 ± 0.026
1.326PheGln: 1.326 ± 0.025
2.347PheArg: 2.347 ± 0.031
2.54PheSer: 2.54 ± 0.037
2.049PheThr: 2.049 ± 0.037
2.933PheVal: 2.933 ± 0.035
0.547PheTrp: 0.547 ± 0.016
0.989PheTyr: 0.989 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
5.333GlyAla: 5.333 ± 0.058
0.979GlyCys: 0.979 ± 0.026
5.037GlyAsp: 5.037 ± 0.067
4.365GlyGlu: 4.365 ± 0.041
3.029GlyPhe: 3.029 ± 0.036
6.373GlyGly: 6.373 ± 0.091
1.698GlyHis: 1.698 ± 0.029
4.059GlyIle: 4.059 ± 0.044
3.532GlyLys: 3.532 ± 0.044
6.481GlyLeu: 6.481 ± 0.058
1.903GlyMet: 1.903 ± 0.03
2.919GlyAsn: 2.919 ± 0.05
2.8GlyPro: 2.8 ± 0.041
2.705GlyGln: 2.705 ± 0.034
4.639GlyArg: 4.639 ± 0.054
5.089GlySer: 5.089 ± 0.065
4.518GlyThr: 4.518 ± 0.064
5.392GlyVal: 5.392 ± 0.051
1.262GlyTrp: 1.262 ± 0.024
2.104GlyTyr: 2.104 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
2.105HisAla: 2.105 ± 0.035
0.364HisCys: 0.364 ± 0.013
1.504HisAsp: 1.504 ± 0.02
1.276HisGlu: 1.276 ± 0.023
0.974HisPhe: 0.974 ± 0.019
1.822HisGly: 1.822 ± 0.032
0.767HisHis: 0.767 ± 0.021
0.853HisIle: 0.853 ± 0.02
0.567HisLys: 0.567 ± 0.015
2.156HisLeu: 2.156 ± 0.031
0.366HisMet: 0.366 ± 0.012
0.709HisAsn: 0.709 ± 0.016
1.504HisPro: 1.504 ± 0.025
1.032HisGln: 1.032 ± 0.022
1.743HisArg: 1.743 ± 0.025
1.446HisSer: 1.446 ± 0.028
1.013HisThr: 1.013 ± 0.021
1.59HisVal: 1.59 ± 0.027
0.47HisTrp: 0.47 ± 0.015
0.687HisTyr: 0.687 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
6.359IleAla: 6.359 ± 0.06
0.617IleCys: 0.617 ± 0.015
4.488IleAsp: 4.488 ± 0.041
4.11IleGlu: 4.11 ± 0.041
1.44IlePhe: 1.44 ± 0.024
4.252IleGly: 4.252 ± 0.049
1.212IleHis: 1.212 ± 0.021
1.917IleIle: 1.917 ± 0.029
1.598IleLys: 1.598 ± 0.026
3.879IleLeu: 3.879 ± 0.048
0.749IleMet: 0.749 ± 0.018
1.721IleAsn: 1.721 ± 0.034
2.534IlePro: 2.534 ± 0.035
2.039IleGln: 2.039 ± 0.026
3.602IleArg: 3.602 ± 0.037
3.323IleSer: 3.323 ± 0.036
2.885IleThr: 2.885 ± 0.037
4.095IleVal: 4.095 ± 0.045
0.573IleTrp: 0.573 ± 0.016
1.165IleTyr: 1.165 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.955LysAla: 2.955 ± 0.042
0.314LysCys: 0.314 ± 0.011
1.69LysAsp: 1.69 ± 0.033
1.823LysGlu: 1.823 ± 0.032
1.21LysPhe: 1.21 ± 0.026
1.996LysGly: 1.996 ± 0.028
0.908LysHis: 0.908 ± 0.021
1.965LysIle: 1.965 ± 0.034
1.778LysLys: 1.778 ± 0.037
3.716LysLeu: 3.716 ± 0.047
0.991LysMet: 0.991 ± 0.025
1.299LysAsn: 1.299 ± 0.027
2.376LysPro: 2.376 ± 0.041
1.952LysGln: 1.952 ± 0.032
2.749LysArg: 2.749 ± 0.039
2.561LysSer: 2.561 ± 0.04
2.381LysThr: 2.381 ± 0.036
2.363LysVal: 2.363 ± 0.041
0.586LysTrp: 0.586 ± 0.015
0.865LysTyr: 0.865 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
9.847LeuAla: 9.847 ± 0.071
1.074LeuCys: 1.074 ± 0.02
6.052LeuAsp: 6.052 ± 0.056
4.962LeuGlu: 4.962 ± 0.047
3.326LeuPhe: 3.326 ± 0.044
6.618LeuGly: 6.618 ± 0.045
2.011LeuHis: 2.011 ± 0.025
4.677LeuIle: 4.677 ± 0.043
3.366LeuLys: 3.366 ± 0.041
8.855LeuLeu: 8.855 ± 0.074
2.115LeuMet: 2.115 ± 0.029
2.873LeuAsn: 2.873 ± 0.038
5.098LeuPro: 5.098 ± 0.046
3.737LeuGln: 3.737 ± 0.042
6.323LeuArg: 6.323 ± 0.058
6.623LeuSer: 6.623 ± 0.062
5.24LeuThr: 5.24 ± 0.049
6.803LeuVal: 6.803 ± 0.058
1.227LeuTrp: 1.227 ± 0.025
2.01LeuTyr: 2.01 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.16MetAla: 2.16 ± 0.033
0.219MetCys: 0.219 ± 0.008
1.158MetAsp: 1.158 ± 0.021
0.982MetGlu: 0.982 ± 0.021
0.813MetPhe: 0.813 ± 0.02
1.493MetGly: 1.493 ± 0.029
0.528MetHis: 0.528 ± 0.014
1.456MetIle: 1.456 ± 0.028
1.035MetLys: 1.035 ± 0.026
2.564MetLeu: 2.564 ± 0.035
0.698MetMet: 0.698 ± 0.018
0.914MetAsn: 0.914 ± 0.018
1.4MetPro: 1.4 ± 0.021
1.161MetGln: 1.161 ± 0.023
1.448MetArg: 1.448 ± 0.024
1.624MetSer: 1.624 ± 0.028
1.624MetThr: 1.624 ± 0.025
1.553MetVal: 1.553 ± 0.023
0.24MetTrp: 0.24 ± 0.01
0.393MetTyr: 0.393 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.289AsnAla: 3.289 ± 0.04
0.352AsnCys: 0.352 ± 0.012
2.331AsnAsp: 2.331 ± 0.044
2.156AsnGlu: 2.156 ± 0.03
1.204AsnPhe: 1.204 ± 0.026
2.822AsnGly: 2.822 ± 0.052
0.909AsnHis: 0.909 ± 0.019
1.42AsnIle: 1.42 ± 0.026
0.966AsnLys: 0.966 ± 0.02
2.943AsnLeu: 2.943 ± 0.04
0.618AsnMet: 0.618 ± 0.015
1.175AsnAsn: 1.175 ± 0.029
2.171AsnPro: 2.171 ± 0.033
1.592AsnGln: 1.592 ± 0.029
2.529AsnArg: 2.529 ± 0.034
2.071AsnSer: 2.071 ± 0.036
1.827AsnThr: 1.827 ± 0.032
2.542AsnVal: 2.542 ± 0.035
0.531AsnTrp: 0.531 ± 0.013
0.867AsnTyr: 0.867 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
4.811ProAla: 4.811 ± 0.054
0.389ProCys: 0.389 ± 0.013
3.234ProAsp: 3.234 ± 0.041
3.605ProGlu: 3.605 ± 0.043
1.796ProPhe: 1.796 ± 0.026
3.439ProGly: 3.439 ± 0.042
1.154ProHis: 1.154 ± 0.024
2.72ProIle: 2.72 ± 0.031
1.916ProLys: 1.916 ± 0.03
4.448ProLeu: 4.448 ± 0.044
1.227ProMet: 1.227 ± 0.026
1.962ProAsn: 1.962 ± 0.032
2.659ProPro: 2.659 ± 0.043
1.963ProGln: 1.963 ± 0.033
2.673ProArg: 2.673 ± 0.037
3.809ProSer: 3.809 ± 0.041
3.191ProThr: 3.191 ± 0.037
3.556ProVal: 3.556 ± 0.038
0.692ProTrp: 0.692 ± 0.018
1.162ProTyr: 1.162 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
3.582GlnAla: 3.582 ± 0.044
0.429GlnCys: 0.429 ± 0.014
1.739GlnAsp: 1.739 ± 0.025
1.696GlnGlu: 1.696 ± 0.029
1.621GlnPhe: 1.621 ± 0.029
2.323GlnGly: 2.323 ± 0.033
1.02GlnHis: 1.02 ± 0.022
2.427GlnIle: 2.427 ± 0.033
1.372GlnLys: 1.372 ± 0.025
4.365GlnLeu: 4.365 ± 0.049
1.039GlnMet: 1.039 ± 0.02
1.349GlnAsn: 1.349 ± 0.026
2.183GlnPro: 2.183 ± 0.031
2.331GlnGln: 2.331 ± 0.037
3.125GlnArg: 3.125 ± 0.032
3.227GlnSer: 3.227 ± 0.044
2.721GlnThr: 2.721 ± 0.033
2.586GlnVal: 2.586 ± 0.036
0.825GlnTrp: 0.825 ± 0.018
1.032GlnTyr: 1.032 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
4.528ArgAla: 4.528 ± 0.045
0.846ArgCys: 0.846 ± 0.02
4.188ArgAsp: 4.188 ± 0.046
3.982ArgGlu: 3.982 ± 0.048
2.957ArgPhe: 2.957 ± 0.038
4.234ArgGly: 4.234 ± 0.048
1.558ArgHis: 1.558 ± 0.025
3.784ArgIle: 3.784 ± 0.041
2.318ArgLys: 2.318 ± 0.04
6.796ArgLeu: 6.796 ± 0.064
1.818ArgMet: 1.818 ± 0.028
2.211ArgAsn: 2.211 ± 0.034
2.972ArgPro: 2.972 ± 0.04
2.823ArgGln: 2.823 ± 0.038
5.111ArgArg: 5.111 ± 0.063
4.457ArgSer: 4.457 ± 0.044
3.219ArgThr: 3.219 ± 0.034
4.575ArgVal: 4.575 ± 0.046
1.252ArgTrp: 1.252 ± 0.023
1.945ArgTyr: 1.945 ± 0.029
0.0ArgXaa: 0.0 ± 0.0
Ser
5.769SerAla: 5.769 ± 0.051
0.683SerCys: 0.683 ± 0.019
4.856SerAsp: 4.856 ± 0.046
4.556SerGlu: 4.556 ± 0.045
2.445SerPhe: 2.445 ± 0.034
5.989SerGly: 5.989 ± 0.068
1.527SerHis: 1.527 ± 0.028
3.746SerIle: 3.746 ± 0.038
2.406SerLys: 2.406 ± 0.037
6.772SerLeu: 6.772 ± 0.059
1.68SerMet: 1.68 ± 0.029
2.345SerAsn: 2.345 ± 0.036
3.75SerPro: 3.75 ± 0.04
2.705SerGln: 2.705 ± 0.038
4.281SerArg: 4.281 ± 0.043
4.863SerSer: 4.863 ± 0.056
3.821SerThr: 3.821 ± 0.048
4.914SerVal: 4.914 ± 0.047
0.862SerTrp: 0.862 ± 0.022
1.484SerTyr: 1.484 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
5.713ThrAla: 5.713 ± 0.055
0.496ThrCys: 0.496 ± 0.015
3.528ThrAsp: 3.528 ± 0.038
3.094ThrGlu: 3.094 ± 0.043
2.128ThrPhe: 2.128 ± 0.034
4.419ThrGly: 4.419 ± 0.059
1.274ThrHis: 1.274 ± 0.023
3.439ThrIle: 3.439 ± 0.045
1.93ThrLys: 1.93 ± 0.03
5.902ThrLeu: 5.902 ± 0.061
1.301ThrMet: 1.301 ± 0.025
1.961ThrAsn: 1.961 ± 0.034
3.443ThrPro: 3.443 ± 0.039
2.104ThrGln: 2.104 ± 0.031
3.384ThrArg: 3.384 ± 0.045
3.887ThrSer: 3.887 ± 0.048
3.502ThrThr: 3.502 ± 0.048
4.225ThrVal: 4.225 ± 0.05
0.798ThrTrp: 0.798 ± 0.019
1.342ThrTyr: 1.342 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
7.543ValAla: 7.543 ± 0.059
0.916ValCys: 0.916 ± 0.021
4.982ValAsp: 4.982 ± 0.052
3.994ValGlu: 3.994 ± 0.043
2.616ValPhe: 2.616 ± 0.034
5.179ValGly: 5.179 ± 0.051
1.548ValHis: 1.548 ± 0.027
3.963ValIle: 3.963 ± 0.045
2.32ValLys: 2.32 ± 0.035
6.456ValLeu: 6.456 ± 0.046
1.685ValMet: 1.685 ± 0.03
2.362ValAsn: 2.362 ± 0.04
3.443ValPro: 3.443 ± 0.046
2.64ValGln: 2.64 ± 0.035
4.59ValArg: 4.59 ± 0.045
4.768ValSer: 4.768 ± 0.047
4.368ValThr: 4.368 ± 0.058
5.818ValVal: 5.818 ± 0.061
0.982ValTrp: 0.982 ± 0.024
1.648ValTyr: 1.648 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.055TrpAla: 1.055 ± 0.022
0.208TrpCys: 0.208 ± 0.009
0.821TrpAsp: 0.821 ± 0.019
0.652TrpGlu: 0.652 ± 0.017
0.574TrpPhe: 0.574 ± 0.02
0.936TrpGly: 0.936 ± 0.022
0.448TrpHis: 0.448 ± 0.014
0.981TrpIle: 0.981 ± 0.02
0.648TrpLys: 0.648 ± 0.018
1.563TrpLeu: 1.563 ± 0.029
0.47TrpMet: 0.47 ± 0.014
0.585TrpAsn: 0.585 ± 0.016
0.684TrpPro: 0.684 ± 0.019
0.799TrpGln: 0.799 ± 0.018
0.977TrpArg: 0.977 ± 0.02
0.966TrpSer: 0.966 ± 0.019
0.835TrpThr: 0.835 ± 0.021
0.925TrpVal: 0.925 ± 0.021
0.26TrpTrp: 0.26 ± 0.01
0.366TrpTyr: 0.366 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.168TyrAla: 2.168 ± 0.03
0.327TyrCys: 0.327 ± 0.011
1.622TyrAsp: 1.622 ± 0.028
1.462TyrGlu: 1.462 ± 0.022
1.028TyrPhe: 1.028 ± 0.022
1.969TyrGly: 1.969 ± 0.03
0.658TyrHis: 0.658 ± 0.018
0.85TyrIle: 0.85 ± 0.021
0.68TyrLys: 0.68 ± 0.016
2.304TyrLeu: 2.304 ± 0.034
0.391TyrMet: 0.391 ± 0.011
0.725TyrAsn: 0.725 ± 0.019
1.2TyrPro: 1.2 ± 0.024
1.15TyrGln: 1.15 ± 0.021
2.117TyrArg: 2.117 ± 0.031
1.466TyrSer: 1.466 ± 0.022
1.16TyrThr: 1.16 ± 0.03
1.602TyrVal: 1.602 ± 0.025
0.434TyrTrp: 0.434 ± 0.013
0.728TyrTyr: 0.728 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.001
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7824 proteins (2504267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski