Amino acid dipepetide frequency for Vulpes vulpes papillomavirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.344AlaAla: 4.344 ± 2.058
0.869AlaCys: 0.869 ± 0.691
3.475AlaAsp: 3.475 ± 1.267
2.606AlaGlu: 2.606 ± 0.521
1.738AlaPhe: 1.738 ± 0.819
2.606AlaGly: 2.606 ± 0.536
0.434AlaHis: 0.434 ± 0.378
2.172AlaIle: 2.172 ± 0.473
4.344AlaLys: 4.344 ± 1.072
6.082AlaLeu: 6.082 ± 2.297
0.434AlaMet: 0.434 ± 0.346
2.172AlaAsn: 2.172 ± 1.291
3.041AlaPro: 3.041 ± 0.84
1.303AlaGln: 1.303 ± 0.471
2.172AlaArg: 2.172 ± 0.622
5.647AlaSer: 5.647 ± 1.102
1.303AlaThr: 1.303 ± 0.643
2.172AlaVal: 2.172 ± 0.694
0.869AlaTrp: 0.869 ± 0.448
2.606AlaTyr: 2.606 ± 0.552
0.0AlaXaa: 0.0 ± 0.0
Cys
1.303CysAla: 1.303 ± 0.793
1.303CysCys: 1.303 ± 0.839
0.869CysAsp: 0.869 ± 0.806
0.869CysGlu: 0.869 ± 0.645
0.434CysPhe: 0.434 ± 0.484
0.434CysGly: 0.434 ± 0.545
0.0CysHis: 0.0 ± 0.0
0.434CysIle: 0.434 ± 0.346
1.738CysLys: 1.738 ± 0.822
2.172CysLeu: 2.172 ± 1.457
0.434CysMet: 0.434 ± 0.513
0.0CysAsn: 0.0 ± 0.0
1.738CysPro: 1.738 ± 0.866
0.869CysGln: 0.869 ± 0.612
0.434CysArg: 0.434 ± 0.606
3.041CysSer: 3.041 ± 1.912
1.738CysThr: 1.738 ± 0.778
1.303CysVal: 1.303 ± 0.914
1.303CysTrp: 1.303 ± 0.41
0.434CysTyr: 0.434 ± 0.346
0.0CysXaa: 0.0 ± 0.0
Asp
4.778AspAla: 4.778 ± 0.652
0.869AspCys: 0.869 ± 0.586
3.041AspAsp: 3.041 ± 1.758
3.91AspGlu: 3.91 ± 1.098
3.041AspPhe: 3.041 ± 0.579
3.475AspGly: 3.475 ± 0.967
0.0AspHis: 0.0 ± 0.0
3.475AspIle: 3.475 ± 1.803
2.606AspLys: 2.606 ± 0.796
7.819AspLeu: 7.819 ± 2.906
0.434AspMet: 0.434 ± 0.403
1.738AspAsn: 1.738 ± 0.64
5.213AspPro: 5.213 ± 1.783
0.434AspGln: 0.434 ± 0.346
1.303AspArg: 1.303 ± 0.643
5.647AspSer: 5.647 ± 1.682
5.647AspThr: 5.647 ± 1.069
3.91AspVal: 3.91 ± 1.849
0.869AspTrp: 0.869 ± 0.691
2.172AspTyr: 2.172 ± 1.009
0.0AspXaa: 0.0 ± 0.0
Glu
4.344GluAla: 4.344 ± 1.109
1.303GluCys: 1.303 ± 1.037
3.475GluAsp: 3.475 ± 0.411
5.213GluGlu: 5.213 ± 2.236
3.041GluPhe: 3.041 ± 0.796
4.778GluGly: 4.778 ± 1.763
1.303GluHis: 1.303 ± 0.9
1.303GluIle: 1.303 ± 0.433
3.041GluLys: 3.041 ± 1.954
5.647GluLeu: 5.647 ± 1.93
0.869GluMet: 0.869 ± 0.411
3.91GluAsn: 3.91 ± 1.219
4.778GluPro: 4.778 ± 1.483
3.041GluGln: 3.041 ± 1.84
3.91GluArg: 3.91 ± 1.793
3.475GluSer: 3.475 ± 1.536
3.041GluThr: 3.041 ± 0.678
5.213GluVal: 5.213 ± 0.897
0.434GluTrp: 0.434 ± 0.403
1.303GluTyr: 1.303 ± 0.433
0.0GluXaa: 0.0 ± 0.0
Phe
2.172PheAla: 2.172 ± 0.742
1.303PheCys: 1.303 ± 0.839
3.91PheAsp: 3.91 ± 1.286
3.475PheGlu: 3.475 ± 1.612
2.606PhePhe: 2.606 ± 1.027
3.475PheGly: 3.475 ± 0.99
1.738PheHis: 1.738 ± 1.406
3.041PheIle: 3.041 ± 0.984
3.91PheLys: 3.91 ± 1.561
4.344PheLeu: 4.344 ± 1.253
1.303PheMet: 1.303 ± 0.429
2.606PheAsn: 2.606 ± 0.613
0.434PhePro: 0.434 ± 0.346
1.303PheGln: 1.303 ± 0.643
1.738PheArg: 1.738 ± 0.877
1.738PheSer: 1.738 ± 0.986
3.041PheThr: 3.041 ± 1.025
1.738PheVal: 1.738 ± 0.67
0.434PheTrp: 0.434 ± 0.346
0.869PheTyr: 0.869 ± 0.49
0.0PheXaa: 0.0 ± 0.0
Gly
2.172GlyAla: 2.172 ± 0.862
1.738GlyCys: 1.738 ± 0.9
4.778GlyAsp: 4.778 ± 1.539
6.516GlyGlu: 6.516 ± 0.978
1.738GlyPhe: 1.738 ± 0.56
3.475GlyGly: 3.475 ± 1.678
1.738GlyHis: 1.738 ± 0.866
4.344GlyIle: 4.344 ± 1.289
3.041GlyLys: 3.041 ± 0.964
2.172GlyLeu: 2.172 ± 1.289
0.869GlyMet: 0.869 ± 0.561
4.344GlyAsn: 4.344 ± 1.497
4.344GlyPro: 4.344 ± 1.214
1.303GlyGln: 1.303 ± 1.451
5.647GlyArg: 5.647 ± 1.789
5.213GlySer: 5.213 ± 1.401
8.254GlyThr: 8.254 ± 2.44
3.041GlyVal: 3.041 ± 1.494
0.869GlyTrp: 0.869 ± 0.645
1.303GlyTyr: 1.303 ± 0.632
0.0GlyXaa: 0.0 ± 0.0
His
0.434HisAla: 0.434 ± 0.403
0.869HisCys: 0.869 ± 0.691
0.0HisAsp: 0.0 ± 0.0
0.434HisGlu: 0.434 ± 0.403
0.869HisPhe: 0.869 ± 0.493
1.738HisGly: 1.738 ± 0.809
0.0HisHis: 0.0 ± 0.0
0.434HisIle: 0.434 ± 0.403
0.434HisLys: 0.434 ± 0.484
2.172HisLeu: 2.172 ± 1.177
0.0HisMet: 0.0 ± 0.0
0.869HisAsn: 0.869 ± 0.561
1.303HisPro: 1.303 ± 0.767
0.869HisGln: 0.869 ± 0.49
1.303HisArg: 1.303 ± 0.433
1.738HisSer: 1.738 ± 0.678
1.738HisThr: 1.738 ± 1.027
0.0HisVal: 0.0 ± 0.0
1.303HisTrp: 1.303 ± 0.966
0.434HisTyr: 0.434 ± 0.606
0.0HisXaa: 0.0 ± 0.0
Ile
1.303IleAla: 1.303 ± 0.793
0.869IleCys: 0.869 ± 0.645
4.344IleAsp: 4.344 ± 2.033
3.475IleGlu: 3.475 ± 1.402
1.303IlePhe: 1.303 ± 0.728
3.475IleGly: 3.475 ± 1.193
0.434IleHis: 0.434 ± 0.346
2.606IleIle: 2.606 ± 1.822
0.869IleLys: 0.869 ± 0.49
3.91IleLeu: 3.91 ± 1.071
0.0IleMet: 0.0 ± 0.0
1.738IleAsn: 1.738 ± 0.678
3.041IlePro: 3.041 ± 1.386
0.869IleGln: 0.869 ± 0.806
0.434IleArg: 0.434 ± 0.346
4.344IleSer: 4.344 ± 1.615
2.172IleThr: 2.172 ± 1.528
6.082IleVal: 6.082 ± 1.804
0.434IleTrp: 0.434 ± 0.378
1.738IleTyr: 1.738 ± 0.725
0.0IleXaa: 0.0 ± 0.0
Lys
1.303LysAla: 1.303 ± 0.849
0.869LysCys: 0.869 ± 0.561
3.475LysAsp: 3.475 ± 1.149
3.041LysGlu: 3.041 ± 1.748
2.172LysPhe: 2.172 ± 1.273
3.91LysGly: 3.91 ± 1.644
2.172LysHis: 2.172 ± 0.7
3.475LysIle: 3.475 ± 0.649
2.606LysLys: 2.606 ± 0.449
4.344LysLeu: 4.344 ± 0.763
0.434LysMet: 0.434 ± 0.403
2.172LysAsn: 2.172 ± 0.797
1.303LysPro: 1.303 ± 1.21
3.041LysGln: 3.041 ± 0.68
6.082LysArg: 6.082 ± 1.224
4.778LysSer: 4.778 ± 2.17
3.041LysThr: 3.041 ± 0.977
2.606LysVal: 2.606 ± 1.055
0.434LysTrp: 0.434 ± 0.403
0.869LysTyr: 0.869 ± 0.691
0.0LysXaa: 0.0 ± 0.0
Leu
5.213LeuAla: 5.213 ± 1.061
1.303LeuCys: 1.303 ± 1.249
5.647LeuAsp: 5.647 ± 1.206
6.95LeuGlu: 6.95 ± 2.608
7.385LeuPhe: 7.385 ± 1.846
6.516LeuGly: 6.516 ± 1.634
1.738LeuHis: 1.738 ± 0.231
3.041LeuIle: 3.041 ± 1.019
4.778LeuLys: 4.778 ± 1.128
9.123LeuLeu: 9.123 ± 2.809
2.172LeuMet: 2.172 ± 1.315
3.475LeuAsn: 3.475 ± 0.981
6.516LeuPro: 6.516 ± 0.817
5.213LeuGln: 5.213 ± 1.987
5.213LeuArg: 5.213 ± 1.197
8.254LeuSer: 8.254 ± 2.231
3.91LeuThr: 3.91 ± 1.141
6.95LeuVal: 6.95 ± 2.303
0.869LeuTrp: 0.869 ± 0.806
3.91LeuTyr: 3.91 ± 1.348
0.0LeuXaa: 0.0 ± 0.0
Met
0.434MetAla: 0.434 ± 0.346
0.434MetCys: 0.434 ± 0.403
1.303MetAsp: 1.303 ± 0.643
0.434MetGlu: 0.434 ± 0.484
0.869MetPhe: 0.869 ± 0.448
0.869MetGly: 0.869 ± 0.448
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.303MetLeu: 1.303 ± 0.433
0.0MetMet: 0.0 ± 0.0
1.738MetAsn: 1.738 ± 0.877
1.303MetPro: 1.303 ± 0.804
0.869MetGln: 0.869 ± 0.448
1.738MetArg: 1.738 ± 0.725
0.869MetSer: 0.869 ± 0.411
1.303MetThr: 1.303 ± 0.471
0.869MetVal: 0.869 ± 0.691
0.0MetTrp: 0.0 ± 0.0
1.303MetTyr: 1.303 ± 0.41
0.0MetXaa: 0.0 ± 0.0
Asn
2.172AsnAla: 2.172 ± 1.276
2.172AsnCys: 2.172 ± 1.342
1.738AsnAsp: 1.738 ± 0.511
2.172AsnGlu: 2.172 ± 0.934
1.303AsnPhe: 1.303 ± 0.849
4.778AsnGly: 4.778 ± 2.338
0.0AsnHis: 0.0 ± 0.0
3.041AsnIle: 3.041 ± 1.407
2.606AsnLys: 2.606 ± 1.027
5.647AsnLeu: 5.647 ± 1.5
1.738AsnMet: 1.738 ± 0.645
2.606AsnAsn: 2.606 ± 1.342
2.606AsnPro: 2.606 ± 1.398
1.738AsnGln: 1.738 ± 0.679
2.606AsnArg: 2.606 ± 1.06
4.778AsnSer: 4.778 ± 1.323
2.172AsnThr: 2.172 ± 1.038
2.606AsnVal: 2.606 ± 1.027
1.303AsnTrp: 1.303 ± 0.966
1.303AsnTyr: 1.303 ± 0.732
0.0AsnXaa: 0.0 ± 0.0
Pro
2.606ProAla: 2.606 ± 0.959
0.434ProCys: 0.434 ± 0.403
3.475ProAsp: 3.475 ± 0.761
2.172ProGlu: 2.172 ± 0.494
2.172ProPhe: 2.172 ± 1.24
4.344ProGly: 4.344 ± 2.464
0.0ProHis: 0.0 ± 0.0
2.606ProIle: 2.606 ± 1.072
4.344ProLys: 4.344 ± 1.041
6.95ProLeu: 6.95 ± 1.865
0.434ProMet: 0.434 ± 0.346
4.344ProAsn: 4.344 ± 1.509
7.819ProPro: 7.819 ± 1.08
3.041ProGln: 3.041 ± 0.988
2.172ProArg: 2.172 ± 1.369
5.647ProSer: 5.647 ± 1.843
4.344ProThr: 4.344 ± 0.761
4.344ProVal: 4.344 ± 1.855
0.434ProTrp: 0.434 ± 0.484
2.606ProTyr: 2.606 ± 1.109
0.0ProXaa: 0.0 ± 0.0
Gln
1.738GlnAla: 1.738 ± 1.422
0.869GlnCys: 0.869 ± 0.612
3.041GlnAsp: 3.041 ± 1.025
2.172GlnGlu: 2.172 ± 0.759
2.172GlnPhe: 2.172 ± 0.832
2.172GlnGly: 2.172 ± 0.755
0.869GlnHis: 0.869 ± 0.411
2.172GlnIle: 2.172 ± 1.276
0.0GlnLys: 0.0 ± 0.0
6.082GlnLeu: 6.082 ± 1.852
0.0GlnMet: 0.0 ± 0.0
1.738GlnAsn: 1.738 ± 0.64
2.606GlnPro: 2.606 ± 0.895
2.172GlnGln: 2.172 ± 1.014
3.041GlnArg: 3.041 ± 1.195
1.738GlnSer: 1.738 ± 1.032
2.606GlnThr: 2.606 ± 0.704
3.041GlnVal: 3.041 ± 1.172
0.869GlnTrp: 0.869 ± 0.691
0.869GlnTyr: 0.869 ± 0.799
0.0GlnXaa: 0.0 ± 0.0
Arg
3.475ArgAla: 3.475 ± 1.011
2.172ArgCys: 2.172 ± 1.237
2.606ArgAsp: 2.606 ± 1.36
2.172ArgGlu: 2.172 ± 0.622
2.172ArgPhe: 2.172 ± 0.989
3.475ArgGly: 3.475 ± 1.4
1.738ArgHis: 1.738 ± 1.017
0.434ArgIle: 0.434 ± 0.378
3.91ArgLys: 3.91 ± 1.001
6.516ArgLeu: 6.516 ± 2.125
1.738ArgMet: 1.738 ± 0.6
3.475ArgAsn: 3.475 ± 0.765
3.91ArgPro: 3.91 ± 1.601
2.172ArgGln: 2.172 ± 0.917
6.082ArgArg: 6.082 ± 2.99
4.778ArgSer: 4.778 ± 1.288
2.172ArgThr: 2.172 ± 0.755
3.475ArgVal: 3.475 ± 0.675
0.0ArgTrp: 0.0 ± 0.0
1.303ArgTyr: 1.303 ± 0.433
0.0ArgXaa: 0.0 ± 0.0
Ser
4.778SerAla: 4.778 ± 2.1
0.0SerCys: 0.0 ± 0.0
4.344SerAsp: 4.344 ± 1.672
7.385SerGlu: 7.385 ± 1.118
3.91SerPhe: 3.91 ± 1.55
5.647SerGly: 5.647 ± 1.25
1.303SerHis: 1.303 ± 0.433
3.91SerIle: 3.91 ± 1.839
2.606SerLys: 2.606 ± 0.928
9.557SerLeu: 9.557 ± 1.799
1.738SerMet: 1.738 ± 1.073
4.344SerAsn: 4.344 ± 0.652
4.344SerPro: 4.344 ± 2.643
3.91SerGln: 3.91 ± 0.953
4.344SerArg: 4.344 ± 1.138
9.557SerSer: 9.557 ± 1.316
7.819SerThr: 7.819 ± 2.39
3.91SerVal: 3.91 ± 1.125
0.869SerTrp: 0.869 ± 0.691
2.172SerTyr: 2.172 ± 1.253
0.0SerXaa: 0.0 ± 0.0
Thr
3.041ThrAla: 3.041 ± 1.047
1.303ThrCys: 1.303 ± 0.594
1.738ThrAsp: 1.738 ± 0.511
3.91ThrGlu: 3.91 ± 0.866
2.606ThrPhe: 2.606 ± 1.254
6.95ThrGly: 6.95 ± 2.161
1.303ThrHis: 1.303 ± 0.737
1.738ThrIle: 1.738 ± 1.057
2.606ThrLys: 2.606 ± 1.176
5.213ThrLeu: 5.213 ± 1.467
1.303ThrMet: 1.303 ± 0.804
3.91ThrAsn: 3.91 ± 1.67
4.344ThrPro: 4.344 ± 1.357
1.303ThrGln: 1.303 ± 0.728
3.041ThrArg: 3.041 ± 1.391
6.516ThrSer: 6.516 ± 1.297
3.041ThrThr: 3.041 ± 1.022
6.082ThrVal: 6.082 ± 1.413
0.869ThrTrp: 0.869 ± 0.448
2.172ThrTyr: 2.172 ± 0.851
0.0ThrXaa: 0.0 ± 0.0
Val
3.041ValAla: 3.041 ± 1.295
1.303ValCys: 1.303 ± 0.594
5.213ValAsp: 5.213 ± 1.269
3.041ValGlu: 3.041 ± 1.788
2.172ValPhe: 2.172 ± 0.851
3.041ValGly: 3.041 ± 1.814
1.738ValHis: 1.738 ± 0.644
3.475ValIle: 3.475 ± 1.142
4.344ValLys: 4.344 ± 0.352
4.344ValLeu: 4.344 ± 1.262
0.434ValMet: 0.434 ± 0.403
1.738ValAsn: 1.738 ± 0.835
3.91ValPro: 3.91 ± 2.063
4.344ValGln: 4.344 ± 2.297
2.172ValArg: 2.172 ± 1.402
6.95ValSer: 6.95 ± 1.272
3.91ValThr: 3.91 ± 0.95
3.91ValVal: 3.91 ± 1.43
0.434ValTrp: 0.434 ± 0.403
2.172ValTyr: 2.172 ± 1.292
0.0ValXaa: 0.0 ± 0.0
Trp
0.434TrpAla: 0.434 ± 0.346
0.0TrpCys: 0.0 ± 0.0
1.303TrpAsp: 1.303 ± 0.41
0.869TrpGlu: 0.869 ± 0.493
0.0TrpPhe: 0.0 ± 0.0
0.434TrpGly: 0.434 ± 0.403
0.434TrpHis: 0.434 ± 0.484
1.303TrpIle: 1.303 ± 0.41
1.738TrpLys: 1.738 ± 0.511
1.738TrpLeu: 1.738 ± 0.948
0.0TrpMet: 0.0 ± 0.0
0.434TrpAsn: 0.434 ± 0.403
1.303TrpPro: 1.303 ± 0.41
0.0TrpGln: 0.0 ± 0.0
1.303TrpArg: 1.303 ± 0.827
0.0TrpSer: 0.0 ± 0.0
0.434TrpThr: 0.434 ± 0.484
0.434TrpVal: 0.434 ± 0.346
0.0TrpTrp: 0.0 ± 0.0
0.434TrpTyr: 0.434 ± 0.346
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.303TyrAla: 1.303 ± 0.866
0.869TyrCys: 0.869 ± 0.799
2.606TyrAsp: 2.606 ± 0.767
2.606TyrGlu: 2.606 ± 1.26
3.475TyrPhe: 3.475 ± 0.587
1.303TyrGly: 1.303 ± 0.471
0.0TyrHis: 0.0 ± 0.0
0.434TyrIle: 0.434 ± 0.403
2.606TyrLys: 2.606 ± 0.812
3.475TyrLeu: 3.475 ± 1.067
0.869TyrMet: 0.869 ± 0.691
1.738TyrAsn: 1.738 ± 0.678
0.434TyrPro: 0.434 ± 0.484
2.172TyrGln: 2.172 ± 0.7
3.041TyrArg: 3.041 ± 0.994
1.738TyrSer: 1.738 ± 0.777
1.303TyrThr: 1.303 ± 0.9
0.0TyrVal: 0.0 ± 0.0
0.0TyrTrp: 0.0 ± 0.0
1.738TyrTyr: 1.738 ± 1.422
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2303 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski