Amino acid dipepetide frequency for Muribaculaceae bacterium Isolate-104 (HZI)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.596AlaAla: 8.596 ± 0.168	0.938AlaCys: 0.938 ± 0.04	5.538AlaAsp: 5.538 ± 0.096	5.406AlaGlu: 5.406 ± 0.078	3.29AlaPhe: 3.29 ± 0.077	6.217AlaGly: 6.217 ± 0.098	1.317AlaHis: 1.317 ± 0.042	5.46AlaIle: 5.46 ± 0.101	4.485AlaLys: 4.485 ± 0.084	7.958AlaLeu: 7.958 ± 0.125	2.54AlaMet: 2.54 ± 0.051	3.199AlaAsn: 3.199 ± 0.06	3.259AlaPro: 3.259 ± 0.061	2.799AlaGln: 2.799 ± 0.062	4.093AlaArg: 4.093 ± 0.083	5.087AlaSer: 5.087 ± 0.078	4.751AlaThr: 4.751 ± 0.074	6.485AlaVal: 6.485 ± 0.112	0.876AlaTrp: 0.876 ± 0.028	2.727AlaTyr: 2.727 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.042	0.22CysCys: 0.22 ± 0.016	0.801CysAsp: 0.801 ± 0.031	0.68CysGlu: 0.68 ± 0.029	0.581CysPhe: 0.581 ± 0.028	1.256CysGly: 1.256 ± 0.041	0.285CysHis: 0.285 ± 0.019	0.774CysIle: 0.774 ± 0.03	0.536CysLys: 0.536 ± 0.027	1.025CysLeu: 1.025 ± 0.038	0.286CysMet: 0.286 ± 0.017	0.554CysAsn: 0.554 ± 0.025	0.574CysPro: 0.574 ± 0.026	0.28CysGln: 0.28 ± 0.022	0.823CysArg: 0.823 ± 0.035	0.867CysSer: 0.867 ± 0.034	0.638CysThr: 0.638 ± 0.029	0.936CysVal: 0.936 ± 0.037	0.132CysTrp: 0.132 ± 0.013	0.531CysTyr: 0.531 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.591AspAla: 4.591 ± 0.073	0.756AspCys: 0.756 ± 0.027	2.979AspAsp: 2.979 ± 0.069	3.989AspGlu: 3.989 ± 0.071	3.072AspPhe: 3.072 ± 0.062	4.253AspGly: 4.253 ± 0.099	0.815AspHis: 0.815 ± 0.032	4.726AspIle: 4.726 ± 0.081	3.527AspLys: 3.527 ± 0.07	4.19AspLeu: 4.19 ± 0.075	1.773AspMet: 1.773 ± 0.047	3.168AspAsn: 3.168 ± 0.058	2.139AspPro: 2.139 ± 0.053	0.981AspGln: 0.981 ± 0.035	3.097AspArg: 3.097 ± 0.066	4.357AspSer: 4.357 ± 0.09	3.351AspThr: 3.351 ± 0.062	3.608AspVal: 3.608 ± 0.066	0.775AspTrp: 0.775 ± 0.028	2.809AspTyr: 2.809 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	5.128GluAla: 5.128 ± 0.093	0.723GluCys: 0.723 ± 0.032	3.005GluAsp: 3.005 ± 0.066	4.0GluGlu: 4.0 ± 0.079	2.495GluPhe: 2.495 ± 0.06	3.582GluGly: 3.582 ± 0.068	1.099GluHis: 1.099 ± 0.038	4.794GluIle: 4.794 ± 0.082	4.297GluLys: 4.297 ± 0.086	5.795GluLeu: 5.795 ± 0.09	1.852GluMet: 1.852 ± 0.048	3.163GluAsn: 3.163 ± 0.058	2.135GluPro: 2.135 ± 0.054	2.137GluGln: 2.137 ± 0.057	3.499GluArg: 3.499 ± 0.065	3.554GluSer: 3.554 ± 0.076	3.045GluThr: 3.045 ± 0.056	3.933GluVal: 3.933 ± 0.082	0.823GluTrp: 0.823 ± 0.031	2.486GluTyr: 2.486 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.463PheAla: 3.463 ± 0.067	0.628PheCys: 0.628 ± 0.026	2.853PheAsp: 2.853 ± 0.07	2.43PheGlu: 2.43 ± 0.052	1.97PhePhe: 1.97 ± 0.062	3.369PheGly: 3.369 ± 0.075	0.786PheHis: 0.786 ± 0.028	2.966PheIle: 2.966 ± 0.069	2.188PheLys: 2.188 ± 0.055	3.308PheLeu: 3.308 ± 0.071	1.229PheMet: 1.229 ± 0.037	2.362PheAsn: 2.362 ± 0.061	1.646PhePro: 1.646 ± 0.042	0.896PheGln: 0.896 ± 0.036	2.183PheArg: 2.183 ± 0.049	3.269PheSer: 3.269 ± 0.06	2.559PheThr: 2.559 ± 0.054	2.791PheVal: 2.791 ± 0.059	0.47PheTrp: 0.47 ± 0.024	1.607PheTyr: 1.607 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	5.679GlyAla: 5.679 ± 0.087	1.092GlyCys: 1.092 ± 0.04	3.887GlyAsp: 3.887 ± 0.078	3.965GlyGlu: 3.965 ± 0.082	3.208GlyPhe: 3.208 ± 0.058	4.811GlyGly: 4.811 ± 0.098	1.27GlyHis: 1.27 ± 0.037	5.157GlyIle: 5.157 ± 0.09	4.705GlyLys: 4.705 ± 0.083	5.382GlyLeu: 5.382 ± 0.091	1.992GlyMet: 1.992 ± 0.051	3.54GlyAsn: 3.54 ± 0.076	1.319GlyPro: 1.319 ± 0.045	1.862GlyGln: 1.862 ± 0.057	3.345GlyArg: 3.345 ± 0.066	4.507GlySer: 4.507 ± 0.089	4.129GlyThr: 4.129 ± 0.076	5.184GlyVal: 5.184 ± 0.08	0.962GlyTrp: 0.962 ± 0.034	3.149GlyTyr: 3.149 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.2HisAla: 1.2 ± 0.037	0.303HisCys: 0.303 ± 0.02	1.01HisAsp: 1.01 ± 0.041	0.931HisGlu: 0.931 ± 0.033	0.874HisPhe: 0.874 ± 0.035	1.265HisGly: 1.265 ± 0.04	0.431HisHis: 0.431 ± 0.02	1.438HisIle: 1.438 ± 0.037	0.927HisLys: 0.927 ± 0.037	1.537HisLeu: 1.537 ± 0.046	0.36HisMet: 0.36 ± 0.019	0.955HisAsn: 0.955 ± 0.037	0.991HisPro: 0.991 ± 0.038	0.459HisGln: 0.459 ± 0.026	1.105HisArg: 1.105 ± 0.042	1.229HisSer: 1.229 ± 0.04	1.111HisThr: 1.111 ± 0.043	0.966HisVal: 0.966 ± 0.037	0.223HisTrp: 0.223 ± 0.018	0.808HisTyr: 0.808 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.731IleAla: 6.731 ± 0.105	0.891IleCys: 0.891 ± 0.034	4.798IleAsp: 4.798 ± 0.075	4.514IleGlu: 4.514 ± 0.075	2.747IlePhe: 2.747 ± 0.061	4.659IleGly: 4.659 ± 0.089	1.165IleHis: 1.165 ± 0.04	4.599IleIle: 4.599 ± 0.099	3.84IleLys: 3.84 ± 0.077	5.302IleLeu: 5.302 ± 0.1	1.61IleMet: 1.61 ± 0.038	3.188IleAsn: 3.188 ± 0.065	2.959IlePro: 2.959 ± 0.063	1.588IleGln: 1.588 ± 0.048	3.132IleArg: 3.132 ± 0.067	4.732IleSer: 4.732 ± 0.076	4.004IleThr: 4.004 ± 0.076	4.753IleVal: 4.753 ± 0.079	0.587IleTrp: 0.587 ± 0.03	2.424IleTyr: 2.424 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.996LysAla: 4.996 ± 0.09	0.571LysCys: 0.571 ± 0.028	3.106LysAsp: 3.106 ± 0.067	4.221LysGlu: 4.221 ± 0.078	2.074LysPhe: 2.074 ± 0.049	3.786LysGly: 3.786 ± 0.072	0.985LysHis: 0.985 ± 0.034	4.04LysIle: 4.04 ± 0.079	3.77LysLys: 3.77 ± 0.087	4.354LysLeu: 4.354 ± 0.072	1.739LysMet: 1.739 ± 0.048	2.792LysAsn: 2.792 ± 0.056	2.278LysPro: 2.278 ± 0.063	1.769LysGln: 1.769 ± 0.049	2.936LysArg: 2.936 ± 0.074	3.622LysSer: 3.622 ± 0.068	3.222LysThr: 3.222 ± 0.068	3.859LysVal: 3.859 ± 0.069	0.785LysTrp: 0.785 ± 0.031	2.27LysTyr: 2.27 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	7.221LeuAla: 7.221 ± 0.114	1.3LeuCys: 1.3 ± 0.038	5.148LeuAsp: 5.148 ± 0.082	4.832LeuGlu: 4.832 ± 0.08	3.74LeuPhe: 3.74 ± 0.07	5.624LeuGly: 5.624 ± 0.094	1.69LeuHis: 1.69 ± 0.048	5.206LeuIle: 5.206 ± 0.097	4.993LeuLys: 4.993 ± 0.076	7.642LeuLeu: 7.642 ± 0.141	2.238LeuMet: 2.238 ± 0.047	4.028LeuAsn: 4.028 ± 0.085	4.179LeuPro: 4.179 ± 0.072	2.515LeuGln: 2.515 ± 0.062	4.968LeuArg: 4.968 ± 0.079	6.706LeuSer: 6.706 ± 0.102	5.289LeuThr: 5.289 ± 0.088	5.11LeuVal: 5.11 ± 0.087	0.962LeuTrp: 0.962 ± 0.036	3.082LeuTyr: 3.082 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.335MetAla: 2.335 ± 0.051	0.337MetCys: 0.337 ± 0.021	1.264MetAsp: 1.264 ± 0.043	1.584MetGlu: 1.584 ± 0.043	1.067MetPhe: 1.067 ± 0.041	1.63MetGly: 1.63 ± 0.047	0.459MetHis: 0.459 ± 0.02	1.57MetIle: 1.57 ± 0.04	2.069MetLys: 2.069 ± 0.045	2.496MetLeu: 2.496 ± 0.057	0.821MetMet: 0.821 ± 0.036	1.404MetAsn: 1.404 ± 0.038	1.375MetPro: 1.375 ± 0.04	0.822MetGln: 0.822 ± 0.036	1.568MetArg: 1.568 ± 0.044	1.925MetSer: 1.925 ± 0.051	1.794MetThr: 1.794 ± 0.047	1.571MetVal: 1.571 ± 0.044	0.277MetTrp: 0.277 ± 0.018	0.755MetTyr: 0.755 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.708AsnAla: 3.708 ± 0.076	0.496AsnCys: 0.496 ± 0.027	2.522AsnAsp: 2.522 ± 0.058	2.563AsnGlu: 2.563 ± 0.054	1.964AsnPhe: 1.964 ± 0.052	3.777AsnGly: 3.777 ± 0.075	0.932AsnHis: 0.932 ± 0.035	3.812AsnIle: 3.812 ± 0.081	2.402AsnLys: 2.402 ± 0.052	4.009AsnLeu: 4.009 ± 0.081	1.185AsnMet: 1.185 ± 0.037	2.409AsnAsn: 2.409 ± 0.066	2.825AsnPro: 2.825 ± 0.058	1.198AsnGln: 1.198 ± 0.047	2.683AsnArg: 2.683 ± 0.06	2.978AsnSer: 2.978 ± 0.075	2.572AsnThr: 2.572 ± 0.059	3.07AsnVal: 3.07 ± 0.063	0.574AsnTrp: 0.574 ± 0.028	1.873AsnTyr: 1.873 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	3.841ProAla: 3.841 ± 0.074	0.404ProCys: 0.404 ± 0.024	3.238ProAsp: 3.238 ± 0.059	3.59ProGlu: 3.59 ± 0.08	1.648ProPhe: 1.648 ± 0.043	3.016ProGly: 3.016 ± 0.061	0.779ProHis: 0.779 ± 0.031	2.06ProIle: 2.06 ± 0.05	1.935ProLys: 1.935 ± 0.063	3.424ProLeu: 3.424 ± 0.065	1.014ProMet: 1.014 ± 0.038	1.438ProAsn: 1.438 ± 0.047	1.058ProPro: 1.058 ± 0.038	1.465ProGln: 1.465 ± 0.04	1.793ProArg: 1.793 ± 0.054	2.503ProSer: 2.503 ± 0.055	2.074ProThr: 2.074 ± 0.055	3.6ProVal: 3.6 ± 0.073	0.488ProTrp: 0.488 ± 0.027	1.574ProTyr: 1.574 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.193GlnAla: 2.193 ± 0.058	0.287GlnCys: 0.287 ± 0.021	1.22GlnAsp: 1.22 ± 0.037	1.626GlnGlu: 1.626 ± 0.05	1.186GlnPhe: 1.186 ± 0.034	1.648GlnGly: 1.648 ± 0.05	0.476GlnHis: 0.476 ± 0.025	1.935GlnIle: 1.935 ± 0.047	1.796GlnLys: 1.796 ± 0.046	2.837GlnLeu: 2.837 ± 0.061	0.88GlnMet: 0.88 ± 0.032	1.424GlnAsn: 1.424 ± 0.041	1.279GlnPro: 1.279 ± 0.042	1.29GlnGln: 1.29 ± 0.053	1.686GlnArg: 1.686 ± 0.043	1.953GlnSer: 1.953 ± 0.056	1.728GlnThr: 1.728 ± 0.051	1.62GlnVal: 1.62 ± 0.048	0.415GlnTrp: 0.415 ± 0.023	1.204GlnTyr: 1.204 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.647ArgAla: 3.647 ± 0.078	0.626ArgCys: 0.626 ± 0.029	2.679ArgAsp: 2.679 ± 0.064	3.163ArgGlu: 3.163 ± 0.058	2.579ArgPhe: 2.579 ± 0.05	2.84ArgGly: 2.84 ± 0.067	1.333ArgHis: 1.333 ± 0.038	4.003ArgIle: 4.003 ± 0.068	3.383ArgLys: 3.383 ± 0.075	5.308ArgLeu: 5.308 ± 0.085	1.596ArgMet: 1.596 ± 0.046	2.819ArgAsn: 2.819 ± 0.067	1.94ArgPro: 1.94 ± 0.049	2.157ArgGln: 2.157 ± 0.057	3.447ArgArg: 3.447 ± 0.075	2.883ArgSer: 2.883 ± 0.066	2.642ArgThr: 2.642 ± 0.062	2.953ArgVal: 2.953 ± 0.061	0.658ArgTrp: 0.658 ± 0.03	2.447ArgTyr: 2.447 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.68SerAla: 5.68 ± 0.087	0.836SerCys: 0.836 ± 0.032	4.145SerAsp: 4.145 ± 0.075	3.886SerGlu: 3.886 ± 0.074	2.903SerPhe: 2.903 ± 0.065	5.221SerGly: 5.221 ± 0.096	1.246SerHis: 1.246 ± 0.042	4.212SerIle: 4.212 ± 0.081	3.202SerLys: 3.202 ± 0.07	6.307SerLeu: 6.307 ± 0.096	1.622SerMet: 1.622 ± 0.048	2.683SerAsn: 2.683 ± 0.064	2.791SerPro: 2.791 ± 0.053	1.9SerGln: 1.9 ± 0.044	3.665SerArg: 3.665 ± 0.079	4.244SerSer: 4.244 ± 0.085	3.556SerThr: 3.556 ± 0.068	5.016SerVal: 5.016 ± 0.081	0.712SerTrp: 0.712 ± 0.03	2.635SerTyr: 2.635 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	5.136ThrAla: 5.136 ± 0.1	0.613ThrCys: 0.613 ± 0.03	3.775ThrAsp: 3.775 ± 0.07	3.302ThrGlu: 3.302 ± 0.066	2.427ThrPhe: 2.427 ± 0.057	4.561ThrGly: 4.561 ± 0.08	0.988ThrHis: 0.988 ± 0.036	3.709ThrIle: 3.709 ± 0.069	2.434ThrLys: 2.434 ± 0.055	5.466ThrLeu: 5.466 ± 0.092	1.19ThrMet: 1.19 ± 0.037	2.165ThrAsn: 2.165 ± 0.05	3.351ThrPro: 3.351 ± 0.061	1.462ThrGln: 1.462 ± 0.04	2.572ThrArg: 2.572 ± 0.064	3.43ThrSer: 3.43 ± 0.07	3.201ThrThr: 3.201 ± 0.06	4.644ThrVal: 4.644 ± 0.075	0.531ThrTrp: 0.531 ± 0.027	2.067ThrTyr: 2.067 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	6.102ValAla: 6.102 ± 0.092	1.075ValCys: 1.075 ± 0.036	4.006ValAsp: 4.006 ± 0.084	4.197ValGlu: 4.197 ± 0.08	2.795ValPhe: 2.795 ± 0.061	4.139ValGly: 4.139 ± 0.083	1.045ValHis: 1.045 ± 0.038	4.366ValIle: 4.366 ± 0.086	4.141ValLys: 4.141 ± 0.067	5.355ValLeu: 5.355 ± 0.089	1.852ValMet: 1.852 ± 0.058	3.351ValAsn: 3.351 ± 0.081	2.97ValPro: 2.97 ± 0.067	1.61ValGln: 1.61 ± 0.046	3.547ValArg: 3.547 ± 0.063	5.017ValSer: 5.017 ± 0.083	4.273ValThr: 4.273 ± 0.087	4.75ValVal: 4.75 ± 0.081	0.741ValTrp: 0.741 ± 0.032	2.477ValTyr: 2.477 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.792TrpAla: 0.792 ± 0.032	0.165TrpCys: 0.165 ± 0.013	0.576TrpAsp: 0.576 ± 0.029	0.636TrpGlu: 0.636 ± 0.031	0.517TrpPhe: 0.517 ± 0.027	0.807TrpGly: 0.807 ± 0.038	0.28TrpHis: 0.28 ± 0.017	0.787TrpIle: 0.787 ± 0.03	0.691TrpLys: 0.691 ± 0.029	1.258TrpLeu: 1.258 ± 0.04	0.342TrpMet: 0.342 ± 0.02	0.664TrpAsn: 0.664 ± 0.03	0.191TrpPro: 0.191 ± 0.016	0.487TrpGln: 0.487 ± 0.024	0.719TrpArg: 0.719 ± 0.032	0.783TrpSer: 0.783 ± 0.034	0.648TrpThr: 0.648 ± 0.032	0.693TrpVal: 0.693 ± 0.03	0.211TrpTrp: 0.211 ± 0.018	0.436TrpTyr: 0.436 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.92TyrAla: 2.92 ± 0.064	0.58TyrCys: 0.58 ± 0.028	2.405TyrAsp: 2.405 ± 0.058	2.03TyrGlu: 2.03 ± 0.053	1.834TyrPhe: 1.834 ± 0.046	2.686TyrGly: 2.686 ± 0.058	0.741TyrHis: 0.741 ± 0.029	2.607TyrIle: 2.607 ± 0.057	1.854TyrLys: 1.854 ± 0.041	3.521TyrLeu: 3.521 ± 0.069	1.002TyrMet: 1.002 ± 0.033	2.244TyrAsn: 2.244 ± 0.071	1.686TyrPro: 1.686 ± 0.052	1.006TyrGln: 1.006 ± 0.037	2.243TyrArg: 2.243 ± 0.057	2.817TyrSer: 2.817 ± 0.066	2.437TyrThr: 2.437 ± 0.065	2.268TyrVal: 2.268 ± 0.053	0.481TyrTrp: 0.481 ± 0.025	1.78TyrTyr: 1.78 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2513 proteins (848909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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