Amino acid dipepetide frequency for Streptococcus virus DT1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.102AlaAla: 3.102 ± 0.838
0.194AlaCys: 0.194 ± 0.163
4.265AlaAsp: 4.265 ± 0.644
3.005AlaGlu: 3.005 ± 0.464
2.52AlaPhe: 2.52 ± 0.844
4.071AlaGly: 4.071 ± 0.737
0.872AlaHis: 0.872 ± 0.273
5.235AlaIle: 5.235 ± 0.821
6.107AlaLys: 6.107 ± 1.134
5.816AlaLeu: 5.816 ± 0.635
1.26AlaMet: 1.26 ± 0.416
4.168AlaAsn: 4.168 ± 0.865
1.745AlaPro: 1.745 ± 0.322
2.23AlaGln: 2.23 ± 0.421
2.423AlaArg: 2.423 ± 0.418
5.235AlaSer: 5.235 ± 0.748
4.75AlaThr: 4.75 ± 0.821
3.781AlaVal: 3.781 ± 0.66
0.969AlaTrp: 0.969 ± 0.249
2.423AlaTyr: 2.423 ± 0.514
0.0AlaXaa: 0.0 ± 0.0
Cys
0.291CysAla: 0.291 ± 0.15
0.0CysCys: 0.0 ± 0.0
0.969CysAsp: 0.969 ± 0.34
0.388CysGlu: 0.388 ± 0.169
0.291CysPhe: 0.291 ± 0.263
0.194CysGly: 0.194 ± 0.135
0.194CysHis: 0.194 ± 0.143
0.194CysIle: 0.194 ± 0.149
0.291CysLys: 0.291 ± 0.183
0.582CysLeu: 0.582 ± 0.269
0.097CysMet: 0.097 ± 0.117
0.388CysAsn: 0.388 ± 0.2
0.291CysPro: 0.291 ± 0.185
0.194CysGln: 0.194 ± 0.138
0.388CysArg: 0.388 ± 0.254
0.291CysSer: 0.291 ± 0.217
0.291CysThr: 0.291 ± 0.193
0.291CysVal: 0.291 ± 0.125
0.194CysTrp: 0.194 ± 0.141
0.291CysTyr: 0.291 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
3.49AspAla: 3.49 ± 0.67
0.388AspCys: 0.388 ± 0.239
4.168AspAsp: 4.168 ± 0.675
4.362AspGlu: 4.362 ± 0.634
3.781AspPhe: 3.781 ± 0.652
5.719AspGly: 5.719 ± 0.712
0.969AspHis: 0.969 ± 0.349
4.847AspIle: 4.847 ± 0.732
5.332AspLys: 5.332 ± 0.887
3.877AspLeu: 3.877 ± 0.696
2.23AspMet: 2.23 ± 0.466
4.653AspAsn: 4.653 ± 1.113
2.133AspPro: 2.133 ± 0.498
1.357AspGln: 1.357 ± 0.281
3.199AspArg: 3.199 ± 0.567
3.199AspSer: 3.199 ± 0.427
3.781AspThr: 3.781 ± 0.678
4.265AspVal: 4.265 ± 0.773
0.872AspTrp: 0.872 ± 0.28
3.005AspTyr: 3.005 ± 0.609
0.0AspXaa: 0.0 ± 0.0
Glu
3.974GluAla: 3.974 ± 0.586
0.388GluCys: 0.388 ± 0.168
3.587GluAsp: 3.587 ± 0.817
3.005GluGlu: 3.005 ± 0.786
2.52GluPhe: 2.52 ± 0.466
3.005GluGly: 3.005 ± 0.443
0.969GluHis: 0.969 ± 0.291
6.01GluIle: 6.01 ± 0.749
3.393GluLys: 3.393 ± 0.616
6.107GluLeu: 6.107 ± 0.844
2.036GluMet: 2.036 ± 0.427
4.653GluAsn: 4.653 ± 0.749
2.326GluPro: 2.326 ± 0.598
2.617GluGln: 2.617 ± 0.497
3.005GluArg: 3.005 ± 0.532
3.005GluSer: 3.005 ± 0.549
3.393GluThr: 3.393 ± 0.531
4.556GluVal: 4.556 ± 0.715
1.454GluTrp: 1.454 ± 0.315
3.296GluTyr: 3.296 ± 0.581
0.0GluXaa: 0.0 ± 0.0
Phe
3.005PheAla: 3.005 ± 0.481
0.194PheCys: 0.194 ± 0.143
3.684PheAsp: 3.684 ± 0.622
2.326PheGlu: 2.326 ± 0.611
2.036PhePhe: 2.036 ± 0.356
3.49PheGly: 3.49 ± 0.773
0.485PheHis: 0.485 ± 0.193
2.811PheIle: 2.811 ± 0.539
4.459PheLys: 4.459 ± 0.698
3.199PheLeu: 3.199 ± 0.592
0.388PheMet: 0.388 ± 0.188
3.102PheAsn: 3.102 ± 0.676
0.582PhePro: 0.582 ± 0.222
1.26PheGln: 1.26 ± 0.311
1.745PheArg: 1.745 ± 0.428
3.393PheSer: 3.393 ± 0.493
2.617PheThr: 2.617 ± 0.445
2.908PheVal: 2.908 ± 0.569
0.582PheTrp: 0.582 ± 0.226
1.842PheTyr: 1.842 ± 0.51
0.0PheXaa: 0.0 ± 0.0
Gly
3.296GlyAla: 3.296 ± 0.646
0.485GlyCys: 0.485 ± 0.237
4.265GlyAsp: 4.265 ± 0.616
3.781GlyGlu: 3.781 ± 0.626
3.199GlyPhe: 3.199 ± 0.637
4.847GlyGly: 4.847 ± 0.906
0.582GlyHis: 0.582 ± 0.244
5.913GlyIle: 5.913 ± 0.709
6.689GlyLys: 6.689 ± 0.886
6.301GlyLeu: 6.301 ± 0.734
1.648GlyMet: 1.648 ± 0.346
4.071GlyAsn: 4.071 ± 0.528
1.066GlyPro: 1.066 ± 0.27
2.714GlyGln: 2.714 ± 0.69
3.005GlyArg: 3.005 ± 0.615
4.653GlySer: 4.653 ± 0.669
4.362GlyThr: 4.362 ± 0.618
3.974GlyVal: 3.974 ± 0.676
1.163GlyTrp: 1.163 ± 0.369
3.296GlyTyr: 3.296 ± 0.482
0.0GlyXaa: 0.0 ± 0.0
His
0.388HisAla: 0.388 ± 0.164
0.097HisCys: 0.097 ± 0.102
0.872HisAsp: 0.872 ± 0.328
0.679HisGlu: 0.679 ± 0.259
0.872HisPhe: 0.872 ± 0.3
1.163HisGly: 1.163 ± 0.379
0.388HisHis: 0.388 ± 0.197
1.163HisIle: 1.163 ± 0.323
0.679HisLys: 0.679 ± 0.246
1.163HisLeu: 1.163 ± 0.325
0.775HisMet: 0.775 ± 0.255
0.679HisAsn: 0.679 ± 0.321
0.582HisPro: 0.582 ± 0.215
0.679HisGln: 0.679 ± 0.272
0.775HisArg: 0.775 ± 0.262
1.066HisSer: 1.066 ± 0.252
0.582HisThr: 0.582 ± 0.287
1.357HisVal: 1.357 ± 0.296
0.097HisTrp: 0.097 ± 0.101
0.872HisTyr: 0.872 ± 0.381
0.0HisXaa: 0.0 ± 0.0
Ile
4.75IleAla: 4.75 ± 0.825
0.485IleCys: 0.485 ± 0.212
5.913IleAsp: 5.913 ± 0.681
4.265IleGlu: 4.265 ± 0.679
1.648IlePhe: 1.648 ± 0.438
4.653IleGly: 4.653 ± 0.696
0.872IleHis: 0.872 ± 0.275
3.296IleIle: 3.296 ± 0.54
6.883IleLys: 6.883 ± 0.773
3.877IleLeu: 3.877 ± 0.703
2.036IleMet: 2.036 ± 0.543
4.556IleAsn: 4.556 ± 0.648
4.168IlePro: 4.168 ± 0.585
3.005IleGln: 3.005 ± 0.57
3.102IleArg: 3.102 ± 0.572
4.362IleSer: 4.362 ± 0.584
4.265IleThr: 4.265 ± 0.687
2.811IleVal: 2.811 ± 0.599
0.872IleTrp: 0.872 ± 0.236
2.714IleTyr: 2.714 ± 0.547
0.0IleXaa: 0.0 ± 0.0
Lys
5.525LysAla: 5.525 ± 0.806
0.291LysCys: 0.291 ± 0.169
4.265LysAsp: 4.265 ± 1.018
6.495LysGlu: 6.495 ± 0.878
3.877LysPhe: 3.877 ± 0.793
6.107LysGly: 6.107 ± 0.587
1.357LysHis: 1.357 ± 0.44
4.847LysIle: 4.847 ± 0.734
6.786LysLys: 6.786 ± 1.144
6.495LysLeu: 6.495 ± 0.823
1.648LysMet: 1.648 ± 0.443
4.847LysAsn: 4.847 ± 0.618
2.908LysPro: 2.908 ± 0.512
3.974LysGln: 3.974 ± 0.538
3.781LysArg: 3.781 ± 0.621
4.071LysSer: 4.071 ± 0.431
5.041LysThr: 5.041 ± 0.689
4.362LysVal: 4.362 ± 0.737
0.969LysTrp: 0.969 ± 0.313
3.005LysTyr: 3.005 ± 0.633
0.0LysXaa: 0.0 ± 0.0
Leu
6.592LeuAla: 6.592 ± 0.697
0.679LeuCys: 0.679 ± 0.275
5.235LeuAsp: 5.235 ± 0.724
6.786LeuGlu: 6.786 ± 1.01
3.102LeuPhe: 3.102 ± 0.391
6.301LeuGly: 6.301 ± 0.944
0.872LeuHis: 0.872 ± 0.347
3.393LeuIle: 3.393 ± 0.466
6.979LeuLys: 6.979 ± 0.704
4.847LeuLeu: 4.847 ± 0.645
1.939LeuMet: 1.939 ± 0.472
5.138LeuAsn: 5.138 ± 0.68
2.908LeuPro: 2.908 ± 0.471
2.811LeuGln: 2.811 ± 0.549
3.393LeuArg: 3.393 ± 0.795
5.235LeuSer: 5.235 ± 0.924
5.041LeuThr: 5.041 ± 0.722
4.071LeuVal: 4.071 ± 0.572
0.485LeuTrp: 0.485 ± 0.283
2.036LeuTyr: 2.036 ± 0.45
0.0LeuXaa: 0.0 ± 0.0
Met
1.939MetAla: 1.939 ± 0.4
0.0MetCys: 0.0 ± 0.0
0.872MetAsp: 0.872 ± 0.235
1.551MetGlu: 1.551 ± 0.481
1.648MetPhe: 1.648 ± 0.317
1.066MetGly: 1.066 ± 0.313
0.291MetHis: 0.291 ± 0.175
1.648MetIle: 1.648 ± 0.352
2.617MetLys: 2.617 ± 0.524
1.648MetLeu: 1.648 ± 0.277
0.388MetMet: 0.388 ± 0.281
0.969MetAsn: 0.969 ± 0.266
1.066MetPro: 1.066 ± 0.286
0.775MetGln: 0.775 ± 0.219
0.872MetArg: 0.872 ± 0.232
1.551MetSer: 1.551 ± 0.509
1.551MetThr: 1.551 ± 0.352
2.423MetVal: 2.423 ± 0.482
0.097MetTrp: 0.097 ± 0.071
0.775MetTyr: 0.775 ± 0.265
0.0MetXaa: 0.0 ± 0.0
Asn
5.235AsnAla: 5.235 ± 1.035
0.388AsnCys: 0.388 ± 0.192
3.49AsnAsp: 3.49 ± 0.497
3.587AsnGlu: 3.587 ± 0.853
2.617AsnPhe: 2.617 ± 0.512
7.173AsnGly: 7.173 ± 1.089
0.872AsnHis: 0.872 ± 0.313
4.459AsnIle: 4.459 ± 0.677
3.781AsnLys: 3.781 ± 0.401
4.847AsnLeu: 4.847 ± 0.558
1.066AsnMet: 1.066 ± 0.289
4.653AsnAsn: 4.653 ± 0.927
3.005AsnPro: 3.005 ± 0.519
2.52AsnGln: 2.52 ± 0.433
2.423AsnArg: 2.423 ± 0.595
4.071AsnSer: 4.071 ± 0.682
3.296AsnThr: 3.296 ± 0.489
3.587AsnVal: 3.587 ± 0.528
1.454AsnTrp: 1.454 ± 0.414
2.23AsnTyr: 2.23 ± 0.474
0.0AsnXaa: 0.0 ± 0.0
Pro
1.551ProAla: 1.551 ± 0.28
0.194ProCys: 0.194 ± 0.19
1.551ProAsp: 1.551 ± 0.395
2.811ProGlu: 2.811 ± 0.531
1.357ProPhe: 1.357 ± 0.331
1.163ProGly: 1.163 ± 0.375
0.582ProHis: 0.582 ± 0.237
1.939ProIle: 1.939 ± 0.359
3.684ProLys: 3.684 ± 0.595
2.617ProLeu: 2.617 ± 0.394
0.485ProMet: 0.485 ± 0.24
3.005ProAsn: 3.005 ± 0.441
0.775ProPro: 0.775 ± 0.346
1.357ProGln: 1.357 ± 0.439
0.775ProArg: 0.775 ± 0.326
2.52ProSer: 2.52 ± 0.38
2.326ProThr: 2.326 ± 0.469
1.745ProVal: 1.745 ± 0.496
0.485ProTrp: 0.485 ± 0.188
0.969ProTyr: 0.969 ± 0.345
0.0ProXaa: 0.0 ± 0.0
Gln
3.684GlnAla: 3.684 ± 0.613
0.388GlnCys: 0.388 ± 0.196
1.648GlnAsp: 1.648 ± 0.363
2.617GlnGlu: 2.617 ± 0.443
1.26GlnPhe: 1.26 ± 0.338
2.908GlnGly: 2.908 ± 0.677
0.679GlnHis: 0.679 ± 0.285
2.23GlnIle: 2.23 ± 0.556
2.811GlnLys: 2.811 ± 0.464
3.296GlnLeu: 3.296 ± 0.454
1.745GlnMet: 1.745 ± 0.288
2.714GlnAsn: 2.714 ± 0.427
0.388GlnPro: 0.388 ± 0.186
2.52GlnGln: 2.52 ± 0.474
2.23GlnArg: 2.23 ± 0.517
2.52GlnSer: 2.52 ± 0.534
2.423GlnThr: 2.423 ± 0.478
1.939GlnVal: 1.939 ± 0.338
0.679GlnTrp: 0.679 ± 0.228
1.842GlnTyr: 1.842 ± 0.417
0.0GlnXaa: 0.0 ± 0.0
Arg
2.036ArgAla: 2.036 ± 0.48
0.097ArgCys: 0.097 ± 0.105
2.423ArgAsp: 2.423 ± 0.39
2.52ArgGlu: 2.52 ± 0.669
2.423ArgPhe: 2.423 ± 0.506
2.908ArgGly: 2.908 ± 0.574
0.872ArgHis: 0.872 ± 0.31
3.296ArgIle: 3.296 ± 0.645
3.005ArgLys: 3.005 ± 0.548
3.296ArgLeu: 3.296 ± 0.559
1.26ArgMet: 1.26 ± 0.354
2.617ArgAsn: 2.617 ± 0.445
1.163ArgPro: 1.163 ± 0.276
2.23ArgGln: 2.23 ± 0.506
1.357ArgArg: 1.357 ± 0.341
1.551ArgSer: 1.551 ± 0.341
2.811ArgThr: 2.811 ± 0.725
3.199ArgVal: 3.199 ± 0.691
1.357ArgTrp: 1.357 ± 0.314
1.939ArgTyr: 1.939 ± 0.479
0.0ArgXaa: 0.0 ± 0.0
Ser
3.296SerAla: 3.296 ± 0.493
0.485SerCys: 0.485 ± 0.211
4.556SerAsp: 4.556 ± 0.502
4.168SerGlu: 4.168 ± 0.592
2.52SerPhe: 2.52 ± 0.46
4.168SerGly: 4.168 ± 0.564
0.775SerHis: 0.775 ± 0.246
4.847SerIle: 4.847 ± 0.63
4.459SerLys: 4.459 ± 0.88
4.653SerLeu: 4.653 ± 0.6
1.842SerMet: 1.842 ± 0.364
4.362SerAsn: 4.362 ± 0.657
2.036SerPro: 2.036 ± 0.392
2.617SerGln: 2.617 ± 0.601
2.811SerArg: 2.811 ± 0.629
4.168SerSer: 4.168 ± 0.58
3.974SerThr: 3.974 ± 0.734
5.332SerVal: 5.332 ± 0.743
0.582SerTrp: 0.582 ± 0.276
1.745SerTyr: 1.745 ± 0.463
0.0SerXaa: 0.0 ± 0.0
Thr
4.459ThrAla: 4.459 ± 0.757
0.388ThrCys: 0.388 ± 0.173
4.362ThrAsp: 4.362 ± 0.708
3.877ThrGlu: 3.877 ± 0.553
3.199ThrPhe: 3.199 ± 0.534
3.199ThrGly: 3.199 ± 0.451
1.26ThrHis: 1.26 ± 0.246
4.362ThrIle: 4.362 ± 0.646
4.944ThrLys: 4.944 ± 0.595
6.398ThrLeu: 6.398 ± 0.882
0.582ThrMet: 0.582 ± 0.203
4.168ThrAsn: 4.168 ± 0.784
1.745ThrPro: 1.745 ± 0.419
2.52ThrGln: 2.52 ± 0.414
1.551ThrArg: 1.551 ± 0.391
3.393ThrSer: 3.393 ± 0.494
2.714ThrThr: 2.714 ± 0.568
3.974ThrVal: 3.974 ± 0.583
0.775ThrTrp: 0.775 ± 0.283
3.49ThrTyr: 3.49 ± 0.676
0.0ThrXaa: 0.0 ± 0.0
Val
4.071ValAla: 4.071 ± 0.695
0.291ValCys: 0.291 ± 0.141
5.525ValAsp: 5.525 ± 0.607
3.877ValGlu: 3.877 ± 0.866
2.617ValPhe: 2.617 ± 0.542
4.265ValGly: 4.265 ± 0.541
0.872ValHis: 0.872 ± 0.311
4.362ValIle: 4.362 ± 0.633
4.459ValLys: 4.459 ± 0.53
3.877ValLeu: 3.877 ± 0.897
1.454ValMet: 1.454 ± 0.43
3.587ValAsn: 3.587 ± 0.673
1.648ValPro: 1.648 ± 0.412
2.036ValGln: 2.036 ± 0.521
2.133ValArg: 2.133 ± 0.461
5.138ValSer: 5.138 ± 0.751
5.138ValThr: 5.138 ± 0.791
3.974ValVal: 3.974 ± 0.737
1.066ValTrp: 1.066 ± 0.261
1.939ValTyr: 1.939 ± 0.436
0.0ValXaa: 0.0 ± 0.0
Trp
0.485TrpAla: 0.485 ± 0.215
0.097TrpCys: 0.097 ± 0.096
1.066TrpAsp: 1.066 ± 0.383
0.969TrpGlu: 0.969 ± 0.26
0.775TrpPhe: 0.775 ± 0.274
0.872TrpGly: 0.872 ± 0.376
0.388TrpHis: 0.388 ± 0.147
0.969TrpIle: 0.969 ± 0.276
0.775TrpLys: 0.775 ± 0.365
1.551TrpLeu: 1.551 ± 0.427
0.097TrpMet: 0.097 ± 0.103
0.872TrpAsn: 0.872 ± 0.265
0.097TrpPro: 0.097 ± 0.102
0.969TrpGln: 0.969 ± 0.268
0.872TrpArg: 0.872 ± 0.266
1.551TrpSer: 1.551 ± 0.428
0.872TrpThr: 0.872 ± 0.262
1.163TrpVal: 1.163 ± 0.297
0.388TrpTrp: 0.388 ± 0.194
0.097TrpTyr: 0.097 ± 0.088
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.005TyrAla: 3.005 ± 0.519
0.582TyrCys: 0.582 ± 0.329
2.908TyrAsp: 2.908 ± 0.526
2.23TyrGlu: 2.23 ± 0.406
1.842TyrPhe: 1.842 ± 0.499
2.036TyrGly: 2.036 ± 0.4
0.775TyrHis: 0.775 ± 0.274
2.714TyrIle: 2.714 ± 0.459
2.52TyrLys: 2.52 ± 0.552
3.49TyrLeu: 3.49 ± 0.547
0.679TyrMet: 0.679 ± 0.236
1.551TyrAsn: 1.551 ± 0.423
1.26TyrPro: 1.26 ± 0.378
2.133TyrGln: 2.133 ± 0.341
2.52TyrArg: 2.52 ± 0.623
2.423TyrSer: 2.423 ± 0.612
2.133TyrThr: 2.133 ± 0.449
2.617TyrVal: 2.617 ± 0.448
0.388TyrTrp: 0.388 ± 0.174
2.326TyrTyr: 2.326 ± 0.636
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (10317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski