Amino acid dipepetide frequency for Psychrosphaera haliotis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.402AlaAla: 6.402 ± 0.108	0.794AlaCys: 0.794 ± 0.035	4.499AlaAsp: 4.499 ± 0.088	5.444AlaGlu: 5.444 ± 0.113	3.32AlaPhe: 3.32 ± 0.071	5.36AlaGly: 5.36 ± 0.1	1.373AlaHis: 1.373 ± 0.038	5.92AlaIle: 5.92 ± 0.086	5.169AlaLys: 5.169 ± 0.1	8.416AlaLeu: 8.416 ± 0.102	2.177AlaMet: 2.177 ± 0.052	4.151AlaAsn: 4.151 ± 0.085	2.557AlaPro: 2.557 ± 0.06	3.174AlaGln: 3.174 ± 0.069	2.892AlaArg: 2.892 ± 0.056	5.305AlaSer: 5.305 ± 0.077	4.239AlaThr: 4.239 ± 0.083	5.314AlaVal: 5.314 ± 0.078	0.811AlaTrp: 0.811 ± 0.031	2.278AlaTyr: 2.278 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.588CysAla: 0.588 ± 0.031	0.112CysCys: 0.112 ± 0.014	0.519CysAsp: 0.519 ± 0.023	0.484CysGlu: 0.484 ± 0.024	0.415CysPhe: 0.415 ± 0.022	0.657CysGly: 0.657 ± 0.037	0.241CysHis: 0.241 ± 0.017	0.557CysIle: 0.557 ± 0.026	0.431CysLys: 0.431 ± 0.024	0.753CysLeu: 0.753 ± 0.029	0.171CysMet: 0.171 ± 0.015	0.39CysAsn: 0.39 ± 0.023	0.392CysPro: 0.392 ± 0.024	0.351CysGln: 0.351 ± 0.021	0.338CysArg: 0.338 ± 0.025	0.663CysSer: 0.663 ± 0.029	0.373CysThr: 0.373 ± 0.02	0.513CysVal: 0.513 ± 0.024	0.09CysTrp: 0.09 ± 0.011	0.242CysTyr: 0.242 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.425AspAla: 4.425 ± 0.098	0.415AspCys: 0.415 ± 0.023	3.334AspAsp: 3.334 ± 0.121	3.819AspGlu: 3.819 ± 0.076	2.835AspPhe: 2.835 ± 0.076	3.948AspGly: 3.948 ± 0.145	1.016AspHis: 1.016 ± 0.041	4.346AspIle: 4.346 ± 0.073	3.771AspLys: 3.771 ± 0.072	5.639AspLeu: 5.639 ± 0.099	1.41AspMet: 1.41 ± 0.045	2.846AspAsn: 2.846 ± 0.075	1.945AspPro: 1.945 ± 0.046	1.901AspGln: 1.901 ± 0.046	2.022AspArg: 2.022 ± 0.05	3.875AspSer: 3.875 ± 0.098	2.776AspThr: 2.776 ± 0.077	4.509AspVal: 4.509 ± 0.088	0.831AspTrp: 0.831 ± 0.036	2.053AspTyr: 2.053 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.9GluAla: 4.9 ± 0.089	0.441GluCys: 0.441 ± 0.024	3.042GluAsp: 3.042 ± 0.064	3.798GluGlu: 3.798 ± 0.074	3.011GluPhe: 3.011 ± 0.064	3.44GluGly: 3.44 ± 0.073	1.455GluHis: 1.455 ± 0.042	4.143GluIle: 4.143 ± 0.08	4.134GluLys: 4.134 ± 0.082	7.559GluLeu: 7.559 ± 0.113	1.636GluMet: 1.636 ± 0.045	3.124GluAsn: 3.124 ± 0.064	2.076GluPro: 2.076 ± 0.061	4.09GluGln: 4.09 ± 0.093	2.826GluArg: 2.826 ± 0.072	4.612GluSer: 4.612 ± 0.079	3.391GluThr: 3.391 ± 0.072	4.516GluVal: 4.516 ± 0.082	0.676GluTrp: 0.676 ± 0.027	2.015GluTyr: 2.015 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.336PheAla: 3.336 ± 0.072	0.421PheCys: 0.421 ± 0.024	3.167PheAsp: 3.167 ± 0.07	3.072PheGlu: 3.072 ± 0.061	1.751PhePhe: 1.751 ± 0.052	3.229PheGly: 3.229 ± 0.068	0.79PheHis: 0.79 ± 0.029	3.146PheIle: 3.146 ± 0.07	2.615PheLys: 2.615 ± 0.063	3.481PheLeu: 3.481 ± 0.079	0.99PheMet: 0.99 ± 0.033	2.523PheAsn: 2.523 ± 0.059	1.377PhePro: 1.377 ± 0.046	1.312PheGln: 1.312 ± 0.04	1.442PheArg: 1.442 ± 0.042	3.765PheSer: 3.765 ± 0.069	2.483PheThr: 2.483 ± 0.062	3.283PheVal: 3.283 ± 0.069	0.512PheTrp: 0.512 ± 0.028	1.541PheTyr: 1.541 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.77GlyAla: 4.77 ± 0.084	0.708GlyCys: 0.708 ± 0.029	3.705GlyAsp: 3.705 ± 0.084	4.01GlyGlu: 4.01 ± 0.079	3.406GlyPhe: 3.406 ± 0.07	4.351GlyGly: 4.351 ± 0.099	1.41GlyHis: 1.41 ± 0.05	4.584GlyIle: 4.584 ± 0.1	3.933GlyLys: 3.933 ± 0.074	6.769GlyLeu: 6.769 ± 0.107	1.639GlyMet: 1.639 ± 0.055	2.874GlyAsn: 2.874 ± 0.065	1.513GlyPro: 1.513 ± 0.047	2.533GlyGln: 2.533 ± 0.059	2.52GlyArg: 2.52 ± 0.064	4.105GlySer: 4.105 ± 0.093	3.519GlyThr: 3.519 ± 0.101	4.591GlyVal: 4.591 ± 0.084	0.807GlyTrp: 0.807 ± 0.033	2.377GlyTyr: 2.377 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.254HisAla: 1.254 ± 0.037	0.256HisCys: 0.256 ± 0.017	1.03HisAsp: 1.03 ± 0.035	1.133HisGlu: 1.133 ± 0.037	1.072HisPhe: 1.072 ± 0.037	1.267HisGly: 1.267 ± 0.04	0.562HisHis: 0.562 ± 0.028	1.384HisIle: 1.384 ± 0.041	1.152HisLys: 1.152 ± 0.04	1.947HisLeu: 1.947 ± 0.052	0.449HisMet: 0.449 ± 0.027	0.999HisAsn: 0.999 ± 0.034	0.9HisPro: 0.9 ± 0.035	1.023HisGln: 1.023 ± 0.032	0.804HisArg: 0.804 ± 0.027	1.271HisSer: 1.271 ± 0.043	0.945HisThr: 0.945 ± 0.037	1.256HisVal: 1.256 ± 0.046	0.291HisTrp: 0.291 ± 0.02	0.746HisTyr: 0.746 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.034IleAla: 6.034 ± 0.082	0.573IleCys: 0.573 ± 0.03	4.765IleAsp: 4.765 ± 0.082	5.237IleGlu: 5.237 ± 0.077	2.463IlePhe: 2.463 ± 0.059	4.488IleGly: 4.488 ± 0.078	1.222IleHis: 1.222 ± 0.041	3.973IleIle: 3.973 ± 0.08	4.481IleLys: 4.481 ± 0.079	5.537IleLeu: 5.537 ± 0.095	1.315IleMet: 1.315 ± 0.043	3.907IleAsn: 3.907 ± 0.07	2.442IlePro: 2.442 ± 0.059	2.253IleGln: 2.253 ± 0.047	2.593IleArg: 2.593 ± 0.053	5.23IleSer: 5.23 ± 0.081	3.951IleThr: 3.951 ± 0.084	4.435IleVal: 4.435 ± 0.079	0.589IleTrp: 0.589 ± 0.032	1.829IleTyr: 1.829 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.222LysAla: 5.222 ± 0.088	0.35LysCys: 0.35 ± 0.023	3.24LysAsp: 3.24 ± 0.072	4.0LysGlu: 4.0 ± 0.079	2.129LysPhe: 2.129 ± 0.054	3.535LysGly: 3.535 ± 0.074	1.324LysHis: 1.324 ± 0.039	3.563LysIle: 3.563 ± 0.074	3.835LysLys: 3.835 ± 0.078	6.187LysLeu: 6.187 ± 0.108	1.611LysMet: 1.611 ± 0.046	3.077LysAsn: 3.077 ± 0.053	2.67LysPro: 2.67 ± 0.06	3.289LysGln: 3.289 ± 0.071	2.699LysArg: 2.699 ± 0.058	4.51LysSer: 4.51 ± 0.089	3.459LysThr: 3.459 ± 0.075	4.655LysVal: 4.655 ± 0.075	0.61LysTrp: 0.61 ± 0.029	1.774LysTyr: 1.774 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	8.831LeuAla: 8.831 ± 0.112	0.772LeuCys: 0.772 ± 0.032	5.802LeuAsp: 5.802 ± 0.097	6.376LeuGlu: 6.376 ± 0.11	4.376LeuPhe: 4.376 ± 0.09	6.098LeuGly: 6.098 ± 0.101	1.784LeuHis: 1.784 ± 0.056	6.627LeuIle: 6.627 ± 0.101	6.255LeuLys: 6.255 ± 0.105	9.897LeuLeu: 9.897 ± 0.144	2.437LeuMet: 2.437 ± 0.056	5.447LeuAsn: 5.447 ± 0.086	4.314LeuPro: 4.314 ± 0.076	3.42LeuGln: 3.42 ± 0.082	3.595LeuArg: 3.595 ± 0.071	8.104LeuSer: 8.104 ± 0.11	6.065LeuThr: 6.065 ± 0.093	7.044LeuVal: 7.044 ± 0.091	0.831LeuTrp: 0.831 ± 0.032	2.546LeuTyr: 2.546 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.169MetAla: 2.169 ± 0.048	0.187MetCys: 0.187 ± 0.016	1.249MetAsp: 1.249 ± 0.041	1.261MetGlu: 1.261 ± 0.038	0.929MetPhe: 0.929 ± 0.035	1.487MetGly: 1.487 ± 0.043	0.42MetHis: 0.42 ± 0.02	1.344MetIle: 1.344 ± 0.049	1.557MetLys: 1.557 ± 0.045	2.515MetLeu: 2.515 ± 0.057	0.671MetMet: 0.671 ± 0.03	1.126MetAsn: 1.126 ± 0.035	1.147MetPro: 1.147 ± 0.038	0.963MetGln: 0.963 ± 0.034	0.995MetArg: 0.995 ± 0.033	1.936MetSer: 1.936 ± 0.051	1.542MetThr: 1.542 ± 0.043	1.607MetVal: 1.607 ± 0.044	0.24MetTrp: 0.24 ± 0.018	0.555MetTyr: 0.555 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.824AsnAla: 3.824 ± 0.082	0.418AsnCys: 0.418 ± 0.021	3.106AsnAsp: 3.106 ± 0.082	3.352AsnGlu: 3.352 ± 0.06	1.87AsnPhe: 1.87 ± 0.051	3.441AsnGly: 3.441 ± 0.088	0.953AsnHis: 0.953 ± 0.033	3.622AsnIle: 3.622 ± 0.073	3.584AsnLys: 3.584 ± 0.062	4.493AsnLeu: 4.493 ± 0.065	1.118AsnMet: 1.118 ± 0.037	3.003AsnAsn: 3.003 ± 0.064	2.087AsnPro: 2.087 ± 0.052	2.297AsnGln: 2.297 ± 0.061	2.053AsnArg: 2.053 ± 0.046	3.488AsnSer: 3.488 ± 0.074	2.82AsnThr: 2.82 ± 0.071	3.514AsnVal: 3.514 ± 0.069	0.698AsnTrp: 0.698 ± 0.033	1.611AsnTyr: 1.611 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.692ProAla: 2.692 ± 0.061	0.234ProCys: 0.234 ± 0.017	2.19ProAsp: 2.19 ± 0.062	2.937ProGlu: 2.937 ± 0.071	1.738ProPhe: 1.738 ± 0.051	2.166ProGly: 2.166 ± 0.057	0.721ProHis: 0.721 ± 0.031	2.595ProIle: 2.595 ± 0.059	2.186ProLys: 2.186 ± 0.055	3.568ProLeu: 3.568 ± 0.058	0.847ProMet: 0.847 ± 0.035	1.979ProAsn: 1.979 ± 0.052	0.969ProPro: 0.969 ± 0.032	1.335ProGln: 1.335 ± 0.039	1.075ProArg: 1.075 ± 0.038	2.423ProSer: 2.423 ± 0.059	2.217ProThr: 2.217 ± 0.049	2.658ProVal: 2.658 ± 0.068	0.389ProTrp: 0.389 ± 0.022	1.087ProTyr: 1.087 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.586GlnAla: 3.586 ± 0.085	0.3GlnCys: 0.3 ± 0.02	1.849GlnAsp: 1.849 ± 0.047	2.35GlnGlu: 2.35 ± 0.059	1.894GlnPhe: 1.894 ± 0.044	2.417GlnGly: 2.417 ± 0.057	0.934GlnHis: 0.934 ± 0.032	2.647GlnIle: 2.647 ± 0.058	2.39GlnLys: 2.39 ± 0.055	4.771GlnLeu: 4.771 ± 0.083	0.941GlnMet: 0.941 ± 0.032	2.022GlnAsn: 2.022 ± 0.06	1.501GlnPro: 1.501 ± 0.043	2.797GlnGln: 2.797 ± 0.074	1.778GlnArg: 1.778 ± 0.052	2.998GlnSer: 2.998 ± 0.064	2.333GlnThr: 2.333 ± 0.058	2.964GlnVal: 2.964 ± 0.059	0.496GlnTrp: 0.496 ± 0.024	1.347GlnTyr: 1.347 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	2.73ArgAla: 2.73 ± 0.067	0.317ArgCys: 0.317 ± 0.018	2.133ArgAsp: 2.133 ± 0.05	2.419ArgGlu: 2.419 ± 0.054	2.004ArgPhe: 2.004 ± 0.055	2.165ArgGly: 2.165 ± 0.061	0.925ArgHis: 0.925 ± 0.031	2.651ArgIle: 2.651 ± 0.056	2.201ArgLys: 2.201 ± 0.044	4.315ArgLeu: 4.315 ± 0.074	0.991ArgMet: 0.991 ± 0.036	1.796ArgAsn: 1.796 ± 0.046	1.278ArgPro: 1.278 ± 0.038	1.677ArgGln: 1.677 ± 0.04	1.791ArgArg: 1.791 ± 0.052	2.375ArgSer: 2.375 ± 0.056	1.877ArgThr: 1.877 ± 0.053	2.814ArgVal: 2.814 ± 0.054	0.498ArgTrp: 0.498 ± 0.022	1.494ArgTyr: 1.494 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.658SerAla: 5.658 ± 0.095	0.52SerCys: 0.52 ± 0.027	4.224SerAsp: 4.224 ± 0.101	4.696SerGlu: 4.696 ± 0.082	3.397SerPhe: 3.397 ± 0.059	4.966SerGly: 4.966 ± 0.085	1.443SerHis: 1.443 ± 0.044	4.954SerIle: 4.954 ± 0.078	4.471SerLys: 4.471 ± 0.08	7.521SerLeu: 7.521 ± 0.106	1.708SerMet: 1.708 ± 0.048	3.76SerAsn: 3.76 ± 0.073	2.317SerPro: 2.317 ± 0.046	2.969SerGln: 2.969 ± 0.07	2.531SerArg: 2.531 ± 0.061	5.398SerSer: 5.398 ± 0.089	3.756SerThr: 3.756 ± 0.08	5.05SerVal: 5.05 ± 0.081	0.819SerTrp: 0.819 ± 0.03	2.23SerTyr: 2.23 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.366ThrAla: 4.366 ± 0.072	0.407ThrCys: 0.407 ± 0.02	3.308ThrAsp: 3.308 ± 0.079	3.53ThrGlu: 3.53 ± 0.064	2.44ThrPhe: 2.44 ± 0.052	4.016ThrGly: 4.016 ± 0.08	1.044ThrHis: 1.044 ± 0.033	3.684ThrIle: 3.684 ± 0.085	3.024ThrLys: 3.024 ± 0.066	5.72ThrLeu: 5.72 ± 0.09	1.083ThrMet: 1.083 ± 0.035	2.698ThrAsn: 2.698 ± 0.062	2.533ThrPro: 2.533 ± 0.051	2.16ThrGln: 2.16 ± 0.051	1.96ThrArg: 1.96 ± 0.049	3.928ThrSer: 3.928 ± 0.071	3.006ThrThr: 3.006 ± 0.072	3.974ThrVal: 3.974 ± 0.092	0.583ThrTrp: 0.583 ± 0.03	1.562ThrTyr: 1.562 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.952ValAla: 5.952 ± 0.091	0.639ValCys: 0.639 ± 0.028	4.262ValAsp: 4.262 ± 0.071	4.758ValGlu: 4.758 ± 0.095	3.074ValPhe: 3.074 ± 0.065	4.492ValGly: 4.492 ± 0.064	1.178ValHis: 1.178 ± 0.036	5.149ValIle: 5.149 ± 0.097	4.276ValLys: 4.276 ± 0.08	6.75ValLeu: 6.75 ± 0.093	1.795ValMet: 1.795 ± 0.049	3.764ValAsn: 3.764 ± 0.076	2.37ValPro: 2.37 ± 0.052	2.192ValGln: 2.192 ± 0.048	2.566ValArg: 2.566 ± 0.058	5.346ValSer: 5.346 ± 0.101	4.162ValThr: 4.162 ± 0.088	5.232ValVal: 5.232 ± 0.098	0.731ValTrp: 0.731 ± 0.033	1.942ValTyr: 1.942 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.734TrpAla: 0.734 ± 0.034	0.11TrpCys: 0.11 ± 0.01	0.561TrpAsp: 0.561 ± 0.026	0.475TrpGlu: 0.475 ± 0.026	0.595TrpPhe: 0.595 ± 0.029	0.601TrpGly: 0.601 ± 0.029	0.315TrpHis: 0.315 ± 0.02	0.587TrpIle: 0.587 ± 0.026	0.483TrpLys: 0.483 ± 0.022	1.531TrpLeu: 1.531 ± 0.049	0.256TrpMet: 0.256 ± 0.02	0.473TrpAsn: 0.473 ± 0.029	0.438TrpPro: 0.438 ± 0.026	0.817TrpGln: 0.817 ± 0.033	0.542TrpArg: 0.542 ± 0.027	0.764TrpSer: 0.764 ± 0.031	0.518TrpThr: 0.518 ± 0.028	0.783TrpVal: 0.783 ± 0.031	0.155TrpTrp: 0.155 ± 0.015	0.338TrpTyr: 0.338 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.122TyrAla: 2.122 ± 0.053	0.309TyrCys: 0.309 ± 0.019	1.73TyrAsp: 1.73 ± 0.047	1.734TyrGlu: 1.734 ± 0.049	1.517TyrPhe: 1.517 ± 0.04	2.001TyrGly: 2.001 ± 0.059	0.631TyrHis: 0.631 ± 0.028	1.84TyrIle: 1.84 ± 0.051	1.793TyrLys: 1.793 ± 0.056	3.255TyrLeu: 3.255 ± 0.067	0.653TyrMet: 0.653 ± 0.029	1.391TyrAsn: 1.391 ± 0.048	1.179TyrPro: 1.179 ± 0.038	1.764TyrGln: 1.764 ± 0.051	1.428TyrArg: 1.428 ± 0.038	2.292TyrSer: 2.292 ± 0.056	1.593TyrThr: 1.593 ± 0.048	1.918TyrVal: 1.918 ± 0.046	0.419TyrTrp: 0.419 ± 0.023	1.036TyrTyr: 1.036 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2692 proteins (866941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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