Amino acid dipepetide frequency for Bifidobacterium stellenboschense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.188AlaAla: 16.188 ± 0.227	1.117AlaCys: 1.117 ± 0.045	8.392AlaAsp: 8.392 ± 0.14	6.139AlaGlu: 6.139 ± 0.11	3.696AlaPhe: 3.696 ± 0.074	10.398AlaGly: 10.398 ± 0.152	2.357AlaHis: 2.357 ± 0.066	5.602AlaIle: 5.602 ± 0.094	5.005AlaLys: 5.005 ± 0.111	10.362AlaLeu: 10.362 ± 0.144	3.384AlaMet: 3.384 ± 0.068	3.349AlaAsn: 3.349 ± 0.073	4.681AlaPro: 4.681 ± 0.113	3.761AlaGln: 3.761 ± 0.089	7.011AlaArg: 7.011 ± 0.116	6.592AlaSer: 6.592 ± 0.104	7.032AlaThr: 7.032 ± 0.108	9.046AlaVal: 9.046 ± 0.121	1.548AlaTrp: 1.548 ± 0.048	2.83AlaTyr: 2.83 ± 0.059	0.001AlaXaa: 0.001 ± 0.001
Cys	1.1CysAla: 1.1 ± 0.041	0.114CysCys: 0.114 ± 0.014	0.535CysAsp: 0.535 ± 0.028	0.462CysGlu: 0.462 ± 0.029	0.31CysPhe: 0.31 ± 0.023	1.035CysGly: 1.035 ± 0.043	0.202CysHis: 0.202 ± 0.014	0.323CysIle: 0.323 ± 0.018	0.192CysLys: 0.192 ± 0.014	0.765CysLeu: 0.765 ± 0.031	0.226CysMet: 0.226 ± 0.018	0.214CysAsn: 0.214 ± 0.016	0.439CysPro: 0.439 ± 0.024	0.171CysGln: 0.171 ± 0.015	0.57CysArg: 0.57 ± 0.029	0.462CysSer: 0.462 ± 0.027	0.493CysThr: 0.493 ± 0.026	0.78CysVal: 0.78 ± 0.034	0.118CysTrp: 0.118 ± 0.012	0.237CysTyr: 0.237 ± 0.015	0.001CysXaa: 0.001 ± 0.001
Asp	8.837AspAla: 8.837 ± 0.137	0.502AspCys: 0.502 ± 0.028	5.528AspAsp: 5.528 ± 0.102	4.874AspGlu: 4.874 ± 0.089	2.216AspPhe: 2.216 ± 0.055	7.139AspGly: 7.139 ± 0.126	1.393AspHis: 1.393 ± 0.042	3.003AspIle: 3.003 ± 0.065	2.419AspLys: 2.419 ± 0.072	5.369AspLeu: 5.369 ± 0.1	1.682AspMet: 1.682 ± 0.054	1.524AspAsn: 1.524 ± 0.051	3.626AspPro: 3.626 ± 0.071	1.753AspGln: 1.753 ± 0.049	3.832AspArg: 3.832 ± 0.083	3.386AspSer: 3.386 ± 0.077	3.63AspThr: 3.63 ± 0.069	5.437AspVal: 5.437 ± 0.097	1.066AspTrp: 1.066 ± 0.04	2.018AspTyr: 2.018 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	6.168GluAla: 6.168 ± 0.123	0.376GluCys: 0.376 ± 0.021	3.004GluAsp: 3.004 ± 0.084	3.126GluGlu: 3.126 ± 0.079	1.807GluPhe: 1.807 ± 0.052	3.823GluGly: 3.823 ± 0.08	1.662GluHis: 1.662 ± 0.05	2.617GluIle: 2.617 ± 0.064	2.072GluLys: 2.072 ± 0.066	5.026GluLeu: 5.026 ± 0.09	1.287GluMet: 1.287 ± 0.043	1.795GluAsn: 1.795 ± 0.055	2.71GluPro: 2.71 ± 0.07	2.207GluGln: 2.207 ± 0.06	4.632GluArg: 4.632 ± 0.088	3.132GluSer: 3.132 ± 0.07	3.651GluThr: 3.651 ± 0.075	3.245GluVal: 3.245 ± 0.08	0.657GluTrp: 0.657 ± 0.032	1.692GluTyr: 1.692 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	4.169PheAla: 4.169 ± 0.076	0.348PheCys: 0.348 ± 0.022	2.738PheAsp: 2.738 ± 0.061	1.707PheGlu: 1.707 ± 0.049	1.132PhePhe: 1.132 ± 0.04	3.193PheGly: 3.193 ± 0.079	0.715PheHis: 0.715 ± 0.031	1.554PheIle: 1.554 ± 0.049	1.089PheLys: 1.089 ± 0.039	2.772PheLeu: 2.772 ± 0.068	0.73PheMet: 0.73 ± 0.027	1.086PheAsn: 1.086 ± 0.04	1.373PhePro: 1.373 ± 0.045	0.857PheGln: 0.857 ± 0.034	1.874PheArg: 1.874 ± 0.047	1.965PheSer: 1.965 ± 0.055	2.46PheThr: 2.46 ± 0.083	2.594PheVal: 2.594 ± 0.06	0.432PheTrp: 0.432 ± 0.025	0.889PheTyr: 0.889 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.61GlyAla: 8.61 ± 0.14	0.765GlyCys: 0.765 ± 0.031	5.666GlyAsp: 5.666 ± 0.088	4.915GlyGlu: 4.915 ± 0.088	3.23GlyPhe: 3.23 ± 0.073	7.091GlyGly: 7.091 ± 0.145	1.749GlyHis: 1.749 ± 0.045	4.366GlyIle: 4.366 ± 0.074	3.816GlyLys: 3.816 ± 0.086	7.18GlyLeu: 7.18 ± 0.109	2.334GlyMet: 2.334 ± 0.058	2.628GlyAsn: 2.628 ± 0.074	2.662GlyPro: 2.662 ± 0.066	2.357GlyGln: 2.357 ± 0.059	5.252GlyArg: 5.252 ± 0.1	5.266GlySer: 5.266 ± 0.097	5.762GlyThr: 5.762 ± 0.118	7.169GlyVal: 7.169 ± 0.111	1.241GlyTrp: 1.241 ± 0.04	2.715GlyTyr: 2.715 ± 0.063	0.002GlyXaa: 0.002 ± 0.001
His	2.47HisAla: 2.47 ± 0.059	0.197HisCys: 0.197 ± 0.016	1.572HisAsp: 1.572 ± 0.043	1.202HisGlu: 1.202 ± 0.044	0.555HisPhe: 0.555 ± 0.025	2.031HisGly: 2.031 ± 0.056	0.524HisHis: 0.524 ± 0.029	1.045HisIle: 1.045 ± 0.041	0.565HisLys: 0.565 ± 0.028	1.58HisLeu: 1.58 ± 0.045	0.595HisMet: 0.595 ± 0.025	0.545HisAsn: 0.545 ± 0.026	1.277HisPro: 1.277 ± 0.045	0.523HisGln: 0.523 ± 0.028	1.409HisArg: 1.409 ± 0.047	0.896HisSer: 0.896 ± 0.033	1.199HisThr: 1.199 ± 0.044	1.853HisVal: 1.853 ± 0.06	0.319HisTrp: 0.319 ± 0.02	0.602HisTyr: 0.602 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.638IleAla: 6.638 ± 0.095	0.518IleCys: 0.518 ± 0.025	4.022IleAsp: 4.022 ± 0.073	2.837IleGlu: 2.837 ± 0.07	1.244IlePhe: 1.244 ± 0.044	4.512IleGly: 4.512 ± 0.088	0.888IleHis: 0.888 ± 0.035	2.657IleIle: 2.657 ± 0.066	1.513IleLys: 1.513 ± 0.055	3.616IleLeu: 3.616 ± 0.08	1.017IleMet: 1.017 ± 0.038	1.511IleAsn: 1.511 ± 0.039	2.555IlePro: 2.555 ± 0.059	1.162IleGln: 1.162 ± 0.04	3.055IleArg: 3.055 ± 0.057	2.447IleSer: 2.447 ± 0.065	3.111IleThr: 3.111 ± 0.07	4.604IleVal: 4.604 ± 0.099	0.454IleTrp: 0.454 ± 0.025	1.034IleTyr: 1.034 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.964LysAla: 4.964 ± 0.097	0.176LysCys: 0.176 ± 0.016	2.594LysAsp: 2.594 ± 0.077	2.072LysGlu: 2.072 ± 0.065	0.91LysPhe: 0.91 ± 0.033	2.761LysGly: 2.761 ± 0.076	0.775LysHis: 0.775 ± 0.031	1.58LysIle: 1.58 ± 0.052	1.668LysLys: 1.668 ± 0.058	3.105LysLeu: 3.105 ± 0.067	0.783LysMet: 0.783 ± 0.037	1.284LysAsn: 1.284 ± 0.046	2.311LysPro: 2.311 ± 0.062	1.277LysGln: 1.277 ± 0.045	2.462LysArg: 2.462 ± 0.049	2.093LysSer: 2.093 ± 0.057	2.762LysThr: 2.762 ± 0.074	2.689LysVal: 2.689 ± 0.068	0.438LysTrp: 0.438 ± 0.026	1.029LysTyr: 1.029 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	10.825LeuAla: 10.825 ± 0.131	0.868LeuCys: 0.868 ± 0.039	6.408LeuAsp: 6.408 ± 0.106	4.344LeuGlu: 4.344 ± 0.099	3.158LeuPhe: 3.158 ± 0.085	6.979LeuGly: 6.979 ± 0.104	1.75LeuHis: 1.75 ± 0.051	4.221LeuIle: 4.221 ± 0.08	3.576LeuLys: 3.576 ± 0.065	7.559LeuLeu: 7.559 ± 0.126	2.115LeuMet: 2.115 ± 0.053	2.618LeuAsn: 2.618 ± 0.06	4.582LeuPro: 4.582 ± 0.081	1.974LeuGln: 1.974 ± 0.05	5.087LeuArg: 5.087 ± 0.094	4.663LeuSer: 4.663 ± 0.082	5.491LeuThr: 5.491 ± 0.089	6.63LeuVal: 6.63 ± 0.11	0.996LeuTrp: 0.996 ± 0.035	2.048LeuTyr: 2.048 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.909MetAla: 2.909 ± 0.055	0.243MetCys: 0.243 ± 0.019	1.41MetAsp: 1.41 ± 0.042	1.051MetGlu: 1.051 ± 0.039	0.866MetPhe: 0.866 ± 0.032	1.882MetGly: 1.882 ± 0.048	0.514MetHis: 0.514 ± 0.028	1.241MetIle: 1.241 ± 0.036	0.858MetLys: 0.858 ± 0.036	2.51MetLeu: 2.51 ± 0.055	0.715MetMet: 0.715 ± 0.03	0.874MetAsn: 0.874 ± 0.033	1.526MetPro: 1.526 ± 0.04	0.739MetGln: 0.739 ± 0.033	1.829MetArg: 1.829 ± 0.051	1.651MetSer: 1.651 ± 0.052	2.12MetThr: 2.12 ± 0.052	1.793MetVal: 1.793 ± 0.053	0.298MetTrp: 0.298 ± 0.021	0.51MetTyr: 0.51 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.478AsnAla: 3.478 ± 0.078	0.179AsnCys: 0.179 ± 0.017	1.978AsnAsp: 1.978 ± 0.042	1.58AsnGlu: 1.58 ± 0.047	0.756AsnPhe: 0.756 ± 0.036	3.316AsnGly: 3.316 ± 0.09	0.638AsnHis: 0.638 ± 0.029	1.4AsnIle: 1.4 ± 0.039	1.107AsnLys: 1.107 ± 0.039	2.489AsnLeu: 2.489 ± 0.056	0.703AsnMet: 0.703 ± 0.031	0.943AsnAsn: 0.943 ± 0.046	2.084AsnPro: 2.084 ± 0.05	0.852AsnGln: 0.852 ± 0.032	1.801AsnArg: 1.801 ± 0.054	1.331AsnSer: 1.331 ± 0.054	1.928AsnThr: 1.928 ± 0.061	2.336AsnVal: 2.336 ± 0.066	0.372AsnTrp: 0.372 ± 0.022	0.786AsnTyr: 0.786 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.823ProAla: 5.823 ± 0.117	0.328ProCys: 0.328 ± 0.019	3.735ProAsp: 3.735 ± 0.073	3.228ProGlu: 3.228 ± 0.072	1.709ProPhe: 1.709 ± 0.046	3.746ProGly: 3.746 ± 0.076	0.996ProHis: 0.996 ± 0.034	2.129ProIle: 2.129 ± 0.053	1.822ProLys: 1.822 ± 0.052	3.974ProLeu: 3.974 ± 0.073	1.123ProMet: 1.123 ± 0.038	1.402ProAsn: 1.402 ± 0.04	1.526ProPro: 1.526 ± 0.053	1.676ProGln: 1.676 ± 0.06	2.685ProArg: 2.685 ± 0.076	3.031ProSer: 3.031 ± 0.072	3.062ProThr: 3.062 ± 0.074	4.059ProVal: 4.059 ± 0.082	0.678ProTrp: 0.678 ± 0.029	1.439ProTyr: 1.439 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.348GlnAla: 3.348 ± 0.094	0.269GlnCys: 0.269 ± 0.021	1.394GlnAsp: 1.394 ± 0.043	1.378GlnGlu: 1.378 ± 0.044	0.911GlnPhe: 0.911 ± 0.04	2.077GlnGly: 2.077 ± 0.052	0.641GlnHis: 0.641 ± 0.029	1.589GlnIle: 1.589 ± 0.054	0.914GlnLys: 0.914 ± 0.042	2.85GlnLeu: 2.85 ± 0.065	0.835GlnMet: 0.835 ± 0.036	0.896GlnAsn: 0.896 ± 0.036	1.681GlnPro: 1.681 ± 0.082	1.399GlnGln: 1.399 ± 0.066	2.045GlnArg: 2.045 ± 0.057	1.856GlnSer: 1.856 ± 0.053	1.62GlnThr: 1.62 ± 0.052	2.273GlnVal: 2.273 ± 0.057	0.526GlnTrp: 0.526 ± 0.024	0.957GlnTyr: 0.957 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	6.042ArgAla: 6.042 ± 0.115	0.519ArgCys: 0.519 ± 0.026	4.093ArgAsp: 4.093 ± 0.094	4.032ArgGlu: 4.032 ± 0.083	2.534ArgPhe: 2.534 ± 0.056	4.155ArgGly: 4.155 ± 0.085	1.677ArgHis: 1.677 ± 0.053	3.732ArgIle: 3.732 ± 0.059	2.448ArgLys: 2.448 ± 0.056	5.769ArgLeu: 5.769 ± 0.095	2.066ArgMet: 2.066 ± 0.052	2.03ArgAsn: 2.03 ± 0.049	2.843ArgPro: 2.843 ± 0.074	2.025ArgGln: 2.025 ± 0.064	5.986ArgArg: 5.986 ± 0.139	3.116ArgSer: 3.116 ± 0.073	3.62ArgThr: 3.62 ± 0.068	4.432ArgVal: 4.432 ± 0.098	0.921ArgTrp: 0.921 ± 0.037	2.032ArgTyr: 2.032 ± 0.053	0.001ArgXaa: 0.001 ± 0.001
Ser	6.09SerAla: 6.09 ± 0.088	0.451SerCys: 0.451 ± 0.023	3.763SerAsp: 3.763 ± 0.072	2.654SerGlu: 2.654 ± 0.064	1.943SerPhe: 1.943 ± 0.051	5.798SerGly: 5.798 ± 0.109	1.114SerHis: 1.114 ± 0.041	2.798SerIle: 2.798 ± 0.057	2.015SerLys: 2.015 ± 0.052	4.745SerLeu: 4.745 ± 0.086	1.508SerMet: 1.508 ± 0.047	1.604SerAsn: 1.604 ± 0.049	2.568SerPro: 2.568 ± 0.06	1.729SerGln: 1.729 ± 0.047	3.462SerArg: 3.462 ± 0.078	3.645SerSer: 3.645 ± 0.121	3.554SerThr: 3.554 ± 0.086	4.212SerVal: 4.212 ± 0.083	0.765SerTrp: 0.765 ± 0.032	1.506SerTyr: 1.506 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	7.183ThrAla: 7.183 ± 0.134	0.506ThrCys: 0.506 ± 0.026	4.155ThrAsp: 4.155 ± 0.092	2.741ThrGlu: 2.741 ± 0.065	2.305ThrPhe: 2.305 ± 0.07	5.843ThrGly: 5.843 ± 0.109	1.209ThrHis: 1.209 ± 0.041	3.506ThrIle: 3.506 ± 0.072	2.202ThrLys: 2.202 ± 0.065	5.822ThrLeu: 5.822 ± 0.093	1.467ThrMet: 1.467 ± 0.041	1.873ThrAsn: 1.873 ± 0.053	3.873ThrPro: 3.873 ± 0.077	1.768ThrGln: 1.768 ± 0.055	3.522ThrArg: 3.522 ± 0.074	3.348ThrSer: 3.348 ± 0.075	4.259ThrThr: 4.259 ± 0.104	5.964ThrVal: 5.964 ± 0.127	0.798ThrTrp: 0.798 ± 0.034	1.69ThrTyr: 1.69 ± 0.064	0.001ThrXaa: 0.001 ± 0.001
Val	9.266ValAla: 9.266 ± 0.121	0.816ValCys: 0.816 ± 0.035	5.409ValAsp: 5.409 ± 0.093	4.221ValGlu: 4.221 ± 0.091	2.947ValPhe: 2.947 ± 0.071	5.427ValGly: 5.427 ± 0.097	1.382ValHis: 1.382 ± 0.043	4.28ValIle: 4.28 ± 0.078	3.028ValLys: 3.028 ± 0.085	6.633ValLeu: 6.633 ± 0.122	1.971ValMet: 1.971 ± 0.047	2.56ValAsn: 2.56 ± 0.064	4.111ValPro: 4.111 ± 0.095	1.838ValGln: 1.838 ± 0.054	4.627ValArg: 4.627 ± 0.082	4.866ValSer: 4.866 ± 0.091	5.791ValThr: 5.791 ± 0.121	6.675ValVal: 6.675 ± 0.122	0.962ValTrp: 0.962 ± 0.038	1.888ValTyr: 1.888 ± 0.052	0.001ValXaa: 0.001 ± 0.001
Trp	1.19TrpAla: 1.19 ± 0.039	0.168TrpCys: 0.168 ± 0.012	0.776TrpAsp: 0.776 ± 0.03	0.57TrpGlu: 0.57 ± 0.03	0.535TrpPhe: 0.535 ± 0.029	0.893TrpGly: 0.893 ± 0.038	0.308TrpHis: 0.308 ± 0.021	0.694TrpIle: 0.694 ± 0.032	0.551TrpLys: 0.551 ± 0.028	1.383TrpLeu: 1.383 ± 0.044	0.384TrpMet: 0.384 ± 0.025	0.549TrpAsn: 0.549 ± 0.027	0.531TrpPro: 0.531 ± 0.03	0.516TrpGln: 0.516 ± 0.024	1.101TrpArg: 1.101 ± 0.041	0.802TrpSer: 0.802 ± 0.032	0.857TrpThr: 0.857 ± 0.03	0.809TrpVal: 0.809 ± 0.033	0.274TrpTrp: 0.274 ± 0.02	0.413TrpTyr: 0.413 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.192TyrAla: 3.192 ± 0.069	0.29TyrCys: 0.29 ± 0.021	2.064TyrAsp: 2.064 ± 0.052	1.56TyrGlu: 1.56 ± 0.049	0.912TyrPhe: 0.912 ± 0.033	2.674TyrGly: 2.674 ± 0.067	0.467TyrHis: 0.467 ± 0.024	1.056TyrIle: 1.056 ± 0.042	0.873TyrLys: 0.873 ± 0.038	2.383TyrLeu: 2.383 ± 0.057	0.613TyrMet: 0.613 ± 0.032	0.773TyrAsn: 0.773 ± 0.032	1.21TyrPro: 1.21 ± 0.047	0.875TyrGln: 0.875 ± 0.035	1.829TyrArg: 1.829 ± 0.05	1.375TyrSer: 1.375 ± 0.04	1.63TyrThr: 1.63 ± 0.064	2.098TyrVal: 2.098 ± 0.055	0.439TyrTrp: 0.439 ± 0.021	0.816TyrTyr: 0.816 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.002XaaThr: 0.002 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.003

Statistics based on 2202 proteins (805556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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