Amino acid dipepetide frequency for Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.921AlaAla: 14.921 ± 2.1
1.072AlaCys: 1.072 ± 0.327
3.127AlaAsp: 3.127 ± 0.581
4.11AlaGlu: 4.11 ± 0.687
3.217AlaPhe: 3.217 ± 0.387
5.004AlaGly: 5.004 ± 0.785
1.787AlaHis: 1.787 ± 0.31
4.289AlaIle: 4.289 ± 0.578
1.43AlaLys: 1.43 ± 0.378
7.595AlaLeu: 7.595 ± 0.866
1.162AlaMet: 1.162 ± 0.309
2.591AlaAsn: 2.591 ± 0.611
6.969AlaPro: 6.969 ± 1.097
2.859AlaGln: 2.859 ± 0.43
6.344AlaArg: 6.344 ± 0.887
5.54AlaSer: 5.54 ± 0.674
4.736AlaThr: 4.736 ± 0.634
5.093AlaVal: 5.093 ± 0.586
1.072AlaTrp: 1.072 ± 0.252
2.502AlaTyr: 2.502 ± 0.375
0.0AlaXaa: 0.0 ± 0.0
Cys
1.34CysAla: 1.34 ± 0.338
0.893CysCys: 0.893 ± 0.264
0.804CysAsp: 0.804 ± 0.229
1.162CysGlu: 1.162 ± 0.416
0.447CysPhe: 0.447 ± 0.157
1.876CysGly: 1.876 ± 0.434
0.893CysHis: 0.893 ± 0.326
0.804CysIle: 0.804 ± 0.247
0.715CysLys: 0.715 ± 0.233
1.251CysLeu: 1.251 ± 0.348
0.268CysMet: 0.268 ± 0.132
1.162CysAsn: 1.162 ± 0.342
0.625CysPro: 0.625 ± 0.179
0.268CysGln: 0.268 ± 0.138
1.072CysArg: 1.072 ± 0.315
1.072CysSer: 1.072 ± 0.379
1.251CysThr: 1.251 ± 0.398
0.715CysVal: 0.715 ± 0.219
0.268CysTrp: 0.268 ± 0.172
1.162CysTyr: 1.162 ± 0.272
0.0CysXaa: 0.0 ± 0.0
Asp
4.199AspAla: 4.199 ± 0.682
0.715AspCys: 0.715 ± 0.23
2.859AspAsp: 2.859 ± 0.565
4.467AspGlu: 4.467 ± 0.726
1.787AspPhe: 1.787 ± 0.424
2.949AspGly: 2.949 ± 0.579
0.893AspHis: 0.893 ± 0.351
1.876AspIle: 1.876 ± 0.273
1.698AspLys: 1.698 ± 0.294
5.45AspLeu: 5.45 ± 0.766
2.323AspMet: 2.323 ± 0.505
2.234AspAsn: 2.234 ± 0.513
2.591AspPro: 2.591 ± 0.448
1.251AspGln: 1.251 ± 0.209
3.485AspArg: 3.485 ± 0.746
3.753AspSer: 3.753 ± 0.584
2.502AspThr: 2.502 ± 0.363
3.127AspVal: 3.127 ± 0.473
0.804AspTrp: 0.804 ± 0.217
2.055AspTyr: 2.055 ± 0.438
0.0AspXaa: 0.0 ± 0.0
Glu
5.093GluAla: 5.093 ± 0.7
1.519GluCys: 1.519 ± 0.403
5.093GluAsp: 5.093 ± 0.635
9.382GluGlu: 9.382 ± 1.646
1.787GluPhe: 1.787 ± 0.347
4.199GluGly: 4.199 ± 0.541
1.162GluHis: 1.162 ± 0.275
2.591GluIle: 2.591 ± 0.549
2.055GluLys: 2.055 ± 0.342
4.914GluLeu: 4.914 ± 0.6
1.43GluMet: 1.43 ± 0.235
1.698GluAsn: 1.698 ± 0.408
4.736GluPro: 4.736 ± 1.158
3.753GluGln: 3.753 ± 0.497
4.557GluArg: 4.557 ± 0.883
3.485GluSer: 3.485 ± 0.631
3.395GluThr: 3.395 ± 0.477
3.753GluVal: 3.753 ± 0.498
0.447GluTrp: 0.447 ± 0.212
1.43GluTyr: 1.43 ± 0.448
0.0GluXaa: 0.0 ± 0.0
Phe
2.77PheAla: 2.77 ± 0.342
0.804PheCys: 0.804 ± 0.302
2.323PheAsp: 2.323 ± 0.553
1.698PheGlu: 1.698 ± 0.395
1.251PhePhe: 1.251 ± 0.377
1.162PheGly: 1.162 ± 0.255
0.447PheHis: 0.447 ± 0.156
1.162PheIle: 1.162 ± 0.309
0.983PheLys: 0.983 ± 0.389
3.038PheLeu: 3.038 ± 0.528
1.34PheMet: 1.34 ± 0.29
1.251PheAsn: 1.251 ± 0.258
2.77PhePro: 2.77 ± 0.469
1.966PheGln: 1.966 ± 0.282
2.949PheArg: 2.949 ± 0.43
3.038PheSer: 3.038 ± 0.529
2.144PheThr: 2.144 ± 0.468
2.591PheVal: 2.591 ± 0.436
0.089PheTrp: 0.089 ± 0.078
1.519PheTyr: 1.519 ± 0.43
0.0PheXaa: 0.0 ± 0.0
Gly
5.272GlyAla: 5.272 ± 0.711
1.34GlyCys: 1.34 ± 0.342
3.306GlyAsp: 3.306 ± 0.447
2.591GlyGlu: 2.591 ± 0.451
2.949GlyPhe: 2.949 ± 0.397
6.612GlyGly: 6.612 ± 0.837
2.502GlyHis: 2.502 ± 0.457
3.127GlyIle: 3.127 ± 0.562
1.876GlyLys: 1.876 ± 0.436
5.093GlyLeu: 5.093 ± 0.704
1.787GlyMet: 1.787 ± 0.419
3.217GlyAsn: 3.217 ± 0.696
3.753GlyPro: 3.753 ± 0.659
3.127GlyGln: 3.127 ± 0.684
4.467GlyArg: 4.467 ± 0.747
4.289GlySer: 4.289 ± 0.573
2.77GlyThr: 2.77 ± 0.461
4.825GlyVal: 4.825 ± 0.74
0.536GlyTrp: 0.536 ± 0.251
1.251GlyTyr: 1.251 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
1.519HisAla: 1.519 ± 0.282
0.447HisCys: 0.447 ± 0.206
0.715HisAsp: 0.715 ± 0.244
1.072HisGlu: 1.072 ± 0.276
0.536HisPhe: 0.536 ± 0.219
2.234HisGly: 2.234 ± 0.385
0.804HisHis: 0.804 ± 0.303
1.251HisIle: 1.251 ± 0.307
0.983HisLys: 0.983 ± 0.344
2.859HisLeu: 2.859 ± 0.568
0.357HisMet: 0.357 ± 0.164
1.162HisAsn: 1.162 ± 0.36
1.876HisPro: 1.876 ± 0.501
0.804HisGln: 0.804 ± 0.244
2.502HisArg: 2.502 ± 0.504
1.519HisSer: 1.519 ± 0.49
1.072HisThr: 1.072 ± 0.203
1.072HisVal: 1.072 ± 0.238
0.268HisTrp: 0.268 ± 0.144
0.625HisTyr: 0.625 ± 0.206
0.0HisXaa: 0.0 ± 0.0
Ile
2.412IleAla: 2.412 ± 0.531
1.162IleCys: 1.162 ± 0.237
1.787IleAsp: 1.787 ± 0.376
2.234IleGlu: 2.234 ± 0.369
1.251IlePhe: 1.251 ± 0.355
2.144IleGly: 2.144 ± 0.499
0.715IleHis: 0.715 ± 0.251
2.055IleIle: 2.055 ± 0.405
2.502IleLys: 2.502 ± 0.544
3.485IleLeu: 3.485 ± 0.515
0.625IleMet: 0.625 ± 0.197
2.591IleAsn: 2.591 ± 0.566
2.323IlePro: 2.323 ± 0.571
1.072IleGln: 1.072 ± 0.314
2.234IleArg: 2.234 ± 0.55
2.77IleSer: 2.77 ± 0.441
3.038IleThr: 3.038 ± 0.525
2.502IleVal: 2.502 ± 0.545
0.536IleTrp: 0.536 ± 0.179
0.715IleTyr: 0.715 ± 0.285
0.0IleXaa: 0.0 ± 0.0
Lys
1.698LysAla: 1.698 ± 0.445
0.625LysCys: 0.625 ± 0.211
2.055LysAsp: 2.055 ± 0.422
1.787LysGlu: 1.787 ± 0.343
1.34LysPhe: 1.34 ± 0.369
1.787LysGly: 1.787 ± 0.504
0.893LysHis: 0.893 ± 0.347
2.234LysIle: 2.234 ± 0.428
3.217LysLys: 3.217 ± 0.792
3.485LysLeu: 3.485 ± 0.733
1.072LysMet: 1.072 ± 0.389
1.34LysAsn: 1.34 ± 0.251
1.966LysPro: 1.966 ± 0.433
1.162LysGln: 1.162 ± 0.321
3.574LysArg: 3.574 ± 0.873
2.412LysSer: 2.412 ± 0.552
2.144LysThr: 2.144 ± 0.475
1.787LysVal: 1.787 ± 0.4
0.357LysTrp: 0.357 ± 0.193
1.43LysTyr: 1.43 ± 0.288
0.0LysXaa: 0.0 ± 0.0
Leu
7.595LeuAla: 7.595 ± 0.782
1.34LeuCys: 1.34 ± 0.381
5.45LeuAsp: 5.45 ± 0.583
4.825LeuGlu: 4.825 ± 0.721
1.698LeuPhe: 1.698 ± 0.379
5.45LeuGly: 5.45 ± 0.602
2.68LeuHis: 2.68 ± 0.52
3.574LeuIle: 3.574 ± 0.695
5.45LeuLys: 5.45 ± 0.691
8.846LeuLeu: 8.846 ± 1.041
2.234LeuMet: 2.234 ± 0.377
4.825LeuAsn: 4.825 ± 0.695
5.272LeuPro: 5.272 ± 0.864
4.289LeuGln: 4.289 ± 0.867
6.88LeuArg: 6.88 ± 1.06
4.646LeuSer: 4.646 ± 0.781
6.791LeuThr: 6.791 ± 1.298
4.557LeuVal: 4.557 ± 0.607
1.787LeuTrp: 1.787 ± 0.33
2.68LeuTyr: 2.68 ± 0.582
0.0LeuXaa: 0.0 ± 0.0
Met
2.68MetAla: 2.68 ± 0.578
0.268MetCys: 0.268 ± 0.151
1.162MetAsp: 1.162 ± 0.239
2.234MetGlu: 2.234 ± 0.446
0.983MetPhe: 0.983 ± 0.299
1.072MetGly: 1.072 ± 0.261
0.715MetHis: 0.715 ± 0.384
0.715MetIle: 0.715 ± 0.216
0.715MetLys: 0.715 ± 0.196
2.323MetLeu: 2.323 ± 0.416
0.715MetMet: 0.715 ± 0.201
1.162MetAsn: 1.162 ± 0.299
1.519MetPro: 1.519 ± 0.375
1.072MetGln: 1.072 ± 0.255
1.876MetArg: 1.876 ± 0.509
1.519MetSer: 1.519 ± 0.311
1.251MetThr: 1.251 ± 0.277
1.608MetVal: 1.608 ± 0.334
0.447MetTrp: 0.447 ± 0.212
0.804MetTyr: 0.804 ± 0.25
0.0MetXaa: 0.0 ± 0.0
Asn
2.591AsnAla: 2.591 ± 0.541
0.893AsnCys: 0.893 ± 0.365
1.966AsnAsp: 1.966 ± 0.612
2.77AsnGlu: 2.77 ± 0.423
2.323AsnPhe: 2.323 ± 0.57
2.234AsnGly: 2.234 ± 0.637
0.715AsnHis: 0.715 ± 0.342
1.876AsnIle: 1.876 ± 0.447
1.34AsnLys: 1.34 ± 0.276
5.361AsnLeu: 5.361 ± 0.697
1.43AsnMet: 1.43 ± 0.37
1.698AsnAsn: 1.698 ± 0.384
3.127AsnPro: 3.127 ± 0.49
1.34AsnGln: 1.34 ± 0.264
2.77AsnArg: 2.77 ± 0.476
3.574AsnSer: 3.574 ± 0.533
2.502AsnThr: 2.502 ± 0.545
2.412AsnVal: 2.412 ± 0.436
0.625AsnTrp: 0.625 ± 0.184
1.876AsnTyr: 1.876 ± 0.476
0.0AsnXaa: 0.0 ± 0.0
Pro
5.629ProAla: 5.629 ± 0.71
0.625ProCys: 0.625 ± 0.225
2.949ProAsp: 2.949 ± 0.366
5.986ProGlu: 5.986 ± 1.229
2.591ProPhe: 2.591 ± 0.511
5.272ProGly: 5.272 ± 0.506
0.983ProHis: 0.983 ± 0.257
1.787ProIle: 1.787 ± 0.329
2.323ProLys: 2.323 ± 0.446
5.361ProLeu: 5.361 ± 0.944
1.787ProMet: 1.787 ± 0.404
3.395ProAsn: 3.395 ± 0.485
9.292ProPro: 9.292 ± 1.524
2.68ProGln: 2.68 ± 0.688
5.093ProArg: 5.093 ± 0.823
6.076ProSer: 6.076 ± 0.831
5.361ProThr: 5.361 ± 0.719
5.004ProVal: 5.004 ± 0.981
0.536ProTrp: 0.536 ± 0.236
1.519ProTyr: 1.519 ± 0.395
0.0ProXaa: 0.0 ± 0.0
Gln
4.289GlnAla: 4.289 ± 0.5
0.625GlnCys: 0.625 ± 0.229
1.966GlnAsp: 1.966 ± 0.357
4.021GlnGlu: 4.021 ± 0.683
1.162GlnPhe: 1.162 ± 0.342
2.502GlnGly: 2.502 ± 0.464
0.983GlnHis: 0.983 ± 0.251
1.698GlnIle: 1.698 ± 0.291
1.43GlnLys: 1.43 ± 0.343
3.574GlnLeu: 3.574 ± 0.418
0.804GlnMet: 0.804 ± 0.244
1.966GlnAsn: 1.966 ± 0.475
3.842GlnPro: 3.842 ± 0.546
3.395GlnGln: 3.395 ± 0.606
3.485GlnArg: 3.485 ± 0.629
2.591GlnSer: 2.591 ± 0.516
2.234GlnThr: 2.234 ± 0.443
2.502GlnVal: 2.502 ± 0.414
0.357GlnTrp: 0.357 ± 0.201
0.715GlnTyr: 0.715 ± 0.203
0.0GlnXaa: 0.0 ± 0.0
Arg
7.059ArgAla: 7.059 ± 0.898
1.698ArgCys: 1.698 ± 0.472
3.931ArgAsp: 3.931 ± 0.935
3.753ArgGlu: 3.753 ± 0.911
2.323ArgPhe: 2.323 ± 0.347
5.986ArgGly: 5.986 ± 0.857
2.502ArgHis: 2.502 ± 0.423
1.876ArgIle: 1.876 ± 0.32
1.876ArgLys: 1.876 ± 0.478
5.45ArgLeu: 5.45 ± 0.902
1.162ArgMet: 1.162 ± 0.35
4.199ArgAsn: 4.199 ± 0.522
7.059ArgPro: 7.059 ± 0.981
3.753ArgGln: 3.753 ± 0.678
10.543ArgArg: 10.543 ± 2.051
4.289ArgSer: 4.289 ± 0.722
2.949ArgThr: 2.949 ± 0.636
3.931ArgVal: 3.931 ± 0.849
1.162ArgTrp: 1.162 ± 0.267
1.43ArgTyr: 1.43 ± 0.323
0.0ArgXaa: 0.0 ± 0.0
Ser
4.557SerAla: 4.557 ± 0.732
1.251SerCys: 1.251 ± 0.354
2.412SerAsp: 2.412 ± 0.332
4.199SerGlu: 4.199 ± 0.648
2.234SerPhe: 2.234 ± 0.434
5.808SerGly: 5.808 ± 0.899
1.787SerHis: 1.787 ± 0.445
2.234SerIle: 2.234 ± 0.534
2.591SerLys: 2.591 ± 0.545
6.612SerLeu: 6.612 ± 0.957
1.608SerMet: 1.608 ± 0.411
2.949SerAsn: 2.949 ± 0.576
5.808SerPro: 5.808 ± 0.833
3.395SerGln: 3.395 ± 0.529
4.199SerArg: 4.199 ± 0.484
4.467SerSer: 4.467 ± 0.728
4.11SerThr: 4.11 ± 0.625
3.842SerVal: 3.842 ± 0.476
0.804SerTrp: 0.804 ± 0.242
1.966SerTyr: 1.966 ± 0.615
0.0SerXaa: 0.0 ± 0.0
Thr
4.199ThrAla: 4.199 ± 0.686
1.162ThrCys: 1.162 ± 0.336
2.949ThrAsp: 2.949 ± 0.462
3.395ThrGlu: 3.395 ± 0.503
3.038ThrPhe: 3.038 ± 0.641
4.289ThrGly: 4.289 ± 0.854
1.162ThrHis: 1.162 ± 0.333
1.698ThrIle: 1.698 ± 0.465
1.519ThrLys: 1.519 ± 0.471
6.433ThrLeu: 6.433 ± 0.795
1.251ThrMet: 1.251 ± 0.275
1.876ThrAsn: 1.876 ± 0.508
4.199ThrPro: 4.199 ± 0.619
2.68ThrGln: 2.68 ± 0.403
3.931ThrArg: 3.931 ± 0.685
3.395ThrSer: 3.395 ± 0.724
4.199ThrThr: 4.199 ± 0.721
5.182ThrVal: 5.182 ± 0.826
0.447ThrTrp: 0.447 ± 0.167
2.055ThrTyr: 2.055 ± 0.46
0.0ThrXaa: 0.0 ± 0.0
Val
5.272ValAla: 5.272 ± 0.65
0.893ValCys: 0.893 ± 0.25
3.127ValAsp: 3.127 ± 0.898
4.199ValGlu: 4.199 ± 0.586
2.77ValPhe: 2.77 ± 0.588
1.966ValGly: 1.966 ± 0.329
0.983ValHis: 0.983 ± 0.303
2.144ValIle: 2.144 ± 0.345
1.519ValLys: 1.519 ± 0.305
5.272ValLeu: 5.272 ± 0.497
2.055ValMet: 2.055 ± 0.36
2.055ValAsn: 2.055 ± 0.324
4.557ValPro: 4.557 ± 0.549
3.127ValGln: 3.127 ± 0.597
4.289ValArg: 4.289 ± 0.629
5.004ValSer: 5.004 ± 0.8
4.199ValThr: 4.199 ± 0.601
4.11ValVal: 4.11 ± 0.596
0.268ValTrp: 0.268 ± 0.132
2.412ValTyr: 2.412 ± 0.455
0.0ValXaa: 0.0 ± 0.0
Trp
0.447TrpAla: 0.447 ± 0.22
0.089TrpCys: 0.089 ± 0.1
0.983TrpAsp: 0.983 ± 0.335
0.983TrpGlu: 0.983 ± 0.282
0.268TrpPhe: 0.268 ± 0.139
0.893TrpGly: 0.893 ± 0.242
0.0TrpHis: 0.0 ± 0.0
0.179TrpIle: 0.179 ± 0.108
0.804TrpLys: 0.804 ± 0.298
0.893TrpLeu: 0.893 ± 0.212
0.357TrpMet: 0.357 ± 0.168
0.804TrpAsn: 0.804 ± 0.264
0.625TrpPro: 0.625 ± 0.218
0.625TrpGln: 0.625 ± 0.244
1.072TrpArg: 1.072 ± 0.345
1.162TrpSer: 1.162 ± 0.265
0.715TrpThr: 0.715 ± 0.253
0.357TrpVal: 0.357 ± 0.163
0.179TrpTrp: 0.179 ± 0.101
0.179TrpTyr: 0.179 ± 0.113
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.876TyrAla: 1.876 ± 0.461
0.625TyrCys: 0.625 ± 0.264
2.055TyrAsp: 2.055 ± 0.41
1.608TyrGlu: 1.608 ± 0.421
1.34TyrPhe: 1.34 ± 0.327
1.251TyrGly: 1.251 ± 0.384
1.072TyrHis: 1.072 ± 0.281
0.983TyrIle: 0.983 ± 0.351
1.34TyrLys: 1.34 ± 0.328
3.574TyrLeu: 3.574 ± 0.638
0.983TyrMet: 0.983 ± 0.435
1.251TyrAsn: 1.251 ± 0.37
1.34TyrPro: 1.34 ± 0.332
1.519TyrGln: 1.519 ± 0.331
1.608TyrArg: 1.608 ± 0.383
2.323TyrSer: 2.323 ± 0.671
1.698TyrThr: 1.698 ± 0.31
1.251TyrVal: 1.251 ± 0.307
0.625TyrTrp: 0.625 ± 0.2
0.357TyrTyr: 0.357 ± 0.169
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 36 proteins (11193 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski