Amino acid dipepetide frequency for Eubacterium sp. CAG:202

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.796AlaAla: 5.796 ± 0.138
1.112AlaCys: 1.112 ± 0.047
4.95AlaAsp: 4.95 ± 0.107
5.403AlaGlu: 5.403 ± 0.132
3.361AlaPhe: 3.361 ± 0.094
4.813AlaGly: 4.813 ± 0.108
0.932AlaHis: 0.932 ± 0.046
5.37AlaIle: 5.37 ± 0.121
5.589AlaLys: 5.589 ± 0.111
6.512AlaLeu: 6.512 ± 0.133
2.066AlaMet: 2.066 ± 0.061
3.217AlaAsn: 3.217 ± 0.074
1.996AlaPro: 1.996 ± 0.061
2.239AlaGln: 2.239 ± 0.071
2.458AlaArg: 2.458 ± 0.08
3.918AlaSer: 3.918 ± 0.093
3.728AlaThr: 3.728 ± 0.097
7.06AlaVal: 7.06 ± 0.126
0.413AlaTrp: 0.413 ± 0.031
2.579AlaTyr: 2.579 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.306CysAla: 1.306 ± 0.056
0.351CysCys: 0.351 ± 0.026
1.103CysAsp: 1.103 ± 0.053
1.063CysGlu: 1.063 ± 0.051
0.661CysPhe: 0.661 ± 0.036
1.794CysGly: 1.794 ± 0.063
0.285CysHis: 0.285 ± 0.023
1.251CysIle: 1.251 ± 0.051
1.222CysLys: 1.222 ± 0.049
1.078CysLeu: 1.078 ± 0.044
0.367CysMet: 0.367 ± 0.03
0.827CysAsn: 0.827 ± 0.039
0.645CysPro: 0.645 ± 0.039
0.332CysGln: 0.332 ± 0.024
0.581CysArg: 0.581 ± 0.034
1.109CysSer: 1.109 ± 0.045
0.919CysThr: 0.919 ± 0.039
1.246CysVal: 1.246 ± 0.055
0.093CysTrp: 0.093 ± 0.014
0.619CysTyr: 0.619 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.803AspAla: 3.803 ± 0.091
1.005AspCys: 1.005 ± 0.041
3.743AspAsp: 3.743 ± 0.084
4.954AspGlu: 4.954 ± 0.107
3.138AspPhe: 3.138 ± 0.075
4.796AspGly: 4.796 ± 0.104
0.581AspHis: 0.581 ± 0.032
5.03AspIle: 5.03 ± 0.092
4.91AspLys: 4.91 ± 0.102
4.216AspLeu: 4.216 ± 0.089
1.708AspMet: 1.708 ± 0.059
3.317AspAsn: 3.317 ± 0.08
1.383AspPro: 1.383 ± 0.062
0.667AspGln: 0.667 ± 0.037
1.938AspArg: 1.938 ± 0.07
3.688AspSer: 3.688 ± 0.09
3.452AspThr: 3.452 ± 0.092
4.075AspVal: 4.075 ± 0.097
0.424AspTrp: 0.424 ± 0.03
3.08AspTyr: 3.08 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
3.896GluAla: 3.896 ± 0.089
0.921GluCys: 0.921 ± 0.046
3.33GluAsp: 3.33 ± 0.095
4.87GluGlu: 4.87 ± 0.129
2.648GluPhe: 2.648 ± 0.065
3.375GluGly: 3.375 ± 0.095
1.069GluHis: 1.069 ± 0.041
5.892GluIle: 5.892 ± 0.126
6.537GluLys: 6.537 ± 0.126
6.022GluLeu: 6.022 ± 0.143
1.898GluMet: 1.898 ± 0.058
5.388GluAsn: 5.388 ± 0.097
1.675GluPro: 1.675 ± 0.073
2.389GluGln: 2.389 ± 0.083
2.502GluArg: 2.502 ± 0.078
3.744GluSer: 3.744 ± 0.088
3.198GluThr: 3.198 ± 0.083
3.894GluVal: 3.894 ± 0.094
0.513GluTrp: 0.513 ± 0.028
2.966GluTyr: 2.966 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
3.538PheAla: 3.538 ± 0.092
0.974PheCys: 0.974 ± 0.044
3.114PheAsp: 3.114 ± 0.077
2.864PheGlu: 2.864 ± 0.08
1.98PhePhe: 1.98 ± 0.079
3.319PheGly: 3.319 ± 0.076
0.55PheHis: 0.55 ± 0.033
3.324PheIle: 3.324 ± 0.099
2.784PheLys: 2.784 ± 0.083
3.381PheLeu: 3.381 ± 0.108
1.185PheMet: 1.185 ± 0.051
2.338PheAsn: 2.338 ± 0.066
1.258PhePro: 1.258 ± 0.056
0.793PheGln: 0.793 ± 0.039
1.322PheArg: 1.322 ± 0.051
3.383PheSer: 3.383 ± 0.1
2.68PheThr: 2.68 ± 0.083
3.227PheVal: 3.227 ± 0.088
0.347PheTrp: 0.347 ± 0.026
1.757PheTyr: 1.757 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.599GlyAla: 4.599 ± 0.113
1.3GlyCys: 1.3 ± 0.046
3.702GlyAsp: 3.702 ± 0.083
4.236GlyGlu: 4.236 ± 0.089
3.153GlyPhe: 3.153 ± 0.08
4.526GlyGly: 4.526 ± 0.117
0.984GlyHis: 0.984 ± 0.046
5.88GlyIle: 5.88 ± 0.121
5.651GlyLys: 5.651 ± 0.109
5.107GlyLeu: 5.107 ± 0.102
1.934GlyMet: 1.934 ± 0.055
3.503GlyAsn: 3.503 ± 0.112
0.994GlyPro: 0.994 ± 0.042
1.472GlyGln: 1.472 ± 0.055
2.455GlyArg: 2.455 ± 0.08
3.985GlySer: 3.985 ± 0.112
4.28GlyThr: 4.28 ± 0.092
5.016GlyVal: 5.016 ± 0.099
0.583GlyTrp: 0.583 ± 0.037
3.056GlyTyr: 3.056 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
0.846HisAla: 0.846 ± 0.046
0.316HisCys: 0.316 ± 0.022
0.712HisAsp: 0.712 ± 0.039
0.69HisGlu: 0.69 ± 0.039
0.676HisPhe: 0.676 ± 0.04
1.085HisGly: 1.085 ± 0.045
0.331HisHis: 0.331 ± 0.037
1.311HisIle: 1.311 ± 0.044
0.995HisLys: 0.995 ± 0.043
1.114HisLeu: 1.114 ± 0.047
0.407HisMet: 0.407 ± 0.027
0.895HisAsn: 0.895 ± 0.042
0.689HisPro: 0.689 ± 0.038
0.331HisGln: 0.331 ± 0.027
0.698HisArg: 0.698 ± 0.036
0.972HisSer: 0.972 ± 0.042
0.988HisThr: 0.988 ± 0.036
0.44HisVal: 0.44 ± 0.032
0.126HisTrp: 0.126 ± 0.016
0.639HisTyr: 0.639 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.166IleAla: 6.166 ± 0.132
1.569IleCys: 1.569 ± 0.058
5.118IleAsp: 5.118 ± 0.102
4.933IleGlu: 4.933 ± 0.106
3.428IlePhe: 3.428 ± 0.112
5.027IleGly: 5.027 ± 0.107
1.01IleHis: 1.01 ± 0.048
6.612IleIle: 6.612 ± 0.133
5.741IleLys: 5.741 ± 0.103
6.479IleLeu: 6.479 ± 0.148
2.053IleMet: 2.053 ± 0.064
4.203IleAsn: 4.203 ± 0.087
3.039IlePro: 3.039 ± 0.087
1.646IleGln: 1.646 ± 0.048
2.689IleArg: 2.689 ± 0.069
5.88IleSer: 5.88 ± 0.123
5.025IleThr: 5.025 ± 0.1
5.279IleVal: 5.279 ± 0.118
0.513IleTrp: 0.513 ± 0.033
2.921IleTyr: 2.921 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.812LysAla: 5.812 ± 0.13
1.034LysCys: 1.034 ± 0.051
4.013LysAsp: 4.013 ± 0.081
5.629LysGlu: 5.629 ± 0.125
2.685LysPhe: 2.685 ± 0.072
4.431LysGly: 4.431 ± 0.092
1.107LysHis: 1.107 ± 0.045
6.413LysIle: 6.413 ± 0.108
6.619LysLys: 6.619 ± 0.126
6.342LysLeu: 6.342 ± 0.11
2.17LysMet: 2.17 ± 0.068
5.134LysAsn: 5.134 ± 0.12
2.508LysPro: 2.508 ± 0.069
2.36LysGln: 2.36 ± 0.071
3.1LysArg: 3.1 ± 0.077
4.838LysSer: 4.838 ± 0.088
4.475LysThr: 4.475 ± 0.096
4.601LysVal: 4.601 ± 0.095
0.537LysTrp: 0.537 ± 0.033
3.458LysTyr: 3.458 ± 0.097
0.0LysXaa: 0.0 ± 0.0
Leu
6.375LeuAla: 6.375 ± 0.123
1.688LeuCys: 1.688 ± 0.058
4.966LeuAsp: 4.966 ± 0.1
5.05LeuGlu: 5.05 ± 0.105
3.71LeuPhe: 3.71 ± 0.106
5.229LeuGly: 5.229 ± 0.099
1.182LeuHis: 1.182 ± 0.049
6.055LeuIle: 6.055 ± 0.142
6.512LeuLys: 6.512 ± 0.101
7.184LeuLeu: 7.184 ± 0.134
2.34LeuMet: 2.34 ± 0.069
4.466LeuAsn: 4.466 ± 0.094
3.096LeuPro: 3.096 ± 0.083
2.062LeuGln: 2.062 ± 0.065
3.016LeuArg: 3.016 ± 0.083
6.323LeuSer: 6.323 ± 0.123
5.014LeuThr: 5.014 ± 0.112
5.173LeuVal: 5.173 ± 0.107
0.592LeuTrp: 0.592 ± 0.034
3.131LeuTyr: 3.131 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
2.077MetAla: 2.077 ± 0.065
0.418MetCys: 0.418 ± 0.028
1.357MetAsp: 1.357 ± 0.049
1.437MetGlu: 1.437 ± 0.054
1.121MetPhe: 1.121 ± 0.044
1.699MetGly: 1.699 ± 0.061
0.416MetHis: 0.416 ± 0.026
1.865MetIle: 1.865 ± 0.063
2.21MetLys: 2.21 ± 0.059
2.674MetLeu: 2.674 ± 0.074
0.67MetMet: 0.67 ± 0.035
1.538MetAsn: 1.538 ± 0.058
1.184MetPro: 1.184 ± 0.05
0.944MetGln: 0.944 ± 0.036
1.058MetArg: 1.058 ± 0.048
1.901MetSer: 1.901 ± 0.058
1.521MetThr: 1.521 ± 0.056
1.512MetVal: 1.512 ± 0.047
0.17MetTrp: 0.17 ± 0.019
0.948MetTyr: 0.948 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
4.188AsnAla: 4.188 ± 0.099
0.992AsnCys: 0.992 ± 0.048
3.048AsnAsp: 3.048 ± 0.079
3.578AsnGlu: 3.578 ± 0.08
2.237AsnPhe: 2.237 ± 0.068
4.68AsnGly: 4.68 ± 0.117
0.778AsnHis: 0.778 ± 0.038
4.725AsnIle: 4.725 ± 0.116
3.936AsnLys: 3.936 ± 0.087
4.179AsnLeu: 4.179 ± 0.101
1.49AsnMet: 1.49 ± 0.05
3.423AsnAsn: 3.423 ± 0.123
2.278AsnPro: 2.278 ± 0.057
1.242AsnGln: 1.242 ± 0.053
1.876AsnArg: 1.876 ± 0.071
3.839AsnSer: 3.839 ± 0.113
3.206AsnThr: 3.206 ± 0.088
3.585AsnVal: 3.585 ± 0.08
0.342AsnTrp: 0.342 ± 0.028
2.437AsnTyr: 2.437 ± 0.086
0.0AsnXaa: 0.0 ± 0.0
Pro
2.115ProAla: 2.115 ± 0.068
0.508ProCys: 0.508 ± 0.033
2.206ProAsp: 2.206 ± 0.062
2.57ProGlu: 2.57 ± 0.081
1.529ProPhe: 1.529 ± 0.057
1.478ProGly: 1.478 ± 0.057
0.533ProHis: 0.533 ± 0.031
2.188ProIle: 2.188 ± 0.07
2.15ProLys: 2.15 ± 0.07
2.592ProLeu: 2.592 ± 0.063
0.763ProMet: 0.763 ± 0.037
1.646ProAsn: 1.646 ± 0.064
0.7ProPro: 0.7 ± 0.04
1.26ProGln: 1.26 ± 0.054
0.844ProArg: 0.844 ± 0.043
2.004ProSer: 2.004 ± 0.059
1.869ProThr: 1.869 ± 0.082
2.76ProVal: 2.76 ± 0.065
0.234ProTrp: 0.234 ± 0.025
1.452ProTyr: 1.452 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
1.932GlnAla: 1.932 ± 0.062
0.305GlnCys: 0.305 ± 0.024
1.039GlnAsp: 1.039 ± 0.047
1.511GlnGlu: 1.511 ± 0.063
0.926GlnPhe: 0.926 ± 0.042
1.472GlnGly: 1.472 ± 0.063
0.382GlnHis: 0.382 ± 0.028
2.161GlnIle: 2.161 ± 0.056
2.347GlnLys: 2.347 ± 0.076
2.497GlnLeu: 2.497 ± 0.077
0.857GlnMet: 0.857 ± 0.043
1.821GlnAsn: 1.821 ± 0.073
0.944GlnPro: 0.944 ± 0.055
0.899GlnGln: 0.899 ± 0.049
1.235GlnArg: 1.235 ± 0.057
1.677GlnSer: 1.677 ± 0.063
1.578GlnThr: 1.578 ± 0.056
1.434GlnVal: 1.434 ± 0.052
0.216GlnTrp: 0.216 ± 0.02
1.101GlnTyr: 1.101 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.25ArgAla: 2.25 ± 0.075
0.513ArgCys: 0.513 ± 0.028
1.837ArgAsp: 1.837 ± 0.061
2.627ArgGlu: 2.627 ± 0.078
1.66ArgPhe: 1.66 ± 0.052
2.055ArgGly: 2.055 ± 0.062
0.656ArgHis: 0.656 ± 0.042
2.937ArgIle: 2.937 ± 0.064
2.981ArgLys: 2.981 ± 0.082
3.279ArgLeu: 3.279 ± 0.086
0.961ArgMet: 0.961 ± 0.043
1.847ArgAsn: 1.847 ± 0.057
1.043ArgPro: 1.043 ± 0.047
1.189ArgGln: 1.189 ± 0.041
1.653ArgArg: 1.653 ± 0.064
1.795ArgSer: 1.795 ± 0.055
1.889ArgThr: 1.889 ± 0.053
2.38ArgVal: 2.38 ± 0.081
0.263ArgTrp: 0.263 ± 0.022
1.593ArgTyr: 1.593 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.081SerAla: 5.081 ± 0.112
0.846SerCys: 0.846 ± 0.037
4.289SerAsp: 4.289 ± 0.101
4.376SerGlu: 4.376 ± 0.098
3.001SerPhe: 3.001 ± 0.093
4.996SerGly: 4.996 ± 0.112
0.926SerHis: 0.926 ± 0.037
4.59SerIle: 4.59 ± 0.1
4.554SerLys: 4.554 ± 0.094
5.533SerLeu: 5.533 ± 0.115
1.549SerMet: 1.549 ± 0.051
3.22SerAsn: 3.22 ± 0.097
1.869SerPro: 1.869 ± 0.057
1.865SerGln: 1.865 ± 0.055
2.245SerArg: 2.245 ± 0.062
4.161SerSer: 4.161 ± 0.124
3.447SerThr: 3.447 ± 0.09
5.403SerVal: 5.403 ± 0.111
0.427SerTrp: 0.427 ± 0.03
2.72SerTyr: 2.72 ± 0.085
0.0SerXaa: 0.0 ± 0.0
Thr
5.286ThrAla: 5.286 ± 0.11
0.65ThrCys: 0.65 ± 0.035
4.024ThrAsp: 4.024 ± 0.084
3.92ThrGlu: 3.92 ± 0.089
2.396ThrPhe: 2.396 ± 0.069
4.287ThrGly: 4.287 ± 0.097
0.895ThrHis: 0.895 ± 0.037
3.987ThrIle: 3.987 ± 0.108
3.788ThrLys: 3.788 ± 0.088
4.882ThrLeu: 4.882 ± 0.094
1.182ThrMet: 1.182 ± 0.046
2.605ThrAsn: 2.605 ± 0.086
2.217ThrPro: 2.217 ± 0.063
1.648ThrGln: 1.648 ± 0.053
1.54ThrArg: 1.54 ± 0.054
3.441ThrSer: 3.441 ± 0.096
3.324ThrThr: 3.324 ± 0.126
5.491ThrVal: 5.491 ± 0.115
0.294ThrTrp: 0.294 ± 0.022
2.261ThrTyr: 2.261 ± 0.084
0.0ThrXaa: 0.0 ± 0.0
Val
5.182ValAla: 5.182 ± 0.125
1.368ValCys: 1.368 ± 0.058
3.949ValAsp: 3.949 ± 0.087
4.084ValGlu: 4.084 ± 0.095
3.388ValPhe: 3.388 ± 0.087
4.033ValGly: 4.033 ± 0.1
0.917ValHis: 0.917 ± 0.045
5.805ValIle: 5.805 ± 0.106
5.266ValLys: 5.266 ± 0.088
6.309ValLeu: 6.309 ± 0.137
1.958ValMet: 1.958 ± 0.062
3.551ValAsn: 3.551 ± 0.1
2.49ValPro: 2.49 ± 0.067
1.691ValGln: 1.691 ± 0.06
2.389ValArg: 2.389 ± 0.07
4.994ValSer: 4.994 ± 0.1
4.711ValThr: 4.711 ± 0.113
4.813ValVal: 4.813 ± 0.099
0.601ValTrp: 0.601 ± 0.037
2.826ValTyr: 2.826 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.435TrpAla: 0.435 ± 0.027
0.153TrpCys: 0.153 ± 0.017
0.437TrpAsp: 0.437 ± 0.032
0.411TrpGlu: 0.411 ± 0.029
0.343TrpPhe: 0.343 ± 0.031
0.513TrpGly: 0.513 ± 0.035
0.153TrpHis: 0.153 ± 0.017
0.519TrpIle: 0.519 ± 0.037
0.479TrpLys: 0.479 ± 0.029
0.641TrpLeu: 0.641 ± 0.039
0.192TrpMet: 0.192 ± 0.022
0.466TrpAsn: 0.466 ± 0.031
0.137TrpPro: 0.137 ± 0.016
0.312TrpGln: 0.312 ± 0.024
0.278TrpArg: 0.278 ± 0.024
0.415TrpSer: 0.415 ± 0.031
0.3TrpThr: 0.3 ± 0.026
0.402TrpVal: 0.402 ± 0.026
0.1TrpTrp: 0.1 ± 0.014
0.387TrpTyr: 0.387 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.827TyrAla: 2.827 ± 0.084
0.829TyrCys: 0.829 ± 0.042
2.966TyrAsp: 2.966 ± 0.09
2.522TyrGlu: 2.522 ± 0.07
2.075TyrPhe: 2.075 ± 0.071
2.809TyrGly: 2.809 ± 0.075
0.575TyrHis: 0.575 ± 0.038
3.414TyrIle: 3.414 ± 0.068
2.995TyrLys: 2.995 ± 0.082
3.143TyrLeu: 3.143 ± 0.094
0.97TyrMet: 0.97 ± 0.047
2.658TyrAsn: 2.658 ± 0.086
1.257TyrPro: 1.257 ± 0.048
0.992TyrGln: 0.992 ± 0.047
1.532TyrArg: 1.532 ± 0.058
3.028TyrSer: 3.028 ± 0.091
2.517TyrThr: 2.517 ± 0.091
2.533TyrVal: 2.533 ± 0.067
0.285TyrTrp: 0.285 ± 0.025
1.995TyrTyr: 1.995 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1817 proteins (547490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski