Amino acid dipepetide frequency for Mycobacterium phage Ogopogo

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.747AlaAla: 13.747 ± 1.731
1.095AlaCys: 1.095 ± 0.232
7.503AlaAsp: 7.503 ± 0.594
7.503AlaGlu: 7.503 ± 0.866
2.738AlaPhe: 2.738 ± 0.344
9.475AlaGly: 9.475 ± 1.124
2.081AlaHis: 2.081 ± 0.299
4.929AlaIle: 4.929 ± 0.559
4.108AlaLys: 4.108 ± 0.543
8.325AlaLeu: 8.325 ± 0.873
2.903AlaMet: 2.903 ± 0.421
3.177AlaAsn: 3.177 ± 0.436
4.71AlaPro: 4.71 ± 0.509
3.834AlaGln: 3.834 ± 0.485
6.736AlaArg: 6.736 ± 0.506
5.093AlaSer: 5.093 ± 0.532
5.203AlaThr: 5.203 ± 0.567
7.394AlaVal: 7.394 ± 0.564
2.465AlaTrp: 2.465 ± 0.393
2.465AlaTyr: 2.465 ± 0.374
0.0AlaXaa: 0.0 ± 0.0
Cys
0.767CysAla: 0.767 ± 0.207
0.055CysCys: 0.055 ± 0.051
1.095CysAsp: 1.095 ± 0.278
1.041CysGlu: 1.041 ± 0.274
0.164CysPhe: 0.164 ± 0.117
1.533CysGly: 1.533 ± 0.353
0.329CysHis: 0.329 ± 0.142
0.383CysIle: 0.383 ± 0.162
0.329CysLys: 0.329 ± 0.141
0.931CysLeu: 0.931 ± 0.239
0.219CysMet: 0.219 ± 0.111
0.493CysAsn: 0.493 ± 0.157
1.26CysPro: 1.26 ± 0.282
0.329CysGln: 0.329 ± 0.157
0.712CysArg: 0.712 ± 0.213
0.657CysSer: 0.657 ± 0.193
0.657CysThr: 0.657 ± 0.172
0.383CysVal: 0.383 ± 0.132
0.274CysTrp: 0.274 ± 0.126
0.329CysTyr: 0.329 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
6.572AspAla: 6.572 ± 0.713
0.931AspCys: 0.931 ± 0.189
4.381AspAsp: 4.381 ± 0.544
3.998AspGlu: 3.998 ± 0.512
1.533AspPhe: 1.533 ± 0.218
6.024AspGly: 6.024 ± 0.54
1.369AspHis: 1.369 ± 0.284
2.355AspIle: 2.355 ± 0.437
2.191AspLys: 2.191 ± 0.309
5.312AspLeu: 5.312 ± 0.591
1.041AspMet: 1.041 ± 0.249
1.588AspAsn: 1.588 ± 0.359
3.998AspPro: 3.998 ± 0.436
2.738AspGln: 2.738 ± 0.419
5.805AspArg: 5.805 ± 0.721
3.615AspSer: 3.615 ± 0.542
3.943AspThr: 3.943 ± 0.505
4.984AspVal: 4.984 ± 0.653
1.533AspTrp: 1.533 ± 0.282
1.862AspTyr: 1.862 ± 0.391
0.0AspXaa: 0.0 ± 0.0
Glu
6.627GluAla: 6.627 ± 0.784
0.876GluCys: 0.876 ± 0.207
3.341GluAsp: 3.341 ± 0.429
3.231GluGlu: 3.231 ± 0.516
1.807GluPhe: 1.807 ± 0.267
3.122GluGly: 3.122 ± 0.499
1.698GluHis: 1.698 ± 0.427
2.738GluIle: 2.738 ± 0.466
1.917GluLys: 1.917 ± 0.303
5.312GluLeu: 5.312 ± 0.618
1.862GluMet: 1.862 ± 0.304
1.753GluAsn: 1.753 ± 0.284
3.615GluPro: 3.615 ± 0.571
2.574GluGln: 2.574 ± 0.423
4.655GluArg: 4.655 ± 0.651
2.629GluSer: 2.629 ± 0.491
4.984GluThr: 4.984 ± 0.558
4.162GluVal: 4.162 ± 0.532
1.369GluTrp: 1.369 ± 0.241
1.588GluTyr: 1.588 ± 0.362
0.0GluXaa: 0.0 ± 0.0
Phe
2.793PheAla: 2.793 ± 0.398
0.274PheCys: 0.274 ± 0.108
2.136PheAsp: 2.136 ± 0.366
1.533PheGlu: 1.533 ± 0.319
0.493PhePhe: 0.493 ± 0.169
3.231PheGly: 3.231 ± 0.602
0.438PheHis: 0.438 ± 0.139
1.643PheIle: 1.643 ± 0.394
1.424PheLys: 1.424 ± 0.281
1.698PheLeu: 1.698 ± 0.259
0.767PheMet: 0.767 ± 0.182
1.095PheAsn: 1.095 ± 0.233
1.26PhePro: 1.26 ± 0.297
0.986PheGln: 0.986 ± 0.295
1.205PheArg: 1.205 ± 0.213
1.862PheSer: 1.862 ± 0.275
1.807PheThr: 1.807 ± 0.253
1.753PheVal: 1.753 ± 0.266
0.548PheTrp: 0.548 ± 0.152
0.712PheTyr: 0.712 ± 0.214
0.0PheXaa: 0.0 ± 0.0
Gly
9.256GlyAla: 9.256 ± 1.227
0.986GlyCys: 0.986 ± 0.285
5.367GlyAsp: 5.367 ± 0.498
3.888GlyGlu: 3.888 ± 0.522
2.848GlyPhe: 2.848 ± 0.324
10.625GlyGly: 10.625 ± 2.03
2.136GlyHis: 2.136 ± 0.314
3.724GlyIle: 3.724 ± 0.581
2.355GlyLys: 2.355 ± 0.305
5.97GlyLeu: 5.97 ± 0.622
1.917GlyMet: 1.917 ± 0.415
2.903GlyAsn: 2.903 ± 0.514
3.779GlyPro: 3.779 ± 0.514
2.574GlyGln: 2.574 ± 0.522
5.751GlyArg: 5.751 ± 0.581
5.696GlySer: 5.696 ± 0.862
6.791GlyThr: 6.791 ± 0.691
5.805GlyVal: 5.805 ± 0.676
3.012GlyTrp: 3.012 ± 0.349
2.245GlyTyr: 2.245 ± 0.389
0.0GlyXaa: 0.0 ± 0.0
His
1.972HisAla: 1.972 ± 0.323
0.329HisCys: 0.329 ± 0.165
0.931HisAsp: 0.931 ± 0.236
1.095HisGlu: 1.095 ± 0.227
0.548HisPhe: 0.548 ± 0.166
1.698HisGly: 1.698 ± 0.325
0.931HisHis: 0.931 ± 0.209
1.424HisIle: 1.424 ± 0.287
0.931HisLys: 0.931 ± 0.22
1.698HisLeu: 1.698 ± 0.302
0.493HisMet: 0.493 ± 0.14
0.602HisAsn: 0.602 ± 0.174
2.191HisPro: 2.191 ± 0.356
0.876HisGln: 0.876 ± 0.274
1.698HisArg: 1.698 ± 0.289
1.205HisSer: 1.205 ± 0.223
1.424HisThr: 1.424 ± 0.363
1.479HisVal: 1.479 ± 0.308
0.602HisTrp: 0.602 ± 0.186
0.931HisTyr: 0.931 ± 0.234
0.0HisXaa: 0.0 ± 0.0
Ile
4.984IleAla: 4.984 ± 0.526
0.822IleCys: 0.822 ± 0.257
3.779IleAsp: 3.779 ± 0.384
3.341IleGlu: 3.341 ± 0.397
0.822IlePhe: 0.822 ± 0.182
4.381IleGly: 4.381 ± 0.447
1.753IleHis: 1.753 ± 0.384
1.479IleIle: 1.479 ± 0.248
1.314IleLys: 1.314 ± 0.26
2.465IleLeu: 2.465 ± 0.382
0.493IleMet: 0.493 ± 0.152
2.191IleAsn: 2.191 ± 0.373
2.903IlePro: 2.903 ± 0.382
1.041IleGln: 1.041 ± 0.254
2.465IleArg: 2.465 ± 0.406
1.972IleSer: 1.972 ± 0.389
4.272IleThr: 4.272 ± 0.643
2.848IleVal: 2.848 ± 0.407
0.986IleTrp: 0.986 ± 0.3
1.205IleTyr: 1.205 ± 0.275
0.0IleXaa: 0.0 ± 0.0
Lys
3.888LysAla: 3.888 ± 0.469
0.274LysCys: 0.274 ± 0.155
1.753LysAsp: 1.753 ± 0.358
1.26LysGlu: 1.26 ± 0.287
0.712LysPhe: 0.712 ± 0.182
2.574LysGly: 2.574 ± 0.358
0.986LysHis: 0.986 ± 0.262
0.876LysIle: 0.876 ± 0.196
1.753LysLys: 1.753 ± 0.386
2.848LysLeu: 2.848 ± 0.455
0.876LysMet: 0.876 ± 0.198
1.205LysAsn: 1.205 ± 0.258
2.574LysPro: 2.574 ± 0.347
1.479LysGln: 1.479 ± 0.249
2.629LysArg: 2.629 ± 0.44
2.136LysSer: 2.136 ± 0.363
2.136LysThr: 2.136 ± 0.443
2.3LysVal: 2.3 ± 0.343
0.986LysTrp: 0.986 ± 0.244
0.767LysTyr: 0.767 ± 0.244
0.0LysXaa: 0.0 ± 0.0
Leu
8.927LeuAla: 8.927 ± 0.81
0.657LeuCys: 0.657 ± 0.2
5.258LeuAsp: 5.258 ± 0.569
4.053LeuGlu: 4.053 ± 0.502
1.807LeuPhe: 1.807 ± 0.259
5.477LeuGly: 5.477 ± 0.545
1.095LeuHis: 1.095 ± 0.289
3.943LeuIle: 3.943 ± 0.489
1.862LeuLys: 1.862 ± 0.296
4.655LeuLeu: 4.655 ± 0.62
1.588LeuMet: 1.588 ± 0.295
2.629LeuAsn: 2.629 ± 0.396
5.039LeuPro: 5.039 ± 0.594
2.465LeuGln: 2.465 ± 0.452
4.327LeuArg: 4.327 ± 0.57
5.093LeuSer: 5.093 ± 0.456
5.367LeuThr: 5.367 ± 0.532
5.203LeuVal: 5.203 ± 0.525
0.986LeuTrp: 0.986 ± 0.253
1.917LeuTyr: 1.917 ± 0.32
0.0LeuXaa: 0.0 ± 0.0
Met
2.136MetAla: 2.136 ± 0.317
0.329MetCys: 0.329 ± 0.219
1.643MetAsp: 1.643 ± 0.372
0.876MetGlu: 0.876 ± 0.181
0.767MetPhe: 0.767 ± 0.264
1.753MetGly: 1.753 ± 0.264
0.219MetHis: 0.219 ± 0.097
1.095MetIle: 1.095 ± 0.253
0.657MetLys: 0.657 ± 0.214
1.369MetLeu: 1.369 ± 0.245
0.493MetMet: 0.493 ± 0.209
1.314MetAsn: 1.314 ± 0.215
1.533MetPro: 1.533 ± 0.294
0.712MetGln: 0.712 ± 0.191
1.314MetArg: 1.314 ± 0.265
3.067MetSer: 3.067 ± 0.386
1.972MetThr: 1.972 ± 0.325
1.424MetVal: 1.424 ± 0.332
0.548MetTrp: 0.548 ± 0.164
0.329MetTyr: 0.329 ± 0.143
0.0MetXaa: 0.0 ± 0.0
Asn
3.286AsnAla: 3.286 ± 0.376
0.383AsnCys: 0.383 ± 0.158
1.314AsnAsp: 1.314 ± 0.227
2.136AsnGlu: 2.136 ± 0.331
0.493AsnPhe: 0.493 ± 0.205
4.108AsnGly: 4.108 ± 0.58
0.931AsnHis: 0.931 ± 0.19
1.479AsnIle: 1.479 ± 0.319
0.986AsnLys: 0.986 ± 0.247
3.067AsnLeu: 3.067 ± 0.366
0.657AsnMet: 0.657 ± 0.162
1.643AsnAsn: 1.643 ± 0.333
3.012AsnPro: 3.012 ± 0.407
0.986AsnGln: 0.986 ± 0.301
1.753AsnArg: 1.753 ± 0.344
1.698AsnSer: 1.698 ± 0.326
2.41AsnThr: 2.41 ± 0.37
1.917AsnVal: 1.917 ± 0.281
0.657AsnTrp: 0.657 ± 0.165
0.602AsnTyr: 0.602 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
6.189ProAla: 6.189 ± 0.688
0.767ProCys: 0.767 ± 0.209
4.436ProAsp: 4.436 ± 0.536
4.82ProGlu: 4.82 ± 0.44
2.3ProPhe: 2.3 ± 0.383
6.079ProGly: 6.079 ± 0.663
1.26ProHis: 1.26 ± 0.273
2.41ProIle: 2.41 ± 0.344
2.026ProLys: 2.026 ± 0.315
4.053ProLeu: 4.053 ± 0.474
1.862ProMet: 1.862 ± 0.371
2.245ProAsn: 2.245 ± 0.297
3.779ProPro: 3.779 ± 0.671
2.41ProGln: 2.41 ± 0.392
3.779ProArg: 3.779 ± 0.458
3.231ProSer: 3.231 ± 0.411
3.45ProThr: 3.45 ± 0.486
3.45ProVal: 3.45 ± 0.42
1.205ProTrp: 1.205 ± 0.268
1.972ProTyr: 1.972 ± 0.271
0.0ProXaa: 0.0 ± 0.0
Gln
4.162GlnAla: 4.162 ± 0.567
0.329GlnCys: 0.329 ± 0.142
1.753GlnAsp: 1.753 ± 0.29
1.424GlnGlu: 1.424 ± 0.364
1.205GlnPhe: 1.205 ± 0.221
2.245GlnGly: 2.245 ± 0.441
0.986GlnHis: 0.986 ± 0.221
1.26GlnIle: 1.26 ± 0.252
1.424GlnLys: 1.424 ± 0.246
2.465GlnLeu: 2.465 ± 0.421
0.876GlnMet: 0.876 ± 0.204
0.986GlnAsn: 0.986 ± 0.271
2.793GlnPro: 2.793 ± 0.417
1.369GlnGln: 1.369 ± 0.299
2.519GlnArg: 2.519 ± 0.351
2.574GlnSer: 2.574 ± 0.334
1.862GlnThr: 1.862 ± 0.334
2.41GlnVal: 2.41 ± 0.305
0.657GlnTrp: 0.657 ± 0.187
1.26GlnTyr: 1.26 ± 0.257
0.0GlnXaa: 0.0 ± 0.0
Arg
6.517ArgAla: 6.517 ± 0.611
1.314ArgCys: 1.314 ± 0.384
4.436ArgAsp: 4.436 ± 0.518
4.491ArgGlu: 4.491 ± 0.656
1.972ArgPhe: 1.972 ± 0.341
4.6ArgGly: 4.6 ± 0.445
1.424ArgHis: 1.424 ± 0.284
3.505ArgIle: 3.505 ± 0.452
2.684ArgLys: 2.684 ± 0.361
4.929ArgLeu: 4.929 ± 0.561
2.355ArgMet: 2.355 ± 0.382
1.917ArgAsn: 1.917 ± 0.348
3.341ArgPro: 3.341 ± 0.413
1.862ArgGln: 1.862 ± 0.339
6.791ArgArg: 6.791 ± 0.899
3.669ArgSer: 3.669 ± 0.364
4.108ArgThr: 4.108 ± 0.496
4.655ArgVal: 4.655 ± 0.598
1.862ArgTrp: 1.862 ± 0.338
2.136ArgTyr: 2.136 ± 0.342
0.0ArgXaa: 0.0 ± 0.0
Ser
5.641SerAla: 5.641 ± 0.74
0.548SerCys: 0.548 ± 0.227
4.162SerAsp: 4.162 ± 0.392
3.341SerGlu: 3.341 ± 0.398
1.479SerPhe: 1.479 ± 0.297
6.353SerGly: 6.353 ± 0.791
1.041SerHis: 1.041 ± 0.247
2.684SerIle: 2.684 ± 0.355
1.862SerLys: 1.862 ± 0.397
3.615SerLeu: 3.615 ± 0.407
1.698SerMet: 1.698 ± 0.311
2.191SerAsn: 2.191 ± 0.32
3.779SerPro: 3.779 ± 0.477
1.917SerGln: 1.917 ± 0.287
3.724SerArg: 3.724 ± 0.423
3.177SerSer: 3.177 ± 0.551
3.998SerThr: 3.998 ± 0.53
3.998SerVal: 3.998 ± 0.402
0.931SerTrp: 0.931 ± 0.204
1.643SerTyr: 1.643 ± 0.26
0.0SerXaa: 0.0 ± 0.0
Thr
6.079ThrAla: 6.079 ± 0.646
0.438ThrCys: 0.438 ± 0.157
4.381ThrAsp: 4.381 ± 0.536
4.491ThrGlu: 4.491 ± 0.437
2.081ThrPhe: 2.081 ± 0.37
6.024ThrGly: 6.024 ± 0.698
1.479ThrHis: 1.479 ± 0.276
4.272ThrIle: 4.272 ± 0.665
2.136ThrLys: 2.136 ± 0.343
4.491ThrLeu: 4.491 ± 0.498
0.986ThrMet: 0.986 ± 0.275
2.081ThrAsn: 2.081 ± 0.359
5.312ThrPro: 5.312 ± 0.482
1.972ThrGln: 1.972 ± 0.29
3.779ThrArg: 3.779 ± 0.484
3.943ThrSer: 3.943 ± 0.47
5.148ThrThr: 5.148 ± 0.602
5.805ThrVal: 5.805 ± 0.694
1.15ThrTrp: 1.15 ± 0.306
1.698ThrTyr: 1.698 ± 0.324
0.0ThrXaa: 0.0 ± 0.0
Val
7.722ValAla: 7.722 ± 0.739
0.986ValCys: 0.986 ± 0.269
4.874ValAsp: 4.874 ± 0.482
4.491ValGlu: 4.491 ± 0.544
2.41ValPhe: 2.41 ± 0.354
4.929ValGly: 4.929 ± 0.505
1.205ValHis: 1.205 ± 0.231
3.122ValIle: 3.122 ± 0.479
2.465ValLys: 2.465 ± 0.391
5.367ValLeu: 5.367 ± 0.619
1.15ValMet: 1.15 ± 0.249
2.026ValAsn: 2.026 ± 0.327
4.108ValPro: 4.108 ± 0.454
2.245ValGln: 2.245 ± 0.273
4.71ValArg: 4.71 ± 0.584
3.669ValSer: 3.669 ± 0.644
4.929ValThr: 4.929 ± 0.453
5.805ValVal: 5.805 ± 0.582
1.807ValTrp: 1.807 ± 0.276
1.479ValTyr: 1.479 ± 0.251
0.0ValXaa: 0.0 ± 0.0
Trp
2.245TrpAla: 2.245 ± 0.309
0.219TrpCys: 0.219 ± 0.103
1.424TrpAsp: 1.424 ± 0.274
0.931TrpGlu: 0.931 ± 0.243
0.548TrpPhe: 0.548 ± 0.171
1.205TrpGly: 1.205 ± 0.24
0.931TrpHis: 0.931 ± 0.217
1.314TrpIle: 1.314 ± 0.285
0.876TrpLys: 0.876 ± 0.193
1.862TrpLeu: 1.862 ± 0.318
1.041TrpMet: 1.041 ± 0.245
0.493TrpAsn: 0.493 ± 0.148
1.26TrpPro: 1.26 ± 0.292
1.041TrpGln: 1.041 ± 0.28
1.753TrpArg: 1.753 ± 0.285
1.533TrpSer: 1.533 ± 0.263
1.369TrpThr: 1.369 ± 0.298
1.479TrpVal: 1.479 ± 0.308
0.822TrpTrp: 0.822 ± 0.179
0.876TrpTyr: 0.876 ± 0.225
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.972TyrAla: 1.972 ± 0.366
0.329TyrCys: 0.329 ± 0.125
1.807TyrAsp: 1.807 ± 0.299
1.917TyrGlu: 1.917 ± 0.364
0.931TyrPhe: 0.931 ± 0.212
2.191TyrGly: 2.191 ± 0.376
0.767TyrHis: 0.767 ± 0.144
0.876TyrIle: 0.876 ± 0.183
0.712TyrLys: 0.712 ± 0.193
1.972TyrLeu: 1.972 ± 0.325
0.219TyrMet: 0.219 ± 0.096
0.986TyrAsn: 0.986 ± 0.25
1.479TyrPro: 1.479 ± 0.273
1.15TyrGln: 1.15 ± 0.25
2.465TyrArg: 2.465 ± 0.38
1.26TyrSer: 1.26 ± 0.24
1.917TyrThr: 1.917 ± 0.322
2.245TyrVal: 2.245 ± 0.356
0.822TyrTrp: 0.822 ± 0.253
0.548TyrTyr: 0.548 ± 0.139
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 110 proteins (18260 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski