Amino acid dipepetide frequency for Cyanobium usitatum str. Tous

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.075AlaAla: 17.075 ± 0.259
1.49AlaCys: 1.49 ± 0.053
5.897AlaAsp: 5.897 ± 0.094
7.558AlaGlu: 7.558 ± 0.134
3.29AlaPhe: 3.29 ± 0.068
10.715AlaGly: 10.715 ± 0.155
1.886AlaHis: 1.886 ± 0.061
5.297AlaIle: 5.297 ± 0.108
2.835AlaLys: 2.835 ± 0.069
15.344AlaLeu: 15.344 ± 0.185
2.694AlaMet: 2.694 ± 0.068
2.851AlaAsn: 2.851 ± 0.071
6.058AlaPro: 6.058 ± 0.115
4.801AlaGln: 4.801 ± 0.084
6.788AlaArg: 6.788 ± 0.093
7.177AlaSer: 7.177 ± 0.113
5.185AlaThr: 5.185 ± 0.088
8.517AlaVal: 8.517 ± 0.132
1.791AlaTrp: 1.791 ± 0.052
2.035AlaTyr: 2.035 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.977CysAla: 0.977 ± 0.039
0.257CysCys: 0.257 ± 0.018
0.627CysAsp: 0.627 ± 0.031
0.565CysGlu: 0.565 ± 0.027
0.427CysPhe: 0.427 ± 0.027
1.275CysGly: 1.275 ± 0.046
0.282CysHis: 0.282 ± 0.021
0.392CysIle: 0.392 ± 0.025
0.238CysLys: 0.238 ± 0.017
1.4CysLeu: 1.4 ± 0.054
0.178CysMet: 0.178 ± 0.016
0.285CysAsn: 0.285 ± 0.019
0.748CysPro: 0.748 ± 0.034
0.493CysGln: 0.493 ± 0.027
1.032CysArg: 1.032 ± 0.035
0.867CysSer: 0.867 ± 0.034
0.478CysThr: 0.478 ± 0.026
0.653CysVal: 0.653 ± 0.033
0.27CysTrp: 0.27 ± 0.02
0.217CysTyr: 0.217 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.923AspAla: 4.923 ± 0.095
0.535AspCys: 0.535 ± 0.029
2.176AspAsp: 2.176 ± 0.082
2.278AspGlu: 2.278 ± 0.065
1.556AspPhe: 1.556 ± 0.055
4.652AspGly: 4.652 ± 0.092
1.004AspHis: 1.004 ± 0.042
1.604AspIle: 1.604 ± 0.061
1.03AspLys: 1.03 ± 0.044
6.753AspLeu: 6.753 ± 0.137
0.633AspMet: 0.633 ± 0.033
1.093AspAsn: 1.093 ± 0.062
3.925AspPro: 3.925 ± 0.078
2.527AspGln: 2.527 ± 0.064
3.471AspArg: 3.471 ± 0.07
2.527AspSer: 2.527 ± 0.062
2.043AspThr: 2.043 ± 0.081
2.771AspVal: 2.771 ± 0.074
0.999AspTrp: 0.999 ± 0.038
1.054AspTyr: 1.054 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.985GluAla: 7.985 ± 0.114
0.388GluCys: 0.388 ± 0.021
1.946GluAsp: 1.946 ± 0.063
3.035GluGlu: 3.035 ± 0.089
1.28GluPhe: 1.28 ± 0.041
4.33GluGly: 4.33 ± 0.078
1.168GluHis: 1.168 ± 0.043
2.27GluIle: 2.27 ± 0.058
1.417GluLys: 1.417 ± 0.059
8.882GluLeu: 8.882 ± 0.138
0.897GluMet: 0.897 ± 0.033
0.973GluAsn: 0.973 ± 0.037
3.373GluPro: 3.373 ± 0.076
3.801GluGln: 3.801 ± 0.098
5.267GluArg: 5.267 ± 0.108
2.657GluSer: 2.657 ± 0.066
2.299GluThr: 2.299 ± 0.054
3.942GluVal: 3.942 ± 0.079
0.699GluTrp: 0.699 ± 0.033
0.641GluTyr: 0.641 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.202PheAla: 3.202 ± 0.059
0.499PheCys: 0.499 ± 0.024
1.978PheAsp: 1.978 ± 0.056
1.859PheGlu: 1.859 ± 0.056
0.985PhePhe: 0.985 ± 0.039
3.009PheGly: 3.009 ± 0.085
0.652PheHis: 0.652 ± 0.033
1.051PheIle: 1.051 ± 0.046
0.785PheLys: 0.785 ± 0.038
3.104PheLeu: 3.104 ± 0.076
0.485PheMet: 0.485 ± 0.027
1.073PheAsn: 1.073 ± 0.047
1.39PhePro: 1.39 ± 0.043
1.163PheGln: 1.163 ± 0.04
1.862PheArg: 1.862 ± 0.048
2.209PheSer: 2.209 ± 0.059
1.56PheThr: 1.56 ± 0.047
1.874PheVal: 1.874 ± 0.057
0.593PheTrp: 0.593 ± 0.032
0.766PheTyr: 0.766 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
8.856GlyAla: 8.856 ± 0.132
1.286GlyCys: 1.286 ± 0.046
4.429GlyAsp: 4.429 ± 0.134
4.782GlyGlu: 4.782 ± 0.093
3.163GlyPhe: 3.163 ± 0.069
7.527GlyGly: 7.527 ± 0.167
1.686GlyHis: 1.686 ± 0.05
3.878GlyIle: 3.878 ± 0.081
2.509GlyLys: 2.509 ± 0.06
11.748GlyLeu: 11.748 ± 0.13
1.874GlyMet: 1.874 ± 0.052
2.139GlyAsn: 2.139 ± 0.094
3.883GlyPro: 3.883 ± 0.077
4.015GlyGln: 4.015 ± 0.077
6.085GlyArg: 6.085 ± 0.104
6.107GlySer: 6.107 ± 0.129
4.023GlyThr: 4.023 ± 0.117
6.142GlyVal: 6.142 ± 0.091
1.87GlyTrp: 1.87 ± 0.055
1.967GlyTyr: 1.967 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.625HisAla: 1.625 ± 0.05
0.364HisCys: 0.364 ± 0.024
0.848HisAsp: 0.848 ± 0.037
0.774HisGlu: 0.774 ± 0.034
0.696HisPhe: 0.696 ± 0.034
1.953HisGly: 1.953 ± 0.05
0.744HisHis: 0.744 ± 0.04
0.659HisIle: 0.659 ± 0.034
0.352HisLys: 0.352 ± 0.021
2.485HisLeu: 2.485 ± 0.06
0.243HisMet: 0.243 ± 0.019
0.514HisAsn: 0.514 ± 0.027
1.593HisPro: 1.593 ± 0.046
1.014HisGln: 1.014 ± 0.039
1.719HisArg: 1.719 ± 0.049
1.144HisSer: 1.144 ± 0.046
0.84HisThr: 0.84 ± 0.038
0.974HisVal: 0.974 ± 0.039
0.549HisTrp: 0.549 ± 0.028
0.484HisTyr: 0.484 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
4.904IleAla: 4.904 ± 0.088
0.524IleCys: 0.524 ± 0.029
2.621IleAsp: 2.621 ± 0.071
2.775IleGlu: 2.775 ± 0.066
1.06IlePhe: 1.06 ± 0.048
4.148IleGly: 4.148 ± 0.084
0.835IleHis: 0.835 ± 0.036
1.035IleIle: 1.035 ± 0.044
1.114IleLys: 1.114 ± 0.038
3.12IleLeu: 3.12 ± 0.079
0.312IleMet: 0.312 ± 0.021
1.386IleAsn: 1.386 ± 0.05
2.352IlePro: 2.352 ± 0.061
1.602IleGln: 1.602 ± 0.043
2.656IleArg: 2.656 ± 0.067
2.894IleSer: 2.894 ± 0.059
2.531IleThr: 2.531 ± 0.069
2.309IleVal: 2.309 ± 0.062
0.618IleTrp: 0.618 ± 0.027
0.825IleTyr: 0.825 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
3.198LysAla: 3.198 ± 0.079
0.149LysCys: 0.149 ± 0.013
1.103LysAsp: 1.103 ± 0.044
1.324LysGlu: 1.324 ± 0.044
0.531LysPhe: 0.531 ± 0.028
2.099LysGly: 2.099 ± 0.06
0.415LysHis: 0.415 ± 0.024
0.927LysIle: 0.927 ± 0.042
0.719LysLys: 0.719 ± 0.037
2.91LysLeu: 2.91 ± 0.063
0.36LysMet: 0.36 ± 0.022
0.535LysAsn: 0.535 ± 0.029
1.736LysPro: 1.736 ± 0.055
1.226LysGln: 1.226 ± 0.051
1.82LysArg: 1.82 ± 0.061
1.221LysSer: 1.221 ± 0.044
1.274LysThr: 1.274 ± 0.044
1.797LysVal: 1.797 ± 0.056
0.196LysTrp: 0.196 ± 0.015
0.392LysTyr: 0.392 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
17.317LeuAla: 17.317 ± 0.19
1.259LeuCys: 1.259 ± 0.045
6.241LeuAsp: 6.241 ± 0.116
9.116LeuGlu: 9.116 ± 0.137
3.436LeuPhe: 3.436 ± 0.076
10.531LeuGly: 10.531 ± 0.148
2.415LeuHis: 2.415 ± 0.061
5.047LeuIle: 5.047 ± 0.089
3.142LeuLys: 3.142 ± 0.062
17.639LeuLeu: 17.639 ± 0.289
2.27LeuMet: 2.27 ± 0.055
3.139LeuAsn: 3.139 ± 0.078
7.901LeuPro: 7.901 ± 0.119
6.727LeuGln: 6.727 ± 0.12
8.973LeuArg: 8.973 ± 0.138
7.493LeuSer: 7.493 ± 0.109
5.467LeuThr: 5.467 ± 0.104
10.065LeuVal: 10.065 ± 0.158
1.904LeuTrp: 1.904 ± 0.059
1.908LeuTyr: 1.908 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.104MetAla: 3.104 ± 0.066
0.08MetCys: 0.08 ± 0.011
0.749MetAsp: 0.749 ± 0.033
1.018MetGlu: 1.018 ± 0.04
0.37MetPhe: 0.37 ± 0.024
1.798MetGly: 1.798 ± 0.054
0.298MetHis: 0.298 ± 0.021
0.554MetIle: 0.554 ± 0.029
0.467MetLys: 0.467 ± 0.03
1.873MetLeu: 1.873 ± 0.058
0.234MetMet: 0.234 ± 0.021
0.448MetAsn: 0.448 ± 0.024
1.237MetPro: 1.237 ± 0.044
0.737MetGln: 0.737 ± 0.036
1.167MetArg: 1.167 ± 0.037
1.011MetSer: 1.011 ± 0.037
1.004MetThr: 1.004 ± 0.04
1.44MetVal: 1.44 ± 0.048
0.114MetTrp: 0.114 ± 0.014
0.179MetTyr: 0.179 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.379AsnAla: 2.379 ± 0.062
0.299AsnCys: 0.299 ± 0.023
1.28AsnAsp: 1.28 ± 0.082
0.95AsnGlu: 0.95 ± 0.037
0.831AsnPhe: 0.831 ± 0.039
2.371AsnGly: 2.371 ± 0.078
0.515AsnHis: 0.515 ± 0.027
0.802AsnIle: 0.802 ± 0.039
0.634AsnLys: 0.634 ± 0.03
3.194AsnLeu: 3.194 ± 0.069
0.331AsnMet: 0.331 ± 0.019
0.699AsnAsn: 0.699 ± 0.048
2.085AsnPro: 2.085 ± 0.063
1.199AsnGln: 1.199 ± 0.042
1.836AsnArg: 1.836 ± 0.046
1.546AsnSer: 1.546 ± 0.05
1.192AsnThr: 1.192 ± 0.045
1.413AsnVal: 1.413 ± 0.052
0.435AsnTrp: 0.435 ± 0.027
0.55AsnTyr: 0.55 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
7.547ProAla: 7.547 ± 0.128
0.599ProCys: 0.599 ± 0.03
3.053ProAsp: 3.053 ± 0.066
4.186ProGlu: 4.186 ± 0.08
1.789ProPhe: 1.789 ± 0.05
5.377ProGly: 5.377 ± 0.108
1.068ProHis: 1.068 ± 0.038
2.232ProIle: 2.232 ± 0.057
1.211ProLys: 1.211 ± 0.041
7.702ProLeu: 7.702 ± 0.126
1.252ProMet: 1.252 ± 0.034
1.348ProAsn: 1.348 ± 0.047
3.175ProPro: 3.175 ± 0.08
2.574ProGln: 2.574 ± 0.067
3.084ProArg: 3.084 ± 0.064
3.634ProSer: 3.634 ± 0.069
2.513ProThr: 2.513 ± 0.059
4.257ProVal: 4.257 ± 0.09
1.065ProTrp: 1.065 ± 0.042
1.076ProTyr: 1.076 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
6.238GlnAla: 6.238 ± 0.117
0.325GlnCys: 0.325 ± 0.021
1.424GlnAsp: 1.424 ± 0.048
2.558GlnGlu: 2.558 ± 0.079
1.093GlnPhe: 1.093 ± 0.046
3.917GlnGly: 3.917 ± 0.075
0.942GlnHis: 0.942 ± 0.045
1.845GlnIle: 1.845 ± 0.048
1.049GlnLys: 1.049 ± 0.04
8.156GlnLeu: 8.156 ± 0.131
0.759GlnMet: 0.759 ± 0.037
0.814GlnAsn: 0.814 ± 0.035
3.107GlnPro: 3.107 ± 0.077
3.591GlnGln: 3.591 ± 0.103
4.462GlnArg: 4.462 ± 0.099
2.287GlnSer: 2.287 ± 0.054
1.592GlnThr: 1.592 ± 0.052
3.653GlnVal: 3.653 ± 0.074
0.873GlnTrp: 0.873 ± 0.038
0.462GlnTyr: 0.462 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
6.097ArgAla: 6.097 ± 0.09
1.053ArgCys: 1.053 ± 0.035
3.034ArgAsp: 3.034 ± 0.062
3.515ArgGlu: 3.515 ± 0.082
2.728ArgPhe: 2.728 ± 0.062
4.797ArgGly: 4.797 ± 0.101
1.802ArgHis: 1.802 ± 0.059
3.122ArgIle: 3.122 ± 0.063
1.499ArgLys: 1.499 ± 0.051
10.325ArgLeu: 10.325 ± 0.152
1.359ArgMet: 1.359 ± 0.047
1.642ArgAsn: 1.642 ± 0.044
3.825ArgPro: 3.825 ± 0.08
4.649ArgGln: 4.649 ± 0.095
6.171ArgArg: 6.171 ± 0.118
4.524ArgSer: 4.524 ± 0.074
2.709ArgThr: 2.709 ± 0.062
4.154ArgVal: 4.154 ± 0.085
1.766ArgTrp: 1.766 ± 0.058
1.627ArgTyr: 1.627 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.316SerAla: 6.316 ± 0.1
0.839SerCys: 0.839 ± 0.037
2.992SerAsp: 2.992 ± 0.067
3.05SerGlu: 3.05 ± 0.069
2.218SerPhe: 2.218 ± 0.071
6.337SerGly: 6.337 ± 0.104
1.26SerHis: 1.26 ± 0.041
2.298SerIle: 2.298 ± 0.062
1.417SerLys: 1.417 ± 0.05
7.507SerLeu: 7.507 ± 0.111
1.179SerMet: 1.179 ± 0.042
1.565SerAsn: 1.565 ± 0.053
3.458SerPro: 3.458 ± 0.069
2.658SerGln: 2.658 ± 0.067
4.218SerArg: 4.218 ± 0.089
4.446SerSer: 4.446 ± 0.098
2.957SerThr: 2.957 ± 0.078
3.527SerVal: 3.527 ± 0.069
1.259SerTrp: 1.259 ± 0.042
1.363SerTyr: 1.363 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.769ThrAla: 5.769 ± 0.099
0.492ThrCys: 0.492 ± 0.03
2.015ThrAsp: 2.015 ± 0.067
2.073ThrGlu: 2.073 ± 0.048
1.314ThrPhe: 1.314 ± 0.039
4.294ThrGly: 4.294 ± 0.118
0.722ThrHis: 0.722 ± 0.034
2.041ThrIle: 2.041 ± 0.062
1.041ThrLys: 1.041 ± 0.043
5.213ThrLeu: 5.213 ± 0.095
0.822ThrMet: 0.822 ± 0.031
1.241ThrAsn: 1.241 ± 0.052
3.358ThrPro: 3.358 ± 0.069
1.392ThrGln: 1.392 ± 0.046
2.333ThrArg: 2.333 ± 0.054
2.967ThrSer: 2.967 ± 0.076
2.542ThrThr: 2.542 ± 0.066
3.289ThrVal: 3.289 ± 0.088
0.634ThrTrp: 0.634 ± 0.026
1.05ThrTyr: 1.05 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
8.409ValAla: 8.409 ± 0.117
0.696ValCys: 0.696 ± 0.033
3.566ValAsp: 3.566 ± 0.083
4.284ValGlu: 4.284 ± 0.081
2.179ValPhe: 2.179 ± 0.065
5.522ValGly: 5.522 ± 0.089
1.168ValHis: 1.168 ± 0.038
3.157ValIle: 3.157 ± 0.075
1.684ValLys: 1.684 ± 0.058
9.45ValLeu: 9.45 ± 0.111
1.383ValMet: 1.383 ± 0.047
1.856ValAsn: 1.856 ± 0.053
3.494ValPro: 3.494 ± 0.066
2.867ValGln: 2.867 ± 0.07
4.287ValArg: 4.287 ± 0.085
3.905ValSer: 3.905 ± 0.072
3.077ValThr: 3.077 ± 0.079
6.404ValVal: 6.404 ± 0.1
0.856ValTrp: 0.856 ± 0.038
1.073ValTyr: 1.073 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.493TrpAla: 1.493 ± 0.047
0.259TrpCys: 0.259 ± 0.022
0.633TrpAsp: 0.633 ± 0.031
0.66TrpGlu: 0.66 ± 0.028
0.556TrpPhe: 0.556 ± 0.027
1.209TrpGly: 1.209 ± 0.044
0.397TrpHis: 0.397 ± 0.022
0.791TrpIle: 0.791 ± 0.03
0.355TrpLys: 0.355 ± 0.02
3.02TrpLeu: 3.02 ± 0.069
0.369TrpMet: 0.369 ± 0.025
0.458TrpAsn: 0.458 ± 0.026
1.009TrpPro: 1.009 ± 0.04
1.287TrpGln: 1.287 ± 0.047
1.473TrpArg: 1.473 ± 0.042
1.13TrpSer: 1.13 ± 0.037
0.522TrpThr: 0.522 ± 0.03
0.944TrpVal: 0.944 ± 0.035
0.369TrpTrp: 0.369 ± 0.02
0.275TrpTyr: 0.275 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.871TyrAla: 1.871 ± 0.057
0.267TyrCys: 0.267 ± 0.02
0.942TyrAsp: 0.942 ± 0.037
0.89TyrGlu: 0.89 ± 0.035
0.598TyrPhe: 0.598 ± 0.034
2.11TyrGly: 2.11 ± 0.061
0.316TyrHis: 0.316 ± 0.022
0.618TyrIle: 0.618 ± 0.031
0.432TyrLys: 0.432 ± 0.027
2.167TyrLeu: 2.167 ± 0.054
0.249TyrMet: 0.249 ± 0.02
0.481TyrAsn: 0.481 ± 0.024
1.032TyrPro: 1.032 ± 0.042
0.825TyrGln: 0.825 ± 0.038
1.692TyrArg: 1.692 ± 0.052
1.116TyrSer: 1.116 ± 0.041
0.793TyrThr: 0.793 ± 0.049
1.194TyrVal: 1.194 ± 0.051
0.35TyrTrp: 0.35 ± 0.02
0.428TyrTyr: 0.428 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2524 proteins (738024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski