Amino acid dipepetide frequency for Persicimonas caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.949AlaAla: 10.949 ± 0.096	1.511AlaCys: 1.511 ± 0.044	7.634AlaAsp: 7.634 ± 0.073	7.901AlaGlu: 7.901 ± 0.086	3.529AlaPhe: 3.529 ± 0.047	8.4AlaGly: 8.4 ± 0.066	2.165AlaHis: 2.165 ± 0.037	4.317AlaIle: 4.317 ± 0.047	3.686AlaLys: 3.686 ± 0.05	10.213AlaLeu: 10.213 ± 0.084	2.18AlaMet: 2.18 ± 0.035	2.735AlaAsn: 2.735 ± 0.046	4.741AlaPro: 4.741 ± 0.055	3.848AlaGln: 3.848 ± 0.04	6.824AlaArg: 6.824 ± 0.077	5.983AlaSer: 5.983 ± 0.065	5.294AlaThr: 5.294 ± 0.066	7.232AlaVal: 7.232 ± 0.055	1.279AlaTrp: 1.279 ± 0.026	2.451AlaTyr: 2.451 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.265CysAla: 1.265 ± 0.036	0.147CysCys: 0.147 ± 0.011	1.193CysAsp: 1.193 ± 0.068	0.972CysGlu: 0.972 ± 0.033	0.358CysPhe: 0.358 ± 0.012	1.213CysGly: 1.213 ± 0.035	0.294CysHis: 0.294 ± 0.013	0.403CysIle: 0.403 ± 0.015	0.295CysLys: 0.295 ± 0.012	0.852CysLeu: 0.852 ± 0.024	0.201CysMet: 0.201 ± 0.009	0.378CysAsn: 0.378 ± 0.021	0.728CysPro: 0.728 ± 0.034	0.432CysGln: 0.432 ± 0.021	0.736CysArg: 0.736 ± 0.02	0.905CysSer: 0.905 ± 0.033	0.746CysThr: 0.746 ± 0.037	0.899CysVal: 0.899 ± 0.03	0.188CysTrp: 0.188 ± 0.016	0.255CysTyr: 0.255 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.461AspAla: 8.461 ± 0.098	0.924AspCys: 0.924 ± 0.045	6.019AspAsp: 6.019 ± 0.089	6.844AspGlu: 6.844 ± 0.068	2.62AspPhe: 2.62 ± 0.033	7.178AspGly: 7.178 ± 0.119	1.375AspHis: 1.375 ± 0.026	3.076AspIle: 3.076 ± 0.041	2.336AspLys: 2.336 ± 0.035	6.001AspLeu: 6.001 ± 0.055	1.193AspMet: 1.193 ± 0.026	2.023AspAsn: 2.023 ± 0.052	3.619AspPro: 3.619 ± 0.049	2.124AspGln: 2.124 ± 0.029	4.053AspArg: 4.053 ± 0.042	3.511AspSer: 3.511 ± 0.05	3.818AspThr: 3.818 ± 0.067	5.363AspVal: 5.363 ± 0.057	1.021AspTrp: 1.021 ± 0.02	1.87AspTyr: 1.87 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.548GluAla: 8.548 ± 0.1	0.755GluCys: 0.755 ± 0.031	4.44GluAsp: 4.44 ± 0.054	6.037GluGlu: 6.037 ± 0.089	2.585GluPhe: 2.585 ± 0.035	5.438GluGly: 5.438 ± 0.058	1.92GluHis: 1.92 ± 0.031	3.262GluIle: 3.262 ± 0.045	2.883GluLys: 2.883 ± 0.05	8.392GluLeu: 8.392 ± 0.084	1.903GluMet: 1.903 ± 0.031	1.801GluAsn: 1.801 ± 0.032	4.136GluPro: 4.136 ± 0.061	3.455GluGln: 3.455 ± 0.045	6.276GluArg: 6.276 ± 0.064	3.76GluSer: 3.76 ± 0.041	3.751GluThr: 3.751 ± 0.045	5.901GluVal: 5.901 ± 0.055	0.966GluTrp: 0.966 ± 0.024	1.7GluTyr: 1.7 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.572PheAla: 3.572 ± 0.047	0.449PheCys: 0.449 ± 0.014	3.242PheAsp: 3.242 ± 0.037	3.327PheGlu: 3.327 ± 0.04	1.435PhePhe: 1.435 ± 0.029	3.469PheGly: 3.469 ± 0.047	0.746PheHis: 0.746 ± 0.017	1.319PheIle: 1.319 ± 0.027	0.964PheLys: 0.964 ± 0.023	2.937PheLeu: 2.937 ± 0.042	0.727PheMet: 0.727 ± 0.018	1.013PheAsn: 1.013 ± 0.019	1.372PhePro: 1.372 ± 0.028	0.993PheGln: 0.993 ± 0.02	2.128PheArg: 2.128 ± 0.028	2.123PheSer: 2.123 ± 0.032	1.74PheThr: 1.74 ± 0.034	2.939PheVal: 2.939 ± 0.044	0.542PheTrp: 0.542 ± 0.017	0.977PheTyr: 0.977 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	7.635GlyAla: 7.635 ± 0.078	1.235GlyCys: 1.235 ± 0.033	6.031GlyAsp: 6.031 ± 0.093	6.728GlyGlu: 6.728 ± 0.061	3.147GlyPhe: 3.147 ± 0.042	6.818GlyGly: 6.818 ± 0.083	1.733GlyHis: 1.733 ± 0.029	3.414GlyIle: 3.414 ± 0.046	2.932GlyLys: 2.932 ± 0.042	7.379GlyLeu: 7.379 ± 0.072	1.756GlyMet: 1.756 ± 0.026	2.136GlyAsn: 2.136 ± 0.043	3.148GlyPro: 3.148 ± 0.043	3.085GlyGln: 3.085 ± 0.047	5.143GlyArg: 5.143 ± 0.057	4.7GlySer: 4.7 ± 0.058	4.647GlyThr: 4.647 ± 0.067	6.14GlyVal: 6.14 ± 0.056	1.291GlyTrp: 1.291 ± 0.026	2.216GlyTyr: 2.216 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.023HisAla: 2.023 ± 0.037	0.247HisCys: 0.247 ± 0.01	1.366HisAsp: 1.366 ± 0.027	1.361HisGlu: 1.361 ± 0.026	0.896HisPhe: 0.896 ± 0.02	1.76HisGly: 1.76 ± 0.031	0.62HisHis: 0.62 ± 0.018	0.952HisIle: 0.952 ± 0.02	0.639HisLys: 0.639 ± 0.019	2.137HisLeu: 2.137 ± 0.03	0.382HisMet: 0.382 ± 0.013	0.493HisAsn: 0.493 ± 0.016	1.304HisPro: 1.304 ± 0.026	0.704HisGln: 0.704 ± 0.016	1.573HisArg: 1.573 ± 0.029	1.024HisSer: 1.024 ± 0.023	1.096HisThr: 1.096 ± 0.022	1.539HisVal: 1.539 ± 0.028	0.362HisTrp: 0.362 ± 0.012	0.644HisTyr: 0.644 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.531IleAla: 4.531 ± 0.05	0.545IleCys: 0.545 ± 0.019	3.887IleAsp: 3.887 ± 0.045	3.83IleGlu: 3.83 ± 0.046	1.574IlePhe: 1.574 ± 0.029	3.509IleGly: 3.509 ± 0.045	0.872IleHis: 0.872 ± 0.019	1.757IleIle: 1.757 ± 0.032	1.245IleLys: 1.245 ± 0.026	3.363IleLeu: 3.363 ± 0.039	0.661IleMet: 0.661 ± 0.017	1.234IleAsn: 1.234 ± 0.027	1.959IlePro: 1.959 ± 0.029	1.178IleGln: 1.178 ± 0.022	2.501IleArg: 2.501 ± 0.036	2.388IleSer: 2.388 ± 0.034	2.167IleThr: 2.167 ± 0.041	3.248IleVal: 3.248 ± 0.045	0.505IleTrp: 0.505 ± 0.016	1.127IleTyr: 1.127 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.421LysAla: 3.421 ± 0.058	0.243LysCys: 0.243 ± 0.011	1.773LysAsp: 1.773 ± 0.032	2.203LysGlu: 2.203 ± 0.04	1.056LysPhe: 1.056 ± 0.021	2.216LysGly: 2.216 ± 0.034	0.677LysHis: 0.677 ± 0.018	1.593LysIle: 1.593 ± 0.027	1.965LysLys: 1.965 ± 0.045	3.812LysLeu: 3.812 ± 0.056	0.847LysMet: 0.847 ± 0.021	0.958LysAsn: 0.958 ± 0.021	1.835LysPro: 1.835 ± 0.035	1.217LysGln: 1.217 ± 0.025	2.431LysArg: 2.431 ± 0.044	1.819LysSer: 1.819 ± 0.031	1.909LysThr: 1.909 ± 0.033	2.457LysVal: 2.457 ± 0.04	0.429LysTrp: 0.429 ± 0.013	0.867LysTyr: 0.867 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	10.609LeuAla: 10.609 ± 0.083	0.953LeuCys: 0.953 ± 0.025	7.505LeuAsp: 7.505 ± 0.074	8.102LeuGlu: 8.102 ± 0.089	3.208LeuPhe: 3.208 ± 0.041	7.689LeuGly: 7.689 ± 0.064	1.832LeuHis: 1.832 ± 0.034	3.677LeuIle: 3.677 ± 0.044	2.642LeuLys: 2.642 ± 0.041	8.878LeuLeu: 8.878 ± 0.089	1.804LeuMet: 1.804 ± 0.03	2.196LeuAsn: 2.196 ± 0.033	4.337LeuPro: 4.337 ± 0.049	3.026LeuGln: 3.026 ± 0.039	6.487LeuArg: 6.487 ± 0.059	5.793LeuSer: 5.793 ± 0.049	4.958LeuThr: 4.958 ± 0.059	7.521LeuVal: 7.521 ± 0.064	1.137LeuTrp: 1.137 ± 0.025	2.201LeuTyr: 2.201 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.17MetAla: 2.17 ± 0.028	0.218MetCys: 0.218 ± 0.011	0.974MetAsp: 0.974 ± 0.02	1.127MetGlu: 1.127 ± 0.024	0.625MetPhe: 0.625 ± 0.016	1.587MetGly: 1.587 ± 0.026	0.426MetHis: 0.426 ± 0.014	0.832MetIle: 0.832 ± 0.02	0.894MetLys: 0.894 ± 0.021	2.173MetLeu: 2.173 ± 0.033	0.523MetMet: 0.523 ± 0.018	0.665MetAsn: 0.665 ± 0.019	1.14MetPro: 1.14 ± 0.021	0.706MetGln: 0.706 ± 0.019	1.529MetArg: 1.529 ± 0.03	1.562MetSer: 1.562 ± 0.025	1.333MetThr: 1.333 ± 0.025	1.437MetVal: 1.437 ± 0.026	0.239MetTrp: 0.239 ± 0.011	0.44MetTyr: 0.44 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.618AsnAla: 2.618 ± 0.038	0.449AsnCys: 0.449 ± 0.028	1.932AsnAsp: 1.932 ± 0.043	1.67AsnGlu: 1.67 ± 0.025	1.005AsnPhe: 1.005 ± 0.021	2.286AsnGly: 2.286 ± 0.042	0.57AsnHis: 0.57 ± 0.015	1.208AsnIle: 1.208 ± 0.025	0.832AsnLys: 0.832 ± 0.021	2.586AsnLeu: 2.586 ± 0.036	0.521AsnMet: 0.521 ± 0.016	0.932AsnAsn: 0.932 ± 0.028	1.864AsnPro: 1.864 ± 0.031	0.966AsnGln: 0.966 ± 0.027	1.684AsnArg: 1.684 ± 0.027	1.404AsnSer: 1.404 ± 0.029	1.482AsnThr: 1.482 ± 0.03	1.897AsnVal: 1.897 ± 0.035	0.413AsnTrp: 0.413 ± 0.016	0.782AsnTyr: 0.782 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.703ProAla: 4.703 ± 0.054	0.41ProCys: 0.41 ± 0.016	4.018ProAsp: 4.018 ± 0.053	4.285ProGlu: 4.285 ± 0.046	1.681ProPhe: 1.681 ± 0.03	3.753ProGly: 3.753 ± 0.042	0.968ProHis: 0.968 ± 0.021	1.939ProIle: 1.939 ± 0.03	1.739ProLys: 1.739 ± 0.031	3.897ProLeu: 3.897 ± 0.04	1.014ProMet: 1.014 ± 0.019	1.622ProAsn: 1.622 ± 0.03	2.4ProPro: 2.4 ± 0.045	1.863ProGln: 1.863 ± 0.031	2.631ProArg: 2.631 ± 0.042	3.213ProSer: 3.213 ± 0.044	2.93ProThr: 2.93 ± 0.04	3.677ProVal: 3.677 ± 0.039	0.657ProTrp: 0.657 ± 0.018	1.191ProTyr: 1.191 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.761GlnAla: 3.761 ± 0.05	0.425GlnCys: 0.425 ± 0.022	1.853GlnAsp: 1.853 ± 0.029	2.112GlnGlu: 2.112 ± 0.03	1.148GlnPhe: 1.148 ± 0.023	2.342GlnGly: 2.342 ± 0.033	0.65GlnHis: 0.65 ± 0.016	1.707GlnIle: 1.707 ± 0.031	1.561GlnLys: 1.561 ± 0.027	3.501GlnLeu: 3.501 ± 0.047	0.968GlnMet: 0.968 ± 0.021	1.067GlnAsn: 1.067 ± 0.024	1.893GlnPro: 1.893 ± 0.03	1.66GlnGln: 1.66 ± 0.046	2.408GlnArg: 2.408 ± 0.031	1.943GlnSer: 1.943 ± 0.033	2.273GlnThr: 2.273 ± 0.035	2.704GlnVal: 2.704 ± 0.039	0.506GlnTrp: 0.506 ± 0.015	0.726GlnTyr: 0.726 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	6.515ArgAla: 6.515 ± 0.075	0.674ArgCys: 0.674 ± 0.02	4.259ArgAsp: 4.259 ± 0.048	4.894ArgGlu: 4.894 ± 0.06	2.649ArgPhe: 2.649 ± 0.039	4.576ArgGly: 4.576 ± 0.057	1.577ArgHis: 1.577 ± 0.035	3.076ArgIle: 3.076 ± 0.044	2.42ArgLys: 2.42 ± 0.039	7.011ArgLeu: 7.011 ± 0.067	1.45ArgMet: 1.45 ± 0.025	1.637ArgAsn: 1.637 ± 0.03	3.06ArgPro: 3.06 ± 0.043	2.757ArgGln: 2.757 ± 0.036	5.621ArgArg: 5.621 ± 0.081	3.459ArgSer: 3.459 ± 0.044	3.151ArgThr: 3.151 ± 0.04	4.897ArgVal: 4.897 ± 0.05	1.09ArgTrp: 1.09 ± 0.023	1.884ArgTyr: 1.884 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.552SerAla: 5.552 ± 0.056	0.858SerCys: 0.858 ± 0.035	4.157SerAsp: 4.157 ± 0.05	3.806SerGlu: 3.806 ± 0.045	2.204SerPhe: 2.204 ± 0.031	5.204SerGly: 5.204 ± 0.057	1.151SerHis: 1.151 ± 0.024	2.31SerIle: 2.31 ± 0.032	1.914SerLys: 1.914 ± 0.032	5.137SerLeu: 5.137 ± 0.057	1.246SerMet: 1.246 ± 0.024	1.746SerAsn: 1.746 ± 0.033	2.965SerPro: 2.965 ± 0.034	2.057SerGln: 2.057 ± 0.031	3.483SerArg: 3.483 ± 0.042	3.91SerSer: 3.91 ± 0.053	3.378SerThr: 3.378 ± 0.049	4.099SerVal: 4.099 ± 0.042	0.827SerTrp: 0.827 ± 0.021	1.486SerTyr: 1.486 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.158ThrAla: 5.158 ± 0.067	0.843ThrCys: 0.843 ± 0.037	3.949ThrAsp: 3.949 ± 0.072	3.254ThrGlu: 3.254 ± 0.044	2.033ThrPhe: 2.033 ± 0.037	4.726ThrGly: 4.726 ± 0.058	1.142ThrHis: 1.142 ± 0.022	2.552ThrIle: 2.552 ± 0.037	1.502ThrLys: 1.502 ± 0.028	5.304ThrLeu: 5.304 ± 0.057	1.007ThrMet: 1.007 ± 0.021	1.525ThrAsn: 1.525 ± 0.031	3.109ThrPro: 3.109 ± 0.042	1.641ThrGln: 1.641 ± 0.027	3.155ThrArg: 3.155 ± 0.041	3.356ThrSer: 3.356 ± 0.045	3.159ThrThr: 3.159 ± 0.048	4.426ThrVal: 4.426 ± 0.064	0.733ThrTrp: 0.733 ± 0.02	1.528ThrTyr: 1.528 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.838ValAla: 7.838 ± 0.067	1.043ValCys: 1.043 ± 0.038	6.47ValAsp: 6.47 ± 0.063	6.612ValGlu: 6.612 ± 0.059	2.665ValPhe: 2.665 ± 0.033	6.084ValGly: 6.084 ± 0.06	1.531ValHis: 1.531 ± 0.026	3.188ValIle: 3.188 ± 0.046	1.926ValLys: 1.926 ± 0.035	6.966ValLeu: 6.966 ± 0.059	1.367ValMet: 1.367 ± 0.025	1.796ValAsn: 1.796 ± 0.035	3.35ValPro: 3.35 ± 0.041	2.095ValGln: 2.095 ± 0.034	4.93ValArg: 4.93 ± 0.05	4.453ValSer: 4.453 ± 0.046	4.115ValThr: 4.115 ± 0.056	6.432ValVal: 6.432 ± 0.068	0.959ValTrp: 0.959 ± 0.025	1.845ValTyr: 1.845 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.162TrpAla: 1.162 ± 0.023	0.174TrpCys: 0.174 ± 0.008	0.781TrpAsp: 0.781 ± 0.022	0.858TrpGlu: 0.858 ± 0.018	0.502TrpPhe: 0.502 ± 0.017	1.008TrpGly: 1.008 ± 0.032	0.313TrpHis: 0.313 ± 0.012	0.564TrpIle: 0.564 ± 0.017	0.559TrpLys: 0.559 ± 0.015	1.541TrpLeu: 1.541 ± 0.028	0.381TrpMet: 0.381 ± 0.012	0.4TrpAsn: 0.4 ± 0.015	0.551TrpPro: 0.551 ± 0.017	0.593TrpGln: 0.593 ± 0.016	1.066TrpArg: 1.066 ± 0.023	0.887TrpSer: 0.887 ± 0.021	0.838TrpThr: 0.838 ± 0.021	0.98TrpVal: 0.98 ± 0.023	0.263TrpTrp: 0.263 ± 0.012	0.361TrpTyr: 0.361 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.381TyrAla: 2.381 ± 0.033	0.358TyrCys: 0.358 ± 0.018	1.947TyrAsp: 1.947 ± 0.037	1.986TyrGlu: 1.986 ± 0.033	1.095TyrPhe: 1.095 ± 0.025	2.058TyrGly: 2.058 ± 0.035	0.561TyrHis: 0.561 ± 0.015	0.933TyrIle: 0.933 ± 0.021	0.794TyrLys: 0.794 ± 0.021	2.474TyrLeu: 2.474 ± 0.031	0.467TyrMet: 0.467 ± 0.015	0.744TyrAsn: 0.744 ± 0.019	1.078TyrPro: 1.078 ± 0.022	0.81TyrGln: 0.81 ± 0.021	1.998TyrArg: 1.998 ± 0.034	1.296TyrSer: 1.296 ± 0.024	1.32TyrThr: 1.32 ± 0.028	1.876TyrVal: 1.876 ± 0.029	0.375TyrTrp: 0.375 ± 0.015	0.771TyrTyr: 0.771 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5752 proteins (2306908 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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