Amino acid dipepetide frequency for Lysobacter defluvii IMMIB APB-9 = DSM 18482

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.59AlaAla: 17.59 ± 0.217
1.111AlaCys: 1.111 ± 0.038
7.33AlaAsp: 7.33 ± 0.106
7.958AlaGlu: 7.958 ± 0.151
3.865AlaPhe: 3.865 ± 0.079
12.871AlaGly: 12.871 ± 0.153
2.44AlaHis: 2.44 ± 0.057
5.0AlaIle: 5.0 ± 0.088
2.403AlaLys: 2.403 ± 0.077
14.644AlaLeu: 14.644 ± 0.204
3.499AlaMet: 3.499 ± 0.076
2.694AlaAsn: 2.694 ± 0.069
6.264AlaPro: 6.264 ± 0.104
3.974AlaGln: 3.974 ± 0.074
10.664AlaArg: 10.664 ± 0.145
6.193AlaSer: 6.193 ± 0.093
6.149AlaThr: 6.149 ± 0.101
8.855AlaVal: 8.855 ± 0.118
2.179AlaTrp: 2.179 ± 0.064
2.284AlaTyr: 2.284 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.874CysAla: 0.874 ± 0.038
0.091CysCys: 0.091 ± 0.011
0.452CysAsp: 0.452 ± 0.025
0.49CysGlu: 0.49 ± 0.029
0.223CysPhe: 0.223 ± 0.017
0.821CysGly: 0.821 ± 0.029
0.246CysHis: 0.246 ± 0.02
0.287CysIle: 0.287 ± 0.023
0.139CysLys: 0.139 ± 0.016
0.675CysLeu: 0.675 ± 0.028
0.133CysMet: 0.133 ± 0.015
0.196CysAsn: 0.196 ± 0.017
0.402CysPro: 0.402 ± 0.029
0.208CysGln: 0.208 ± 0.018
0.576CysArg: 0.576 ± 0.028
0.44CysSer: 0.44 ± 0.025
0.429CysThr: 0.429 ± 0.022
0.61CysVal: 0.61 ± 0.031
0.107CysTrp: 0.107 ± 0.012
0.177CysTyr: 0.177 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
8.241AspAla: 8.241 ± 0.119
0.436AspCys: 0.436 ± 0.027
3.356AspAsp: 3.356 ± 0.075
3.879AspGlu: 3.879 ± 0.08
2.069AspPhe: 2.069 ± 0.052
6.356AspGly: 6.356 ± 0.11
1.268AspHis: 1.268 ± 0.05
2.277AspIle: 2.277 ± 0.06
1.135AspLys: 1.135 ± 0.048
5.725AspLeu: 5.725 ± 0.093
1.127AspMet: 1.127 ± 0.039
1.231AspAsn: 1.231 ± 0.043
4.276AspPro: 4.276 ± 0.074
1.739AspGln: 1.739 ± 0.046
4.712AspArg: 4.712 ± 0.087
2.437AspSer: 2.437 ± 0.055
2.727AspThr: 2.727 ± 0.058
4.208AspVal: 4.208 ± 0.082
1.131AspTrp: 1.131 ± 0.039
1.608AspTyr: 1.608 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
8.406GluAla: 8.406 ± 0.147
0.396GluCys: 0.396 ± 0.025
3.153GluAsp: 3.153 ± 0.071
3.359GluGlu: 3.359 ± 0.087
1.904GluPhe: 1.904 ± 0.056
5.298GluGly: 5.298 ± 0.08
1.503GluHis: 1.503 ± 0.042
2.501GluIle: 2.501 ± 0.069
1.472GluLys: 1.472 ± 0.057
7.18GluLeu: 7.18 ± 0.112
1.317GluMet: 1.317 ± 0.036
1.161GluAsn: 1.161 ± 0.04
3.367GluPro: 3.367 ± 0.068
2.831GluGln: 2.831 ± 0.062
6.22GluArg: 6.22 ± 0.118
2.708GluSer: 2.708 ± 0.06
2.503GluThr: 2.503 ± 0.06
5.207GluVal: 5.207 ± 0.094
0.92GluTrp: 0.92 ± 0.036
1.359GluTyr: 1.359 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.82PheAla: 3.82 ± 0.078
0.291PheCys: 0.291 ± 0.022
2.637PheAsp: 2.637 ± 0.061
2.152PheGlu: 2.152 ± 0.05
1.145PhePhe: 1.145 ± 0.045
3.364PheGly: 3.364 ± 0.069
0.801PheHis: 0.801 ± 0.029
1.177PheIle: 1.177 ± 0.043
0.675PheLys: 0.675 ± 0.033
2.988PheLeu: 2.988 ± 0.064
0.647PheMet: 0.647 ± 0.029
0.962PheAsn: 0.962 ± 0.04
1.382PhePro: 1.382 ± 0.049
0.935PheGln: 0.935 ± 0.035
2.241PheArg: 2.241 ± 0.053
1.743PheSer: 1.743 ± 0.049
1.754PheThr: 1.754 ± 0.048
2.448PheVal: 2.448 ± 0.067
0.488PheTrp: 0.488 ± 0.031
0.756PheTyr: 0.756 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
9.829GlyAla: 9.829 ± 0.131
0.759GlyCys: 0.759 ± 0.031
5.306GlyAsp: 5.306 ± 0.096
6.327GlyGlu: 6.327 ± 0.11
3.482GlyPhe: 3.482 ± 0.082
8.331GlyGly: 8.331 ± 0.139
2.267GlyHis: 2.267 ± 0.067
3.928GlyIle: 3.928 ± 0.078
2.57GlyLys: 2.57 ± 0.076
9.695GlyLeu: 9.695 ± 0.131
2.549GlyMet: 2.549 ± 0.065
2.468GlyAsn: 2.468 ± 0.068
3.844GlyPro: 3.844 ± 0.082
3.143GlyGln: 3.143 ± 0.07
7.348GlyArg: 7.348 ± 0.103
5.086GlySer: 5.086 ± 0.106
4.969GlyThr: 4.969 ± 0.08
6.759GlyVal: 6.759 ± 0.104
1.723GlyTrp: 1.723 ± 0.059
2.395GlyTyr: 2.395 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
3.038HisAla: 3.038 ± 0.075
0.267HisCys: 0.267 ± 0.02
1.382HisAsp: 1.382 ± 0.042
1.275HisGlu: 1.275 ± 0.043
0.805HisPhe: 0.805 ± 0.039
2.422HisGly: 2.422 ± 0.069
0.599HisHis: 0.599 ± 0.032
0.673HisIle: 0.673 ± 0.031
0.396HisLys: 0.396 ± 0.024
2.147HisLeu: 2.147 ± 0.054
0.433HisMet: 0.433 ± 0.025
0.483HisAsn: 0.483 ± 0.026
1.509HisPro: 1.509 ± 0.054
0.686HisGln: 0.686 ± 0.029
1.735HisArg: 1.735 ± 0.055
0.982HisSer: 0.982 ± 0.037
0.97HisThr: 0.97 ± 0.037
1.708HisVal: 1.708 ± 0.053
0.386HisTrp: 0.386 ± 0.021
0.568HisTyr: 0.568 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.472IleAla: 5.472 ± 0.095
0.291IleCys: 0.291 ± 0.021
2.953IleAsp: 2.953 ± 0.061
3.049IleGlu: 3.049 ± 0.074
0.949IlePhe: 0.949 ± 0.04
4.105IleGly: 4.105 ± 0.085
0.813IleHis: 0.813 ± 0.034
1.306IleIle: 1.306 ± 0.056
0.851IleLys: 0.851 ± 0.042
2.878IleLeu: 2.878 ± 0.073
0.57IleMet: 0.57 ± 0.033
1.15IleAsn: 1.15 ± 0.044
2.059IlePro: 2.059 ± 0.056
1.064IleGln: 1.064 ± 0.04
2.766IleArg: 2.766 ± 0.069
1.84IleSer: 1.84 ± 0.056
2.02IleThr: 2.02 ± 0.054
2.783IleVal: 2.783 ± 0.077
0.352IleTrp: 0.352 ± 0.023
0.729IleTyr: 0.729 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
2.746LysAla: 2.746 ± 0.089
0.106LysCys: 0.106 ± 0.011
1.176LysAsp: 1.176 ± 0.045
1.034LysGlu: 1.034 ± 0.046
0.604LysPhe: 0.604 ± 0.033
1.71LysGly: 1.71 ± 0.053
0.453LysHis: 0.453 ± 0.025
0.858LysIle: 0.858 ± 0.04
0.727LysLys: 0.727 ± 0.045
2.411LysLeu: 2.411 ± 0.059
0.484LysMet: 0.484 ± 0.03
0.434LysAsn: 0.434 ± 0.024
1.315LysPro: 1.315 ± 0.045
0.848LysGln: 0.848 ± 0.043
1.716LysArg: 1.716 ± 0.055
1.103LysSer: 1.103 ± 0.051
1.065LysThr: 1.065 ± 0.041
1.999LysVal: 1.999 ± 0.07
0.291LysTrp: 0.291 ± 0.022
0.498LysTyr: 0.498 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
15.557LeuAla: 15.557 ± 0.207
0.79LeuCys: 0.79 ± 0.03
7.162LeuAsp: 7.162 ± 0.103
7.118LeuGlu: 7.118 ± 0.129
3.219LeuPhe: 3.219 ± 0.069
9.189LeuGly: 9.189 ± 0.128
2.383LeuHis: 2.383 ± 0.064
2.986LeuIle: 2.986 ± 0.074
2.336LeuLys: 2.336 ± 0.063
11.764LeuLeu: 11.764 ± 0.191
2.206LeuMet: 2.206 ± 0.06
1.973LeuAsn: 1.973 ± 0.049
6.434LeuPro: 6.434 ± 0.106
3.87LeuGln: 3.87 ± 0.079
8.942LeuArg: 8.942 ± 0.115
5.245LeuSer: 5.245 ± 0.091
4.203LeuThr: 4.203 ± 0.07
9.375LeuVal: 9.375 ± 0.152
1.284LeuTrp: 1.284 ± 0.048
1.985LeuTyr: 1.985 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.843MetAla: 2.843 ± 0.078
0.119MetCys: 0.119 ± 0.013
1.35MetAsp: 1.35 ± 0.047
1.277MetGlu: 1.277 ± 0.043
0.671MetPhe: 0.671 ± 0.031
1.712MetGly: 1.712 ± 0.055
0.488MetHis: 0.488 ± 0.024
0.857MetIle: 0.857 ± 0.035
0.685MetLys: 0.685 ± 0.031
2.626MetLeu: 2.626 ± 0.068
0.483MetMet: 0.483 ± 0.027
0.616MetAsn: 0.616 ± 0.03
1.38MetPro: 1.38 ± 0.047
0.881MetGln: 0.881 ± 0.031
1.836MetArg: 1.836 ± 0.051
1.373MetSer: 1.373 ± 0.044
1.283MetThr: 1.283 ± 0.043
1.658MetVal: 1.658 ± 0.053
0.222MetTrp: 0.222 ± 0.018
0.387MetTyr: 0.387 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.79AsnAla: 2.79 ± 0.061
0.204AsnCys: 0.204 ± 0.016
1.216AsnAsp: 1.216 ± 0.048
1.162AsnGlu: 1.162 ± 0.042
0.724AsnPhe: 0.724 ± 0.035
2.03AsnGly: 2.03 ± 0.052
0.478AsnHis: 0.478 ± 0.026
0.997AsnIle: 0.997 ± 0.038
0.479AsnLys: 0.479 ± 0.029
2.361AsnLeu: 2.361 ± 0.055
0.425AsnMet: 0.425 ± 0.026
0.562AsnAsn: 0.562 ± 0.027
1.756AsnPro: 1.756 ± 0.053
0.656AsnGln: 0.656 ± 0.028
1.733AsnArg: 1.733 ± 0.045
0.98AsnSer: 0.98 ± 0.045
1.169AsnThr: 1.169 ± 0.043
1.677AsnVal: 1.677 ± 0.045
0.344AsnTrp: 0.344 ± 0.023
0.564AsnTyr: 0.564 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
7.57ProAla: 7.57 ± 0.135
0.304ProCys: 0.304 ± 0.021
4.009ProAsp: 4.009 ± 0.078
4.034ProGlu: 4.034 ± 0.086
1.625ProPhe: 1.625 ± 0.041
5.986ProGly: 5.986 ± 0.099
1.103ProHis: 1.103 ± 0.042
1.675ProIle: 1.675 ± 0.057
0.995ProLys: 0.995 ± 0.042
5.253ProLeu: 5.253 ± 0.098
1.349ProMet: 1.349 ± 0.041
0.993ProAsn: 0.993 ± 0.039
3.122ProPro: 3.122 ± 0.09
1.62ProGln: 1.62 ± 0.052
3.963ProArg: 3.963 ± 0.078
2.593ProSer: 2.593 ± 0.059
2.296ProThr: 2.296 ± 0.059
4.94ProVal: 4.94 ± 0.093
0.842ProTrp: 0.842 ± 0.033
1.12ProTyr: 1.12 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.907GlnAla: 4.907 ± 0.094
0.206GlnCys: 0.206 ± 0.016
1.54GlnAsp: 1.54 ± 0.044
1.702GlnGlu: 1.702 ± 0.052
1.012GlnPhe: 1.012 ± 0.037
2.598GlnGly: 2.598 ± 0.058
0.686GlnHis: 0.686 ± 0.028
1.095GlnIle: 1.095 ± 0.043
0.717GlnLys: 0.717 ± 0.04
3.921GlnLeu: 3.921 ± 0.072
0.777GlnMet: 0.777 ± 0.033
0.543GlnAsn: 0.543 ± 0.03
2.013GlnPro: 2.013 ± 0.053
1.575GlnGln: 1.575 ± 0.044
3.053GlnArg: 3.053 ± 0.062
1.434GlnSer: 1.434 ± 0.049
1.162GlnThr: 1.162 ± 0.04
3.337GlnVal: 3.337 ± 0.074
0.587GlnTrp: 0.587 ± 0.028
0.693GlnTyr: 0.693 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
9.008ArgAla: 9.008 ± 0.128
0.532ArgCys: 0.532 ± 0.029
4.644ArgAsp: 4.644 ± 0.07
5.867ArgGlu: 5.867 ± 0.099
3.093ArgPhe: 3.093 ± 0.074
6.337ArgGly: 6.337 ± 0.091
2.219ArgHis: 2.219 ± 0.053
3.982ArgIle: 3.982 ± 0.069
1.85ArgLys: 1.85 ± 0.058
9.343ArgLeu: 9.343 ± 0.139
2.175ArgMet: 2.175 ± 0.06
1.903ArgAsn: 1.903 ± 0.056
4.156ArgPro: 4.156 ± 0.079
2.999ArgGln: 2.999 ± 0.054
6.766ArgArg: 6.766 ± 0.112
3.686ArgSer: 3.686 ± 0.077
3.468ArgThr: 3.468 ± 0.07
6.007ArgVal: 6.007 ± 0.109
1.43ArgTrp: 1.43 ± 0.054
2.149ArgTyr: 2.149 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.607SerAla: 5.607 ± 0.091
0.382SerCys: 0.382 ± 0.026
2.587SerAsp: 2.587 ± 0.067
2.461SerGlu: 2.461 ± 0.059
1.694SerPhe: 1.694 ± 0.047
5.334SerGly: 5.334 ± 0.103
1.05SerHis: 1.05 ± 0.036
2.051SerIle: 2.051 ± 0.061
1.024SerLys: 1.024 ± 0.04
5.174SerLeu: 5.174 ± 0.083
1.107SerMet: 1.107 ± 0.04
1.18SerAsn: 1.18 ± 0.043
2.663SerPro: 2.663 ± 0.072
1.534SerGln: 1.534 ± 0.048
3.932SerArg: 3.932 ± 0.072
2.575SerSer: 2.575 ± 0.075
2.547SerThr: 2.547 ± 0.06
3.533SerVal: 3.533 ± 0.08
0.728SerTrp: 0.728 ± 0.031
1.123SerTyr: 1.123 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
5.775ThrAla: 5.775 ± 0.089
0.349ThrCys: 0.349 ± 0.021
2.545ThrAsp: 2.545 ± 0.055
2.157ThrGlu: 2.157 ± 0.06
1.391ThrPhe: 1.391 ± 0.045
5.262ThrGly: 5.262 ± 0.087
1.005ThrHis: 1.005 ± 0.04
1.847ThrIle: 1.847 ± 0.053
0.747ThrLys: 0.747 ± 0.036
5.483ThrLeu: 5.483 ± 0.077
0.88ThrMet: 0.88 ± 0.04
0.935ThrAsn: 0.935 ± 0.04
3.192ThrPro: 3.192 ± 0.058
1.166ThrGln: 1.166 ± 0.037
3.804ThrArg: 3.804 ± 0.073
2.21ThrSer: 2.21 ± 0.052
2.44ThrThr: 2.44 ± 0.063
3.98ThrVal: 3.98 ± 0.077
0.681ThrTrp: 0.681 ± 0.03
0.921ThrTyr: 0.921 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
10.176ValAla: 10.176 ± 0.139
0.622ValCys: 0.622 ± 0.031
5.076ValAsp: 5.076 ± 0.081
5.572ValGlu: 5.572 ± 0.082
2.563ValPhe: 2.563 ± 0.065
6.073ValGly: 6.073 ± 0.119
1.783ValHis: 1.783 ± 0.055
3.087ValIle: 3.087 ± 0.07
1.557ValLys: 1.557 ± 0.051
9.168ValLeu: 9.168 ± 0.117
1.704ValMet: 1.704 ± 0.054
1.835ValAsn: 1.835 ± 0.052
4.329ValPro: 4.329 ± 0.082
2.363ValGln: 2.363 ± 0.054
6.116ValArg: 6.116 ± 0.094
3.689ValSer: 3.689 ± 0.071
3.771ValThr: 3.771 ± 0.075
7.108ValVal: 7.108 ± 0.122
0.848ValTrp: 0.848 ± 0.037
1.46ValTyr: 1.46 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
1.267TrpAla: 1.267 ± 0.042
0.13TrpCys: 0.13 ± 0.014
0.762TrpAsp: 0.762 ± 0.032
0.708TrpGlu: 0.708 ± 0.028
0.564TrpPhe: 0.564 ± 0.03
0.995TrpGly: 0.995 ± 0.041
0.383TrpHis: 0.383 ± 0.024
0.733TrpIle: 0.733 ± 0.035
0.395TrpLys: 0.395 ± 0.023
2.238TrpLeu: 2.238 ± 0.07
0.467TrpMet: 0.467 ± 0.03
0.426TrpAsn: 0.426 ± 0.029
0.82TrpPro: 0.82 ± 0.035
0.664TrpGln: 0.664 ± 0.03
1.352TrpArg: 1.352 ± 0.048
0.848TrpSer: 0.848 ± 0.036
0.766TrpThr: 0.766 ± 0.032
1.05TrpVal: 1.05 ± 0.04
0.355TrpTrp: 0.355 ± 0.023
0.333TrpTyr: 0.333 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.452TyrAla: 2.452 ± 0.063
0.192TyrCys: 0.192 ± 0.018
1.302TyrAsp: 1.302 ± 0.045
1.183TyrGlu: 1.183 ± 0.045
0.804TyrPhe: 0.804 ± 0.036
1.984TyrGly: 1.984 ± 0.054
0.494TyrHis: 0.494 ± 0.026
0.683TyrIle: 0.683 ± 0.035
0.424TyrLys: 0.424 ± 0.024
2.345TyrLeu: 2.345 ± 0.055
0.418TyrMet: 0.418 ± 0.025
0.563TyrAsn: 0.563 ± 0.032
1.108TyrPro: 1.108 ± 0.037
0.801TyrGln: 0.801 ± 0.029
2.138TyrArg: 2.138 ± 0.055
1.123TyrSer: 1.123 ± 0.052
1.08TyrThr: 1.08 ± 0.038
1.659TyrVal: 1.659 ± 0.053
0.359TyrTrp: 0.359 ± 0.021
0.568TyrTyr: 0.568 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2443 proteins (739019 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski