Amino acid dipepetide frequency for Bradyrhizobium sp. (strain ORS 278)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.839AlaAla: 18.839 ± 0.164	1.139AlaCys: 1.139 ± 0.024	7.025AlaAsp: 7.025 ± 0.064	7.293AlaGlu: 7.293 ± 0.077	4.324AlaPhe: 4.324 ± 0.053	10.407AlaGly: 10.407 ± 0.082	2.281AlaHis: 2.281 ± 0.037	6.655AlaIle: 6.655 ± 0.055	4.642AlaLys: 4.642 ± 0.051	13.27AlaLeu: 13.27 ± 0.111	3.542AlaMet: 3.542 ± 0.047	3.123AlaAsn: 3.123 ± 0.049	6.068AlaPro: 6.068 ± 0.071	4.296AlaGln: 4.296 ± 0.055	8.964AlaArg: 8.964 ± 0.089	6.994AlaSer: 6.994 ± 0.073	6.635AlaThr: 6.635 ± 0.072	9.049AlaVal: 9.049 ± 0.074	1.518AlaTrp: 1.518 ± 0.026	2.517AlaTyr: 2.517 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.023	0.108CysCys: 0.108 ± 0.007	0.525CysAsp: 0.525 ± 0.018	0.434CysGlu: 0.434 ± 0.016	0.32CysPhe: 0.32 ± 0.013	0.953CysGly: 0.953 ± 0.027	0.245CysHis: 0.245 ± 0.011	0.396CysIle: 0.396 ± 0.013	0.217CysLys: 0.217 ± 0.009	0.771CysLeu: 0.771 ± 0.021	0.163CysMet: 0.163 ± 0.009	0.232CysAsn: 0.232 ± 0.011	0.441CysPro: 0.441 ± 0.015	0.222CysGln: 0.222 ± 0.009	0.673CysArg: 0.673 ± 0.021	0.482CysSer: 0.482 ± 0.015	0.419CysThr: 0.419 ± 0.015	0.619CysVal: 0.619 ± 0.018	0.123CysTrp: 0.123 ± 0.008	0.209CysTyr: 0.209 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.902AspAla: 6.902 ± 0.067	0.48AspCys: 0.48 ± 0.015	3.201AspAsp: 3.201 ± 0.041	3.175AspGlu: 3.175 ± 0.042	2.061AspPhe: 2.061 ± 0.032	5.132AspGly: 5.132 ± 0.07	1.354AspHis: 1.354 ± 0.028	3.065AspIle: 3.065 ± 0.038	1.875AspLys: 1.875 ± 0.037	5.556AspLeu: 5.556 ± 0.049	1.208AspMet: 1.208 ± 0.026	1.355AspAsn: 1.355 ± 0.026	3.43AspPro: 3.43 ± 0.046	1.785AspGln: 1.785 ± 0.03	4.168AspArg: 4.168 ± 0.044	2.269AspSer: 2.269 ± 0.039	2.431AspThr: 2.431 ± 0.037	4.383AspVal: 4.383 ± 0.048	0.896AspTrp: 0.896 ± 0.023	1.461AspTyr: 1.461 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.883GluAla: 6.883 ± 0.072	0.326GluCys: 0.326 ± 0.012	2.34GluAsp: 2.34 ± 0.04	2.463GluGlu: 2.463 ± 0.046	1.69GluPhe: 1.69 ± 0.029	3.469GluGly: 3.469 ± 0.046	1.126GluHis: 1.126 ± 0.024	3.414GluIle: 3.414 ± 0.048	1.956GluLys: 1.956 ± 0.032	5.421GluLeu: 5.421 ± 0.053	1.381GluMet: 1.381 ± 0.026	1.253GluAsn: 1.253 ± 0.021	2.603GluPro: 2.603 ± 0.037	2.225GluGln: 2.225 ± 0.033	4.714GluArg: 4.714 ± 0.056	2.281GluSer: 2.281 ± 0.032	3.209GluThr: 3.209 ± 0.048	3.629GluVal: 3.629 ± 0.049	0.613GluTrp: 0.613 ± 0.018	0.831GluTyr: 0.831 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	4.834PheAla: 4.834 ± 0.052	0.406PheCys: 0.406 ± 0.016	2.514PheAsp: 2.514 ± 0.038	1.937PheGlu: 1.937 ± 0.031	1.35PhePhe: 1.35 ± 0.028	3.649PheGly: 3.649 ± 0.047	0.704PheHis: 0.704 ± 0.019	1.643PheIle: 1.643 ± 0.034	1.147PheLys: 1.147 ± 0.024	3.092PheLeu: 3.092 ± 0.043	0.771PheMet: 0.771 ± 0.019	1.151PheAsn: 1.151 ± 0.027	1.577PhePro: 1.577 ± 0.03	0.978PheGln: 0.978 ± 0.024	2.131PheArg: 2.131 ± 0.034	2.091PheSer: 2.091 ± 0.03	1.985PheThr: 1.985 ± 0.031	2.877PheVal: 2.877 ± 0.039	0.512PheTrp: 0.512 ± 0.016	0.844PheTyr: 0.844 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.32GlyAla: 9.32 ± 0.088	0.877GlyCys: 0.877 ± 0.021	4.225GlyAsp: 4.225 ± 0.049	4.233GlyGlu: 4.233 ± 0.048	3.554GlyPhe: 3.554 ± 0.05	7.213GlyGly: 7.213 ± 0.093	1.885GlyHis: 1.885 ± 0.035	4.407GlyIle: 4.407 ± 0.054	3.141GlyLys: 3.141 ± 0.048	8.716GlyLeu: 8.716 ± 0.081	2.118GlyMet: 2.118 ± 0.036	2.214GlyAsn: 2.214 ± 0.052	3.564GlyPro: 3.564 ± 0.042	2.843GlyGln: 2.843 ± 0.042	6.106GlyArg: 6.106 ± 0.061	4.773GlySer: 4.773 ± 0.09	4.647GlyThr: 4.647 ± 0.081	6.012GlyVal: 6.012 ± 0.063	1.29GlyTrp: 1.29 ± 0.026	2.259GlyTyr: 2.259 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.438HisAla: 2.438 ± 0.033	0.225HisCys: 0.225 ± 0.011	1.306HisAsp: 1.306 ± 0.03	0.993HisGlu: 0.993 ± 0.02	0.784HisPhe: 0.784 ± 0.018	2.009HisGly: 2.009 ± 0.036	0.653HisHis: 0.653 ± 0.023	0.905HisIle: 0.905 ± 0.019	0.49HisLys: 0.49 ± 0.015	1.986HisLeu: 1.986 ± 0.036	0.448HisMet: 0.448 ± 0.014	0.452HisAsn: 0.452 ± 0.015	1.338HisPro: 1.338 ± 0.027	0.632HisGln: 0.632 ± 0.017	1.486HisArg: 1.486 ± 0.026	0.913HisSer: 0.913 ± 0.024	0.783HisThr: 0.783 ± 0.02	1.569HisVal: 1.569 ± 0.029	0.332HisTrp: 0.332 ± 0.013	0.528HisTyr: 0.528 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	7.755IleAla: 7.755 ± 0.074	0.508IleCys: 0.508 ± 0.016	3.682IleAsp: 3.682 ± 0.043	3.365IleGlu: 3.365 ± 0.039	1.611IlePhe: 1.611 ± 0.029	5.158IleGly: 5.158 ± 0.064	0.883IleHis: 0.883 ± 0.02	2.31IleIle: 2.31 ± 0.037	1.766IleLys: 1.766 ± 0.032	4.123IleLeu: 4.123 ± 0.048	0.996IleMet: 0.996 ± 0.022	1.505IleAsn: 1.505 ± 0.025	2.295IlePro: 2.295 ± 0.036	1.224IleGln: 1.224 ± 0.023	3.223IleArg: 3.223 ± 0.043	3.07IleSer: 3.07 ± 0.041	2.82IleThr: 2.82 ± 0.037	4.426IleVal: 4.426 ± 0.051	0.593IleTrp: 0.593 ± 0.017	1.161IleTyr: 1.161 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.453LysAla: 4.453 ± 0.058	0.164LysCys: 0.164 ± 0.01	1.821LysAsp: 1.821 ± 0.035	1.513LysGlu: 1.513 ± 0.029	0.997LysPhe: 0.997 ± 0.023	2.583LysGly: 2.583 ± 0.041	0.614LysHis: 0.614 ± 0.02	1.835LysIle: 1.835 ± 0.029	1.303LysLys: 1.303 ± 0.034	3.636LysLeu: 3.636 ± 0.049	0.83LysMet: 0.83 ± 0.018	0.805LysAsn: 0.805 ± 0.019	2.42LysPro: 2.42 ± 0.041	1.199LysGln: 1.199 ± 0.023	2.332LysArg: 2.332 ± 0.035	1.988LysSer: 1.988 ± 0.033	2.112LysThr: 2.112 ± 0.032	2.545LysVal: 2.545 ± 0.037	0.373LysTrp: 0.373 ± 0.014	0.677LysTyr: 0.677 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.786LeuAla: 13.786 ± 0.105	0.877LeuCys: 0.877 ± 0.021	5.85LeuAsp: 5.85 ± 0.066	4.458LeuGlu: 4.458 ± 0.047	3.486LeuPhe: 3.486 ± 0.046	8.111LeuGly: 8.111 ± 0.079	1.854LeuHis: 1.854 ± 0.03	5.168LeuIle: 5.168 ± 0.057	3.658LeuLys: 3.658 ± 0.045	9.608LeuLeu: 9.608 ± 0.109	2.296LeuMet: 2.296 ± 0.039	2.522LeuAsn: 2.522 ± 0.035	5.532LeuPro: 5.532 ± 0.056	3.052LeuGln: 3.052 ± 0.042	6.904LeuArg: 6.904 ± 0.071	6.527LeuSer: 6.527 ± 0.056	5.742LeuThr: 5.742 ± 0.056	7.437LeuVal: 7.437 ± 0.073	1.165LeuTrp: 1.165 ± 0.026	1.941LeuTyr: 1.941 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.934MetAla: 2.934 ± 0.04	0.172MetCys: 0.172 ± 0.008	1.02MetAsp: 1.02 ± 0.019	0.914MetGlu: 0.914 ± 0.021	0.757MetPhe: 0.757 ± 0.018	1.581MetGly: 1.581 ± 0.033	0.451MetHis: 0.451 ± 0.013	1.428MetIle: 1.428 ± 0.032	0.915MetLys: 0.915 ± 0.022	2.588MetLeu: 2.588 ± 0.038	0.714MetMet: 0.714 ± 0.019	0.666MetAsn: 0.666 ± 0.017	1.498MetPro: 1.498 ± 0.028	0.857MetGln: 0.857 ± 0.02	1.826MetArg: 1.826 ± 0.029	1.783MetSer: 1.783 ± 0.027	1.918MetThr: 1.918 ± 0.033	1.644MetVal: 1.644 ± 0.034	0.21MetTrp: 0.21 ± 0.009	0.341MetTyr: 0.341 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.299AsnAla: 3.299 ± 0.056	0.234AsnCys: 0.234 ± 0.013	1.443AsnAsp: 1.443 ± 0.031	1.232AsnGlu: 1.232 ± 0.023	0.953AsnPhe: 0.953 ± 0.021	2.447AsnGly: 2.447 ± 0.058	0.482AsnHis: 0.482 ± 0.014	1.37AsnIle: 1.37 ± 0.026	0.8AsnLys: 0.8 ± 0.02	2.537AsnLeu: 2.537 ± 0.033	0.59AsnMet: 0.59 ± 0.016	0.773AsnAsn: 0.773 ± 0.027	1.77AsnPro: 1.77 ± 0.032	0.806AsnGln: 0.806 ± 0.018	1.666AsnArg: 1.666 ± 0.029	1.301AsnSer: 1.301 ± 0.034	1.298AsnThr: 1.298 ± 0.031	2.096AsnVal: 2.096 ± 0.033	0.426AsnTrp: 0.426 ± 0.016	0.712AsnTyr: 0.712 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.82ProAla: 6.82 ± 0.069	0.353ProCys: 0.353 ± 0.015	3.567ProAsp: 3.567 ± 0.044	3.321ProGlu: 3.321 ± 0.037	1.978ProPhe: 1.978 ± 0.032	4.336ProGly: 4.336 ± 0.047	1.084ProHis: 1.084 ± 0.024	2.385ProIle: 2.385 ± 0.034	1.886ProLys: 1.886 ± 0.034	4.804ProLeu: 4.804 ± 0.054	1.235ProMet: 1.235 ± 0.026	1.456ProAsn: 1.456 ± 0.029	3.022ProPro: 3.022 ± 0.065	1.861ProGln: 1.861 ± 0.033	3.298ProArg: 3.298 ± 0.041	3.087ProSer: 3.087 ± 0.038	2.64ProThr: 2.64 ± 0.034	4.149ProVal: 4.149 ± 0.046	0.75ProTrp: 0.75 ± 0.02	1.192ProTyr: 1.192 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.345GlnAla: 4.345 ± 0.052	0.228GlnCys: 0.228 ± 0.013	1.497GlnAsp: 1.497 ± 0.027	1.306GlnGlu: 1.306 ± 0.027	1.123GlnPhe: 1.123 ± 0.025	2.373GlnGly: 2.373 ± 0.037	0.652GlnHis: 0.652 ± 0.018	1.833GlnIle: 1.833 ± 0.027	1.053GlnLys: 1.053 ± 0.024	3.392GlnLeu: 3.392 ± 0.046	0.881GlnMet: 0.881 ± 0.022	0.833GlnAsn: 0.833 ± 0.019	1.981GlnPro: 1.981 ± 0.034	1.479GlnGln: 1.479 ± 0.034	2.715GlnArg: 2.715 ± 0.041	1.898GlnSer: 1.898 ± 0.036	1.865GlnThr: 1.865 ± 0.035	2.339GlnVal: 2.339 ± 0.039	0.448GlnTrp: 0.448 ± 0.014	0.611GlnTyr: 0.611 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.219ArgAla: 8.219 ± 0.075	0.575ArgCys: 0.575 ± 0.018	4.2ArgAsp: 4.2 ± 0.044	4.06ArgGlu: 4.06 ± 0.052	2.789ArgPhe: 2.789 ± 0.042	4.936ArgGly: 4.936 ± 0.046	1.667ArgHis: 1.667 ± 0.034	3.983ArgIle: 3.983 ± 0.05	2.382ArgLys: 2.382 ± 0.041	7.797ArgLeu: 7.797 ± 0.084	1.861ArgMet: 1.861 ± 0.023	1.902ArgAsn: 1.902 ± 0.03	3.707ArgPro: 3.707 ± 0.046	2.501ArgGln: 2.501 ± 0.039	5.67ArgArg: 5.67 ± 0.069	3.923ArgSer: 3.923 ± 0.043	3.333ArgThr: 3.333 ± 0.046	4.665ArgVal: 4.665 ± 0.049	1.035ArgTrp: 1.035 ± 0.023	1.679ArgTyr: 1.679 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.76SerAla: 6.76 ± 0.076	0.478SerCys: 0.478 ± 0.017	3.128SerAsp: 3.128 ± 0.039	2.866SerGlu: 2.866 ± 0.042	2.36SerPhe: 2.36 ± 0.032	5.687SerGly: 5.687 ± 0.081	1.117SerHis: 1.117 ± 0.026	2.795SerIle: 2.795 ± 0.041	1.693SerLys: 1.693 ± 0.032	5.507SerLeu: 5.507 ± 0.058	1.343SerMet: 1.343 ± 0.027	1.518SerAsn: 1.518 ± 0.039	2.966SerPro: 2.966 ± 0.044	1.711SerGln: 1.711 ± 0.029	3.862SerArg: 3.862 ± 0.048	3.473SerSer: 3.473 ± 0.062	2.92SerThr: 2.92 ± 0.054	4.045SerVal: 4.045 ± 0.051	0.835SerTrp: 0.835 ± 0.022	1.447SerTyr: 1.447 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	6.711ThrAla: 6.711 ± 0.065	0.425ThrCys: 0.425 ± 0.015	2.762ThrAsp: 2.762 ± 0.038	2.59ThrGlu: 2.59 ± 0.044	2.052ThrPhe: 2.052 ± 0.033	4.89ThrGly: 4.89 ± 0.061	0.996ThrHis: 0.996 ± 0.025	3.159ThrIle: 3.159 ± 0.052	1.646ThrLys: 1.646 ± 0.026	5.747ThrLeu: 5.747 ± 0.07	1.265ThrMet: 1.265 ± 0.023	1.385ThrAsn: 1.385 ± 0.031	3.317ThrPro: 3.317 ± 0.038	1.592ThrGln: 1.592 ± 0.034	3.404ThrArg: 3.404 ± 0.038	3.274ThrSer: 3.274 ± 0.06	3.282ThrThr: 3.282 ± 0.092	4.325ThrVal: 4.325 ± 0.078	0.652ThrTrp: 0.652 ± 0.015	1.197ThrTyr: 1.197 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.593ValAla: 9.593 ± 0.073	0.638ValCys: 0.638 ± 0.017	4.09ValAsp: 4.09 ± 0.046	4.068ValGlu: 4.068 ± 0.046	2.57ValPhe: 2.57 ± 0.037	5.523ValGly: 5.523 ± 0.055	1.401ValHis: 1.401 ± 0.029	4.121ValIle: 4.121 ± 0.046	2.506ValLys: 2.506 ± 0.041	7.548ValLeu: 7.548 ± 0.068	1.818ValMet: 1.818 ± 0.032	2.058ValAsn: 2.058 ± 0.033	3.889ValPro: 3.889 ± 0.04	2.221ValGln: 2.221 ± 0.034	4.827ValArg: 4.827 ± 0.048	4.386ValSer: 4.386 ± 0.054	4.691ValThr: 4.691 ± 0.067	6.163ValVal: 6.163 ± 0.054	0.9ValTrp: 0.9 ± 0.021	1.455ValTyr: 1.455 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.154TrpAla: 1.154 ± 0.022	0.137TrpCys: 0.137 ± 0.009	0.617TrpAsp: 0.617 ± 0.019	0.486TrpGlu: 0.486 ± 0.017	0.511TrpPhe: 0.511 ± 0.019	0.907TrpGly: 0.907 ± 0.024	0.354TrpHis: 0.354 ± 0.013	0.714TrpIle: 0.714 ± 0.02	0.462TrpLys: 0.462 ± 0.018	1.634TrpLeu: 1.634 ± 0.03	0.349TrpMet: 0.349 ± 0.012	0.446TrpAsn: 0.446 ± 0.016	0.734TrpPro: 0.734 ± 0.021	0.574TrpGln: 0.574 ± 0.017	1.201TrpArg: 1.201 ± 0.026	0.863TrpSer: 0.863 ± 0.02	0.84TrpThr: 0.84 ± 0.023	0.755TrpVal: 0.755 ± 0.019	0.23TrpTrp: 0.23 ± 0.009	0.292TrpTyr: 0.292 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.495TyrAla: 2.495 ± 0.038	0.242TyrCys: 0.242 ± 0.01	1.375TyrAsp: 1.375 ± 0.025	1.121TyrGlu: 1.121 ± 0.027	0.92TyrPhe: 0.92 ± 0.022	2.031TyrGly: 2.031 ± 0.031	0.468TyrHis: 0.468 ± 0.013	0.888TyrIle: 0.888 ± 0.02	0.664TyrLys: 0.664 ± 0.019	2.238TyrLeu: 2.238 ± 0.031	0.409TyrMet: 0.409 ± 0.014	0.586TyrAsn: 0.586 ± 0.017	1.074TyrPro: 1.074 ± 0.024	0.796TyrGln: 0.796 ± 0.019	1.712TyrArg: 1.712 ± 0.028	1.138TyrSer: 1.138 ± 0.024	1.103TyrThr: 1.103 ± 0.023	1.737TyrVal: 1.737 ± 0.028	0.36TyrTrp: 0.36 ± 0.012	0.619TyrTyr: 0.619 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6701 proteins (2117499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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