Amino acid dipepetide frequency for Hyphomonas pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.413AlaAla: 14.413 ± 0.178	1.201AlaCys: 1.201 ± 0.039	7.148AlaAsp: 7.148 ± 0.086	8.332AlaGlu: 8.332 ± 0.122	4.372AlaPhe: 4.372 ± 0.071	9.725AlaGly: 9.725 ± 0.116	2.178AlaHis: 2.178 ± 0.048	5.939AlaIle: 5.939 ± 0.087	4.229AlaLys: 4.229 ± 0.079	12.188AlaLeu: 12.188 ± 0.161	3.544AlaMet: 3.544 ± 0.058	3.014AlaAsn: 3.014 ± 0.059	5.318AlaPro: 5.318 ± 0.082	3.693AlaGln: 3.693 ± 0.067	7.771AlaArg: 7.771 ± 0.108	6.556AlaSer: 6.556 ± 0.084	5.223AlaThr: 5.223 ± 0.082	7.336AlaVal: 7.336 ± 0.088	1.544AlaTrp: 1.544 ± 0.043	2.788AlaTyr: 2.788 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.962CysAla: 0.962 ± 0.037	0.104CysCys: 0.104 ± 0.01	0.54CysAsp: 0.54 ± 0.025	0.522CysGlu: 0.522 ± 0.024	0.345CysPhe: 0.345 ± 0.023	0.867CysGly: 0.867 ± 0.032	0.21CysHis: 0.21 ± 0.015	0.387CysIle: 0.387 ± 0.019	0.242CysLys: 0.242 ± 0.015	0.793CysLeu: 0.793 ± 0.033	0.174CysMet: 0.174 ± 0.012	0.235CysAsn: 0.235 ± 0.015	0.466CysPro: 0.466 ± 0.023	0.268CysGln: 0.268 ± 0.017	0.524CysArg: 0.524 ± 0.022	0.428CysSer: 0.428 ± 0.022	0.404CysThr: 0.404 ± 0.021	0.611CysVal: 0.611 ± 0.023	0.104CysTrp: 0.104 ± 0.01	0.206CysTyr: 0.206 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.056AspAla: 7.056 ± 0.087	0.411AspCys: 0.411 ± 0.02	3.663AspAsp: 3.663 ± 0.091	4.232AspGlu: 4.232 ± 0.08	2.352AspPhe: 2.352 ± 0.048	5.417AspGly: 5.417 ± 0.071	1.219AspHis: 1.219 ± 0.037	3.47AspIle: 3.47 ± 0.061	2.166AspLys: 2.166 ± 0.048	6.164AspLeu: 6.164 ± 0.08	1.85AspMet: 1.85 ± 0.046	1.425AspAsn: 1.425 ± 0.041	3.358AspPro: 3.358 ± 0.062	1.85AspGln: 1.85 ± 0.039	3.852AspArg: 3.852 ± 0.062	2.652AspSer: 2.652 ± 0.059	3.336AspThr: 3.336 ± 0.052	4.458AspVal: 4.458 ± 0.073	1.129AspTrp: 1.129 ± 0.038	1.834AspTyr: 1.834 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	8.781GluAla: 8.781 ± 0.115	0.416GluCys: 0.416 ± 0.021	4.257GluAsp: 4.257 ± 0.077	4.404GluGlu: 4.404 ± 0.096	2.008GluPhe: 2.008 ± 0.049	5.161GluGly: 5.161 ± 0.069	1.212GluHis: 1.212 ± 0.035	3.782GluIle: 3.782 ± 0.056	2.838GluLys: 2.838 ± 0.062	5.556GluLeu: 5.556 ± 0.077	1.845GluMet: 1.845 ± 0.042	1.854GluAsn: 1.854 ± 0.042	2.743GluPro: 2.743 ± 0.062	2.305GluGln: 2.305 ± 0.05	4.623GluArg: 4.623 ± 0.079	2.975GluSer: 2.975 ± 0.05	4.612GluThr: 4.612 ± 0.075	4.057GluVal: 4.057 ± 0.072	0.831GluTrp: 0.831 ± 0.029	1.366GluTyr: 1.366 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.182PheAla: 4.182 ± 0.076	0.374PheCys: 0.374 ± 0.02	2.739PheAsp: 2.739 ± 0.059	2.495PheGlu: 2.495 ± 0.053	1.346PhePhe: 1.346 ± 0.039	3.577PheGly: 3.577 ± 0.077	0.689PheHis: 0.689 ± 0.025	1.758PheIle: 1.758 ± 0.05	1.126PheLys: 1.126 ± 0.033	3.391PheLeu: 3.391 ± 0.071	0.93PheMet: 0.93 ± 0.03	1.135PheAsn: 1.135 ± 0.035	1.512PhePro: 1.512 ± 0.038	1.026PheGln: 1.026 ± 0.031	2.134PheArg: 2.134 ± 0.047	2.355PheSer: 2.355 ± 0.05	1.962PheThr: 1.962 ± 0.045	2.47PheVal: 2.47 ± 0.052	0.545PheTrp: 0.545 ± 0.024	0.943PheTyr: 0.943 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.924GlyAla: 8.924 ± 0.112	0.743GlyCys: 0.743 ± 0.031	4.833GlyAsp: 4.833 ± 0.068	5.38GlyGlu: 5.38 ± 0.078	3.443GlyPhe: 3.443 ± 0.065	7.077GlyGly: 7.077 ± 0.087	1.849GlyHis: 1.849 ± 0.04	4.28GlyIle: 4.28 ± 0.064	3.685GlyLys: 3.685 ± 0.066	8.719GlyLeu: 8.719 ± 0.102	2.402GlyMet: 2.402 ± 0.054	2.212GlyAsn: 2.212 ± 0.049	3.463GlyPro: 3.463 ± 0.064	2.904GlyGln: 2.904 ± 0.055	5.353GlyArg: 5.353 ± 0.079	4.342GlySer: 4.342 ± 0.059	4.295GlyThr: 4.295 ± 0.073	6.018GlyVal: 6.018 ± 0.085	1.41GlyTrp: 1.41 ± 0.041	2.381GlyTyr: 2.381 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.15HisAla: 2.15 ± 0.052	0.194HisCys: 0.194 ± 0.013	1.16HisAsp: 1.16 ± 0.038	1.171HisGlu: 1.171 ± 0.029	0.78HisPhe: 0.78 ± 0.029	1.745HisGly: 1.745 ± 0.044	0.516HisHis: 0.516 ± 0.026	1.005HisIle: 1.005 ± 0.033	0.645HisLys: 0.645 ± 0.028	1.868HisLeu: 1.868 ± 0.044	0.521HisMet: 0.521 ± 0.022	0.497HisAsn: 0.497 ± 0.025	1.156HisPro: 1.156 ± 0.037	0.548HisGln: 0.548 ± 0.023	1.17HisArg: 1.17 ± 0.036	0.936HisSer: 0.936 ± 0.031	0.918HisThr: 0.918 ± 0.031	1.437HisVal: 1.437 ± 0.035	0.302HisTrp: 0.302 ± 0.019	0.572HisTyr: 0.572 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.74IleAla: 6.74 ± 0.085	0.571IleCys: 0.571 ± 0.024	3.447IleAsp: 3.447 ± 0.06	3.782IleGlu: 3.782 ± 0.063	1.68IlePhe: 1.68 ± 0.051	4.766IleGly: 4.766 ± 0.082	0.947IleHis: 0.947 ± 0.031	2.717IleIle: 2.717 ± 0.058	1.551IleLys: 1.551 ± 0.047	4.744IleLeu: 4.744 ± 0.067	1.214IleMet: 1.214 ± 0.039	1.495IleAsn: 1.495 ± 0.038	2.292IlePro: 2.292 ± 0.048	1.439IleGln: 1.439 ± 0.04	3.077IleArg: 3.077 ± 0.051	3.412IleSer: 3.412 ± 0.058	2.926IleThr: 2.926 ± 0.055	3.929IleVal: 3.929 ± 0.065	0.696IleTrp: 0.696 ± 0.025	1.255IleTyr: 1.255 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.034LysAla: 5.034 ± 0.074	0.187LysCys: 0.187 ± 0.012	2.292LysAsp: 2.292 ± 0.059	2.123LysGlu: 2.123 ± 0.055	1.06LysPhe: 1.06 ± 0.035	3.033LysGly: 3.033 ± 0.06	0.728LysHis: 0.728 ± 0.027	1.821LysIle: 1.821 ± 0.046	1.646LysLys: 1.646 ± 0.054	3.592LysLeu: 3.592 ± 0.069	0.942LysMet: 0.942 ± 0.028	0.991LysAsn: 0.991 ± 0.032	2.363LysPro: 2.363 ± 0.056	1.255LysGln: 1.255 ± 0.031	2.719LysArg: 2.719 ± 0.061	2.274LysSer: 2.274 ± 0.046	2.375LysThr: 2.375 ± 0.052	2.569LysVal: 2.569 ± 0.063	0.487LysTrp: 0.487 ± 0.019	0.803LysTyr: 0.803 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.68LeuAla: 11.68 ± 0.14	0.824LeuCys: 0.824 ± 0.032	5.784LeuAsp: 5.784 ± 0.078	6.002LeuGlu: 6.002 ± 0.095	3.532LeuPhe: 3.532 ± 0.066	7.668LeuGly: 7.668 ± 0.098	1.618LeuHis: 1.618 ± 0.046	5.182LeuIle: 5.182 ± 0.082	4.446LeuLys: 4.446 ± 0.073	8.24LeuLeu: 8.24 ± 0.121	2.599LeuMet: 2.599 ± 0.05	2.915LeuAsn: 2.915 ± 0.056	5.159LeuPro: 5.159 ± 0.068	3.028LeuGln: 3.028 ± 0.061	5.772LeuArg: 5.772 ± 0.085	6.887LeuSer: 6.887 ± 0.092	5.813LeuThr: 5.813 ± 0.08	6.605LeuVal: 6.605 ± 0.095	1.102LeuTrp: 1.102 ± 0.038	2.127LeuTyr: 2.127 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.337MetAla: 3.337 ± 0.062	0.192MetCys: 0.192 ± 0.014	1.497MetAsp: 1.497 ± 0.04	1.504MetGlu: 1.504 ± 0.04	0.833MetPhe: 0.833 ± 0.029	2.074MetGly: 2.074 ± 0.046	0.428MetHis: 0.428 ± 0.021	1.443MetIle: 1.443 ± 0.038	1.253MetLys: 1.253 ± 0.029	2.45MetLeu: 2.45 ± 0.05	0.838MetMet: 0.838 ± 0.03	0.836MetAsn: 0.836 ± 0.028	1.51MetPro: 1.51 ± 0.036	0.922MetGln: 0.922 ± 0.026	1.747MetArg: 1.747 ± 0.043	1.929MetSer: 1.929 ± 0.042	1.997MetThr: 1.997 ± 0.047	1.672MetVal: 1.672 ± 0.036	0.224MetTrp: 0.224 ± 0.016	0.366MetTyr: 0.366 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.243AsnAla: 3.243 ± 0.062	0.25AsnCys: 0.25 ± 0.016	1.529AsnAsp: 1.529 ± 0.042	1.497AsnGlu: 1.497 ± 0.039	1.039AsnPhe: 1.039 ± 0.034	2.583AsnGly: 2.583 ± 0.054	0.491AsnHis: 0.491 ± 0.022	1.53AsnIle: 1.53 ± 0.041	0.852AsnLys: 0.852 ± 0.031	2.73AsnLeu: 2.73 ± 0.059	0.786AsnMet: 0.786 ± 0.026	0.743AsnAsn: 0.743 ± 0.029	1.835AsnPro: 1.835 ± 0.051	0.859AsnGln: 0.859 ± 0.026	1.718AsnArg: 1.718 ± 0.039	1.339AsnSer: 1.339 ± 0.036	1.474AsnThr: 1.474 ± 0.033	2.008AsnVal: 2.008 ± 0.044	0.492AsnTrp: 0.492 ± 0.022	0.766AsnTyr: 0.766 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.444ProAla: 5.444 ± 0.088	0.32ProCys: 0.32 ± 0.019	3.891ProAsp: 3.891 ± 0.073	4.483ProGlu: 4.483 ± 0.075	1.887ProPhe: 1.887 ± 0.043	4.246ProGly: 4.246 ± 0.063	1.008ProHis: 1.008 ± 0.03	2.329ProIle: 2.329 ± 0.05	1.956ProLys: 1.956 ± 0.044	4.255ProLeu: 4.255 ± 0.066	1.174ProMet: 1.174 ± 0.032	1.437ProAsn: 1.437 ± 0.043	2.356ProPro: 2.356 ± 0.07	1.64ProGln: 1.64 ± 0.04	2.456ProArg: 2.456 ± 0.053	2.796ProSer: 2.796 ± 0.049	2.255ProThr: 2.255 ± 0.045	4.133ProVal: 4.133 ± 0.063	0.62ProTrp: 0.62 ± 0.026	1.184ProTyr: 1.184 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.02GlnAla: 4.02 ± 0.077	0.211GlnCys: 0.211 ± 0.015	1.799GlnAsp: 1.799 ± 0.042	1.845GlnGlu: 1.845 ± 0.045	1.072GlnPhe: 1.072 ± 0.033	2.437GlnGly: 2.437 ± 0.048	0.592GlnHis: 0.592 ± 0.023	1.91GlnIle: 1.91 ± 0.039	1.3GlnLys: 1.3 ± 0.036	2.942GlnLeu: 2.942 ± 0.061	1.005GlnMet: 1.005 ± 0.034	0.937GlnAsn: 0.937 ± 0.029	1.663GlnPro: 1.663 ± 0.041	1.183GlnGln: 1.183 ± 0.032	2.229GlnArg: 2.229 ± 0.05	1.933GlnSer: 1.933 ± 0.048	1.987GlnThr: 1.987 ± 0.045	2.175GlnVal: 2.175 ± 0.045	0.377GlnTrp: 0.377 ± 0.019	0.659GlnTyr: 0.659 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.913ArgAla: 6.913 ± 0.105	0.454ArgCys: 0.454 ± 0.02	3.695ArgAsp: 3.695 ± 0.065	4.229ArgGlu: 4.229 ± 0.069	2.513ArgPhe: 2.513 ± 0.056	4.225ArgGly: 4.225 ± 0.059	1.385ArgHis: 1.385 ± 0.042	3.672ArgIle: 3.672 ± 0.072	2.79ArgLys: 2.79 ± 0.058	7.257ArgLeu: 7.257 ± 0.104	1.794ArgMet: 1.794 ± 0.044	1.824ArgAsn: 1.824 ± 0.044	3.081ArgPro: 3.081 ± 0.052	2.438ArgGln: 2.438 ± 0.05	4.561ArgArg: 4.561 ± 0.084	3.204ArgSer: 3.204 ± 0.059	3.229ArgThr: 3.229 ± 0.058	4.246ArgVal: 4.246 ± 0.065	0.865ArgTrp: 0.865 ± 0.027	1.659ArgTyr: 1.659 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.434SerAla: 6.434 ± 0.106	0.438SerCys: 0.438 ± 0.02	3.645SerAsp: 3.645 ± 0.073	3.531SerGlu: 3.531 ± 0.063	2.259SerPhe: 2.259 ± 0.048	5.642SerGly: 5.642 ± 0.085	1.094SerHis: 1.094 ± 0.031	2.862SerIle: 2.862 ± 0.061	1.95SerLys: 1.95 ± 0.044	5.834SerLeu: 5.834 ± 0.069	1.49SerMet: 1.49 ± 0.035	1.584SerAsn: 1.584 ± 0.043	2.936SerPro: 2.936 ± 0.051	1.821SerGln: 1.821 ± 0.051	3.604SerArg: 3.604 ± 0.05	3.194SerSer: 3.194 ± 0.07	2.744SerThr: 2.744 ± 0.053	4.113SerVal: 4.113 ± 0.07	0.833SerTrp: 0.833 ± 0.027	1.385SerTyr: 1.385 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.021ThrAla: 6.021 ± 0.08	0.463ThrCys: 0.463 ± 0.022	3.365ThrAsp: 3.365 ± 0.055	3.247ThrGlu: 3.247 ± 0.058	1.911ThrPhe: 1.911 ± 0.051	5.394ThrGly: 5.394 ± 0.079	1.058ThrHis: 1.058 ± 0.033	2.785ThrIle: 2.785 ± 0.056	1.653ThrLys: 1.653 ± 0.043	5.923ThrLeu: 5.923 ± 0.074	1.11ThrMet: 1.11 ± 0.033	1.353ThrAsn: 1.353 ± 0.042	3.537ThrPro: 3.537 ± 0.057	1.592ThrGln: 1.592 ± 0.039	3.266ThrArg: 3.266 ± 0.072	3.072ThrSer: 3.072 ± 0.051	2.565ThrThr: 2.565 ± 0.052	3.899ThrVal: 3.899 ± 0.056	0.682ThrTrp: 0.682 ± 0.025	1.527ThrTyr: 1.527 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.286ValAla: 7.286 ± 0.089	0.667ValCys: 0.667 ± 0.027	4.166ValAsp: 4.166 ± 0.065	4.552ValGlu: 4.552 ± 0.074	2.754ValPhe: 2.754 ± 0.057	4.853ValGly: 4.853 ± 0.09	1.275ValHis: 1.275 ± 0.035	4.013ValIle: 4.013 ± 0.063	2.599ValLys: 2.599 ± 0.051	6.41ValLeu: 6.41 ± 0.087	1.855ValMet: 1.855 ± 0.046	2.104ValAsn: 2.104 ± 0.053	3.373ValPro: 3.373 ± 0.064	2.039ValGln: 2.039 ± 0.047	4.638ValArg: 4.638 ± 0.071	4.848ValSer: 4.848 ± 0.062	4.295ValThr: 4.295 ± 0.077	4.529ValVal: 4.529 ± 0.073	0.974ValTrp: 0.974 ± 0.03	1.584ValTyr: 1.584 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.269TrpAla: 1.269 ± 0.042	0.155TrpCys: 0.155 ± 0.012	0.701TrpAsp: 0.701 ± 0.025	0.658TrpGlu: 0.658 ± 0.027	0.542TrpPhe: 0.542 ± 0.024	0.984TrpGly: 0.984 ± 0.032	0.318TrpHis: 0.318 ± 0.019	0.723TrpIle: 0.723 ± 0.023	0.537TrpLys: 0.537 ± 0.022	1.588TrpLeu: 1.588 ± 0.045	0.432TrpMet: 0.432 ± 0.021	0.483TrpAsn: 0.483 ± 0.021	0.693TrpPro: 0.693 ± 0.027	0.612TrpGln: 0.612 ± 0.023	1.126TrpArg: 1.126 ± 0.035	0.879TrpSer: 0.879 ± 0.031	0.789TrpThr: 0.789 ± 0.028	0.848TrpVal: 0.848 ± 0.03	0.229TrpTrp: 0.229 ± 0.016	0.295TrpTyr: 0.295 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.628TyrAla: 2.628 ± 0.048	0.217TyrCys: 0.217 ± 0.014	1.743TyrAsp: 1.743 ± 0.045	1.638TyrGlu: 1.638 ± 0.045	0.962TyrPhe: 0.962 ± 0.033	2.236TyrGly: 2.236 ± 0.05	0.475TyrHis: 0.475 ± 0.017	1.075TyrIle: 1.075 ± 0.035	0.831TyrLys: 0.831 ± 0.029	2.337TyrLeu: 2.337 ± 0.057	0.547TyrMet: 0.547 ± 0.023	0.692TyrAsn: 0.692 ± 0.025	1.054TyrPro: 1.054 ± 0.035	0.852TyrGln: 0.852 ± 0.025	1.692TyrArg: 1.692 ± 0.046	1.385TyrSer: 1.385 ± 0.042	1.226TyrThr: 1.226 ± 0.04	1.702TyrVal: 1.702 ± 0.043	0.412TyrTrp: 0.412 ± 0.021	0.738TyrTyr: 0.738 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3301 proteins (1037903 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---