Amino acid dipepetide frequency for TM7 phylum sp. oral taxon 353

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.817AlaAla: 9.817 ± 0.331
0.533AlaCys: 0.533 ± 0.05
5.27AlaAsp: 5.27 ± 0.188
5.858AlaGlu: 5.858 ± 0.218
2.687AlaPhe: 2.687 ± 0.139
6.391AlaGly: 6.391 ± 0.191
1.441AlaHis: 1.441 ± 0.092
5.929AlaIle: 5.929 ± 0.185
5.967AlaLys: 5.967 ± 0.183
7.435AlaLeu: 7.435 ± 0.233
2.148AlaMet: 2.148 ± 0.125
3.546AlaAsn: 3.546 ± 0.176
3.046AlaPro: 3.046 ± 0.163
3.089AlaGln: 3.089 ± 0.149
4.797AlaArg: 4.797 ± 0.202
5.591AlaSer: 5.591 ± 0.206
4.085AlaThr: 4.085 ± 0.158
6.603AlaVal: 6.603 ± 0.178
0.903AlaTrp: 0.903 ± 0.062
2.263AlaTyr: 2.263 ± 0.118
0.0AlaXaa: 0.0 ± 0.0
Cys
0.495CysAla: 0.495 ± 0.058
0.065CysCys: 0.065 ± 0.018
0.484CysAsp: 0.484 ± 0.055
0.392CysGlu: 0.392 ± 0.051
0.277CysPhe: 0.277 ± 0.04
0.593CysGly: 0.593 ± 0.059
0.158CysHis: 0.158 ± 0.032
0.402CysIle: 0.402 ± 0.049
0.462CysLys: 0.462 ± 0.054
0.636CysLeu: 0.636 ± 0.062
0.25CysMet: 0.25 ± 0.038
0.315CysAsn: 0.315 ± 0.042
0.381CysPro: 0.381 ± 0.051
0.392CysGln: 0.392 ± 0.042
0.49CysArg: 0.49 ± 0.054
0.511CysSer: 0.511 ± 0.047
0.343CysThr: 0.343 ± 0.044
0.424CysVal: 0.424 ± 0.05
0.06CysTrp: 0.06 ± 0.016
0.228CysTyr: 0.228 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
4.411AspAla: 4.411 ± 0.163
0.43AspCys: 0.43 ± 0.062
4.068AspAsp: 4.068 ± 0.21
4.65AspGlu: 4.65 ± 0.173
2.866AspPhe: 2.866 ± 0.139
4.808AspGly: 4.808 ± 0.186
0.821AspHis: 0.821 ± 0.069
4.808AspIle: 4.808 ± 0.181
4.547AspLys: 4.547 ± 0.164
4.922AspLeu: 4.922 ± 0.16
1.365AspMet: 1.365 ± 0.092
2.866AspAsn: 2.866 ± 0.152
2.007AspPro: 2.007 ± 0.106
1.822AspGln: 1.822 ± 0.097
2.747AspArg: 2.747 ± 0.139
3.905AspSer: 3.905 ± 0.152
3.051AspThr: 3.051 ± 0.136
4.014AspVal: 4.014 ± 0.161
0.685AspTrp: 0.685 ± 0.071
2.132AspTyr: 2.132 ± 0.103
0.0AspXaa: 0.0 ± 0.0
Glu
4.89GluAla: 4.89 ± 0.184
0.408GluCys: 0.408 ± 0.047
3.122GluAsp: 3.122 ± 0.137
3.764GluGlu: 3.764 ± 0.213
2.322GluPhe: 2.322 ± 0.113
2.894GluGly: 2.894 ± 0.134
1.077GluHis: 1.077 ± 0.081
4.574GluIle: 4.574 ± 0.172
4.574GluLys: 4.574 ± 0.177
7.136GluLeu: 7.136 ± 0.235
1.648GluMet: 1.648 ± 0.101
2.845GluAsn: 2.845 ± 0.126
1.904GluPro: 1.904 ± 0.097
2.866GluGln: 2.866 ± 0.134
3.541GluArg: 3.541 ± 0.167
3.367GluSer: 3.367 ± 0.149
3.171GluThr: 3.171 ± 0.135
4.259GluVal: 4.259 ± 0.17
0.604GluTrp: 0.604 ± 0.054
1.996GluTyr: 1.996 ± 0.12
0.0GluXaa: 0.0 ± 0.0
Phe
3.622PheAla: 3.622 ± 0.162
0.392PheCys: 0.392 ± 0.045
2.763PheAsp: 2.763 ± 0.12
1.904PheGlu: 1.904 ± 0.11
1.365PhePhe: 1.365 ± 0.098
3.095PheGly: 3.095 ± 0.147
0.631PheHis: 0.631 ± 0.065
2.72PheIle: 2.72 ± 0.126
1.735PheLys: 1.735 ± 0.097
3.176PheLeu: 3.176 ± 0.149
0.995PheMet: 0.995 ± 0.079
1.686PheAsn: 1.686 ± 0.092
1.082PhePro: 1.082 ± 0.072
1.039PheGln: 1.039 ± 0.069
1.702PheArg: 1.702 ± 0.104
2.66PheSer: 2.66 ± 0.127
2.393PheThr: 2.393 ± 0.14
2.535PheVal: 2.535 ± 0.123
0.566PheTrp: 0.566 ± 0.058
1.452PheTyr: 1.452 ± 0.087
0.0PheXaa: 0.0 ± 0.0
Gly
5.118GlyAla: 5.118 ± 0.184
0.462GlyCys: 0.462 ± 0.052
4.106GlyAsp: 4.106 ± 0.2
4.155GlyGlu: 4.155 ± 0.161
2.714GlyPhe: 2.714 ± 0.139
5.39GlyGly: 5.39 ± 0.265
1.099GlyHis: 1.099 ± 0.092
4.504GlyIle: 4.504 ± 0.176
4.781GlyLys: 4.781 ± 0.163
6.358GlyLeu: 6.358 ± 0.207
1.512GlyMet: 1.512 ± 0.109
2.73GlyAsn: 2.73 ± 0.144
1.414GlyPro: 1.414 ± 0.089
2.442GlyGln: 2.442 ± 0.106
3.514GlyArg: 3.514 ± 0.148
4.471GlySer: 4.471 ± 0.185
3.383GlyThr: 3.383 ± 0.148
5.477GlyVal: 5.477 ± 0.193
0.903GlyTrp: 0.903 ± 0.067
2.518GlyTyr: 2.518 ± 0.121
0.0GlyXaa: 0.0 ± 0.0
His
1.305HisAla: 1.305 ± 0.089
0.163HisCys: 0.163 ± 0.028
1.033HisAsp: 1.033 ± 0.092
1.202HisGlu: 1.202 ± 0.092
0.772HisPhe: 0.772 ± 0.064
1.262HisGly: 1.262 ± 0.082
0.506HisHis: 0.506 ± 0.059
1.305HisIle: 1.305 ± 0.082
0.984HisLys: 0.984 ± 0.071
1.512HisLeu: 1.512 ± 0.089
0.446HisMet: 0.446 ± 0.042
0.936HisAsn: 0.936 ± 0.08
1.012HisPro: 1.012 ± 0.079
0.696HisGln: 0.696 ± 0.061
0.908HisArg: 0.908 ± 0.073
1.186HisSer: 1.186 ± 0.094
0.957HisThr: 0.957 ± 0.073
1.077HisVal: 1.077 ± 0.083
0.218HisTrp: 0.218 ± 0.032
0.718HisTyr: 0.718 ± 0.069
0.0HisXaa: 0.0 ± 0.0
Ile
6.706IleAla: 6.706 ± 0.232
0.642IleCys: 0.642 ± 0.063
5.129IleAsp: 5.129 ± 0.171
4.193IleGlu: 4.193 ± 0.154
2.491IlePhe: 2.491 ± 0.155
4.667IleGly: 4.667 ± 0.174
1.137IleHis: 1.137 ± 0.08
5.771IleIle: 5.771 ± 0.236
4.313IleLys: 4.313 ± 0.199
5.912IleLeu: 5.912 ± 0.179
1.414IleMet: 1.414 ± 0.086
3.002IleAsn: 3.002 ± 0.122
2.388IlePro: 2.388 ± 0.114
2.219IleGln: 2.219 ± 0.108
3.274IleArg: 3.274 ± 0.143
4.737IleSer: 4.737 ± 0.171
4.253IleThr: 4.253 ± 0.169
5.08IleVal: 5.08 ± 0.216
0.647IleTrp: 0.647 ± 0.054
2.051IleTyr: 2.051 ± 0.108
0.0IleXaa: 0.0 ± 0.0
Lys
4.585LysAla: 4.585 ± 0.174
0.37LysCys: 0.37 ± 0.044
3.693LysAsp: 3.693 ± 0.159
3.824LysGlu: 3.824 ± 0.18
2.279LysPhe: 2.279 ± 0.115
3.209LysGly: 3.209 ± 0.148
1.371LysHis: 1.371 ± 0.102
4.683LysIle: 4.683 ± 0.173
5.618LysLys: 5.618 ± 0.24
6.451LysLeu: 6.451 ± 0.189
1.61LysMet: 1.61 ± 0.087
3.791LysAsn: 3.791 ± 0.165
2.747LysPro: 2.747 ± 0.138
2.845LysGln: 2.845 ± 0.138
3.563LysArg: 3.563 ± 0.142
4.395LysSer: 4.395 ± 0.188
4.058LysThr: 4.058 ± 0.143
3.715LysVal: 3.715 ± 0.17
0.609LysTrp: 0.609 ± 0.068
2.393LysTyr: 2.393 ± 0.15
0.0LysXaa: 0.0 ± 0.0
Leu
9.872LeuAla: 9.872 ± 0.272
0.696LeuCys: 0.696 ± 0.065
5.472LeuAsp: 5.472 ± 0.201
5.352LeuGlu: 5.352 ± 0.182
3.274LeuPhe: 3.274 ± 0.154
5.526LeuGly: 5.526 ± 0.206
1.735LeuHis: 1.735 ± 0.102
5.793LeuIle: 5.793 ± 0.202
5.461LeuLys: 5.461 ± 0.168
8.512LeuLeu: 8.512 ± 0.251
2.165LeuMet: 2.165 ± 0.121
3.459LeuAsn: 3.459 ± 0.147
4.27LeuPro: 4.27 ± 0.157
3.443LeuGln: 3.443 ± 0.121
5.352LeuArg: 5.352 ± 0.201
6.956LeuSer: 6.956 ± 0.218
4.868LeuThr: 4.868 ± 0.175
6.211LeuVal: 6.211 ± 0.19
0.876LeuTrp: 0.876 ± 0.077
2.671LeuTyr: 2.671 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
2.268MetAla: 2.268 ± 0.106
0.152MetCys: 0.152 ± 0.027
1.131MetAsp: 1.131 ± 0.084
1.077MetGlu: 1.077 ± 0.094
0.778MetPhe: 0.778 ± 0.066
1.262MetGly: 1.262 ± 0.104
0.419MetHis: 0.419 ± 0.048
1.583MetIle: 1.583 ± 0.104
1.713MetLys: 1.713 ± 0.093
2.214MetLeu: 2.214 ± 0.144
0.647MetMet: 0.647 ± 0.084
1.273MetAsn: 1.273 ± 0.074
0.968MetPro: 0.968 ± 0.079
0.897MetGln: 0.897 ± 0.069
1.392MetArg: 1.392 ± 0.085
1.74MetSer: 1.74 ± 0.103
1.398MetThr: 1.398 ± 0.076
1.447MetVal: 1.447 ± 0.094
0.163MetTrp: 0.163 ± 0.03
0.734MetTyr: 0.734 ± 0.063
0.0MetXaa: 0.0 ± 0.0
Asn
3.16AsnAla: 3.16 ± 0.159
0.359AsnCys: 0.359 ± 0.052
2.763AsnAsp: 2.763 ± 0.142
2.573AsnGlu: 2.573 ± 0.135
1.653AsnPhe: 1.653 ± 0.101
3.367AsnGly: 3.367 ± 0.152
0.674AsnHis: 0.674 ± 0.061
3.47AsnIle: 3.47 ± 0.147
3.166AsnLys: 3.166 ± 0.121
3.96AsnLeu: 3.96 ± 0.158
1.023AsnMet: 1.023 ± 0.075
2.589AsnAsn: 2.589 ± 0.14
2.241AsnPro: 2.241 ± 0.122
1.915AsnGln: 1.915 ± 0.125
2.23AsnArg: 2.23 ± 0.11
3.242AsnSer: 3.242 ± 0.172
2.208AsnThr: 2.208 ± 0.119
2.676AsnVal: 2.676 ± 0.107
0.5AsnTrp: 0.5 ± 0.057
1.681AsnTyr: 1.681 ± 0.103
0.0AsnXaa: 0.0 ± 0.0
Pro
3.176ProAla: 3.176 ± 0.155
0.223ProCys: 0.223 ± 0.04
2.6ProAsp: 2.6 ± 0.107
3.084ProGlu: 3.084 ± 0.149
1.452ProPhe: 1.452 ± 0.089
2.605ProGly: 2.605 ± 0.114
0.832ProHis: 0.832 ± 0.075
2.186ProIle: 2.186 ± 0.108
2.497ProLys: 2.497 ± 0.131
3.176ProLeu: 3.176 ± 0.117
0.816ProMet: 0.816 ± 0.067
2.012ProAsn: 2.012 ± 0.107
1.561ProPro: 1.561 ± 0.114
1.441ProGln: 1.441 ± 0.098
1.931ProArg: 1.931 ± 0.119
2.703ProSer: 2.703 ± 0.137
2.143ProThr: 2.143 ± 0.124
2.72ProVal: 2.72 ± 0.115
0.348ProTrp: 0.348 ± 0.039
1.039ProTyr: 1.039 ± 0.069
0.0ProXaa: 0.0 ± 0.0
Gln
3.421GlnAla: 3.421 ± 0.159
0.19GlnCys: 0.19 ± 0.03
1.588GlnAsp: 1.588 ± 0.089
2.072GlnGlu: 2.072 ± 0.119
1.43GlnPhe: 1.43 ± 0.086
1.8GlnGly: 1.8 ± 0.11
0.887GlnHis: 0.887 ± 0.072
2.676GlnIle: 2.676 ± 0.119
3.057GlnLys: 3.057 ± 0.135
4.052GlnLeu: 4.052 ± 0.153
0.838GlnMet: 0.838 ± 0.065
1.757GlnAsn: 1.757 ± 0.109
1.92GlnPro: 1.92 ± 0.14
2.094GlnGln: 2.094 ± 0.119
2.54GlnArg: 2.54 ± 0.128
2.415GlnSer: 2.415 ± 0.125
2.409GlnThr: 2.409 ± 0.126
2.04GlnVal: 2.04 ± 0.107
0.354GlnTrp: 0.354 ± 0.053
1.218GlnTyr: 1.218 ± 0.082
0.0GlnXaa: 0.0 ± 0.0
Arg
4.34ArgAla: 4.34 ± 0.155
0.354ArgCys: 0.354 ± 0.043
3.432ArgAsp: 3.432 ± 0.14
3.486ArgGlu: 3.486 ± 0.17
2.056ArgPhe: 2.056 ± 0.091
3.22ArgGly: 3.22 ± 0.168
1.251ArgHis: 1.251 ± 0.098
3.258ArgIle: 3.258 ± 0.134
3.078ArgLys: 3.078 ± 0.173
5.281ArgLeu: 5.281 ± 0.201
1.229ArgMet: 1.229 ± 0.087
2.241ArgAsn: 2.241 ± 0.111
1.925ArgPro: 1.925 ± 0.106
3.122ArgGln: 3.122 ± 0.142
4.079ArgArg: 4.079 ± 0.185
3.486ArgSer: 3.486 ± 0.146
2.616ArgThr: 2.616 ± 0.119
3.568ArgVal: 3.568 ± 0.144
0.533ArgTrp: 0.533 ± 0.057
1.855ArgTyr: 1.855 ± 0.114
0.0ArgXaa: 0.0 ± 0.0
Ser
5.417SerAla: 5.417 ± 0.167
0.446SerCys: 0.446 ± 0.055
3.911SerAsp: 3.911 ± 0.143
4.063SerGlu: 4.063 ± 0.202
2.779SerPhe: 2.779 ± 0.15
5.444SerGly: 5.444 ± 0.218
1.093SerHis: 1.093 ± 0.065
4.395SerIle: 4.395 ± 0.184
3.987SerLys: 3.987 ± 0.19
6.413SerLeu: 6.413 ± 0.189
1.523SerMet: 1.523 ± 0.081
2.915SerAsn: 2.915 ± 0.122
2.796SerPro: 2.796 ± 0.143
2.66SerGln: 2.66 ± 0.116
3.622SerArg: 3.622 ± 0.168
5.004SerSer: 5.004 ± 0.21
3.557SerThr: 3.557 ± 0.149
4.422SerVal: 4.422 ± 0.165
0.653SerTrp: 0.653 ± 0.063
2.094SerTyr: 2.094 ± 0.119
0.0SerXaa: 0.0 ± 0.0
Thr
5.134ThrAla: 5.134 ± 0.197
0.354ThrCys: 0.354 ± 0.048
3.274ThrAsp: 3.274 ± 0.133
2.812ThrGlu: 2.812 ± 0.122
1.936ThrPhe: 1.936 ± 0.104
3.889ThrGly: 3.889 ± 0.142
1.077ThrHis: 1.077 ± 0.077
4.281ThrIle: 4.281 ± 0.159
3.073ThrLys: 3.073 ± 0.131
4.656ThrLeu: 4.656 ± 0.175
1.213ThrMet: 1.213 ± 0.075
2.214ThrAsn: 2.214 ± 0.124
3.019ThrPro: 3.019 ± 0.16
1.517ThrGln: 1.517 ± 0.1
2.458ThrArg: 2.458 ± 0.124
3.497ThrSer: 3.497 ± 0.163
3.117ThrThr: 3.117 ± 0.15
4.155ThrVal: 4.155 ± 0.174
0.522ThrTrp: 0.522 ± 0.055
1.61ThrTyr: 1.61 ± 0.1
0.0ThrXaa: 0.0 ± 0.0
Val
6.456ValAla: 6.456 ± 0.224
0.685ValCys: 0.685 ± 0.067
4.4ValAsp: 4.4 ± 0.16
4.248ValGlu: 4.248 ± 0.16
2.535ValPhe: 2.535 ± 0.127
4.563ValGly: 4.563 ± 0.17
1.044ValHis: 1.044 ± 0.075
4.944ValIle: 4.944 ± 0.192
4.433ValLys: 4.433 ± 0.169
5.977ValLeu: 5.977 ± 0.214
1.528ValMet: 1.528 ± 0.091
3.198ValAsn: 3.198 ± 0.15
2.35ValPro: 2.35 ± 0.117
2.176ValGln: 2.176 ± 0.116
3.59ValArg: 3.59 ± 0.164
4.77ValSer: 4.77 ± 0.19
3.481ValThr: 3.481 ± 0.14
5.591ValVal: 5.591 ± 0.221
0.658ValTrp: 0.658 ± 0.059
2.078ValTyr: 2.078 ± 0.099
0.0ValXaa: 0.0 ± 0.0
Trp
0.68TrpAla: 0.68 ± 0.067
0.114TrpCys: 0.114 ± 0.026
0.538TrpAsp: 0.538 ± 0.064
0.359TrpGlu: 0.359 ± 0.045
0.435TrpPhe: 0.435 ± 0.052
0.609TrpGly: 0.609 ± 0.054
0.288TrpHis: 0.288 ± 0.04
0.566TrpIle: 0.566 ± 0.061
0.468TrpLys: 0.468 ± 0.052
1.43TrpLeu: 1.43 ± 0.095
0.294TrpMet: 0.294 ± 0.042
0.402TrpAsn: 0.402 ± 0.052
0.315TrpPro: 0.315 ± 0.043
0.702TrpGln: 0.702 ± 0.069
0.865TrpArg: 0.865 ± 0.065
0.647TrpSer: 0.647 ± 0.073
0.484TrpThr: 0.484 ± 0.052
0.544TrpVal: 0.544 ± 0.048
0.218TrpTrp: 0.218 ± 0.044
0.37TrpTyr: 0.37 ± 0.051
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.524TyrAla: 2.524 ± 0.127
0.321TyrCys: 0.321 ± 0.039
2.148TyrAsp: 2.148 ± 0.117
1.893TyrGlu: 1.893 ± 0.104
1.409TyrPhe: 1.409 ± 0.094
2.458TyrGly: 2.458 ± 0.119
0.658TyrHis: 0.658 ± 0.065
2.181TyrIle: 2.181 ± 0.134
1.898TyrLys: 1.898 ± 0.122
2.752TyrLeu: 2.752 ± 0.124
0.587TyrMet: 0.587 ± 0.058
1.67TyrAsn: 1.67 ± 0.121
1.202TyrPro: 1.202 ± 0.083
1.382TyrGln: 1.382 ± 0.089
1.817TyrArg: 1.817 ± 0.094
1.909TyrSer: 1.909 ± 0.106
1.833TyrThr: 1.833 ± 0.102
2.148TyrVal: 2.148 ± 0.094
0.31TyrTrp: 0.31 ± 0.039
1.235TyrTyr: 1.235 ± 0.095
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 656 proteins (183858 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski