Amino acid dipepetide frequency for Bluetongue virus 16

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.707AlaAla: 6.707 ± 1.24
1.204AlaCys: 1.204 ± 0.48
3.439AlaAsp: 3.439 ± 0.399
4.643AlaGlu: 4.643 ± 1.181
1.892AlaPhe: 1.892 ± 0.696
2.58AlaGly: 2.58 ± 0.77
0.516AlaHis: 0.516 ± 0.209
5.159AlaIle: 5.159 ± 1.241
3.439AlaLys: 3.439 ± 0.891
6.707AlaLeu: 6.707 ± 0.975
1.892AlaMet: 1.892 ± 0.692
2.408AlaAsn: 2.408 ± 0.514
2.923AlaPro: 2.923 ± 0.731
1.892AlaGln: 1.892 ± 0.487
3.439AlaArg: 3.439 ± 1.165
2.752AlaSer: 2.752 ± 0.626
5.159AlaThr: 5.159 ± 0.914
4.299AlaVal: 4.299 ± 0.673
1.032AlaTrp: 1.032 ± 0.236
3.439AlaTyr: 3.439 ± 0.23
0.0AlaXaa: 0.0 ± 0.0
Cys
0.516CysAla: 0.516 ± 0.259
0.516CysCys: 0.516 ± 0.273
0.344CysAsp: 0.344 ± 0.332
0.516CysGlu: 0.516 ± 0.286
0.86CysPhe: 0.86 ± 0.465
1.72CysGly: 1.72 ± 0.517
0.344CysHis: 0.344 ± 0.189
0.344CysIle: 0.344 ± 0.253
0.86CysLys: 0.86 ± 0.503
1.032CysLeu: 1.032 ± 0.291
0.172CysMet: 0.172 ± 0.124
0.344CysAsn: 0.344 ± 0.203
0.344CysPro: 0.344 ± 0.216
0.344CysGln: 0.344 ± 0.275
0.344CysArg: 0.344 ± 0.199
0.688CysSer: 0.688 ± 0.413
0.344CysThr: 0.344 ± 0.19
0.86CysVal: 0.86 ± 0.356
0.172CysTrp: 0.172 ± 0.124
1.548CysTyr: 1.548 ± 0.686
0.0CysXaa: 0.0 ± 0.0
Asp
2.923AspAla: 2.923 ± 0.664
0.516AspCys: 0.516 ± 0.185
4.643AspAsp: 4.643 ± 0.855
6.707AspGlu: 6.707 ± 1.687
2.58AspPhe: 2.58 ± 0.638
2.752AspGly: 2.752 ± 0.47
1.548AspHis: 1.548 ± 0.402
3.955AspIle: 3.955 ± 0.572
2.752AspLys: 2.752 ± 0.84
6.019AspLeu: 6.019 ± 1.288
2.58AspMet: 2.58 ± 0.822
0.688AspAsn: 0.688 ± 0.665
2.923AspPro: 2.923 ± 0.386
0.516AspGln: 0.516 ± 0.221
3.783AspArg: 3.783 ± 0.65
3.611AspSer: 3.611 ± 0.779
3.095AspThr: 3.095 ± 0.6
7.051AspVal: 7.051 ± 1.076
0.516AspTrp: 0.516 ± 0.401
2.064AspTyr: 2.064 ± 0.571
0.0AspXaa: 0.0 ± 0.0
Glu
6.019GluAla: 6.019 ± 0.934
0.344GluCys: 0.344 ± 0.332
4.127GluAsp: 4.127 ± 0.759
8.426GluGlu: 8.426 ± 1.354
3.267GluPhe: 3.267 ± 0.918
3.439GluGly: 3.439 ± 0.756
1.204GluHis: 1.204 ± 0.297
5.503GluIle: 5.503 ± 1.331
3.611GluLys: 3.611 ± 0.912
5.847GluLeu: 5.847 ± 0.622
2.408GluMet: 2.408 ± 0.386
1.548GluAsn: 1.548 ± 0.266
3.267GluPro: 3.267 ± 0.968
2.408GluGln: 2.408 ± 0.502
6.019GluArg: 6.019 ± 1.069
3.439GluSer: 3.439 ± 0.859
1.72GluThr: 1.72 ± 0.399
4.471GluVal: 4.471 ± 0.252
1.72GluTrp: 1.72 ± 0.659
2.58GluTyr: 2.58 ± 0.346
0.0GluXaa: 0.0 ± 0.0
Phe
2.064PheAla: 2.064 ± 0.882
0.344PheCys: 0.344 ± 0.215
2.923PheAsp: 2.923 ± 1.026
2.923PheGlu: 2.923 ± 0.404
2.236PhePhe: 2.236 ± 0.852
2.58PheGly: 2.58 ± 0.492
1.376PheHis: 1.376 ± 0.501
2.752PheIle: 2.752 ± 0.84
2.923PheLys: 2.923 ± 0.648
3.439PheLeu: 3.439 ± 0.903
1.204PheMet: 1.204 ± 0.427
1.548PheAsn: 1.548 ± 0.363
1.892PhePro: 1.892 ± 0.702
1.376PheGln: 1.376 ± 0.317
3.439PheArg: 3.439 ± 0.893
2.58PheSer: 2.58 ± 0.413
2.408PheThr: 2.408 ± 0.572
1.72PheVal: 1.72 ± 0.569
0.344PheTrp: 0.344 ± 0.203
3.095PheTyr: 3.095 ± 0.71
0.0PheXaa: 0.0 ± 0.0
Gly
4.127GlyAla: 4.127 ± 0.786
0.86GlyCys: 0.86 ± 0.368
4.643GlyAsp: 4.643 ± 0.65
4.643GlyGlu: 4.643 ± 0.85
2.58GlyPhe: 2.58 ± 0.357
2.064GlyGly: 2.064 ± 0.432
1.204GlyHis: 1.204 ± 0.315
3.267GlyIle: 3.267 ± 0.582
2.58GlyLys: 2.58 ± 0.777
3.611GlyLeu: 3.611 ± 0.584
2.064GlyMet: 2.064 ± 0.418
1.72GlyAsn: 1.72 ± 0.487
2.064GlyPro: 2.064 ± 0.724
1.376GlyGln: 1.376 ± 0.541
3.955GlyArg: 3.955 ± 0.636
2.752GlySer: 2.752 ± 0.838
1.72GlyThr: 1.72 ± 0.355
4.643GlyVal: 4.643 ± 1.266
0.86GlyTrp: 0.86 ± 0.274
2.58GlyTyr: 2.58 ± 0.675
0.0GlyXaa: 0.0 ± 0.0
His
1.548HisAla: 1.548 ± 0.417
0.688HisCys: 0.688 ± 0.235
0.86HisAsp: 0.86 ± 0.342
0.516HisGlu: 0.516 ± 0.336
1.032HisPhe: 1.032 ± 0.561
1.548HisGly: 1.548 ± 0.565
0.172HisHis: 0.172 ± 0.166
1.892HisIle: 1.892 ± 0.496
1.032HisLys: 1.032 ± 0.621
2.408HisLeu: 2.408 ± 0.638
1.548HisMet: 1.548 ± 0.612
1.548HisAsn: 1.548 ± 0.221
1.376HisPro: 1.376 ± 0.366
1.032HisGln: 1.032 ± 0.354
2.236HisArg: 2.236 ± 0.627
1.204HisSer: 1.204 ± 0.264
1.376HisThr: 1.376 ± 0.524
1.204HisVal: 1.204 ± 0.486
0.344HisTrp: 0.344 ± 0.196
0.86HisTyr: 0.86 ± 0.313
0.0HisXaa: 0.0 ± 0.0
Ile
5.675IleAla: 5.675 ± 0.697
0.344IleCys: 0.344 ± 0.332
4.127IleAsp: 4.127 ± 0.804
3.783IleGlu: 3.783 ± 0.581
2.58IlePhe: 2.58 ± 0.595
4.471IleGly: 4.471 ± 0.511
1.548IleHis: 1.548 ± 0.553
2.923IleIle: 2.923 ± 0.646
4.815IleLys: 4.815 ± 0.656
6.191IleLeu: 6.191 ± 0.818
2.408IleMet: 2.408 ± 0.585
3.267IleAsn: 3.267 ± 0.795
2.58IlePro: 2.58 ± 0.534
3.439IleGln: 3.439 ± 0.488
4.643IleArg: 4.643 ± 0.716
4.299IleSer: 4.299 ± 0.648
3.611IleThr: 3.611 ± 0.66
3.783IleVal: 3.783 ± 0.559
0.688IleTrp: 0.688 ± 0.21
2.408IleTyr: 2.408 ± 0.694
0.0IleXaa: 0.0 ± 0.0
Lys
3.095LysAla: 3.095 ± 0.793
0.344LysCys: 0.344 ± 0.189
2.923LysAsp: 2.923 ± 0.759
3.267LysGlu: 3.267 ± 0.789
2.923LysPhe: 2.923 ± 0.579
3.267LysGly: 3.267 ± 0.567
1.892LysHis: 1.892 ± 0.596
4.815LysIle: 4.815 ± 0.924
4.815LysLys: 4.815 ± 1.305
3.611LysLeu: 3.611 ± 0.537
2.923LysMet: 2.923 ± 0.691
1.72LysAsn: 1.72 ± 0.458
1.548LysPro: 1.548 ± 0.987
2.58LysGln: 2.58 ± 0.82
4.643LysArg: 4.643 ± 0.948
2.752LysSer: 2.752 ± 0.876
2.236LysThr: 2.236 ± 0.489
4.471LysVal: 4.471 ± 0.688
0.516LysTrp: 0.516 ± 0.369
1.892LysTyr: 1.892 ± 0.394
0.0LysXaa: 0.0 ± 0.0
Leu
4.987LeuAla: 4.987 ± 1.039
1.204LeuCys: 1.204 ± 0.39
5.503LeuAsp: 5.503 ± 0.835
5.847LeuGlu: 5.847 ± 0.741
3.095LeuPhe: 3.095 ± 0.898
3.955LeuGly: 3.955 ± 1.12
1.892LeuHis: 1.892 ± 0.343
5.159LeuIle: 5.159 ± 0.765
6.019LeuLys: 6.019 ± 1.011
6.019LeuLeu: 6.019 ± 1.29
2.064LeuMet: 2.064 ± 0.507
4.299LeuAsn: 4.299 ± 0.67
5.331LeuPro: 5.331 ± 0.895
2.923LeuGln: 2.923 ± 0.967
7.223LeuArg: 7.223 ± 0.806
5.675LeuSer: 5.675 ± 0.702
4.643LeuThr: 4.643 ± 0.831
4.471LeuVal: 4.471 ± 0.845
1.032LeuTrp: 1.032 ± 0.422
2.752LeuTyr: 2.752 ± 0.915
0.0LeuXaa: 0.0 ± 0.0
Met
2.236MetAla: 2.236 ± 0.329
0.516MetCys: 0.516 ± 0.25
2.408MetAsp: 2.408 ± 0.536
1.892MetGlu: 1.892 ± 0.548
2.236MetPhe: 2.236 ± 0.491
1.376MetGly: 1.376 ± 0.696
1.548MetHis: 1.548 ± 0.619
3.439MetIle: 3.439 ± 0.587
2.408MetLys: 2.408 ± 0.55
3.955MetLeu: 3.955 ± 1.017
2.064MetMet: 2.064 ± 0.448
1.376MetAsn: 1.376 ± 0.437
1.548MetPro: 1.548 ± 0.715
1.376MetGln: 1.376 ± 0.436
3.611MetArg: 3.611 ± 0.629
2.064MetSer: 2.064 ± 0.59
1.892MetThr: 1.892 ± 0.668
2.236MetVal: 2.236 ± 0.365
0.516MetTrp: 0.516 ± 0.254
0.688MetTyr: 0.688 ± 0.233
0.0MetXaa: 0.0 ± 0.0
Asn
2.923AsnAla: 2.923 ± 0.973
0.344AsnCys: 0.344 ± 0.395
3.095AsnAsp: 3.095 ± 0.494
3.955AsnGlu: 3.955 ± 0.637
2.064AsnPhe: 2.064 ± 0.57
2.58AsnGly: 2.58 ± 0.481
1.376AsnHis: 1.376 ± 0.828
1.892AsnIle: 1.892 ± 0.477
1.032AsnLys: 1.032 ± 0.601
2.923AsnLeu: 2.923 ± 0.601
1.548AsnMet: 1.548 ± 0.361
1.376AsnAsn: 1.376 ± 0.436
2.58AsnPro: 2.58 ± 0.546
1.548AsnGln: 1.548 ± 0.405
2.408AsnArg: 2.408 ± 0.449
2.064AsnSer: 2.064 ± 0.886
1.892AsnThr: 1.892 ± 0.37
3.267AsnVal: 3.267 ± 0.585
0.344AsnTrp: 0.344 ± 0.215
0.688AsnTyr: 0.688 ± 0.208
0.0AsnXaa: 0.0 ± 0.0
Pro
1.892ProAla: 1.892 ± 0.481
0.516ProCys: 0.516 ± 0.333
3.611ProAsp: 3.611 ± 0.768
2.923ProGlu: 2.923 ± 0.703
1.376ProPhe: 1.376 ± 0.397
2.752ProGly: 2.752 ± 0.535
0.688ProHis: 0.688 ± 0.27
2.923ProIle: 2.923 ± 0.768
1.72ProLys: 1.72 ± 0.505
4.299ProLeu: 4.299 ± 0.519
1.204ProMet: 1.204 ± 0.438
1.548ProAsn: 1.548 ± 0.422
1.548ProPro: 1.548 ± 0.425
2.064ProGln: 2.064 ± 0.454
2.923ProArg: 2.923 ± 0.493
1.892ProSer: 1.892 ± 0.638
3.267ProThr: 3.267 ± 1.203
2.58ProVal: 2.58 ± 0.489
0.516ProTrp: 0.516 ± 0.229
2.58ProTyr: 2.58 ± 0.629
0.0ProXaa: 0.0 ± 0.0
Gln
1.892GlnAla: 1.892 ± 0.438
0.516GlnCys: 0.516 ± 0.317
1.204GlnAsp: 1.204 ± 0.409
2.58GlnGlu: 2.58 ± 0.774
1.204GlnPhe: 1.204 ± 0.267
2.236GlnGly: 2.236 ± 0.645
0.688GlnHis: 0.688 ± 0.319
4.127GlnIle: 4.127 ± 0.992
1.548GlnLys: 1.548 ± 0.419
2.923GlnLeu: 2.923 ± 0.672
1.548GlnMet: 1.548 ± 0.838
1.72GlnAsn: 1.72 ± 0.541
1.72GlnPro: 1.72 ± 0.505
1.376GlnGln: 1.376 ± 0.489
3.439GlnArg: 3.439 ± 0.609
2.064GlnSer: 2.064 ± 0.59
1.548GlnThr: 1.548 ± 0.577
3.095GlnVal: 3.095 ± 0.835
0.516GlnTrp: 0.516 ± 0.277
1.204GlnTyr: 1.204 ± 0.284
0.0GlnXaa: 0.0 ± 0.0
Arg
4.127ArgAla: 4.127 ± 0.985
0.688ArgCys: 0.688 ± 0.388
4.987ArgAsp: 4.987 ± 0.53
5.159ArgGlu: 5.159 ± 0.909
4.815ArgPhe: 4.815 ± 0.845
3.095ArgGly: 3.095 ± 0.305
1.032ArgHis: 1.032 ± 0.411
5.331ArgIle: 5.331 ± 0.939
3.611ArgLys: 3.611 ± 0.843
4.299ArgLeu: 4.299 ± 0.555
3.095ArgMet: 3.095 ± 0.591
4.299ArgAsn: 4.299 ± 0.726
1.72ArgPro: 1.72 ± 0.477
2.408ArgGln: 2.408 ± 0.523
3.783ArgArg: 3.783 ± 0.389
3.095ArgSer: 3.095 ± 0.546
4.127ArgThr: 4.127 ± 0.74
6.707ArgVal: 6.707 ± 0.63
1.548ArgTrp: 1.548 ± 0.656
2.408ArgTyr: 2.408 ± 0.518
0.0ArgXaa: 0.0 ± 0.0
Ser
3.783SerAla: 3.783 ± 0.869
0.0SerCys: 0.0 ± 0.0
2.58SerAsp: 2.58 ± 0.522
3.267SerGlu: 3.267 ± 0.516
1.892SerPhe: 1.892 ± 0.547
3.267SerGly: 3.267 ± 0.978
1.892SerHis: 1.892 ± 0.412
3.783SerIle: 3.783 ± 0.475
1.72SerLys: 1.72 ± 0.433
4.299SerLeu: 4.299 ± 0.828
2.236SerMet: 2.236 ± 0.348
2.236SerAsn: 2.236 ± 0.598
2.064SerPro: 2.064 ± 0.578
2.752SerGln: 2.752 ± 0.323
3.783SerArg: 3.783 ± 0.782
3.955SerSer: 3.955 ± 0.77
4.127SerThr: 4.127 ± 0.756
4.815SerVal: 4.815 ± 0.801
0.86SerTrp: 0.86 ± 0.269
2.064SerTyr: 2.064 ± 0.471
0.0SerXaa: 0.0 ± 0.0
Thr
2.752ThrAla: 2.752 ± 0.719
1.032ThrCys: 1.032 ± 0.735
2.064ThrAsp: 2.064 ± 0.583
2.752ThrGlu: 2.752 ± 0.574
1.72ThrPhe: 1.72 ± 0.582
2.923ThrGly: 2.923 ± 0.807
2.064ThrHis: 2.064 ± 0.763
3.955ThrIle: 3.955 ± 0.835
3.439ThrLys: 3.439 ± 0.848
5.503ThrLeu: 5.503 ± 1.118
1.892ThrMet: 1.892 ± 0.524
2.236ThrAsn: 2.236 ± 0.526
2.923ThrPro: 2.923 ± 0.511
2.064ThrGln: 2.064 ± 0.569
2.923ThrArg: 2.923 ± 0.411
2.236ThrSer: 2.236 ± 0.693
3.611ThrThr: 3.611 ± 0.658
3.095ThrVal: 3.095 ± 0.579
0.516ThrTrp: 0.516 ± 0.37
2.58ThrTyr: 2.58 ± 0.811
0.0ThrXaa: 0.0 ± 0.0
Val
4.127ValAla: 4.127 ± 1.022
1.204ValCys: 1.204 ± 0.545
3.439ValAsp: 3.439 ± 0.604
4.127ValGlu: 4.127 ± 0.525
2.923ValPhe: 2.923 ± 0.622
4.127ValGly: 4.127 ± 0.377
1.72ValHis: 1.72 ± 0.439
3.439ValIle: 3.439 ± 1.086
4.643ValLys: 4.643 ± 0.785
7.051ValLeu: 7.051 ± 1.534
4.127ValMet: 4.127 ± 0.826
2.408ValAsn: 2.408 ± 0.493
3.267ValPro: 3.267 ± 0.606
3.955ValGln: 3.955 ± 0.548
5.503ValArg: 5.503 ± 1.198
4.471ValSer: 4.471 ± 1.105
2.923ValThr: 2.923 ± 1.028
3.439ValVal: 3.439 ± 0.702
1.032ValTrp: 1.032 ± 0.186
2.752ValTyr: 2.752 ± 0.65
0.0ValXaa: 0.0 ± 0.0
Trp
0.86TrpAla: 0.86 ± 0.358
0.172TrpCys: 0.172 ± 0.124
0.86TrpAsp: 0.86 ± 0.277
0.86TrpGlu: 0.86 ± 0.44
0.86TrpPhe: 0.86 ± 0.264
0.344TrpGly: 0.344 ± 0.194
0.86TrpHis: 0.86 ± 0.555
1.032TrpIle: 1.032 ± 0.365
1.204TrpLys: 1.204 ± 0.296
1.204TrpLeu: 1.204 ± 0.58
0.516TrpMet: 0.516 ± 0.286
1.204TrpAsn: 1.204 ± 0.484
0.0TrpPro: 0.0 ± 0.0
0.516TrpGln: 0.516 ± 0.448
0.172TrpArg: 0.172 ± 0.168
0.86TrpSer: 0.86 ± 0.464
0.516TrpThr: 0.516 ± 0.237
0.86TrpVal: 0.86 ± 0.442
0.344TrpTrp: 0.344 ± 0.199
0.344TrpTyr: 0.344 ± 0.332
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.439TyrAla: 3.439 ± 1.152
0.86TyrCys: 0.86 ± 0.478
3.439TyrAsp: 3.439 ± 0.721
2.58TyrGlu: 2.58 ± 0.7
1.032TyrPhe: 1.032 ± 0.293
2.236TyrGly: 2.236 ± 0.276
0.86TyrHis: 0.86 ± 0.446
1.892TyrIle: 1.892 ± 0.322
2.064TyrLys: 2.064 ± 0.306
2.752TyrLeu: 2.752 ± 0.424
1.72TyrMet: 1.72 ± 0.4
2.408TyrAsn: 2.408 ± 0.681
1.204TyrPro: 1.204 ± 0.432
1.204TyrGln: 1.204 ± 0.471
2.064TyrArg: 2.064 ± 0.493
2.923TyrSer: 2.923 ± 0.794
2.064TyrThr: 2.064 ± 0.385
3.611TyrVal: 3.611 ± 0.918
0.172TyrTrp: 0.172 ± 0.166
0.86TyrTyr: 0.86 ± 0.42
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (5816 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski