Amino acid dipepetide frequency for Methanosarcina spherical virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.841AlaAla: 2.841 ± 1.146
0.71AlaCys: 0.71 ± 0.59
2.131AlaAsp: 2.131 ± 0.678
2.486AlaGlu: 2.486 ± 0.982
2.486AlaPhe: 2.486 ± 0.774
6.747AlaGly: 6.747 ± 1.327
0.71AlaHis: 0.71 ± 0.433
6.037AlaIle: 6.037 ± 1.404
3.551AlaLys: 3.551 ± 1.435
8.168AlaLeu: 8.168 ± 1.688
1.065AlaMet: 1.065 ± 0.484
2.486AlaAsn: 2.486 ± 0.932
1.065AlaPro: 1.065 ± 0.678
1.42AlaGln: 1.42 ± 0.593
2.486AlaArg: 2.486 ± 1.277
4.972AlaSer: 4.972 ± 1.573
3.196AlaThr: 3.196 ± 0.953
4.972AlaVal: 4.972 ± 1.728
0.355AlaTrp: 0.355 ± 0.306
2.841AlaTyr: 2.841 ± 0.926
0.0AlaXaa: 0.0 ± 0.0
Cys
0.355CysAla: 0.355 ± 0.295
0.0CysCys: 0.0 ± 0.0
1.42CysAsp: 1.42 ± 0.686
0.355CysGlu: 0.355 ± 0.306
0.71CysPhe: 0.71 ± 0.443
1.42CysGly: 1.42 ± 0.842
0.0CysHis: 0.0 ± 0.0
0.71CysIle: 0.71 ± 0.505
1.776CysLys: 1.776 ± 0.796
1.42CysLeu: 1.42 ± 0.711
0.71CysMet: 0.71 ± 0.858
0.71CysAsn: 0.71 ± 0.507
1.42CysPro: 1.42 ± 0.736
0.0CysGln: 0.0 ± 0.0
1.42CysArg: 1.42 ± 0.724
1.42CysSer: 1.42 ± 0.546
1.42CysThr: 1.42 ± 0.741
0.71CysVal: 0.71 ± 0.381
0.355CysTrp: 0.355 ± 0.366
1.065CysTyr: 1.065 ± 0.456
0.0CysXaa: 0.0 ± 0.0
Asp
3.551AspAla: 3.551 ± 1.055
1.42AspCys: 1.42 ± 0.517
3.551AspAsp: 3.551 ± 1.335
2.131AspGlu: 2.131 ± 0.736
2.131AspPhe: 2.131 ± 1.248
2.841AspGly: 2.841 ± 0.823
0.0AspHis: 0.0 ± 0.0
3.196AspIle: 3.196 ± 0.873
2.486AspLys: 2.486 ± 0.721
3.906AspLeu: 3.906 ± 0.877
1.065AspMet: 1.065 ± 0.567
3.196AspAsn: 3.196 ± 1.137
2.131AspPro: 2.131 ± 1.061
1.776AspGln: 1.776 ± 0.558
2.486AspArg: 2.486 ± 0.9
3.906AspSer: 3.906 ± 0.995
2.841AspThr: 2.841 ± 1.003
2.486AspVal: 2.486 ± 0.682
0.355AspTrp: 0.355 ± 0.367
2.131AspTyr: 2.131 ± 0.643
0.0AspXaa: 0.0 ± 0.0
Glu
7.457GluAla: 7.457 ± 2.296
0.355GluCys: 0.355 ± 0.357
1.776GluAsp: 1.776 ± 0.67
8.878GluGlu: 8.878 ± 3.639
1.776GluPhe: 1.776 ± 0.836
4.972GluGly: 4.972 ± 1.692
0.71GluHis: 0.71 ± 0.443
4.972GluIle: 4.972 ± 1.345
7.102GluLys: 7.102 ± 2.095
5.682GluLeu: 5.682 ± 1.308
2.131GluMet: 2.131 ± 0.736
4.261GluAsn: 4.261 ± 1.032
2.131GluPro: 2.131 ± 0.757
2.841GluGln: 2.841 ± 1.135
2.486GluArg: 2.486 ± 0.863
4.616GluSer: 4.616 ± 1.449
4.261GluThr: 4.261 ± 1.093
2.486GluVal: 2.486 ± 0.702
0.355GluTrp: 0.355 ± 0.375
2.486GluTyr: 2.486 ± 1.072
0.0GluXaa: 0.0 ± 0.0
Phe
1.42PheAla: 1.42 ± 0.725
0.71PheCys: 0.71 ± 0.588
2.841PheAsp: 2.841 ± 1.001
3.196PheGlu: 3.196 ± 1.035
1.776PhePhe: 1.776 ± 0.594
2.486PheGly: 2.486 ± 0.946
0.355PheHis: 0.355 ± 0.31
1.776PheIle: 1.776 ± 1.044
4.616PheLys: 4.616 ± 1.397
4.261PheLeu: 4.261 ± 1.039
1.42PheMet: 1.42 ± 0.728
3.906PheAsn: 3.906 ± 0.988
2.486PhePro: 2.486 ± 0.669
0.355PheGln: 0.355 ± 0.354
2.486PheArg: 2.486 ± 0.912
1.776PheSer: 1.776 ± 0.933
3.551PheThr: 3.551 ± 1.255
1.065PheVal: 1.065 ± 0.456
0.0PheTrp: 0.0 ± 0.0
1.776PheTyr: 1.776 ± 0.632
0.0PheXaa: 0.0 ± 0.0
Gly
4.616GlyAla: 4.616 ± 1.595
2.131GlyCys: 2.131 ± 1.374
3.551GlyAsp: 3.551 ± 1.028
4.616GlyGlu: 4.616 ± 1.183
2.841GlyPhe: 2.841 ± 0.857
8.523GlyGly: 8.523 ± 2.847
0.71GlyHis: 0.71 ± 0.492
4.616GlyIle: 4.616 ± 0.772
7.457GlyLys: 7.457 ± 1.606
3.551GlyLeu: 3.551 ± 0.886
0.71GlyMet: 0.71 ± 0.413
2.841GlyAsn: 2.841 ± 0.846
0.0GlyPro: 0.0 ± 0.0
2.131GlyGln: 2.131 ± 0.845
1.776GlyArg: 1.776 ± 0.641
9.233GlySer: 9.233 ± 2.021
4.261GlyThr: 4.261 ± 1.538
4.972GlyVal: 4.972 ± 0.978
1.065GlyTrp: 1.065 ± 0.478
3.196GlyTyr: 3.196 ± 1.189
0.0GlyXaa: 0.0 ± 0.0
His
0.355HisAla: 0.355 ± 0.306
0.71HisCys: 0.71 ± 0.521
0.0HisAsp: 0.0 ± 0.0
1.065HisGlu: 1.065 ± 0.637
1.065HisPhe: 1.065 ± 0.608
0.355HisGly: 0.355 ± 0.375
0.0HisHis: 0.0 ± 0.0
0.71HisIle: 0.71 ± 0.515
0.0HisLys: 0.0 ± 0.0
1.065HisLeu: 1.065 ± 0.547
0.0HisMet: 0.0 ± 0.0
0.355HisAsn: 0.355 ± 0.31
0.71HisPro: 0.71 ± 0.411
0.0HisGln: 0.0 ± 0.0
1.42HisArg: 1.42 ± 0.624
0.355HisSer: 0.355 ± 0.354
0.355HisThr: 0.355 ± 0.332
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.355HisTyr: 0.355 ± 0.31
0.0HisXaa: 0.0 ± 0.0
Ile
5.327IleAla: 5.327 ± 1.202
1.065IleCys: 1.065 ± 0.761
5.327IleAsp: 5.327 ± 1.6
6.392IleGlu: 6.392 ± 1.876
1.776IlePhe: 1.776 ± 0.924
5.682IleGly: 5.682 ± 1.433
1.42IleHis: 1.42 ± 0.65
6.392IleIle: 6.392 ± 1.234
8.878IleLys: 8.878 ± 2.274
3.196IleLeu: 3.196 ± 0.979
0.355IleMet: 0.355 ± 0.319
4.261IleAsn: 4.261 ± 0.779
4.261IlePro: 4.261 ± 0.924
2.486IleGln: 2.486 ± 0.919
4.972IleArg: 4.972 ± 1.397
3.906IleSer: 3.906 ± 0.975
3.196IleThr: 3.196 ± 1.264
3.196IleVal: 3.196 ± 0.955
0.355IleTrp: 0.355 ± 0.31
2.131IleTyr: 2.131 ± 0.722
0.0IleXaa: 0.0 ± 0.0
Lys
5.682LysAla: 5.682 ± 1.576
2.486LysCys: 2.486 ± 0.923
2.131LysAsp: 2.131 ± 0.928
7.102LysGlu: 7.102 ± 2.094
2.841LysPhe: 2.841 ± 0.891
6.037LysGly: 6.037 ± 1.295
1.42LysHis: 1.42 ± 0.897
8.523LysIle: 8.523 ± 1.868
7.102LysLys: 7.102 ± 2.373
3.906LysLeu: 3.906 ± 0.904
2.131LysMet: 2.131 ± 1.014
3.906LysAsn: 3.906 ± 1.485
2.131LysPro: 2.131 ± 1.015
3.906LysGln: 3.906 ± 1.46
1.776LysArg: 1.776 ± 0.753
4.972LysSer: 4.972 ± 1.915
8.523LysThr: 8.523 ± 1.671
2.486LysVal: 2.486 ± 1.146
0.0LysTrp: 0.0 ± 0.0
3.906LysTyr: 3.906 ± 0.99
0.0LysXaa: 0.0 ± 0.0
Leu
4.616LeuAla: 4.616 ± 1.117
0.71LeuCys: 0.71 ± 0.535
3.551LeuAsp: 3.551 ± 1.018
6.037LeuGlu: 6.037 ± 1.584
3.906LeuPhe: 3.906 ± 0.978
3.196LeuGly: 3.196 ± 0.945
0.355LeuHis: 0.355 ± 0.383
5.682LeuIle: 5.682 ± 1.308
6.747LeuLys: 6.747 ± 1.433
6.392LeuLeu: 6.392 ± 1.557
1.776LeuMet: 1.776 ± 0.852
4.616LeuAsn: 4.616 ± 1.454
4.261LeuPro: 4.261 ± 1.144
2.486LeuGln: 2.486 ± 1.247
5.682LeuArg: 5.682 ± 1.343
4.616LeuSer: 4.616 ± 1.15
4.616LeuThr: 4.616 ± 1.342
3.196LeuVal: 3.196 ± 1.194
1.776LeuTrp: 1.776 ± 0.851
5.327LeuTyr: 5.327 ± 1.358
0.0LeuXaa: 0.0 ± 0.0
Met
0.355MetAla: 0.355 ± 0.351
0.0MetCys: 0.0 ± 0.0
2.131MetAsp: 2.131 ± 0.699
1.065MetGlu: 1.065 ± 0.665
1.42MetPhe: 1.42 ± 0.776
0.71MetGly: 0.71 ± 0.411
0.0MetHis: 0.0 ± 0.0
1.776MetIle: 1.776 ± 0.692
1.065MetLys: 1.065 ± 0.607
1.776MetLeu: 1.776 ± 1.119
0.71MetMet: 0.71 ± 0.481
0.71MetAsn: 0.71 ± 0.62
1.065MetPro: 1.065 ± 0.546
1.776MetGln: 1.776 ± 0.654
1.42MetArg: 1.42 ± 0.706
2.841MetSer: 2.841 ± 0.857
1.065MetThr: 1.065 ± 0.766
2.131MetVal: 2.131 ± 0.802
0.355MetTrp: 0.355 ± 0.335
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.486AsnAla: 2.486 ± 1.115
1.42AsnCys: 1.42 ± 0.81
2.131AsnAsp: 2.131 ± 0.678
3.551AsnGlu: 3.551 ± 0.911
2.841AsnPhe: 2.841 ± 0.806
4.261AsnGly: 4.261 ± 1.179
0.0AsnHis: 0.0 ± 0.0
4.972AsnIle: 4.972 ± 1.202
4.616AsnLys: 4.616 ± 1.339
3.196AsnLeu: 3.196 ± 1.024
0.71AsnMet: 0.71 ± 0.502
0.355AsnAsn: 0.355 ± 0.31
2.486AsnPro: 2.486 ± 0.647
1.776AsnGln: 1.776 ± 1.05
2.841AsnArg: 2.841 ± 1.039
4.261AsnSer: 4.261 ± 1.403
1.776AsnThr: 1.776 ± 1.227
4.972AsnVal: 4.972 ± 1.162
0.71AsnTrp: 0.71 ± 0.455
1.776AsnTyr: 1.776 ± 0.692
0.0AsnXaa: 0.0 ± 0.0
Pro
4.261ProAla: 4.261 ± 1.031
0.0ProCys: 0.0 ± 0.0
2.131ProAsp: 2.131 ± 0.557
2.841ProGlu: 2.841 ± 0.917
1.065ProPhe: 1.065 ± 0.505
1.42ProGly: 1.42 ± 0.75
0.355ProHis: 0.355 ± 0.367
4.261ProIle: 4.261 ± 1.117
2.131ProLys: 2.131 ± 0.791
3.906ProLeu: 3.906 ± 0.954
1.065ProMet: 1.065 ± 0.594
1.42ProAsn: 1.42 ± 0.632
0.0ProPro: 0.0 ± 0.0
1.065ProGln: 1.065 ± 0.571
1.42ProArg: 1.42 ± 0.633
2.131ProSer: 2.131 ± 0.834
3.196ProThr: 3.196 ± 0.83
2.486ProVal: 2.486 ± 0.917
0.0ProTrp: 0.0 ± 0.0
1.42ProTyr: 1.42 ± 0.595
0.0ProXaa: 0.0 ± 0.0
Gln
2.841GlnAla: 2.841 ± 0.543
0.355GlnCys: 0.355 ± 0.31
1.42GlnAsp: 1.42 ± 0.696
3.551GlnGlu: 3.551 ± 1.132
0.0GlnPhe: 0.0 ± 0.0
0.71GlnGly: 0.71 ± 0.468
0.0GlnHis: 0.0 ± 0.0
1.42GlnIle: 1.42 ± 0.522
2.131GlnLys: 2.131 ± 0.652
3.196GlnLeu: 3.196 ± 1.076
1.065GlnMet: 1.065 ± 0.573
1.065GlnAsn: 1.065 ± 0.667
0.355GlnPro: 0.355 ± 0.354
1.42GlnGln: 1.42 ± 0.808
1.776GlnArg: 1.776 ± 0.869
3.906GlnSer: 3.906 ± 1.089
3.196GlnThr: 3.196 ± 0.871
1.776GlnVal: 1.776 ± 0.795
0.0GlnTrp: 0.0 ± 0.0
2.841GlnTyr: 2.841 ± 0.8
0.0GlnXaa: 0.0 ± 0.0
Arg
1.776ArgAla: 1.776 ± 0.731
1.776ArgCys: 1.776 ± 1.036
0.355ArgAsp: 0.355 ± 0.31
3.196ArgGlu: 3.196 ± 1.085
3.196ArgPhe: 3.196 ± 0.895
2.131ArgGly: 2.131 ± 0.917
0.71ArgHis: 0.71 ± 0.509
4.616ArgIle: 4.616 ± 1.493
3.196ArgLys: 3.196 ± 1.086
4.972ArgLeu: 4.972 ± 1.599
1.065ArgMet: 1.065 ± 0.645
3.551ArgAsn: 3.551 ± 1.321
1.776ArgPro: 1.776 ± 0.892
2.131ArgGln: 2.131 ± 0.64
3.196ArgArg: 3.196 ± 1.204
2.486ArgSer: 2.486 ± 0.796
3.906ArgThr: 3.906 ± 1.106
4.616ArgVal: 4.616 ± 0.765
0.355ArgTrp: 0.355 ± 0.409
3.196ArgTyr: 3.196 ± 1.325
0.0ArgXaa: 0.0 ± 0.0
Ser
3.906SerAla: 3.906 ± 1.334
0.71SerCys: 0.71 ± 0.414
2.841SerAsp: 2.841 ± 0.998
3.551SerGlu: 3.551 ± 1.19
4.972SerPhe: 4.972 ± 1.12
7.812SerGly: 7.812 ± 2.11
0.355SerHis: 0.355 ± 0.44
3.906SerIle: 3.906 ± 0.83
4.972SerLys: 4.972 ± 1.491
7.457SerLeu: 7.457 ± 1.604
1.065SerMet: 1.065 ± 0.538
3.906SerAsn: 3.906 ± 1.098
1.42SerPro: 1.42 ± 0.471
3.551SerGln: 3.551 ± 1.386
4.261SerArg: 4.261 ± 1.406
9.588SerSer: 9.588 ± 3.996
3.906SerThr: 3.906 ± 1.278
2.841SerVal: 2.841 ± 1.045
0.355SerTrp: 0.355 ± 0.354
3.196SerTyr: 3.196 ± 0.761
0.0SerXaa: 0.0 ± 0.0
Thr
4.261ThrAla: 4.261 ± 1.342
0.71ThrCys: 0.71 ± 0.443
5.327ThrAsp: 5.327 ± 1.402
3.196ThrGlu: 3.196 ± 1.102
2.131ThrPhe: 2.131 ± 0.73
7.457ThrGly: 7.457 ± 1.777
0.355ThrHis: 0.355 ± 0.328
4.261ThrIle: 4.261 ± 1.007
4.261ThrLys: 4.261 ± 1.505
4.972ThrLeu: 4.972 ± 1.144
1.42ThrMet: 1.42 ± 0.677
3.551ThrAsn: 3.551 ± 1.056
2.841ThrPro: 2.841 ± 1.279
1.776ThrGln: 1.776 ± 0.759
2.486ThrArg: 2.486 ± 0.912
3.906ThrSer: 3.906 ± 1.075
6.747ThrThr: 6.747 ± 2.715
3.551ThrVal: 3.551 ± 1.141
1.42ThrTrp: 1.42 ± 0.654
2.131ThrTyr: 2.131 ± 0.996
0.0ThrXaa: 0.0 ± 0.0
Val
2.131ValAla: 2.131 ± 0.761
1.42ValCys: 1.42 ± 0.801
1.42ValAsp: 1.42 ± 0.577
3.551ValGlu: 3.551 ± 0.93
2.131ValPhe: 2.131 ± 0.783
2.841ValGly: 2.841 ± 0.986
0.355ValHis: 0.355 ± 0.367
4.972ValIle: 4.972 ± 1.473
6.392ValLys: 6.392 ± 1.407
3.906ValLeu: 3.906 ± 1.005
1.42ValMet: 1.42 ± 0.622
4.261ValAsn: 4.261 ± 1.291
3.551ValPro: 3.551 ± 1.453
1.065ValGln: 1.065 ± 0.555
4.261ValArg: 4.261 ± 1.249
1.776ValSer: 1.776 ± 0.843
3.906ValThr: 3.906 ± 0.796
3.196ValVal: 3.196 ± 1.254
1.065ValTrp: 1.065 ± 0.646
1.065ValTyr: 1.065 ± 0.518
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.355TrpAsp: 0.355 ± 0.326
1.065TrpGlu: 1.065 ± 0.633
0.71TrpPhe: 0.71 ± 0.431
0.71TrpGly: 0.71 ± 0.486
0.0TrpHis: 0.0 ± 0.0
0.355TrpIle: 0.355 ± 0.306
1.065TrpLys: 1.065 ± 0.635
1.065TrpLeu: 1.065 ± 0.497
1.065TrpMet: 1.065 ± 0.604
0.355TrpAsn: 0.355 ± 0.383
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.355TrpArg: 0.355 ± 0.357
0.355TrpSer: 0.355 ± 0.335
0.71TrpThr: 0.71 ± 0.432
0.71TrpVal: 0.71 ± 0.443
0.0TrpTrp: 0.0 ± 0.0
0.355TrpTyr: 0.355 ± 0.295
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.486TyrAla: 2.486 ± 0.856
0.71TyrCys: 0.71 ± 0.381
3.196TyrAsp: 3.196 ± 0.967
3.906TyrGlu: 3.906 ± 1.029
2.486TyrPhe: 2.486 ± 0.744
2.486TyrGly: 2.486 ± 1.096
1.065TyrHis: 1.065 ± 0.561
1.42TyrIle: 1.42 ± 0.796
1.776TyrLys: 1.776 ± 0.684
3.551TyrLeu: 3.551 ± 0.577
1.065TyrMet: 1.065 ± 0.632
1.42TyrAsn: 1.42 ± 0.454
2.486TyrPro: 2.486 ± 1.047
1.065TyrGln: 1.065 ± 0.467
3.196TyrArg: 3.196 ± 1.116
3.551TyrSer: 3.551 ± 1.29
2.131TyrThr: 2.131 ± 0.89
2.841TyrVal: 2.841 ± 0.798
0.355TyrTrp: 0.355 ± 0.378
1.776TyrTyr: 1.776 ± 0.892
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 22 proteins (2817 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski