Amino acid dipepetide frequency for Acetobacter sp. CAG:267

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.461AlaAla: 11.461 ± 0.329
0.982AlaCys: 0.982 ± 0.055
5.645AlaAsp: 5.645 ± 0.129
7.505AlaGlu: 7.505 ± 0.171
3.684AlaPhe: 3.684 ± 0.119
7.233AlaGly: 7.233 ± 0.151
1.166AlaHis: 1.166 ± 0.052
4.313AlaIle: 4.313 ± 0.112
5.967AlaLys: 5.967 ± 0.129
8.335AlaLeu: 8.335 ± 0.144
2.229AlaMet: 2.229 ± 0.068
3.157AlaAsn: 3.157 ± 0.089
3.308AlaPro: 3.308 ± 0.11
2.868AlaGln: 2.868 ± 0.082
3.935AlaArg: 3.935 ± 0.093
4.41AlaSer: 4.41 ± 0.103
3.302AlaThr: 3.302 ± 0.103
7.484AlaVal: 7.484 ± 0.165
0.782AlaTrp: 0.782 ± 0.049
3.346AlaTyr: 3.346 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
1.044CysAla: 1.044 ± 0.053
0.282CysCys: 0.282 ± 0.025
0.587CysAsp: 0.587 ± 0.038
0.662CysGlu: 0.662 ± 0.04
0.695CysPhe: 0.695 ± 0.042
1.183CysGly: 1.183 ± 0.048
0.232CysHis: 0.232 ± 0.021
0.843CysIle: 0.843 ± 0.056
0.608CysLys: 0.608 ± 0.037
1.289CysLeu: 1.289 ± 0.056
0.27CysMet: 0.27 ± 0.025
0.448CysAsn: 0.448 ± 0.032
0.658CysPro: 0.658 ± 0.049
0.357CysGln: 0.357 ± 0.027
0.944CysArg: 0.944 ± 0.055
0.849CysSer: 0.849 ± 0.048
0.554CysThr: 0.554 ± 0.037
0.66CysVal: 0.66 ± 0.039
0.135CysTrp: 0.135 ± 0.019
0.569CysTyr: 0.569 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
4.365AspAla: 4.365 ± 0.106
0.766AspCys: 0.766 ± 0.048
3.161AspAsp: 3.161 ± 0.109
4.296AspGlu: 4.296 ± 0.109
3.234AspPhe: 3.234 ± 0.104
4.601AspGly: 4.601 ± 0.164
0.585AspHis: 0.585 ± 0.033
4.624AspIle: 4.624 ± 0.11
4.296AspLys: 4.296 ± 0.132
4.508AspLeu: 4.508 ± 0.094
1.64AspMet: 1.64 ± 0.062
2.916AspAsn: 2.916 ± 0.087
1.193AspPro: 1.193 ± 0.057
0.706AspGln: 0.706 ± 0.047
2.237AspArg: 2.237 ± 0.075
2.634AspSer: 2.634 ± 0.085
2.773AspThr: 2.773 ± 0.075
3.767AspVal: 3.767 ± 0.099
0.643AspTrp: 0.643 ± 0.04
2.462AspTyr: 2.462 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
5.581GluAla: 5.581 ± 0.135
0.6GluCys: 0.6 ± 0.042
3.647GluAsp: 3.647 ± 0.095
5.274GluGlu: 5.274 ± 0.149
2.561GluPhe: 2.561 ± 0.072
3.505GluGly: 3.505 ± 0.099
1.237GluHis: 1.237 ± 0.054
5.197GluIle: 5.197 ± 0.113
6.403GluLys: 6.403 ± 0.152
6.123GluLeu: 6.123 ± 0.133
1.926GluMet: 1.926 ± 0.068
4.446GluAsn: 4.446 ± 0.104
1.855GluPro: 1.855 ± 0.073
2.64GluGln: 2.64 ± 0.079
3.503GluArg: 3.503 ± 0.098
2.572GluSer: 2.572 ± 0.073
3.95GluThr: 3.95 ± 0.107
3.705GluVal: 3.705 ± 0.1
0.633GluTrp: 0.633 ± 0.036
2.393GluTyr: 2.393 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
4.41PheAla: 4.41 ± 0.123
0.859PheCys: 0.859 ± 0.044
2.789PheAsp: 2.789 ± 0.075
2.476PheGlu: 2.476 ± 0.077
2.405PhePhe: 2.405 ± 0.087
3.331PheGly: 3.331 ± 0.094
0.583PheHis: 0.583 ± 0.036
3.055PheIle: 3.055 ± 0.095
2.505PheLys: 2.505 ± 0.078
4.433PheLeu: 4.433 ± 0.123
1.335PheMet: 1.335 ± 0.048
2.221PheAsn: 2.221 ± 0.073
1.588PhePro: 1.588 ± 0.071
1.015PheGln: 1.015 ± 0.048
1.851PheArg: 1.851 ± 0.061
3.497PheSer: 3.497 ± 0.089
2.098PheThr: 2.098 ± 0.067
2.825PheVal: 2.825 ± 0.079
0.579PheTrp: 0.579 ± 0.036
2.026PheTyr: 2.026 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
5.581GlyAla: 5.581 ± 0.135
1.071GlyCys: 1.071 ± 0.058
3.414GlyAsp: 3.414 ± 0.094
4.539GlyGlu: 4.539 ± 0.101
3.236GlyPhe: 3.236 ± 0.094
5.205GlyGly: 5.205 ± 0.158
1.198GlyHis: 1.198 ± 0.056
5.282GlyIle: 5.282 ± 0.12
5.722GlyLys: 5.722 ± 0.148
5.963GlyLeu: 5.963 ± 0.124
1.899GlyMet: 1.899 ± 0.068
3.408GlyAsn: 3.408 ± 0.147
0.986GlyPro: 0.986 ± 0.044
2.109GlyGln: 2.109 ± 0.069
3.875GlyArg: 3.875 ± 0.11
4.06GlySer: 4.06 ± 0.115
4.095GlyThr: 4.095 ± 0.14
4.605GlyVal: 4.605 ± 0.121
0.772GlyTrp: 0.772 ± 0.049
2.991GlyTyr: 2.991 ± 0.109
0.0GlyXaa: 0.0 ± 0.0
His
1.127HisAla: 1.127 ± 0.043
0.295HisCys: 0.295 ± 0.027
0.807HisAsp: 0.807 ± 0.042
0.878HisGlu: 0.878 ± 0.04
0.805HisPhe: 0.805 ± 0.042
1.146HisGly: 1.146 ± 0.052
0.326HisHis: 0.326 ± 0.029
1.177HisIle: 1.177 ± 0.05
0.998HisLys: 0.998 ± 0.046
1.405HisLeu: 1.405 ± 0.057
0.268HisMet: 0.268 ± 0.022
0.969HisAsn: 0.969 ± 0.045
0.882HisPro: 0.882 ± 0.043
0.538HisGln: 0.538 ± 0.038
0.861HisArg: 0.861 ± 0.04
0.836HisSer: 0.836 ± 0.042
0.766HisThr: 0.766 ± 0.044
0.728HisVal: 0.728 ± 0.039
0.183HisTrp: 0.183 ± 0.019
0.689HisTyr: 0.689 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.969IleAla: 5.969 ± 0.113
0.973IleCys: 0.973 ± 0.051
3.852IleAsp: 3.852 ± 0.104
3.987IleGlu: 3.987 ± 0.103
2.895IlePhe: 2.895 ± 0.086
4.269IleGly: 4.269 ± 0.164
0.876IleHis: 0.876 ± 0.038
4.307IleIle: 4.307 ± 0.119
4.504IleLys: 4.504 ± 0.134
6.131IleLeu: 6.131 ± 0.149
1.598IleMet: 1.598 ± 0.064
3.381IleAsn: 3.381 ± 0.101
2.615IlePro: 2.615 ± 0.073
1.463IleGln: 1.463 ± 0.057
3.296IleArg: 3.296 ± 0.088
4.711IleSer: 4.711 ± 0.105
3.514IleThr: 3.514 ± 0.116
4.105IleVal: 4.105 ± 0.084
0.604IleTrp: 0.604 ± 0.039
2.306IleTyr: 2.306 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
6.023LysAla: 6.023 ± 0.134
0.675LysCys: 0.675 ± 0.041
4.116LysAsp: 4.116 ± 0.12
5.392LysGlu: 5.392 ± 0.135
2.547LysPhe: 2.547 ± 0.085
3.956LysGly: 3.956 ± 0.087
1.017LysHis: 1.017 ± 0.043
5.322LysIle: 5.322 ± 0.133
5.913LysLys: 5.913 ± 0.147
6.106LysLeu: 6.106 ± 0.136
1.974LysMet: 1.974 ± 0.062
4.29LysAsn: 4.29 ± 0.116
2.329LysPro: 2.329 ± 0.086
2.337LysGln: 2.337 ± 0.073
3.381LysArg: 3.381 ± 0.084
3.939LysSer: 3.939 ± 0.108
4.165LysThr: 4.165 ± 0.102
4.163LysVal: 4.163 ± 0.103
0.558LysTrp: 0.558 ± 0.032
2.555LysTyr: 2.555 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
8.574LeuAla: 8.574 ± 0.169
1.341LeuCys: 1.341 ± 0.062
4.807LeuAsp: 4.807 ± 0.109
5.469LeuGlu: 5.469 ± 0.126
4.587LeuPhe: 4.587 ± 0.127
6.112LeuGly: 6.112 ± 0.123
1.469LeuHis: 1.469 ± 0.057
5.174LeuIle: 5.174 ± 0.138
7.071LeuLys: 7.071 ± 0.137
9.059LeuLeu: 9.059 ± 0.219
2.246LeuMet: 2.246 ± 0.073
4.57LeuAsn: 4.57 ± 0.095
4.195LeuPro: 4.195 ± 0.106
3.163LeuGln: 3.163 ± 0.088
4.614LeuArg: 4.614 ± 0.117
6.546LeuSer: 6.546 ± 0.134
4.576LeuThr: 4.576 ± 0.096
4.981LeuVal: 4.981 ± 0.124
1.013LeuTrp: 1.013 ± 0.05
3.487LeuTyr: 3.487 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
2.534MetAla: 2.534 ± 0.087
0.203MetCys: 0.203 ± 0.019
1.2MetAsp: 1.2 ± 0.047
1.461MetGlu: 1.461 ± 0.056
1.158MetPhe: 1.158 ± 0.053
1.407MetGly: 1.407 ± 0.056
0.459MetHis: 0.459 ± 0.032
1.372MetIle: 1.372 ± 0.056
1.934MetLys: 1.934 ± 0.062
2.644MetLeu: 2.644 ± 0.078
0.704MetMet: 0.704 ± 0.041
1.056MetAsn: 1.056 ± 0.047
1.281MetPro: 1.281 ± 0.058
1.054MetGln: 1.054 ± 0.048
1.283MetArg: 1.283 ± 0.054
1.635MetSer: 1.635 ± 0.057
1.31MetThr: 1.31 ± 0.056
1.465MetVal: 1.465 ± 0.061
0.205MetTrp: 0.205 ± 0.021
0.747MetTyr: 0.747 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
4.178AsnAla: 4.178 ± 0.108
0.556AsnCys: 0.556 ± 0.033
2.291AsnAsp: 2.291 ± 0.075
2.787AsnGlu: 2.787 ± 0.075
2.235AsnPhe: 2.235 ± 0.07
4.234AsnGly: 4.234 ± 0.149
0.724AsnHis: 0.724 ± 0.035
3.833AsnIle: 3.833 ± 0.098
2.982AsnLys: 2.982 ± 0.086
4.491AsnLeu: 4.491 ± 0.106
1.278AsnMet: 1.278 ± 0.061
2.565AsnAsn: 2.565 ± 0.106
2.381AsnPro: 2.381 ± 0.071
1.413AsnGln: 1.413 ± 0.065
2.545AsnArg: 2.545 ± 0.076
2.727AsnSer: 2.727 ± 0.09
2.412AsnThr: 2.412 ± 0.073
3.061AsnVal: 3.061 ± 0.099
0.442AsnTrp: 0.442 ± 0.034
1.831AsnTyr: 1.831 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
3.68ProAla: 3.68 ± 0.102
0.401ProCys: 0.401 ± 0.032
2.638ProAsp: 2.638 ± 0.079
3.794ProGlu: 3.794 ± 0.108
1.623ProPhe: 1.623 ± 0.07
2.119ProGly: 2.119 ± 0.067
0.708ProHis: 0.708 ± 0.042
1.598ProIle: 1.598 ± 0.058
2.1ProLys: 2.1 ± 0.079
3.375ProLeu: 3.375 ± 0.077
0.722ProMet: 0.722 ± 0.043
1.463ProAsn: 1.463 ± 0.05
1.017ProPro: 1.017 ± 0.049
1.557ProGln: 1.557 ± 0.063
1.314ProArg: 1.314 ± 0.064
1.824ProSer: 1.824 ± 0.07
1.507ProThr: 1.507 ± 0.057
2.922ProVal: 2.922 ± 0.094
0.396ProTrp: 0.396 ± 0.031
1.65ProTyr: 1.65 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
2.765GlnAla: 2.765 ± 0.088
0.305GlnCys: 0.305 ± 0.028
1.611GlnAsp: 1.611 ± 0.054
2.146GlnGlu: 2.146 ± 0.07
1.094GlnPhe: 1.094 ± 0.049
1.934GlnGly: 1.934 ± 0.061
0.482GlnHis: 0.482 ± 0.033
2.109GlnIle: 2.109 ± 0.066
2.953GlnLys: 2.953 ± 0.094
2.312GlnLeu: 2.312 ± 0.078
0.849GlnMet: 0.849 ± 0.04
2.117GlnAsn: 2.117 ± 0.068
1.16GlnPro: 1.16 ± 0.055
1.293GlnGln: 1.293 ± 0.059
1.627GlnArg: 1.627 ± 0.065
1.613GlnSer: 1.613 ± 0.065
1.828GlnThr: 1.828 ± 0.066
1.706GlnVal: 1.706 ± 0.055
0.228GlnTrp: 0.228 ± 0.022
1.121GlnTyr: 1.121 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.613ArgAla: 3.613 ± 0.099
0.567ArgCys: 0.567 ± 0.036
2.271ArgAsp: 2.271 ± 0.069
3.618ArgGlu: 3.618 ± 0.092
2.482ArgPhe: 2.482 ± 0.076
3.02ArgGly: 3.02 ± 0.078
1.032ArgHis: 1.032 ± 0.048
3.57ArgIle: 3.57 ± 0.094
3.655ArgLys: 3.655 ± 0.094
5.068ArgLeu: 5.068 ± 0.118
1.27ArgMet: 1.27 ± 0.057
2.345ArgAsn: 2.345 ± 0.069
1.882ArgPro: 1.882 ± 0.068
2.102ArgGln: 2.102 ± 0.073
3.395ArgArg: 3.395 ± 0.097
2.459ArgSer: 2.459 ± 0.068
2.291ArgThr: 2.291 ± 0.07
2.576ArgVal: 2.576 ± 0.073
0.463ArgTrp: 0.463 ± 0.037
2.013ArgTyr: 2.013 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.527SerAla: 5.527 ± 0.121
0.793SerCys: 0.793 ± 0.038
3.221SerAsp: 3.221 ± 0.102
3.564SerGlu: 3.564 ± 0.094
2.906SerPhe: 2.906 ± 0.076
5.544SerGly: 5.544 ± 0.128
0.838SerHis: 0.838 ± 0.049
3.184SerIle: 3.184 ± 0.098
3.2SerLys: 3.2 ± 0.089
5.676SerLeu: 5.676 ± 0.123
1.173SerMet: 1.173 ± 0.048
2.175SerAsn: 2.175 ± 0.06
2.347SerPro: 2.347 ± 0.081
1.756SerGln: 1.756 ± 0.066
3.184SerArg: 3.184 ± 0.079
3.86SerSer: 3.86 ± 0.138
2.426SerThr: 2.426 ± 0.079
3.983SerVal: 3.983 ± 0.09
0.604SerTrp: 0.604 ± 0.037
2.322SerTyr: 2.322 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
5.479ThrAla: 5.479 ± 0.147
0.494ThrCys: 0.494 ± 0.04
3.016ThrAsp: 3.016 ± 0.092
3.283ThrGlu: 3.283 ± 0.087
2.121ThrPhe: 2.121 ± 0.063
4.008ThrGly: 4.008 ± 0.133
0.857ThrHis: 0.857 ± 0.043
2.866ThrIle: 2.866 ± 0.086
2.526ThrLys: 2.526 ± 0.079
4.745ThrLeu: 4.745 ± 0.108
0.982ThrMet: 0.982 ± 0.049
1.841ThrAsn: 1.841 ± 0.082
2.648ThrPro: 2.648 ± 0.08
1.281ThrGln: 1.281 ± 0.049
1.914ThrArg: 1.914 ± 0.06
2.794ThrSer: 2.794 ± 0.08
2.37ThrThr: 2.37 ± 0.082
3.975ThrVal: 3.975 ± 0.107
0.359ThrTrp: 0.359 ± 0.023
1.779ThrTyr: 1.779 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
5.164ValAla: 5.164 ± 0.104
1.071ValCys: 1.071 ± 0.053
3.356ValAsp: 3.356 ± 0.114
3.719ValGlu: 3.719 ± 0.101
3.198ValPhe: 3.198 ± 0.102
3.79ValGly: 3.79 ± 0.091
0.992ValHis: 0.992 ± 0.049
4.408ValIle: 4.408 ± 0.116
4.323ValLys: 4.323 ± 0.101
6.488ValLeu: 6.488 ± 0.134
1.559ValMet: 1.559 ± 0.066
2.914ValAsn: 2.914 ± 0.09
2.389ValPro: 2.389 ± 0.068
1.783ValGln: 1.783 ± 0.069
3.165ValArg: 3.165 ± 0.089
4.761ValSer: 4.761 ± 0.105
3.13ValThr: 3.13 ± 0.097
4.373ValVal: 4.373 ± 0.11
0.762ValTrp: 0.762 ± 0.043
2.665ValTyr: 2.665 ± 0.086
0.0ValXaa: 0.0 ± 0.0
Trp
0.658TrpAla: 0.658 ± 0.04
0.135TrpCys: 0.135 ± 0.018
0.508TrpAsp: 0.508 ± 0.037
0.54TrpGlu: 0.54 ± 0.031
0.49TrpPhe: 0.49 ± 0.033
0.71TrpGly: 0.71 ± 0.041
0.282TrpHis: 0.282 ± 0.026
0.565TrpIle: 0.565 ± 0.032
0.594TrpLys: 0.594 ± 0.039
1.33TrpLeu: 1.33 ± 0.063
0.239TrpMet: 0.239 ± 0.024
0.56TrpAsn: 0.56 ± 0.038
0.266TrpPro: 0.266 ± 0.023
0.515TrpGln: 0.515 ± 0.034
0.558TrpArg: 0.558 ± 0.039
0.502TrpSer: 0.502 ± 0.032
0.425TrpThr: 0.425 ± 0.029
0.535TrpVal: 0.535 ± 0.034
0.114TrpTrp: 0.114 ± 0.014
0.396TrpTyr: 0.396 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.381TyrAla: 3.381 ± 0.095
0.502TyrCys: 0.502 ± 0.033
2.47TyrAsp: 2.47 ± 0.077
2.36TyrGlu: 2.36 ± 0.078
1.926TyrPhe: 1.926 ± 0.069
2.704TyrGly: 2.704 ± 0.101
0.621TyrHis: 0.621 ± 0.036
2.559TyrIle: 2.559 ± 0.069
2.501TyrLys: 2.501 ± 0.082
3.572TyrLeu: 3.572 ± 0.1
0.953TyrMet: 0.953 ± 0.043
2.125TyrAsn: 2.125 ± 0.077
1.428TyrPro: 1.428 ± 0.058
1.303TyrGln: 1.303 ± 0.055
2.21TyrArg: 2.21 ± 0.079
2.053TyrSer: 2.053 ± 0.07
1.843TyrThr: 1.843 ± 0.07
2.389TyrVal: 2.389 ± 0.087
0.446TyrTrp: 0.446 ± 0.035
1.779TyrTyr: 1.779 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1538 proteins (481817 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski