Amino acid dipepetide frequency for Hydrogenophilus thermoluteolus (Pseudomonas hydrogenothermophila)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.078AlaAla: 18.078 ± 0.234	1.19AlaCys: 1.19 ± 0.049	5.251AlaAsp: 5.251 ± 0.09	8.708AlaGlu: 8.708 ± 0.136	4.545AlaPhe: 4.545 ± 0.078	8.152AlaGly: 8.152 ± 0.116	3.352AlaHis: 3.352 ± 0.079	6.62AlaIle: 6.62 ± 0.112	4.094AlaLys: 4.094 ± 0.086	15.933AlaLeu: 15.933 ± 0.212	2.761AlaMet: 2.761 ± 0.074	2.919AlaAsn: 2.919 ± 0.066	6.41AlaPro: 6.41 ± 0.115	6.145AlaGln: 6.145 ± 0.117	9.333AlaArg: 9.333 ± 0.132	5.052AlaSer: 5.052 ± 0.101	6.484AlaThr: 6.484 ± 0.115	9.941AlaVal: 9.941 ± 0.127	2.442AlaTrp: 2.442 ± 0.069	2.527AlaTyr: 2.527 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.198CysAla: 1.198 ± 0.046	0.122CysCys: 0.122 ± 0.014	0.603CysAsp: 0.603 ± 0.028	0.505CysGlu: 0.505 ± 0.03	0.307CysPhe: 0.307 ± 0.019	0.955CysGly: 0.955 ± 0.036	0.356CysHis: 0.356 ± 0.022	0.303CysIle: 0.303 ± 0.022	0.187CysLys: 0.187 ± 0.016	0.725CysLeu: 0.725 ± 0.033	0.132CysMet: 0.132 ± 0.015	0.237CysAsn: 0.237 ± 0.02	0.61CysPro: 0.61 ± 0.037	0.267CysGln: 0.267 ± 0.02	0.672CysArg: 0.672 ± 0.032	0.418CysSer: 0.418 ± 0.029	0.508CysThr: 0.508 ± 0.029	0.617CysVal: 0.617 ± 0.027	0.146CysTrp: 0.146 ± 0.015	0.31CysTyr: 0.31 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	7.029AspAla: 7.029 ± 0.124	0.471AspCys: 0.471 ± 0.027	2.566AspAsp: 2.566 ± 0.059	3.687AspGlu: 3.687 ± 0.086	1.78AspPhe: 1.78 ± 0.049	3.967AspGly: 3.967 ± 0.084	1.191AspHis: 1.191 ± 0.038	1.65AspIle: 1.65 ± 0.048	1.247AspLys: 1.247 ± 0.047	5.025AspLeu: 5.025 ± 0.091	0.564AspMet: 0.564 ± 0.032	0.891AspAsn: 0.891 ± 0.038	3.955AspPro: 3.955 ± 0.081	1.337AspGln: 1.337 ± 0.045	3.816AspArg: 3.816 ± 0.07	1.561AspSer: 1.561 ± 0.049	2.315AspThr: 2.315 ± 0.062	3.134AspVal: 3.134 ± 0.063	1.089AspTrp: 1.089 ± 0.037	1.24AspTyr: 1.24 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	9.19GluAla: 9.19 ± 0.129	0.45GluCys: 0.45 ± 0.028	1.908GluAsp: 1.908 ± 0.051	3.337GluGlu: 3.337 ± 0.087	1.609GluPhe: 1.609 ± 0.052	4.192GluGly: 4.192 ± 0.086	1.296GluHis: 1.296 ± 0.046	3.5GluIle: 3.5 ± 0.069	2.476GluLys: 2.476 ± 0.065	5.933GluLeu: 5.933 ± 0.097	1.535GluMet: 1.535 ± 0.048	1.568GluAsn: 1.568 ± 0.048	3.38GluPro: 3.38 ± 0.085	2.48GluGln: 2.48 ± 0.064	6.615GluArg: 6.615 ± 0.123	2.675GluSer: 2.675 ± 0.066	4.329GluThr: 4.329 ± 0.089	4.484GluVal: 4.484 ± 0.085	1.292GluTrp: 1.292 ± 0.044	1.205GluTyr: 1.205 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	5.273PheAla: 5.273 ± 0.093	0.379PheCys: 0.379 ± 0.023	2.389PheAsp: 2.389 ± 0.056	2.052PheGlu: 2.052 ± 0.05	1.526PhePhe: 1.526 ± 0.051	3.057PheGly: 3.057 ± 0.071	0.835PheHis: 0.835 ± 0.036	1.323PheIle: 1.323 ± 0.042	0.769PheLys: 0.769 ± 0.034	3.732PheLeu: 3.732 ± 0.081	0.505PheMet: 0.505 ± 0.024	0.767PheAsn: 0.767 ± 0.031	1.857PhePro: 1.857 ± 0.049	1.007PheGln: 1.007 ± 0.04	2.304PheArg: 2.304 ± 0.048	1.852PheSer: 1.852 ± 0.052	1.862PheThr: 1.862 ± 0.051	3.159PheVal: 3.159 ± 0.077	0.71PheTrp: 0.71 ± 0.036	0.882PheTyr: 0.882 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	8.165GlyAla: 8.165 ± 0.139	0.92GlyCys: 0.92 ± 0.039	3.52GlyAsp: 3.52 ± 0.071	4.715GlyGlu: 4.715 ± 0.086	3.044GlyPhe: 3.044 ± 0.059	5.356GlyGly: 5.356 ± 0.117	1.669GlyHis: 1.669 ± 0.049	4.102GlyIle: 4.102 ± 0.082	3.231GlyLys: 3.231 ± 0.066	7.148GlyLeu: 7.148 ± 0.102	1.85GlyMet: 1.85 ± 0.056	1.871GlyAsn: 1.871 ± 0.059	2.572GlyPro: 2.572 ± 0.067	2.485GlyGln: 2.485 ± 0.067	4.972GlyArg: 4.972 ± 0.088	3.335GlySer: 3.335 ± 0.07	3.866GlyThr: 3.866 ± 0.076	6.606GlyVal: 6.606 ± 0.109	1.688GlyTrp: 1.688 ± 0.05	2.096GlyTyr: 2.096 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.87HisAla: 2.87 ± 0.072	0.285HisCys: 0.285 ± 0.021	1.264HisAsp: 1.264 ± 0.047	1.379HisGlu: 1.379 ± 0.047	1.08HisPhe: 1.08 ± 0.04	2.006HisGly: 2.006 ± 0.055	0.902HisHis: 0.902 ± 0.048	0.802HisIle: 0.802 ± 0.034	0.506HisLys: 0.506 ± 0.025	2.671HisLeu: 2.671 ± 0.064	0.306HisMet: 0.306 ± 0.02	0.515HisAsn: 0.515 ± 0.03	2.005HisPro: 2.005 ± 0.06	0.798HisGln: 0.798 ± 0.036	1.869HisArg: 1.869 ± 0.052	0.838HisSer: 0.838 ± 0.039	1.136HisThr: 1.136 ± 0.038	1.337HisVal: 1.337 ± 0.045	0.547HisTrp: 0.547 ± 0.027	0.801HisTyr: 0.801 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	7.365IleAla: 7.365 ± 0.111	0.369IleCys: 0.369 ± 0.024	3.33IleAsp: 3.33 ± 0.073	3.684IleGlu: 3.684 ± 0.073	1.329IlePhe: 1.329 ± 0.048	3.779IleGly: 3.779 ± 0.083	1.019IleHis: 1.019 ± 0.039	1.561IleIle: 1.561 ± 0.052	1.221IleLys: 1.221 ± 0.044	4.161IleLeu: 4.161 ± 0.085	0.584IleMet: 0.584 ± 0.032	1.111IleAsn: 1.111 ± 0.044	2.719IlePro: 2.719 ± 0.062	1.229IleGln: 1.229 ± 0.051	3.138IleArg: 3.138 ± 0.067	1.671IleSer: 1.671 ± 0.05	2.66IleThr: 2.66 ± 0.07	3.967IleVal: 3.967 ± 0.079	0.549IleTrp: 0.549 ± 0.028	0.892IleTyr: 0.892 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.813LysAla: 3.813 ± 0.071	0.161LysCys: 0.161 ± 0.016	1.128LysAsp: 1.128 ± 0.047	1.848LysGlu: 1.848 ± 0.064	0.707LysPhe: 0.707 ± 0.031	2.462LysGly: 2.462 ± 0.066	0.581LysHis: 0.581 ± 0.028	1.618LysIle: 1.618 ± 0.056	1.338LysLys: 1.338 ± 0.053	2.81LysLeu: 2.81 ± 0.079	0.686LysMet: 0.686 ± 0.034	0.976LysAsn: 0.976 ± 0.044	1.933LysPro: 1.933 ± 0.062	1.141LysGln: 1.141 ± 0.039	2.96LysArg: 2.96 ± 0.065	1.423LysSer: 1.423 ± 0.041	2.005LysThr: 2.005 ± 0.056	2.176LysVal: 2.176 ± 0.073	0.391LysTrp: 0.391 ± 0.025	0.612LysTyr: 0.612 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	15.407LeuAla: 15.407 ± 0.163	0.934LeuCys: 0.934 ± 0.036	5.746LeuAsp: 5.746 ± 0.096	6.234LeuGlu: 6.234 ± 0.095	4.279LeuPhe: 4.279 ± 0.085	7.813LeuGly: 7.813 ± 0.126	2.186LeuHis: 2.186 ± 0.059	5.025LeuIle: 5.025 ± 0.081	3.347LeuLys: 3.347 ± 0.075	11.756LeuLeu: 11.756 ± 0.176	1.776LeuMet: 1.776 ± 0.054	2.246LeuAsn: 2.246 ± 0.054	6.972LeuPro: 6.972 ± 0.098	3.265LeuGln: 3.265 ± 0.08	7.584LeuArg: 7.584 ± 0.097	5.1LeuSer: 5.1 ± 0.089	6.902LeuThr: 6.902 ± 0.092	8.012LeuVal: 8.012 ± 0.135	1.876LeuTrp: 1.876 ± 0.063	2.177LeuTyr: 2.177 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.333MetAla: 2.333 ± 0.064	0.112MetCys: 0.112 ± 0.013	0.749MetAsp: 0.749 ± 0.031	0.936MetGlu: 0.936 ± 0.038	0.401MetPhe: 0.401 ± 0.025	1.578MetGly: 1.578 ± 0.052	0.4MetHis: 0.4 ± 0.025	0.95MetIle: 0.95 ± 0.034	0.818MetLys: 0.818 ± 0.035	1.783MetLeu: 1.783 ± 0.051	0.45MetMet: 0.45 ± 0.028	0.715MetAsn: 0.715 ± 0.031	1.098MetPro: 1.098 ± 0.041	0.675MetGln: 0.675 ± 0.034	1.618MetArg: 1.618 ± 0.052	1.073MetSer: 1.073 ± 0.039	1.393MetThr: 1.393 ± 0.044	1.493MetVal: 1.493 ± 0.049	0.174MetTrp: 0.174 ± 0.017	0.233MetTyr: 0.233 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.912AsnAla: 2.912 ± 0.07	0.246AsnCys: 0.246 ± 0.02	1.319AsnAsp: 1.319 ± 0.046	1.404AsnGlu: 1.404 ± 0.045	0.731AsnPhe: 0.731 ± 0.034	2.163AsnGly: 2.163 ± 0.059	0.582AsnHis: 0.582 ± 0.031	0.846AsnIle: 0.846 ± 0.035	0.595AsnLys: 0.595 ± 0.03	2.462AsnLeu: 2.462 ± 0.069	0.338AsnMet: 0.338 ± 0.022	0.512AsnAsn: 0.512 ± 0.028	1.975AsnPro: 1.975 ± 0.054	0.845AsnGln: 0.845 ± 0.036	1.988AsnArg: 1.988 ± 0.051	0.769AsnSer: 0.769 ± 0.037	1.157AsnThr: 1.157 ± 0.041	1.717AsnVal: 1.717 ± 0.051	0.393AsnTrp: 0.393 ± 0.02	0.488AsnTyr: 0.488 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.655ProAla: 5.655 ± 0.11	0.499ProCys: 0.499 ± 0.029	3.443ProAsp: 3.443 ± 0.077	5.415ProGlu: 5.415 ± 0.107	2.409ProPhe: 2.409 ± 0.063	3.966ProGly: 3.966 ± 0.071	1.494ProHis: 1.494 ± 0.051	2.511ProIle: 2.511 ± 0.065	2.05ProLys: 2.05 ± 0.057	6.101ProLeu: 6.101 ± 0.097	1.075ProMet: 1.075 ± 0.04	1.81ProAsn: 1.81 ± 0.05	3.531ProPro: 3.531 ± 0.091	2.398ProGln: 2.398 ± 0.062	3.29ProArg: 3.29 ± 0.082	2.494ProSer: 2.494 ± 0.072	3.157ProThr: 3.157 ± 0.072	4.296ProVal: 4.296 ± 0.079	1.059ProTrp: 1.059 ± 0.044	1.406ProTyr: 1.406 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.712GlnAla: 4.712 ± 0.098	0.283GlnCys: 0.283 ± 0.022	1.1GlnAsp: 1.1 ± 0.043	2.055GlnGlu: 2.055 ± 0.06	1.152GlnPhe: 1.152 ± 0.04	2.406GlnGly: 2.406 ± 0.065	0.815GlnHis: 0.815 ± 0.035	1.838GlnIle: 1.838 ± 0.053	1.31GlnLys: 1.31 ± 0.045	4.14GlnLeu: 4.14 ± 0.077	0.874GlnMet: 0.874 ± 0.034	0.819GlnAsn: 0.819 ± 0.034	2.435GlnPro: 2.435 ± 0.061	1.859GlnGln: 1.859 ± 0.066	3.214GlnArg: 3.214 ± 0.07	1.618GlnSer: 1.618 ± 0.05	2.179GlnThr: 2.179 ± 0.057	2.441GlnVal: 2.441 ± 0.065	0.85GlnTrp: 0.85 ± 0.041	0.725GlnTyr: 0.725 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	8.673ArgAla: 8.673 ± 0.126	0.686ArgCys: 0.686 ± 0.039	3.915ArgAsp: 3.915 ± 0.077	4.867ArgGlu: 4.867 ± 0.086	3.723ArgPhe: 3.723 ± 0.074	4.324ArgGly: 4.324 ± 0.066	1.978ArgHis: 1.978 ± 0.056	4.089ArgIle: 4.089 ± 0.082	2.052ArgLys: 2.052 ± 0.057	9.2ArgLeu: 9.2 ± 0.13	1.64ArgMet: 1.64 ± 0.048	1.817ArgAsn: 1.817 ± 0.053	3.429ArgPro: 3.429 ± 0.082	2.922ArgGln: 2.922 ± 0.073	5.793ArgArg: 5.793 ± 0.093	3.032ArgSer: 3.032 ± 0.063	3.866ArgThr: 3.866 ± 0.081	5.532ArgVal: 5.532 ± 0.106	1.904ArgTrp: 1.904 ± 0.059	2.448ArgTyr: 2.448 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.076SerAla: 5.076 ± 0.1	0.393SerCys: 0.393 ± 0.023	2.466SerAsp: 2.466 ± 0.061	2.915SerGlu: 2.915 ± 0.07	1.528SerPhe: 1.528 ± 0.053	4.181SerGly: 4.181 ± 0.076	0.979SerHis: 0.979 ± 0.039	1.748SerIle: 1.748 ± 0.047	1.134SerLys: 1.134 ± 0.049	4.418SerLeu: 4.418 ± 0.08	0.84SerMet: 0.84 ± 0.032	1.068SerAsn: 1.068 ± 0.041	2.573SerPro: 2.573 ± 0.059	1.291SerGln: 1.291 ± 0.041	2.848SerArg: 2.848 ± 0.065	1.838SerSer: 1.838 ± 0.055	1.845SerThr: 1.845 ± 0.058	3.133SerVal: 3.133 ± 0.062	0.755SerTrp: 0.755 ± 0.032	0.889SerTyr: 0.889 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.817ThrAla: 6.817 ± 0.11	0.435ThrCys: 0.435 ± 0.025	2.302ThrAsp: 2.302 ± 0.056	3.137ThrGlu: 3.137 ± 0.072	2.09ThrPhe: 2.09 ± 0.054	4.188ThrGly: 4.188 ± 0.096	1.444ThrHis: 1.444 ± 0.047	2.637ThrIle: 2.637 ± 0.069	1.251ThrLys: 1.251 ± 0.049	7.404ThrLeu: 7.404 ± 0.11	0.878ThrMet: 0.878 ± 0.036	1.226ThrAsn: 1.226 ± 0.046	4.29ThrPro: 4.29 ± 0.101	2.186ThrGln: 2.186 ± 0.06	3.544ThrArg: 3.544 ± 0.073	1.985ThrSer: 1.985 ± 0.056	3.128ThrThr: 3.128 ± 0.062	5.041ThrVal: 5.041 ± 0.09	0.833ThrTrp: 0.833 ± 0.036	1.104ThrTyr: 1.104 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	11.069ValAla: 11.069 ± 0.156	0.718ValCys: 0.718 ± 0.029	3.612ValAsp: 3.612 ± 0.071	4.463ValGlu: 4.463 ± 0.086	2.353ValPhe: 2.353 ± 0.056	5.501ValGly: 5.501 ± 0.105	1.58ValHis: 1.58 ± 0.046	3.8ValIle: 3.8 ± 0.084	2.291ValLys: 2.291 ± 0.07	7.653ValLeu: 7.653 ± 0.113	1.571ValMet: 1.571 ± 0.049	1.51ValAsn: 1.51 ± 0.049	3.935ValPro: 3.935 ± 0.083	2.263ValGln: 2.263 ± 0.054	6.059ValArg: 6.059 ± 0.106	3.518ValSer: 3.518 ± 0.075	5.31ValThr: 5.31 ± 0.103	7.252ValVal: 7.252 ± 0.139	1.441ValTrp: 1.441 ± 0.051	1.323ValTyr: 1.323 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.804TrpAla: 1.804 ± 0.053	0.223TrpCys: 0.223 ± 0.018	0.701TrpAsp: 0.701 ± 0.031	0.965TrpGlu: 0.965 ± 0.035	0.752TrpPhe: 0.752 ± 0.036	1.201TrpGly: 1.201 ± 0.045	0.626TrpHis: 0.626 ± 0.034	0.735TrpIle: 0.735 ± 0.032	0.39TrpLys: 0.39 ± 0.025	2.783TrpLeu: 2.783 ± 0.072	0.337TrpMet: 0.337 ± 0.024	0.368TrpAsn: 0.368 ± 0.022	0.962TrpPro: 0.962 ± 0.041	1.323TrpGln: 1.323 ± 0.052	1.978TrpArg: 1.978 ± 0.064	0.825TrpSer: 0.825 ± 0.034	0.668TrpThr: 0.668 ± 0.033	1.519TrpVal: 1.519 ± 0.054	0.518TrpTrp: 0.518 ± 0.029	0.436TrpTyr: 0.436 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.497TyrAla: 2.497 ± 0.053	0.302TyrCys: 0.302 ± 0.021	1.201TyrAsp: 1.201 ± 0.045	1.149TyrGlu: 1.149 ± 0.045	0.895TyrPhe: 0.895 ± 0.037	1.964TyrGly: 1.964 ± 0.055	0.634TyrHis: 0.634 ± 0.026	0.678TyrIle: 0.678 ± 0.031	0.462TyrLys: 0.462 ± 0.027	2.799TyrLeu: 2.799 ± 0.07	0.279TyrMet: 0.279 ± 0.019	0.495TyrAsn: 0.495 ± 0.033	1.416TyrPro: 1.416 ± 0.051	0.913TyrGln: 0.913 ± 0.037	2.297TyrArg: 2.297 ± 0.054	0.842TyrSer: 0.842 ± 0.034	1.15TyrThr: 1.15 ± 0.042	1.365TyrVal: 1.365 ± 0.047	0.459TyrTrp: 0.459 ± 0.029	0.634TyrTyr: 0.634 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2138 proteins (712812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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