Amino acid dipepetide frequency for Streptomyces globosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	28.514AlaAla: 28.514 ± 0.283	1.219AlaCys: 1.219 ± 0.029	9.217AlaAsp: 9.217 ± 0.084	9.706AlaGlu: 9.706 ± 0.102	3.703AlaPhe: 3.703 ± 0.045	15.931AlaGly: 15.931 ± 0.135	3.01AlaHis: 3.01 ± 0.036	2.927AlaIle: 2.927 ± 0.048	2.705AlaLys: 2.705 ± 0.055	15.589AlaLeu: 15.589 ± 0.133	2.541AlaMet: 2.541 ± 0.034	1.859AlaAsn: 1.859 ± 0.033	8.856AlaPro: 8.856 ± 0.121	3.762AlaGln: 3.762 ± 0.049	11.423AlaArg: 11.423 ± 0.098	5.853AlaSer: 5.853 ± 0.055	6.389AlaThr: 6.389 ± 0.056	13.655AlaVal: 13.655 ± 0.107	2.087AlaTrp: 2.087 ± 0.036	2.933AlaTyr: 2.933 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.191CysAla: 1.191 ± 0.024	0.085CysCys: 0.085 ± 0.007	0.459CysAsp: 0.459 ± 0.016	0.402CysGlu: 0.402 ± 0.014	0.226CysPhe: 0.226 ± 0.01	1.001CysGly: 1.001 ± 0.025	0.178CysHis: 0.178 ± 0.009	0.186CysIle: 0.186 ± 0.01	0.128CysLys: 0.128 ± 0.008	0.799CysLeu: 0.799 ± 0.018	0.12CysMet: 0.12 ± 0.008	0.135CysAsn: 0.135 ± 0.008	0.506CysPro: 0.506 ± 0.016	0.137CysGln: 0.137 ± 0.007	0.659CysArg: 0.659 ± 0.017	0.42CysSer: 0.42 ± 0.016	0.575CysThr: 0.575 ± 0.017	0.617CysVal: 0.617 ± 0.019	0.117CysTrp: 0.117 ± 0.007	0.15CysTyr: 0.15 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.883AspAla: 7.883 ± 0.073	0.465AspCys: 0.465 ± 0.016	3.011AspAsp: 3.011 ± 0.042	3.437AspGlu: 3.437 ± 0.04	1.498AspPhe: 1.498 ± 0.028	6.421AspGly: 6.421 ± 0.055	1.294AspHis: 1.294 ± 0.025	1.702AspIle: 1.702 ± 0.033	1.057AspLys: 1.057 ± 0.028	6.005AspLeu: 6.005 ± 0.065	0.75AspMet: 0.75 ± 0.02	0.815AspAsn: 0.815 ± 0.024	4.787AspPro: 4.787 ± 0.055	1.304AspGln: 1.304 ± 0.026	5.201AspArg: 5.201 ± 0.056	2.284AspSer: 2.284 ± 0.034	3.142AspThr: 3.142 ± 0.043	4.232AspVal: 4.232 ± 0.051	0.995AspTrp: 0.995 ± 0.021	1.008AspTyr: 1.008 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	8.29GluAla: 8.29 ± 0.082	0.379GluCys: 0.379 ± 0.013	2.852GluAsp: 2.852 ± 0.035	3.598GluGlu: 3.598 ± 0.052	1.456GluPhe: 1.456 ± 0.025	4.392GluGly: 4.392 ± 0.048	1.453GluHis: 1.453 ± 0.029	1.953GluIle: 1.953 ± 0.033	1.314GluLys: 1.314 ± 0.032	6.689GluLeu: 6.689 ± 0.064	0.81GluMet: 0.81 ± 0.022	0.946GluAsn: 0.946 ± 0.023	3.539GluPro: 3.539 ± 0.042	2.182GluGln: 2.182 ± 0.039	5.382GluArg: 5.382 ± 0.056	2.253GluSer: 2.253 ± 0.036	2.617GluThr: 2.617 ± 0.04	4.377GluVal: 4.377 ± 0.055	0.767GluTrp: 0.767 ± 0.02	1.06GluTyr: 1.06 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.875PheAla: 3.875 ± 0.044	0.264PheCys: 0.264 ± 0.011	1.868PheAsp: 1.868 ± 0.034	1.417PheGlu: 1.417 ± 0.026	0.841PhePhe: 0.841 ± 0.021	2.935PheGly: 2.935 ± 0.041	0.611PheHis: 0.611 ± 0.017	0.618PheIle: 0.618 ± 0.018	0.479PheLys: 0.479 ± 0.017	2.555PheLeu: 2.555 ± 0.038	0.383PheMet: 0.383 ± 0.015	0.489PheAsn: 0.489 ± 0.018	1.413PhePro: 1.413 ± 0.026	0.585PheGln: 0.585 ± 0.019	1.89PheArg: 1.89 ± 0.03	1.359PheSer: 1.359 ± 0.029	1.999PheThr: 1.999 ± 0.034	1.99PheVal: 1.99 ± 0.031	0.408PheTrp: 0.408 ± 0.014	0.54PheTyr: 0.54 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	12.695GlyAla: 12.695 ± 0.108	0.885GlyCys: 0.885 ± 0.024	5.001GlyAsp: 5.001 ± 0.055	5.088GlyGlu: 5.088 ± 0.049	2.914GlyPhe: 2.914 ± 0.041	9.793GlyGly: 9.793 ± 0.102	2.327GlyHis: 2.327 ± 0.034	3.458GlyIle: 3.458 ± 0.05	2.209GlyLys: 2.209 ± 0.037	9.785GlyLeu: 9.785 ± 0.083	2.031GlyMet: 2.031 ± 0.032	1.571GlyAsn: 1.571 ± 0.034	6.1GlyPro: 6.1 ± 0.068	2.554GlyGln: 2.554 ± 0.038	8.858GlyArg: 8.858 ± 0.08	5.475GlySer: 5.475 ± 0.061	6.259GlyThr: 6.259 ± 0.057	7.322GlyVal: 7.322 ± 0.077	1.694GlyTrp: 1.694 ± 0.028	2.144GlyTyr: 2.144 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.821HisAla: 2.821 ± 0.04	0.23HisCys: 0.23 ± 0.01	1.242HisAsp: 1.242 ± 0.025	1.1HisGlu: 1.1 ± 0.024	0.598HisPhe: 0.598 ± 0.018	2.403HisGly: 2.403 ± 0.033	0.646HisHis: 0.646 ± 0.02	0.608HisIle: 0.608 ± 0.017	0.321HisLys: 0.321 ± 0.013	2.419HisLeu: 2.419 ± 0.039	0.341HisMet: 0.341 ± 0.015	0.33HisAsn: 0.33 ± 0.015	1.877HisPro: 1.877 ± 0.033	0.569HisGln: 0.569 ± 0.017	2.222HisArg: 2.222 ± 0.032	0.953HisSer: 0.953 ± 0.021	1.375HisThr: 1.375 ± 0.028	1.707HisVal: 1.707 ± 0.032	0.37HisTrp: 0.37 ± 0.015	0.431HisTyr: 0.431 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.529IleAla: 4.529 ± 0.058	0.245IleCys: 0.245 ± 0.011	1.938IleAsp: 1.938 ± 0.028	1.731IleGlu: 1.731 ± 0.028	0.556IlePhe: 0.556 ± 0.019	3.282IleGly: 3.282 ± 0.045	0.549IleHis: 0.549 ± 0.019	0.718IleIle: 0.718 ± 0.021	0.628IleLys: 0.628 ± 0.021	2.118IleLeu: 2.118 ± 0.036	0.384IleMet: 0.384 ± 0.016	0.56IleAsn: 0.56 ± 0.018	1.654IlePro: 1.654 ± 0.027	0.623IleGln: 0.623 ± 0.019	2.2IleArg: 2.2 ± 0.03	1.444IleSer: 1.444 ± 0.026	1.962IleThr: 1.962 ± 0.034	2.251IleVal: 2.251 ± 0.038	0.301IleTrp: 0.301 ± 0.014	0.417IleTyr: 0.417 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.932LysAla: 2.932 ± 0.06	0.102LysCys: 0.102 ± 0.008	1.162LysAsp: 1.162 ± 0.027	1.1LysGlu: 1.1 ± 0.033	0.409LysPhe: 0.409 ± 0.016	1.707LysGly: 1.707 ± 0.039	0.389LysHis: 0.389 ± 0.015	0.771LysIle: 0.771 ± 0.024	0.713LysLys: 0.713 ± 0.028	1.736LysLeu: 1.736 ± 0.037	0.357LysMet: 0.357 ± 0.015	0.453LysAsn: 0.453 ± 0.016	1.255LysPro: 1.255 ± 0.03	0.597LysGln: 0.597 ± 0.022	1.308LysArg: 1.308 ± 0.03	0.955LysSer: 0.955 ± 0.023	1.173LysThr: 1.173 ± 0.026	1.676LysVal: 1.676 ± 0.031	0.23LysTrp: 0.23 ± 0.011	0.385LysTyr: 0.385 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.829LeuAla: 16.829 ± 0.142	0.869LeuCys: 0.869 ± 0.022	6.548LeuAsp: 6.548 ± 0.073	4.839LeuGlu: 4.839 ± 0.057	2.538LeuPhe: 2.538 ± 0.04	9.436LeuGly: 9.436 ± 0.068	2.348LeuHis: 2.348 ± 0.036	2.678LeuIle: 2.678 ± 0.042	1.769LeuLys: 1.769 ± 0.035	11.585LeuLeu: 11.585 ± 0.1	1.519LeuMet: 1.519 ± 0.027	1.486LeuAsn: 1.486 ± 0.032	6.915LeuPro: 6.915 ± 0.066	2.092LeuGln: 2.092 ± 0.033	9.079LeuArg: 9.079 ± 0.085	4.909LeuSer: 4.909 ± 0.048	6.235LeuThr: 6.235 ± 0.053	8.681LeuVal: 8.681 ± 0.08	1.297LeuTrp: 1.297 ± 0.026	1.809LeuTyr: 1.809 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.348MetAla: 2.348 ± 0.033	0.128MetCys: 0.128 ± 0.007	0.891MetAsp: 0.891 ± 0.021	0.745MetGlu: 0.745 ± 0.022	0.424MetPhe: 0.424 ± 0.015	1.249MetGly: 1.249 ± 0.027	0.336MetHis: 0.336 ± 0.013	0.542MetIle: 0.542 ± 0.019	0.394MetLys: 0.394 ± 0.014	1.642MetLeu: 1.642 ± 0.03	0.257MetMet: 0.257 ± 0.011	0.413MetAsn: 0.413 ± 0.014	1.128MetPro: 1.128 ± 0.024	0.451MetGln: 0.451 ± 0.015	1.39MetArg: 1.39 ± 0.028	1.225MetSer: 1.225 ± 0.023	1.343MetThr: 1.343 ± 0.022	1.212MetVal: 1.212 ± 0.026	0.199MetTrp: 0.199 ± 0.01	0.308MetTyr: 0.308 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.044AsnAla: 2.044 ± 0.034	0.145AsnCys: 0.145 ± 0.009	0.801AsnAsp: 0.801 ± 0.022	0.73AsnGlu: 0.73 ± 0.023	0.454AsnPhe: 0.454 ± 0.016	1.661AsnGly: 1.661 ± 0.045	0.371AsnHis: 0.371 ± 0.012	0.562AsnIle: 0.562 ± 0.018	0.358AsnLys: 0.358 ± 0.015	1.545AsnLeu: 1.545 ± 0.03	0.278AsnMet: 0.278 ± 0.012	0.369AsnAsn: 0.369 ± 0.016	1.305AsnPro: 1.305 ± 0.028	0.463AsnGln: 0.463 ± 0.017	1.21AsnArg: 1.21 ± 0.027	0.754AsnSer: 0.754 ± 0.022	1.059AsnThr: 1.059 ± 0.028	1.188AsnVal: 1.188 ± 0.026	0.257AsnTrp: 0.257 ± 0.012	0.342AsnTyr: 0.342 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	11.499ProAla: 11.499 ± 0.133	0.379ProCys: 0.379 ± 0.013	4.589ProAsp: 4.589 ± 0.056	4.463ProGlu: 4.463 ± 0.053	1.496ProPhe: 1.496 ± 0.026	7.595ProGly: 7.595 ± 0.077	1.4ProHis: 1.4 ± 0.03	1.094ProIle: 1.094 ± 0.023	1.108ProLys: 1.108 ± 0.028	5.564ProLeu: 5.564 ± 0.058	0.988ProMet: 0.988 ± 0.025	0.835ProAsn: 0.835 ± 0.021	4.14ProPro: 4.14 ± 0.082	2.01ProGln: 2.01 ± 0.041	4.297ProArg: 4.297 ± 0.059	3.121ProSer: 3.121 ± 0.043	2.739ProThr: 2.739 ± 0.046	5.717ProVal: 5.717 ± 0.067	0.945ProTrp: 0.945 ± 0.021	1.43ProTyr: 1.43 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.017GlnAla: 4.017 ± 0.052	0.173GlnCys: 0.173 ± 0.01	1.304GlnAsp: 1.304 ± 0.027	1.445GlnGlu: 1.445 ± 0.028	0.608GlnPhe: 0.608 ± 0.018	2.267GlnGly: 2.267 ± 0.037	0.609GlnHis: 0.609 ± 0.017	0.917GlnIle: 0.917 ± 0.024	0.534GlnLys: 0.534 ± 0.019	2.721GlnLeu: 2.721 ± 0.043	0.453GlnMet: 0.453 ± 0.015	0.438GlnAsn: 0.438 ± 0.014	1.717GlnPro: 1.717 ± 0.037	1.138GlnGln: 1.138 ± 0.029	2.242GlnArg: 2.242 ± 0.034	1.119GlnSer: 1.119 ± 0.023	1.231GlnThr: 1.231 ± 0.029	2.226GlnVal: 2.226 ± 0.033	0.45GlnTrp: 0.45 ± 0.014	0.544GlnTyr: 0.544 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.831ArgAla: 10.831 ± 0.097	0.605ArgCys: 0.605 ± 0.019	4.227ArgAsp: 4.227 ± 0.054	4.874ArgGlu: 4.874 ± 0.051	2.386ArgPhe: 2.386 ± 0.031	6.298ArgGly: 6.298 ± 0.057	2.233ArgHis: 2.233 ± 0.037	3.388ArgIle: 3.388 ± 0.044	1.568ArgLys: 1.568 ± 0.028	9.431ArgLeu: 9.431 ± 0.077	1.798ArgMet: 1.798 ± 0.033	1.296ArgAsn: 1.296 ± 0.026	5.645ArgPro: 5.645 ± 0.069	2.269ArgGln: 2.269 ± 0.033	8.271ArgArg: 8.271 ± 0.091	4.073ArgSer: 4.073 ± 0.047	5.655ArgThr: 5.655 ± 0.059	5.696ArgVal: 5.696 ± 0.052	1.389ArgTrp: 1.389 ± 0.024	1.715ArgTyr: 1.715 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.873SerAla: 6.873 ± 0.067	0.397SerCys: 0.397 ± 0.014	2.395SerAsp: 2.395 ± 0.033	2.162SerGlu: 2.162 ± 0.039	1.476SerPhe: 1.476 ± 0.028	5.72SerGly: 5.72 ± 0.061	0.948SerHis: 0.948 ± 0.021	1.209SerIle: 1.209 ± 0.028	0.884SerLys: 0.884 ± 0.022	4.626SerLeu: 4.626 ± 0.047	0.924SerMet: 0.924 ± 0.021	0.773SerAsn: 0.773 ± 0.02	3.166SerPro: 3.166 ± 0.036	1.094SerGln: 1.094 ± 0.026	3.567SerArg: 3.567 ± 0.043	2.469SerSer: 2.469 ± 0.04	2.609SerThr: 2.609 ± 0.039	3.927SerVal: 3.927 ± 0.045	0.804SerTrp: 0.804 ± 0.022	1.096SerTyr: 1.096 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.565ThrAla: 9.565 ± 0.087	0.377ThrCys: 0.377 ± 0.014	3.129ThrAsp: 3.129 ± 0.038	2.822ThrGlu: 2.822 ± 0.044	1.391ThrPhe: 1.391 ± 0.026	6.639ThrGly: 6.639 ± 0.073	1.075ThrHis: 1.075 ± 0.022	1.353ThrIle: 1.353 ± 0.033	0.92ThrLys: 0.92 ± 0.029	5.234ThrLeu: 5.234 ± 0.055	0.837ThrMet: 0.837 ± 0.021	0.832ThrAsn: 0.832 ± 0.022	4.018ThrPro: 4.018 ± 0.05	1.162ThrGln: 1.162 ± 0.027	3.82ThrArg: 3.82 ± 0.044	2.626ThrSer: 2.626 ± 0.04	3.256ThrThr: 3.256 ± 0.05	5.541ThrVal: 5.541 ± 0.059	0.835ThrTrp: 0.835 ± 0.023	1.155ThrTyr: 1.155 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.527ValAla: 10.527 ± 0.074	0.81ValCys: 0.81 ± 0.021	4.562ValAsp: 4.562 ± 0.052	4.618ValGlu: 4.618 ± 0.055	2.487ValPhe: 2.487 ± 0.039	6.148ValGly: 6.148 ± 0.06	2.058ValHis: 2.058 ± 0.028	2.474ValIle: 2.474 ± 0.04	1.618ValLys: 1.618 ± 0.037	9.686ValLeu: 9.686 ± 0.083	1.345ValMet: 1.345 ± 0.026	1.574ValAsn: 1.574 ± 0.029	5.556ValPro: 5.556 ± 0.058	2.031ValGln: 2.031 ± 0.034	7.437ValArg: 7.437 ± 0.068	4.057ValSer: 4.057 ± 0.054	4.811ValThr: 4.811 ± 0.047	7.644ValVal: 7.644 ± 0.075	1.144ValTrp: 1.144 ± 0.024	1.532ValTyr: 1.532 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.743TrpAla: 1.743 ± 0.032	0.168TrpCys: 0.168 ± 0.009	0.771TrpAsp: 0.771 ± 0.019	0.774TrpGlu: 0.774 ± 0.022	0.479TrpPhe: 0.479 ± 0.017	1.052TrpGly: 1.052 ± 0.023	0.363TrpHis: 0.363 ± 0.015	0.534TrpIle: 0.534 ± 0.016	0.355TrpLys: 0.355 ± 0.015	1.742TrpLeu: 1.742 ± 0.033	0.275TrpMet: 0.275 ± 0.011	0.365TrpAsn: 0.365 ± 0.014	0.809TrpPro: 0.809 ± 0.021	0.612TrpGln: 0.612 ± 0.017	1.346TrpArg: 1.346 ± 0.025	0.922TrpSer: 0.922 ± 0.023	1.035TrpThr: 1.035 ± 0.024	0.944TrpVal: 0.944 ± 0.024	0.332TrpTrp: 0.332 ± 0.013	0.337TrpTyr: 0.337 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.871TyrAla: 2.871 ± 0.04	0.163TyrCys: 0.163 ± 0.008	1.324TyrAsp: 1.324 ± 0.03	1.257TyrGlu: 1.257 ± 0.026	0.579TyrPhe: 0.579 ± 0.018	2.235TyrGly: 2.235 ± 0.035	0.364TyrHis: 0.364 ± 0.013	0.395TyrIle: 0.395 ± 0.015	0.347TyrLys: 0.347 ± 0.013	1.991TyrLeu: 1.991 ± 0.033	0.234TyrMet: 0.234 ± 0.011	0.357TyrAsn: 0.357 ± 0.013	1.026TyrPro: 1.026 ± 0.027	0.516TyrGln: 0.516 ± 0.016	1.848TyrArg: 1.848 ± 0.033	0.849TyrSer: 0.849 ± 0.02	1.122TyrThr: 1.122 ± 0.026	1.518TyrVal: 1.518 ± 0.028	0.338TyrTrp: 0.338 ± 0.013	0.379TyrTyr: 0.379 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6315 proteins (2132909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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