Amino acid dipepetide frequency for Halioglobus lutimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.214AlaAla: 12.214 ± 0.145	1.214AlaCys: 1.214 ± 0.036	6.196AlaAsp: 6.196 ± 0.067	7.086AlaGlu: 7.086 ± 0.09	3.51AlaPhe: 3.51 ± 0.049	8.88AlaGly: 8.88 ± 0.09	1.936AlaHis: 1.936 ± 0.037	5.262AlaIle: 5.262 ± 0.066	2.73AlaLys: 2.73 ± 0.055	11.645AlaLeu: 11.645 ± 0.105	3.119AlaMet: 3.119 ± 0.049	2.996AlaAsn: 2.996 ± 0.053	4.125AlaPro: 4.125 ± 0.064	4.298AlaGln: 4.298 ± 0.055	6.688AlaArg: 6.688 ± 0.083	6.117AlaSer: 6.117 ± 0.081	5.133AlaThr: 5.133 ± 0.066	7.736AlaVal: 7.736 ± 0.078	1.373AlaTrp: 1.373 ± 0.033	2.665AlaTyr: 2.665 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.129CysAla: 1.129 ± 0.03	0.161CysCys: 0.161 ± 0.009	0.616CysAsp: 0.616 ± 0.024	0.639CysGlu: 0.639 ± 0.021	0.384CysPhe: 0.384 ± 0.016	1.012CysGly: 1.012 ± 0.033	0.342CysHis: 0.342 ± 0.023	0.527CysIle: 0.527 ± 0.019	0.315CysLys: 0.315 ± 0.015	1.063CysLeu: 1.063 ± 0.03	0.224CysMet: 0.224 ± 0.013	0.312CysAsn: 0.312 ± 0.015	0.543CysPro: 0.543 ± 0.022	0.396CysGln: 0.396 ± 0.018	0.634CysArg: 0.634 ± 0.021	0.737CysSer: 0.737 ± 0.026	0.526CysThr: 0.526 ± 0.02	0.687CysVal: 0.687 ± 0.023	0.142CysTrp: 0.142 ± 0.012	0.304CysTyr: 0.304 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.011AspAla: 6.011 ± 0.08	0.668AspCys: 0.668 ± 0.022	3.365AspAsp: 3.365 ± 0.06	3.957AspGlu: 3.957 ± 0.06	2.385AspPhe: 2.385 ± 0.042	4.528AspGly: 4.528 ± 0.066	1.252AspHis: 1.252 ± 0.031	3.455AspIle: 3.455 ± 0.053	2.068AspLys: 2.068 ± 0.039	5.745AspLeu: 5.745 ± 0.077	1.553AspMet: 1.553 ± 0.03	1.974AspAsn: 1.974 ± 0.04	2.99AspPro: 2.99 ± 0.047	2.067AspGln: 2.067 ± 0.039	3.382AspArg: 3.382 ± 0.049	3.415AspSer: 3.415 ± 0.059	2.945AspThr: 2.945 ± 0.051	4.041AspVal: 4.041 ± 0.057	1.105AspTrp: 1.105 ± 0.027	2.14AspTyr: 2.14 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.534GluAla: 6.534 ± 0.07	0.492GluCys: 0.492 ± 0.019	3.493GluAsp: 3.493 ± 0.049	4.31GluGlu: 4.31 ± 0.074	2.234GluPhe: 2.234 ± 0.043	4.399GluGly: 4.399 ± 0.065	1.533GluHis: 1.533 ± 0.036	3.441GluIle: 3.441 ± 0.051	2.561GluLys: 2.561 ± 0.046	7.242GluLeu: 7.242 ± 0.097	1.668GluMet: 1.668 ± 0.039	2.121GluAsn: 2.121 ± 0.035	2.563GluPro: 2.563 ± 0.051	3.652GluGln: 3.652 ± 0.06	4.376GluArg: 4.376 ± 0.061	3.544GluSer: 3.544 ± 0.054	3.085GluThr: 3.085 ± 0.046	4.615GluVal: 4.615 ± 0.069	0.77GluTrp: 0.77 ± 0.025	1.748GluTyr: 1.748 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.617PheAla: 3.617 ± 0.044	0.49PheCys: 0.49 ± 0.02	2.558PheAsp: 2.558 ± 0.044	2.24PheGlu: 2.24 ± 0.042	1.501PhePhe: 1.501 ± 0.037	3.131PheGly: 3.131 ± 0.052	0.832PheHis: 0.832 ± 0.026	1.783PheIle: 1.783 ± 0.037	1.102PheLys: 1.102 ± 0.025	3.371PheLeu: 3.371 ± 0.058	0.893PheMet: 0.893 ± 0.027	1.398PheAsn: 1.398 ± 0.033	1.588PhePro: 1.588 ± 0.034	1.181PheGln: 1.181 ± 0.03	1.992PheArg: 1.992 ± 0.041	2.801PheSer: 2.801 ± 0.052	2.175PheThr: 2.175 ± 0.047	2.433PheVal: 2.433 ± 0.045	0.461PheTrp: 0.461 ± 0.02	1.159PheTyr: 1.159 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.404GlyAla: 7.404 ± 0.094	0.956GlyCys: 0.956 ± 0.032	4.734GlyAsp: 4.734 ± 0.071	5.486GlyGlu: 5.486 ± 0.06	3.32GlyPhe: 3.32 ± 0.05	6.467GlyGly: 6.467 ± 0.097	1.647GlyHis: 1.647 ± 0.037	4.467GlyIle: 4.467 ± 0.055	3.443GlyLys: 3.443 ± 0.06	8.15GlyLeu: 8.15 ± 0.086	2.374GlyMet: 2.374 ± 0.038	2.576GlyAsn: 2.576 ± 0.042	2.7GlyPro: 2.7 ± 0.047	2.959GlyGln: 2.959 ± 0.047	4.738GlyArg: 4.738 ± 0.064	4.932GlySer: 4.932 ± 0.062	3.967GlyThr: 3.967 ± 0.055	5.979GlyVal: 5.979 ± 0.074	1.202GlyTrp: 1.202 ± 0.032	2.567GlyTyr: 2.567 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.007HisAla: 2.007 ± 0.041	0.348HisCys: 0.348 ± 0.017	1.077HisAsp: 1.077 ± 0.029	1.089HisGlu: 1.089 ± 0.03	0.924HisPhe: 0.924 ± 0.029	1.829HisGly: 1.829 ± 0.04	0.611HisHis: 0.611 ± 0.024	1.135HisIle: 1.135 ± 0.03	0.644HisLys: 0.644 ± 0.023	2.23HisLeu: 2.23 ± 0.047	0.528HisMet: 0.528 ± 0.022	0.692HisAsn: 0.692 ± 0.024	1.339HisPro: 1.339 ± 0.033	0.902HisGln: 0.902 ± 0.028	1.523HisArg: 1.523 ± 0.034	1.361HisSer: 1.361 ± 0.035	1.05HisThr: 1.05 ± 0.026	1.305HisVal: 1.305 ± 0.03	0.392HisTrp: 0.392 ± 0.017	0.827HisTyr: 0.827 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.829IleAla: 5.829 ± 0.072	0.584IleCys: 0.584 ± 0.022	3.606IleAsp: 3.606 ± 0.055	3.52IleGlu: 3.52 ± 0.058	1.632IlePhe: 1.632 ± 0.032	4.059IleGly: 4.059 ± 0.057	1.12IleHis: 1.12 ± 0.029	2.301IleIle: 2.301 ± 0.046	1.725IleLys: 1.725 ± 0.037	4.208IleLeu: 4.208 ± 0.052	1.033IleMet: 1.033 ± 0.024	1.997IleAsn: 1.997 ± 0.037	2.52IlePro: 2.52 ± 0.04	1.523IleGln: 1.523 ± 0.035	2.848IleArg: 2.848 ± 0.045	3.363IleSer: 3.363 ± 0.051	2.944IleThr: 2.944 ± 0.043	3.503IleVal: 3.503 ± 0.054	0.572IleTrp: 0.572 ± 0.021	1.381IleTyr: 1.381 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.387LysAla: 3.387 ± 0.056	0.224LysCys: 0.224 ± 0.013	1.637LysAsp: 1.637 ± 0.037	1.799LysGlu: 1.799 ± 0.038	0.951LysPhe: 0.951 ± 0.026	2.408LysGly: 2.408 ± 0.043	0.742LysHis: 0.742 ± 0.026	1.627LysIle: 1.627 ± 0.036	1.453LysLys: 1.453 ± 0.048	3.551LysLeu: 3.551 ± 0.053	0.814LysMet: 0.814 ± 0.027	1.07LysAsn: 1.07 ± 0.029	1.779LysPro: 1.779 ± 0.038	1.505LysGln: 1.505 ± 0.034	2.272LysArg: 2.272 ± 0.043	1.948LysSer: 1.948 ± 0.046	1.763LysThr: 1.763 ± 0.03	2.472LysVal: 2.472 ± 0.044	0.407LysTrp: 0.407 ± 0.017	0.817LysTyr: 0.817 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.059LeuAla: 12.059 ± 0.117	1.176LeuCys: 1.176 ± 0.032	6.437LeuAsp: 6.437 ± 0.072	6.681LeuGlu: 6.681 ± 0.087	3.763LeuPhe: 3.763 ± 0.06	8.214LeuGly: 8.214 ± 0.083	2.232LeuHis: 2.232 ± 0.048	4.626LeuIle: 4.626 ± 0.069	3.408LeuLys: 3.408 ± 0.055	11.477LeuLeu: 11.477 ± 0.128	2.455LeuMet: 2.455 ± 0.047	3.122LeuAsn: 3.122 ± 0.043	5.396LeuPro: 5.396 ± 0.066	4.672LeuGln: 4.672 ± 0.064	6.675LeuArg: 6.675 ± 0.078	6.667LeuSer: 6.667 ± 0.072	5.118LeuThr: 5.118 ± 0.07	7.437LeuVal: 7.437 ± 0.083	1.284LeuTrp: 1.284 ± 0.032	2.582LeuTyr: 2.582 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.808MetAla: 2.808 ± 0.048	0.192MetCys: 0.192 ± 0.012	1.427MetAsp: 1.427 ± 0.035	1.515MetGlu: 1.515 ± 0.029	0.796MetPhe: 0.796 ± 0.027	2.002MetGly: 2.002 ± 0.037	0.559MetHis: 0.559 ± 0.022	1.213MetIle: 1.213 ± 0.03	1.008MetLys: 1.008 ± 0.022	2.619MetLeu: 2.619 ± 0.05	0.669MetMet: 0.669 ± 0.026	0.887MetAsn: 0.887 ± 0.025	1.325MetPro: 1.325 ± 0.03	1.136MetGln: 1.136 ± 0.027	1.607MetArg: 1.607 ± 0.033	1.778MetSer: 1.778 ± 0.034	1.415MetThr: 1.415 ± 0.03	1.758MetVal: 1.758 ± 0.037	0.237MetTrp: 0.237 ± 0.013	0.499MetTyr: 0.499 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.29AsnAla: 3.29 ± 0.053	0.366AsnCys: 0.366 ± 0.02	1.683AsnAsp: 1.683 ± 0.041	1.713AsnGlu: 1.713 ± 0.032	1.158AsnPhe: 1.158 ± 0.032	2.455AsnGly: 2.455 ± 0.044	0.668AsnHis: 0.668 ± 0.024	1.723AsnIle: 1.723 ± 0.041	1.012AsnLys: 1.012 ± 0.03	3.118AsnLeu: 3.118 ± 0.045	0.799AsnMet: 0.799 ± 0.021	1.133AsnAsn: 1.133 ± 0.029	2.084AsnPro: 2.084 ± 0.034	1.161AsnGln: 1.161 ± 0.031	2.028AsnArg: 2.028 ± 0.037	1.819AsnSer: 1.819 ± 0.038	1.835AsnThr: 1.835 ± 0.04	2.149AsnVal: 2.149 ± 0.044	0.548AsnTrp: 0.548 ± 0.022	1.019AsnTyr: 1.019 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.126ProAla: 5.126 ± 0.077	0.372ProCys: 0.372 ± 0.016	3.138ProAsp: 3.138 ± 0.051	3.775ProGlu: 3.775 ± 0.048	1.689ProPhe: 1.689 ± 0.032	4.601ProGly: 4.601 ± 0.067	1.008ProHis: 1.008 ± 0.028	1.952ProIle: 1.952 ± 0.035	1.189ProLys: 1.189 ± 0.032	4.769ProLeu: 4.769 ± 0.065	1.201ProMet: 1.201 ± 0.028	1.25ProAsn: 1.25 ± 0.036	1.985ProPro: 1.985 ± 0.043	1.831ProGln: 1.831 ± 0.038	2.612ProArg: 2.612 ± 0.05	2.4ProSer: 2.4 ± 0.042	2.11ProThr: 2.11 ± 0.042	3.865ProVal: 3.865 ± 0.047	0.71ProTrp: 0.71 ± 0.025	1.15ProTyr: 1.15 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.472GlnAla: 4.472 ± 0.049	0.358GlnCys: 0.358 ± 0.017	1.955GlnAsp: 1.955 ± 0.04	2.279GlnGlu: 2.279 ± 0.041	1.422GlnPhe: 1.422 ± 0.032	3.125GlnGly: 3.125 ± 0.047	0.946GlnHis: 0.946 ± 0.028	1.841GlnIle: 1.841 ± 0.035	1.168GlnLys: 1.168 ± 0.031	4.809GlnLeu: 4.809 ± 0.07	1.001GlnMet: 1.001 ± 0.025	0.995GlnAsn: 0.995 ± 0.028	1.948GlnPro: 1.948 ± 0.037	2.346GlnGln: 2.346 ± 0.044	3.265GlnArg: 3.265 ± 0.054	2.262GlnSer: 2.262 ± 0.043	1.798GlnThr: 1.798 ± 0.038	3.065GlnVal: 3.065 ± 0.051	0.677GlnTrp: 0.677 ± 0.021	1.089GlnTyr: 1.089 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.806ArgAla: 5.806 ± 0.07	0.68ArgCys: 0.68 ± 0.024	3.768ArgAsp: 3.768 ± 0.054	4.726ArgGlu: 4.726 ± 0.061	2.644ArgPhe: 2.644 ± 0.048	4.371ArgGly: 4.371 ± 0.057	1.505ArgHis: 1.505 ± 0.031	3.361ArgIle: 3.361 ± 0.051	2.384ArgLys: 2.384 ± 0.05	6.766ArgLeu: 6.766 ± 0.069	1.649ArgMet: 1.649 ± 0.033	2.059ArgAsn: 2.059 ± 0.039	2.637ArgPro: 2.637 ± 0.045	2.837ArgGln: 2.837 ± 0.051	4.286ArgArg: 4.286 ± 0.067	3.707ArgSer: 3.707 ± 0.046	2.65ArgThr: 2.65 ± 0.043	4.472ArgVal: 4.472 ± 0.053	1.008ArgTrp: 1.008 ± 0.026	2.065ArgTyr: 2.065 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.431SerAla: 6.431 ± 0.072	0.623SerCys: 0.623 ± 0.022	3.331SerAsp: 3.331 ± 0.052	3.581SerGlu: 3.581 ± 0.058	2.297SerPhe: 2.297 ± 0.044	5.589SerGly: 5.589 ± 0.059	1.287SerHis: 1.287 ± 0.026	3.142SerIle: 3.142 ± 0.048	1.811SerLys: 1.811 ± 0.041	6.633SerLeu: 6.633 ± 0.079	1.587SerMet: 1.587 ± 0.034	1.935SerAsn: 1.935 ± 0.034	2.942SerPro: 2.942 ± 0.052	2.159SerGln: 2.159 ± 0.039	3.932SerArg: 3.932 ± 0.059	3.743SerSer: 3.743 ± 0.06	3.037SerThr: 3.037 ± 0.045	4.384SerVal: 4.384 ± 0.064	0.92SerTrp: 0.92 ± 0.024	1.648SerTyr: 1.648 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.347ThrAla: 5.347 ± 0.056	0.49ThrCys: 0.49 ± 0.023	2.993ThrAsp: 2.993 ± 0.047	2.911ThrGlu: 2.911 ± 0.048	1.703ThrPhe: 1.703 ± 0.036	4.762ThrGly: 4.762 ± 0.057	1.047ThrHis: 1.047 ± 0.027	2.41ThrIle: 2.41 ± 0.043	1.02ThrLys: 1.02 ± 0.03	5.976ThrLeu: 5.976 ± 0.077	1.072ThrMet: 1.072 ± 0.029	1.377ThrAsn: 1.377 ± 0.034	2.931ThrPro: 2.931 ± 0.054	1.647ThrGln: 1.647 ± 0.039	3.231ThrArg: 3.231 ± 0.05	2.894ThrSer: 2.894 ± 0.045	2.612ThrThr: 2.612 ± 0.046	3.938ThrVal: 3.938 ± 0.057	0.681ThrTrp: 0.681 ± 0.023	1.289ThrTyr: 1.289 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.754ValAla: 7.754 ± 0.086	0.772ValCys: 0.772 ± 0.025	4.609ValAsp: 4.609 ± 0.054	4.749ValGlu: 4.749 ± 0.072	2.698ValPhe: 2.698 ± 0.044	5.096ValGly: 5.096 ± 0.066	1.502ValHis: 1.502 ± 0.032	4.133ValIle: 4.133 ± 0.052	2.365ValLys: 2.365 ± 0.046	7.272ValLeu: 7.272 ± 0.081	1.811ValMet: 1.811 ± 0.04	2.506ValAsn: 2.506 ± 0.041	3.387ValPro: 3.387 ± 0.045	2.379ValGln: 2.379 ± 0.04	3.966ValArg: 3.966 ± 0.052	4.828ValSer: 4.828 ± 0.067	4.049ValThr: 4.049 ± 0.055	5.724ValVal: 5.724 ± 0.076	0.805ValTrp: 0.805 ± 0.024	1.882ValTyr: 1.882 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.08TrpAla: 1.08 ± 0.031	0.183TrpCys: 0.183 ± 0.011	0.748TrpAsp: 0.748 ± 0.028	0.784TrpGlu: 0.784 ± 0.023	0.533TrpPhe: 0.533 ± 0.02	0.947TrpGly: 0.947 ± 0.029	0.369TrpHis: 0.369 ± 0.018	0.64TrpIle: 0.64 ± 0.023	0.424TrpLys: 0.424 ± 0.019	1.713TrpLeu: 1.713 ± 0.04	0.39TrpMet: 0.39 ± 0.016	0.447TrpAsn: 0.447 ± 0.019	0.601TrpPro: 0.601 ± 0.021	0.867TrpGln: 0.867 ± 0.027	1.047TrpArg: 1.047 ± 0.029	0.873TrpSer: 0.873 ± 0.028	0.673TrpThr: 0.673 ± 0.024	0.991TrpVal: 0.991 ± 0.028	0.226TrpTrp: 0.226 ± 0.014	0.442TrpTyr: 0.442 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.62TyrAla: 2.62 ± 0.048	0.345TyrCys: 0.345 ± 0.017	1.675TyrAsp: 1.675 ± 0.037	1.538TyrGlu: 1.538 ± 0.034	1.159TyrPhe: 1.159 ± 0.031	2.194TyrGly: 2.194 ± 0.045	0.676TyrHis: 0.676 ± 0.024	1.232TyrIle: 1.232 ± 0.031	0.794TyrLys: 0.794 ± 0.025	3.124TyrLeu: 3.124 ± 0.053	0.609TyrMet: 0.609 ± 0.02	0.915TyrAsn: 0.915 ± 0.024	1.349TyrPro: 1.349 ± 0.037	1.304TyrGln: 1.304 ± 0.034	2.28TyrArg: 2.28 ± 0.039	1.822TyrSer: 1.822 ± 0.037	1.447TyrThr: 1.447 ± 0.033	1.734TyrVal: 1.734 ± 0.035	0.457TyrTrp: 0.457 ± 0.017	0.951TyrTyr: 0.951 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4080 proteins (1394984 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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