Amino acid dipepetide frequency for Coprobacillus sp. CAG:826

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.208AlaAla: 3.208 ± 0.11
0.924AlaCys: 0.924 ± 0.047
2.525AlaAsp: 2.525 ± 0.071
3.105AlaGlu: 3.105 ± 0.088
3.257AlaPhe: 3.257 ± 0.095
3.177AlaGly: 3.177 ± 0.09
1.313AlaHis: 1.313 ± 0.049
5.28AlaIle: 5.28 ± 0.126
4.963AlaLys: 4.963 ± 0.101
7.064AlaLeu: 7.064 ± 0.137
1.815AlaMet: 1.815 ± 0.073
2.712AlaAsn: 2.712 ± 0.074
1.622AlaPro: 1.622 ± 0.068
1.525AlaGln: 1.525 ± 0.056
2.288AlaArg: 2.288 ± 0.077
4.389AlaSer: 4.389 ± 0.109
3.519AlaThr: 3.519 ± 0.109
3.376AlaVal: 3.376 ± 0.089
0.494AlaTrp: 0.494 ± 0.035
3.074AlaTyr: 3.074 ± 0.092
0.002AlaXaa: 0.002 ± 0.002
Cys
0.695CysAla: 0.695 ± 0.044
0.191CysCys: 0.191 ± 0.031
0.683CysAsp: 0.683 ± 0.038
0.582CysGlu: 0.582 ± 0.04
0.763CysPhe: 0.763 ± 0.038
1.13CysGly: 1.13 ± 0.049
0.269CysHis: 0.269 ± 0.024
0.826CysIle: 0.826 ± 0.044
0.708CysLys: 0.708 ± 0.043
1.191CysLeu: 1.191 ± 0.052
0.25CysMet: 0.25 ± 0.025
0.466CysAsn: 0.466 ± 0.03
0.529CysPro: 0.529 ± 0.039
0.286CysGln: 0.286 ± 0.026
0.378CysArg: 0.378 ± 0.03
0.84CysSer: 0.84 ± 0.047
0.557CysThr: 0.557 ± 0.036
0.702CysVal: 0.702 ± 0.036
0.063CysTrp: 0.063 ± 0.012
0.668CysTyr: 0.668 ± 0.04
0.0CysXaa: 0.0 ± 0.0
Asp
3.813AspAla: 3.813 ± 0.1
0.597AspCys: 0.597 ± 0.034
3.183AspAsp: 3.183 ± 0.083
5.07AspGlu: 5.07 ± 0.114
3.103AspPhe: 3.103 ± 0.09
3.681AspGly: 3.681 ± 0.102
1.221AspHis: 1.221 ± 0.048
4.32AspIle: 4.32 ± 0.101
3.309AspLys: 3.309 ± 0.072
4.853AspLeu: 4.853 ± 0.11
1.364AspMet: 1.364 ± 0.051
2.416AspAsn: 2.416 ± 0.067
1.586AspPro: 1.586 ± 0.061
1.738AspGln: 1.738 ± 0.057
1.714AspArg: 1.714 ± 0.057
2.973AspSer: 2.973 ± 0.097
2.643AspThr: 2.643 ± 0.078
3.889AspVal: 3.889 ± 0.094
0.504AspTrp: 0.504 ± 0.029
3.189AspTyr: 3.189 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
4.41GluAla: 4.41 ± 0.099
0.63GluCys: 0.63 ± 0.041
4.242GluAsp: 4.242 ± 0.117
7.788GluGlu: 7.788 ± 0.17
2.523GluPhe: 2.523 ± 0.076
4.288GluGly: 4.288 ± 0.101
1.433GluHis: 1.433 ± 0.057
6.162GluIle: 6.162 ± 0.122
7.933GluLys: 7.933 ± 0.143
5.862GluLeu: 5.862 ± 0.124
2.317GluMet: 2.317 ± 0.073
4.923GluAsn: 4.923 ± 0.113
1.702GluPro: 1.702 ± 0.066
2.185GluGln: 2.185 ± 0.072
2.664GluArg: 2.664 ± 0.08
3.17GluSer: 3.17 ± 0.089
3.845GluThr: 3.845 ± 0.101
4.885GluVal: 4.885 ± 0.108
0.613GluTrp: 0.613 ± 0.036
2.906GluTyr: 2.906 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
2.857PheAla: 2.857 ± 0.084
0.557PheCys: 0.557 ± 0.037
3.158PheAsp: 3.158 ± 0.091
2.866PheGlu: 2.866 ± 0.08
2.597PhePhe: 2.597 ± 0.099
2.645PheGly: 2.645 ± 0.08
1.233PheHis: 1.233 ± 0.058
4.267PheIle: 4.267 ± 0.113
3.233PheLys: 3.233 ± 0.088
5.185PheLeu: 5.185 ± 0.133
1.265PheMet: 1.265 ± 0.056
2.099PheAsn: 2.099 ± 0.059
1.475PhePro: 1.475 ± 0.054
1.618PheGln: 1.618 ± 0.058
1.38PheArg: 1.38 ± 0.056
3.847PheSer: 3.847 ± 0.09
2.883PheThr: 2.883 ± 0.081
3.204PheVal: 3.204 ± 0.082
0.387PheTrp: 0.387 ± 0.033
2.521PheTyr: 2.521 ± 0.088
0.0PheXaa: 0.0 ± 0.0
Gly
3.658GlyAla: 3.658 ± 0.103
0.817GlyCys: 0.817 ± 0.051
2.885GlyAsp: 2.885 ± 0.078
3.626GlyGlu: 3.626 ± 0.088
3.009GlyPhe: 3.009 ± 0.077
3.53GlyGly: 3.53 ± 0.107
1.256GlyHis: 1.256 ± 0.051
4.984GlyIle: 4.984 ± 0.12
5.099GlyLys: 5.099 ± 0.103
5.259GlyLeu: 5.259 ± 0.128
1.54GlyMet: 1.54 ± 0.065
3.063GlyAsn: 3.063 ± 0.089
1.216GlyPro: 1.216 ± 0.054
1.559GlyGln: 1.559 ± 0.06
2.038GlyArg: 2.038 ± 0.062
3.557GlySer: 3.557 ± 0.102
3.839GlyThr: 3.839 ± 0.132
3.883GlyVal: 3.883 ± 0.099
0.613GlyTrp: 0.613 ± 0.041
3.315GlyTyr: 3.315 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
1.301HisAla: 1.301 ± 0.051
0.324HisCys: 0.324 ± 0.025
1.189HisAsp: 1.189 ± 0.051
1.532HisGlu: 1.532 ± 0.055
1.284HisPhe: 1.284 ± 0.056
1.174HisGly: 1.174 ± 0.051
0.849HisHis: 0.849 ± 0.053
1.769HisIle: 1.769 ± 0.059
0.962HisLys: 0.962 ± 0.044
2.193HisLeu: 2.193 ± 0.083
0.584HisMet: 0.584 ± 0.037
0.828HisAsn: 0.828 ± 0.043
1.082HisPro: 1.082 ± 0.049
0.977HisGln: 0.977 ± 0.05
0.811HisArg: 0.811 ± 0.04
1.153HisSer: 1.153 ± 0.05
1.04HisThr: 1.04 ± 0.046
1.395HisVal: 1.395 ± 0.054
0.168HisTrp: 0.168 ± 0.021
1.225HisTyr: 1.225 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.368IleAla: 5.368 ± 0.113
0.964IleCys: 0.964 ± 0.047
4.736IleAsp: 4.736 ± 0.109
5.904IleGlu: 5.904 ± 0.105
3.742IlePhe: 3.742 ± 0.103
4.683IleGly: 4.683 ± 0.11
2.002IleHis: 2.002 ± 0.068
5.887IleIle: 5.887 ± 0.155
4.832IleLys: 4.832 ± 0.094
7.828IleLeu: 7.828 ± 0.158
1.746IleMet: 1.746 ± 0.058
3.238IleAsn: 3.238 ± 0.096
2.889IlePro: 2.889 ± 0.103
3.238IleGln: 3.238 ± 0.084
3.097IleArg: 3.097 ± 0.087
5.553IleSer: 5.553 ± 0.13
4.61IleThr: 4.61 ± 0.114
5.435IleVal: 5.435 ± 0.122
0.504IleTrp: 0.504 ± 0.035
3.614IleTyr: 3.614 ± 0.083
0.0IleXaa: 0.0 ± 0.0
Lys
5.002LysAla: 5.002 ± 0.101
0.679LysCys: 0.679 ± 0.034
5.023LysAsp: 5.023 ± 0.093
9.66LysGlu: 9.66 ± 0.175
2.067LysPhe: 2.067 ± 0.07
4.509LysGly: 4.509 ± 0.096
1.204LysHis: 1.204 ± 0.049
5.811LysIle: 5.811 ± 0.114
9.339LysLys: 9.339 ± 0.161
4.834LysLeu: 4.834 ± 0.101
2.786LysMet: 2.786 ± 0.083
4.761LysAsn: 4.761 ± 0.1
1.775LysPro: 1.775 ± 0.061
2.042LysGln: 2.042 ± 0.059
3.374LysArg: 3.374 ± 0.087
3.677LysSer: 3.677 ± 0.087
4.313LysThr: 4.313 ± 0.092
5.095LysVal: 5.095 ± 0.104
0.687LysTrp: 0.687 ± 0.044
3.139LysTyr: 3.139 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
5.893LeuAla: 5.893 ± 0.135
1.202LeuCys: 1.202 ± 0.046
5.498LeuAsp: 5.498 ± 0.12
6.75LeuGlu: 6.75 ± 0.137
5.242LeuPhe: 5.242 ± 0.146
5.521LeuGly: 5.521 ± 0.119
1.994LeuHis: 1.994 ± 0.071
6.585LeuIle: 6.585 ± 0.166
8.158LeuLys: 8.158 ± 0.141
9.887LeuLeu: 9.887 ± 0.196
2.401LeuMet: 2.401 ± 0.07
4.099LeuAsn: 4.099 ± 0.095
3.441LeuPro: 3.441 ± 0.085
2.416LeuGln: 2.416 ± 0.071
3.151LeuArg: 3.151 ± 0.087
7.349LeuSer: 7.349 ± 0.145
5.326LeuThr: 5.326 ± 0.111
5.475LeuVal: 5.475 ± 0.099
0.706LeuTrp: 0.706 ± 0.042
4.036LeuTyr: 4.036 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
1.586MetAla: 1.586 ± 0.063
0.256MetCys: 0.256 ± 0.026
1.597MetAsp: 1.597 ± 0.063
1.977MetGlu: 1.977 ± 0.063
1.017MetPhe: 1.017 ± 0.046
1.53MetGly: 1.53 ± 0.063
0.498MetHis: 0.498 ± 0.035
2.332MetIle: 2.332 ± 0.08
3.242MetLys: 3.242 ± 0.085
2.103MetLeu: 2.103 ± 0.069
0.964MetMet: 0.964 ± 0.049
1.704MetAsn: 1.704 ± 0.062
0.973MetPro: 0.973 ± 0.042
0.885MetGln: 0.885 ± 0.047
1.05MetArg: 1.05 ± 0.05
1.429MetSer: 1.429 ± 0.053
1.351MetThr: 1.351 ± 0.057
1.616MetVal: 1.616 ± 0.065
0.197MetTrp: 0.197 ± 0.022
0.813MetTyr: 0.813 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.326AsnAla: 3.326 ± 0.085
0.487AsnCys: 0.487 ± 0.032
3.051AsnAsp: 3.051 ± 0.089
4.026AsnGlu: 4.026 ± 0.101
2.21AsnPhe: 2.21 ± 0.087
3.502AsnGly: 3.502 ± 0.093
1.34AsnHis: 1.34 ± 0.049
3.502AsnIle: 3.502 ± 0.082
3.303AsnLys: 3.303 ± 0.085
4.12AsnLeu: 4.12 ± 0.103
1.277AsnMet: 1.277 ± 0.054
2.431AsnAsn: 2.431 ± 0.092
1.985AsnPro: 1.985 ± 0.067
2.147AsnGln: 2.147 ± 0.071
1.717AsnArg: 1.717 ± 0.058
2.607AsnSer: 2.607 ± 0.091
2.443AsnThr: 2.443 ± 0.078
3.118AsnVal: 3.118 ± 0.089
0.405AsnTrp: 0.405 ± 0.029
2.769AsnTyr: 2.769 ± 0.088
0.0AsnXaa: 0.0 ± 0.0
Pro
1.338ProAla: 1.338 ± 0.054
0.326ProCys: 0.326 ± 0.03
1.389ProAsp: 1.389 ± 0.05
2.063ProGlu: 2.063 ± 0.074
1.906ProPhe: 1.906 ± 0.069
1.471ProGly: 1.471 ± 0.066
0.725ProHis: 0.725 ± 0.037
2.553ProIle: 2.553 ± 0.079
2.095ProLys: 2.095 ± 0.061
3.292ProLeu: 3.292 ± 0.086
0.773ProMet: 0.773 ± 0.038
1.689ProAsn: 1.689 ± 0.056
0.511ProPro: 0.511 ± 0.038
0.927ProGln: 0.927 ± 0.039
0.874ProArg: 0.874 ± 0.048
2.532ProSer: 2.532 ± 0.077
2.288ProThr: 2.288 ± 0.088
1.777ProVal: 1.777 ± 0.066
0.267ProTrp: 0.267 ± 0.027
1.773ProTyr: 1.773 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
1.714GlnAla: 1.714 ± 0.066
0.334GlnCys: 0.334 ± 0.028
1.788GlnAsp: 1.788 ± 0.06
2.555GlnGlu: 2.555 ± 0.082
1.416GlnPhe: 1.416 ± 0.056
1.637GlnGly: 1.637 ± 0.057
0.5GlnHis: 0.5 ± 0.031
2.668GlnIle: 2.668 ± 0.088
3.065GlnLys: 3.065 ± 0.079
2.593GlnLeu: 2.593 ± 0.079
1.006GlnMet: 1.006 ± 0.046
1.969GlnAsn: 1.969 ± 0.067
0.807GlnPro: 0.807 ± 0.042
0.933GlnGln: 0.933 ± 0.041
1.082GlnArg: 1.082 ± 0.048
1.616GlnSer: 1.616 ± 0.058
1.559GlnThr: 1.559 ± 0.058
1.882GlnVal: 1.882 ± 0.065
0.219GlnTrp: 0.219 ± 0.021
1.626GlnTyr: 1.626 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
1.92ArgAla: 1.92 ± 0.073
0.389ArgCys: 0.389 ± 0.029
1.66ArgAsp: 1.66 ± 0.061
2.311ArgGlu: 2.311 ± 0.075
1.927ArgPhe: 1.927 ± 0.063
1.882ArgGly: 1.882 ± 0.072
0.708ArgHis: 0.708 ± 0.041
3.252ArgIle: 3.252 ± 0.082
3.343ArgLys: 3.343 ± 0.098
3.504ArgLeu: 3.504 ± 0.094
1.145ArgMet: 1.145 ± 0.052
1.88ArgAsn: 1.88 ± 0.062
1.084ArgPro: 1.084 ± 0.05
0.962ArgGln: 0.962 ± 0.049
1.538ArgArg: 1.538 ± 0.064
1.809ArgSer: 1.809 ± 0.063
1.765ArgThr: 1.765 ± 0.06
2.452ArgVal: 2.452 ± 0.071
0.294ArgTrp: 0.294 ± 0.029
1.853ArgTyr: 1.853 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
3.366SerAla: 3.366 ± 0.095
0.895SerCys: 0.895 ± 0.044
2.996SerAsp: 2.996 ± 0.088
3.313SerGlu: 3.313 ± 0.085
3.927SerPhe: 3.927 ± 0.105
3.839SerGly: 3.839 ± 0.099
1.322SerHis: 1.322 ± 0.052
5.374SerIle: 5.374 ± 0.118
4.561SerLys: 4.561 ± 0.1
7.32SerLeu: 7.32 ± 0.146
1.639SerMet: 1.639 ± 0.07
3.2SerAsn: 3.2 ± 0.1
1.651SerPro: 1.651 ± 0.062
1.59SerGln: 1.59 ± 0.059
2.051SerArg: 2.051 ± 0.065
5.444SerSer: 5.444 ± 0.172
3.668SerThr: 3.668 ± 0.11
3.763SerVal: 3.763 ± 0.098
0.582SerTrp: 0.582 ± 0.032
3.582SerTyr: 3.582 ± 0.101
0.0SerXaa: 0.0 ± 0.0
Thr
2.925ThrAla: 2.925 ± 0.098
0.681ThrCys: 0.681 ± 0.046
2.475ThrAsp: 2.475 ± 0.082
2.88ThrGlu: 2.88 ± 0.087
3.164ThrPhe: 3.164 ± 0.093
3.16ThrGly: 3.16 ± 0.099
1.214ThrHis: 1.214 ± 0.053
5.267ThrIle: 5.267 ± 0.117
3.941ThrLys: 3.941 ± 0.094
6.208ThrLeu: 6.208 ± 0.126
1.435ThrMet: 1.435 ± 0.063
2.572ThrAsn: 2.572 ± 0.076
2.347ThrPro: 2.347 ± 0.075
1.412ThrGln: 1.412 ± 0.061
1.853ThrArg: 1.853 ± 0.063
4.166ThrSer: 4.166 ± 0.111
3.513ThrThr: 3.513 ± 0.122
3.07ThrVal: 3.07 ± 0.111
0.55ThrTrp: 0.55 ± 0.034
3.116ThrTyr: 3.116 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
3.988ValAla: 3.988 ± 0.098
0.786ValCys: 0.786 ± 0.041
3.662ValAsp: 3.662 ± 0.088
4.427ValGlu: 4.427 ± 0.11
3.013ValPhe: 3.013 ± 0.086
3.904ValGly: 3.904 ± 0.09
1.242ValHis: 1.242 ± 0.053
5.078ValIle: 5.078 ± 0.108
4.336ValLys: 4.336 ± 0.101
6.055ValLeu: 6.055 ± 0.139
1.563ValMet: 1.563 ± 0.058
2.943ValAsn: 2.943 ± 0.093
1.939ValPro: 1.939 ± 0.069
1.761ValGln: 1.761 ± 0.055
2.37ValArg: 2.37 ± 0.078
4.542ValSer: 4.542 ± 0.099
3.836ValThr: 3.836 ± 0.129
4.248ValVal: 4.248 ± 0.105
0.462ValTrp: 0.462 ± 0.031
2.725ValTyr: 2.725 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.412TrpAla: 0.412 ± 0.029
0.134TrpCys: 0.134 ± 0.018
0.492TrpAsp: 0.492 ± 0.032
0.458TrpGlu: 0.458 ± 0.031
0.397TrpPhe: 0.397 ± 0.034
0.487TrpGly: 0.487 ± 0.036
0.197TrpHis: 0.197 ± 0.019
0.695TrpIle: 0.695 ± 0.036
0.672TrpLys: 0.672 ± 0.042
0.819TrpLeu: 0.819 ± 0.042
0.273TrpMet: 0.273 ± 0.022
0.616TrpAsn: 0.616 ± 0.039
0.231TrpPro: 0.231 ± 0.023
0.197TrpGln: 0.197 ± 0.022
0.244TrpArg: 0.244 ± 0.024
0.492TrpSer: 0.492 ± 0.031
0.448TrpThr: 0.448 ± 0.036
0.443TrpVal: 0.443 ± 0.026
0.141TrpTrp: 0.141 ± 0.022
0.403TrpTyr: 0.403 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.851TyrAla: 2.851 ± 0.071
0.605TyrCys: 0.605 ± 0.038
2.933TyrAsp: 2.933 ± 0.096
3.591TyrGlu: 3.591 ± 0.108
2.714TyrPhe: 2.714 ± 0.083
2.996TyrGly: 2.996 ± 0.079
1.319TyrHis: 1.319 ± 0.047
3.257TyrIle: 3.257 ± 0.082
2.683TyrLys: 2.683 ± 0.079
4.96TyrLeu: 4.96 ± 0.087
0.973TyrMet: 0.973 ± 0.047
2.16TyrAsn: 2.16 ± 0.069
1.721TyrPro: 1.721 ± 0.064
2.572TyrGln: 2.572 ± 0.086
2.004TyrArg: 2.004 ± 0.066
2.937TyrSer: 2.937 ± 0.091
2.504TyrThr: 2.504 ± 0.076
3.173TyrVal: 3.173 ± 0.086
0.395TyrTrp: 0.395 ± 0.031
2.677TyrTyr: 2.677 ± 0.086
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.002XaaAsp: 0.002 ± 0.002
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 1394 proteins (475966 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski