Amino acid dipepetide frequency for Salipiger thiooxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.28AlaAla: 17.28 ± 0.145	1.209AlaCys: 1.209 ± 0.026	6.531AlaAsp: 6.531 ± 0.065	8.897AlaGlu: 8.897 ± 0.085	4.386AlaPhe: 4.386 ± 0.048	10.986AlaGly: 10.986 ± 0.094	2.288AlaHis: 2.288 ± 0.04	5.555AlaIle: 5.555 ± 0.06	3.101AlaLys: 3.101 ± 0.055	14.939AlaLeu: 14.939 ± 0.145	3.948AlaMet: 3.948 ± 0.047	2.403AlaAsn: 2.403 ± 0.044	6.45AlaPro: 6.45 ± 0.067	4.345AlaGln: 4.345 ± 0.055	9.656AlaArg: 9.656 ± 0.077	5.822AlaSer: 5.822 ± 0.06	6.018AlaThr: 6.018 ± 0.066	8.594AlaVal: 8.594 ± 0.077	1.568AlaTrp: 1.568 ± 0.032	2.443AlaTyr: 2.443 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.183CysAla: 1.183 ± 0.029	0.125CysCys: 0.125 ± 0.008	0.633CysAsp: 0.633 ± 0.018	0.514CysGlu: 0.514 ± 0.019	0.336CysPhe: 0.336 ± 0.014	1.013CysGly: 1.013 ± 0.027	0.279CysHis: 0.279 ± 0.012	0.412CysIle: 0.412 ± 0.014	0.199CysLys: 0.199 ± 0.011	0.902CysLeu: 0.902 ± 0.025	0.197CysMet: 0.197 ± 0.01	0.212CysAsn: 0.212 ± 0.012	0.53CysPro: 0.53 ± 0.019	0.227CysGln: 0.227 ± 0.011	0.63CysArg: 0.63 ± 0.018	0.49CysSer: 0.49 ± 0.017	0.472CysThr: 0.472 ± 0.018	0.648CysVal: 0.648 ± 0.02	0.123CysTrp: 0.123 ± 0.008	0.206CysTyr: 0.206 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.327AspAla: 7.327 ± 0.068	0.564AspCys: 0.564 ± 0.018	3.168AspAsp: 3.168 ± 0.057	3.696AspGlu: 3.696 ± 0.051	2.155AspPhe: 2.155 ± 0.039	5.662AspGly: 5.662 ± 0.065	1.308AspHis: 1.308 ± 0.033	2.775AspIle: 2.775 ± 0.042	1.423AspLys: 1.423 ± 0.032	6.05AspLeu: 6.05 ± 0.06	1.608AspMet: 1.608 ± 0.032	1.113AspAsn: 1.113 ± 0.025	3.789AspPro: 3.789 ± 0.051	1.492AspGln: 1.492 ± 0.032	4.374AspArg: 4.374 ± 0.057	2.251AspSer: 2.251 ± 0.039	2.918AspThr: 2.918 ± 0.048	3.953AspVal: 3.953 ± 0.057	1.199AspTrp: 1.199 ± 0.026	1.542AspTyr: 1.542 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.777GluAla: 8.777 ± 0.092	0.369GluCys: 0.369 ± 0.016	3.455GluAsp: 3.455 ± 0.046	3.667GluGlu: 3.667 ± 0.061	1.732GluPhe: 1.732 ± 0.037	5.231GluGly: 5.231 ± 0.056	1.207GluHis: 1.207 ± 0.027	3.721GluIle: 3.721 ± 0.057	1.983GluLys: 1.983 ± 0.041	5.606GluLeu: 5.606 ± 0.062	1.907GluMet: 1.907 ± 0.031	1.578GluAsn: 1.578 ± 0.03	2.87GluPro: 2.87 ± 0.042	1.932GluGln: 1.932 ± 0.038	4.621GluArg: 4.621 ± 0.056	2.351GluSer: 2.351 ± 0.038	4.132GluThr: 4.132 ± 0.057	4.423GluVal: 4.423 ± 0.051	0.683GluTrp: 0.683 ± 0.021	1.022GluTyr: 1.022 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.464PheAla: 4.464 ± 0.057	0.406PheCys: 0.406 ± 0.014	2.66PheAsp: 2.66 ± 0.039	2.293PheGlu: 2.293 ± 0.035	1.379PhePhe: 1.379 ± 0.032	3.719PheGly: 3.719 ± 0.06	0.716PheHis: 0.716 ± 0.021	1.563PheIle: 1.563 ± 0.034	0.729PheLys: 0.729 ± 0.02	3.426PheLeu: 3.426 ± 0.053	0.831PheMet: 0.831 ± 0.022	0.949PheAsn: 0.949 ± 0.03	1.598PhePro: 1.598 ± 0.029	0.93PheGln: 0.93 ± 0.024	2.377PheArg: 2.377 ± 0.037	2.052PheSer: 2.052 ± 0.035	2.027PheThr: 2.027 ± 0.035	2.686PheVal: 2.686 ± 0.045	0.587PheTrp: 0.587 ± 0.021	0.886PheTyr: 0.886 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.595GlyAla: 10.595 ± 0.09	0.945GlyCys: 0.945 ± 0.026	4.796GlyAsp: 4.796 ± 0.068	4.92GlyGlu: 4.92 ± 0.052	3.723GlyPhe: 3.723 ± 0.053	7.633GlyGly: 7.633 ± 0.089	2.068GlyHis: 2.068 ± 0.034	4.7GlyIle: 4.7 ± 0.053	2.783GlyLys: 2.783 ± 0.047	9.667GlyLeu: 9.667 ± 0.101	2.63GlyMet: 2.63 ± 0.039	2.042GlyAsn: 2.042 ± 0.046	3.944GlyPro: 3.944 ± 0.054	2.965GlyGln: 2.965 ± 0.038	6.221GlyArg: 6.221 ± 0.067	4.465GlySer: 4.465 ± 0.055	4.922GlyThr: 4.922 ± 0.056	6.541GlyVal: 6.541 ± 0.055	1.57GlyTrp: 1.57 ± 0.036	2.335GlyTyr: 2.335 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.385HisAla: 2.385 ± 0.046	0.239HisCys: 0.239 ± 0.012	1.336HisAsp: 1.336 ± 0.032	1.146HisGlu: 1.146 ± 0.027	0.812HisPhe: 0.812 ± 0.02	2.09HisGly: 2.09 ± 0.039	0.542HisHis: 0.542 ± 0.018	0.862HisIle: 0.862 ± 0.023	0.443HisLys: 0.443 ± 0.016	2.101HisLeu: 2.101 ± 0.037	0.568HisMet: 0.568 ± 0.02	0.419HisAsn: 0.419 ± 0.018	1.38HisPro: 1.38 ± 0.032	0.509HisGln: 0.509 ± 0.016	1.45HisArg: 1.45 ± 0.031	0.891HisSer: 0.891 ± 0.028	0.763HisThr: 0.763 ± 0.021	1.558HisVal: 1.558 ± 0.034	0.372HisTrp: 0.372 ± 0.014	0.511HisTyr: 0.511 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.918IleAla: 6.918 ± 0.071	0.596IleCys: 0.596 ± 0.017	3.197IleAsp: 3.197 ± 0.04	3.447IleGlu: 3.447 ± 0.049	1.748IlePhe: 1.748 ± 0.038	4.634IleGly: 4.634 ± 0.06	0.891IleHis: 0.891 ± 0.028	1.935IleIle: 1.935 ± 0.042	1.053IleLys: 1.053 ± 0.027	4.629IleLeu: 4.629 ± 0.059	1.008IleMet: 1.008 ± 0.026	1.126IleAsn: 1.126 ± 0.028	2.318IlePro: 2.318 ± 0.037	1.032IleGln: 1.032 ± 0.025	3.234IleArg: 3.234 ± 0.043	2.705IleSer: 2.705 ± 0.042	2.632IleThr: 2.632 ± 0.041	3.783IleVal: 3.783 ± 0.049	0.669IleTrp: 0.669 ± 0.019	1.064IleTyr: 1.064 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.368LysAla: 3.368 ± 0.054	0.162LysCys: 0.162 ± 0.011	1.469LysAsp: 1.469 ± 0.035	1.311LysGlu: 1.311 ± 0.029	0.743LysPhe: 0.743 ± 0.024	2.433LysGly: 2.433 ± 0.046	0.501LysHis: 0.501 ± 0.017	1.371LysIle: 1.371 ± 0.034	0.961LysLys: 0.961 ± 0.032	2.707LysLeu: 2.707 ± 0.046	0.732LysMet: 0.732 ± 0.021	0.59LysAsn: 0.59 ± 0.023	1.594LysPro: 1.594 ± 0.033	0.76LysGln: 0.76 ± 0.023	1.997LysArg: 1.997 ± 0.037	1.434LysSer: 1.434 ± 0.028	1.708LysThr: 1.708 ± 0.038	2.013LysVal: 2.013 ± 0.045	0.326LysTrp: 0.326 ± 0.015	0.511LysTyr: 0.511 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.743LeuAla: 13.743 ± 0.123	1.096LeuCys: 1.096 ± 0.024	6.109LeuAsp: 6.109 ± 0.066	5.679LeuGlu: 5.679 ± 0.064	3.537LeuPhe: 3.537 ± 0.057	9.02LeuGly: 9.02 ± 0.088	1.952LeuHis: 1.952 ± 0.035	4.699LeuIle: 4.699 ± 0.062	2.78LeuLys: 2.78 ± 0.044	9.694LeuLeu: 9.694 ± 0.098	2.684LeuMet: 2.684 ± 0.042	2.436LeuAsn: 2.436 ± 0.037	5.954LeuPro: 5.954 ± 0.064	2.718LeuGln: 2.718 ± 0.041	7.794LeuArg: 7.794 ± 0.076	6.761LeuSer: 6.761 ± 0.066	5.9LeuThr: 5.9 ± 0.062	7.412LeuVal: 7.412 ± 0.085	1.362LeuTrp: 1.362 ± 0.027	1.972LeuTyr: 1.972 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.455MetAla: 3.455 ± 0.049	0.191MetCys: 0.191 ± 0.012	1.29MetAsp: 1.29 ± 0.027	1.344MetGlu: 1.344 ± 0.031	0.777MetPhe: 0.777 ± 0.024	2.263MetGly: 2.263 ± 0.041	0.484MetHis: 0.484 ± 0.017	1.497MetIle: 1.497 ± 0.032	0.991MetLys: 0.991 ± 0.024	2.705MetLeu: 2.705 ± 0.041	0.781MetMet: 0.781 ± 0.026	0.785MetAsn: 0.785 ± 0.022	1.56MetPro: 1.56 ± 0.031	0.94MetGln: 0.94 ± 0.024	1.953MetArg: 1.953 ± 0.03	1.851MetSer: 1.851 ± 0.034	2.163MetThr: 2.163 ± 0.036	1.899MetVal: 1.899 ± 0.032	0.228MetTrp: 0.228 ± 0.013	0.339MetTyr: 0.339 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.903AsnAla: 2.903 ± 0.042	0.258AsnCys: 0.258 ± 0.014	1.28AsnAsp: 1.28 ± 0.029	1.103AsnGlu: 1.103 ± 0.025	0.826AsnPhe: 0.826 ± 0.022	2.19AsnGly: 2.19 ± 0.041	0.47AsnHis: 0.47 ± 0.019	1.188AsnIle: 1.188 ± 0.03	0.539AsnLys: 0.539 ± 0.023	2.246AsnLeu: 2.246 ± 0.039	0.63AsnMet: 0.63 ± 0.019	0.582AsnAsn: 0.582 ± 0.019	1.702AsnPro: 1.702 ± 0.03	0.589AsnGln: 0.589 ± 0.019	1.675AsnArg: 1.675 ± 0.032	1.046AsnSer: 1.046 ± 0.03	1.211AsnThr: 1.211 ± 0.03	1.714AsnVal: 1.714 ± 0.031	0.401AsnTrp: 0.401 ± 0.015	0.6AsnTyr: 0.6 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.282ProAla: 6.282 ± 0.062	0.416ProCys: 0.416 ± 0.016	3.948ProAsp: 3.948 ± 0.052	4.763ProGlu: 4.763 ± 0.059	1.951ProPhe: 1.951 ± 0.037	5.151ProGly: 5.151 ± 0.057	1.112ProHis: 1.112 ± 0.031	2.092ProIle: 2.092 ± 0.032	1.399ProLys: 1.399 ± 0.036	4.974ProLeu: 4.974 ± 0.061	1.333ProMet: 1.333 ± 0.027	1.13ProAsn: 1.13 ± 0.025	2.422ProPro: 2.422 ± 0.043	1.677ProGln: 1.677 ± 0.033	3.258ProArg: 3.258 ± 0.05	2.66ProSer: 2.66 ± 0.044	2.324ProThr: 2.324 ± 0.044	4.548ProVal: 4.548 ± 0.049	0.697ProTrp: 0.697 ± 0.025	1.143ProTyr: 1.143 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.813GlnAla: 3.813 ± 0.057	0.222GlnCys: 0.222 ± 0.011	1.587GlnAsp: 1.587 ± 0.029	1.545GlnGlu: 1.545 ± 0.032	0.987GlnPhe: 0.987 ± 0.023	2.507GlnGly: 2.507 ± 0.038	0.546GlnHis: 0.546 ± 0.019	1.86GlnIle: 1.86 ± 0.033	0.92GlnLys: 0.92 ± 0.023	2.797GlnLeu: 2.797 ± 0.043	0.978GlnMet: 0.978 ± 0.023	0.75GlnAsn: 0.75 ± 0.021	1.564GlnPro: 1.564 ± 0.03	1.027GlnGln: 1.027 ± 0.031	2.186GlnArg: 2.186 ± 0.038	1.608GlnSer: 1.608 ± 0.031	1.63GlnThr: 1.63 ± 0.037	2.274GlnVal: 2.274 ± 0.034	0.37GlnTrp: 0.37 ± 0.013	0.553GlnTyr: 0.553 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	8.661ArgAla: 8.661 ± 0.079	0.544ArgCys: 0.544 ± 0.018	4.555ArgAsp: 4.555 ± 0.058	4.276ArgGlu: 4.276 ± 0.059	2.83ArgPhe: 2.83 ± 0.045	5.199ArgGly: 5.199 ± 0.049	1.72ArgHis: 1.72 ± 0.034	3.906ArgIle: 3.906 ± 0.053	2.119ArgLys: 2.119 ± 0.04	7.87ArgLeu: 7.87 ± 0.079	2.089ArgMet: 2.089 ± 0.034	1.822ArgAsn: 1.822 ± 0.034	3.667ArgPro: 3.667 ± 0.057	2.298ArgGln: 2.298 ± 0.044	5.675ArgArg: 5.675 ± 0.078	3.564ArgSer: 3.564 ± 0.05	3.198ArgThr: 3.198 ± 0.04	4.969ArgVal: 4.969 ± 0.068	1.004ArgTrp: 1.004 ± 0.025	1.636ArgTyr: 1.636 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.913SerAla: 5.913 ± 0.066	0.492SerCys: 0.492 ± 0.018	3.17SerAsp: 3.17 ± 0.044	3.053SerGlu: 3.053 ± 0.052	2.217SerPhe: 2.217 ± 0.04	5.502SerGly: 5.502 ± 0.058	1.085SerHis: 1.085 ± 0.026	2.339SerIle: 2.339 ± 0.036	1.324SerLys: 1.324 ± 0.031	5.047SerLeu: 5.047 ± 0.067	1.357SerMet: 1.357 ± 0.03	1.219SerAsn: 1.219 ± 0.027	2.597SerPro: 2.597 ± 0.044	1.514SerGln: 1.514 ± 0.032	3.541SerArg: 3.541 ± 0.051	2.655SerSer: 2.655 ± 0.047	2.456SerThr: 2.456 ± 0.042	3.839SerVal: 3.839 ± 0.049	0.767SerTrp: 0.767 ± 0.019	1.35SerTyr: 1.35 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.262ThrAla: 6.262 ± 0.057	0.486ThrCys: 0.486 ± 0.018	3.025ThrAsp: 3.025 ± 0.046	3.187ThrGlu: 3.187 ± 0.042	1.894ThrPhe: 1.894 ± 0.038	5.599ThrGly: 5.599 ± 0.053	1.049ThrHis: 1.049 ± 0.028	2.522ThrIle: 2.522 ± 0.041	1.106ThrLys: 1.106 ± 0.025	6.181ThrLeu: 6.181 ± 0.062	1.264ThrMet: 1.264 ± 0.027	1.147ThrAsn: 1.147 ± 0.026	3.556ThrPro: 3.556 ± 0.05	1.485ThrGln: 1.485 ± 0.029	3.754ThrArg: 3.754 ± 0.047	2.627ThrSer: 2.627 ± 0.042	2.743ThrThr: 2.743 ± 0.047	4.353ThrVal: 4.353 ± 0.057	0.694ThrTrp: 0.694 ± 0.019	1.154ThrTyr: 1.154 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	9.22ValAla: 9.22 ± 0.073	0.639ValCys: 0.639 ± 0.019	3.803ValAsp: 3.803 ± 0.048	4.457ValGlu: 4.457 ± 0.059	2.875ValPhe: 2.875 ± 0.043	5.458ValGly: 5.458 ± 0.06	1.342ValHis: 1.342 ± 0.028	4.048ValIle: 4.048 ± 0.052	1.867ValLys: 1.867 ± 0.04	7.848ValLeu: 7.848 ± 0.087	2.074ValMet: 2.074 ± 0.031	1.848ValAsn: 1.848 ± 0.038	3.941ValPro: 3.941 ± 0.044	2.043ValGln: 2.043 ± 0.038	4.451ValArg: 4.451 ± 0.055	4.355ValSer: 4.355 ± 0.052	4.959ValThr: 4.959 ± 0.066	5.741ValVal: 5.741 ± 0.06	0.973ValTrp: 0.973 ± 0.022	1.455ValTyr: 1.455 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.313TrpAla: 1.313 ± 0.029	0.138TrpCys: 0.138 ± 0.009	0.766TrpAsp: 0.766 ± 0.023	0.68TrpGlu: 0.68 ± 0.022	0.537TrpPhe: 0.537 ± 0.017	1.07TrpGly: 1.07 ± 0.026	0.336TrpHis: 0.336 ± 0.013	0.707TrpIle: 0.707 ± 0.018	0.486TrpLys: 0.486 ± 0.018	1.707TrpLeu: 1.707 ± 0.035	0.414TrpMet: 0.414 ± 0.015	0.423TrpAsn: 0.423 ± 0.015	0.745TrpPro: 0.745 ± 0.024	0.62TrpGln: 0.62 ± 0.019	1.173TrpArg: 1.173 ± 0.029	0.812TrpSer: 0.812 ± 0.019	0.836TrpThr: 0.836 ± 0.021	0.907TrpVal: 0.907 ± 0.024	0.211TrpTrp: 0.211 ± 0.011	0.281TrpTyr: 0.281 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.555TyrAla: 2.555 ± 0.042	0.233TyrCys: 0.233 ± 0.013	1.588TyrAsp: 1.588 ± 0.031	1.292TyrGlu: 1.292 ± 0.028	0.83TyrPhe: 0.83 ± 0.026	2.108TyrGly: 2.108 ± 0.038	0.48TyrHis: 0.48 ± 0.018	0.867TyrIle: 0.867 ± 0.022	0.486TyrLys: 0.486 ± 0.019	2.207TyrLeu: 2.207 ± 0.038	0.465TyrMet: 0.465 ± 0.016	0.575TyrAsn: 0.575 ± 0.021	1.099TyrPro: 1.099 ± 0.026	0.622TyrGln: 0.622 ± 0.021	1.583TyrArg: 1.583 ± 0.031	1.035TyrSer: 1.035 ± 0.026	1.078TyrThr: 1.078 ± 0.026	1.542TyrVal: 1.542 ± 0.031	0.358TyrTrp: 0.358 ± 0.017	0.542TyrTyr: 0.542 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5563 proteins (1713591 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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