Amino acid dipepetide frequency for Bifidobacterium phage BlindUri1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.773AlaAla: 6.773 ± 1.044
0.529AlaCys: 0.529 ± 0.223
5.292AlaAsp: 5.292 ± 0.784
3.916AlaGlu: 3.916 ± 0.604
1.905AlaPhe: 1.905 ± 0.5
3.916AlaGly: 3.916 ± 0.722
1.058AlaHis: 1.058 ± 0.308
5.292AlaIle: 5.292 ± 0.727
5.503AlaLys: 5.503 ± 0.845
6.773AlaLeu: 6.773 ± 0.769
2.011AlaMet: 2.011 ± 0.512
3.916AlaAsn: 3.916 ± 0.61
3.387AlaPro: 3.387 ± 0.755
4.762AlaGln: 4.762 ± 0.857
3.598AlaArg: 3.598 ± 0.599
4.339AlaSer: 4.339 ± 0.625
4.445AlaThr: 4.445 ± 0.955
6.667AlaVal: 6.667 ± 0.98
1.27AlaTrp: 1.27 ± 0.452
2.434AlaTyr: 2.434 ± 0.606
0.0AlaXaa: 0.0 ± 0.0
Cys
0.423CysAla: 0.423 ± 0.196
0.0CysCys: 0.0 ± 0.0
0.423CysAsp: 0.423 ± 0.21
0.423CysGlu: 0.423 ± 0.208
0.0CysPhe: 0.0 ± 0.0
0.635CysGly: 0.635 ± 0.305
0.106CysHis: 0.106 ± 0.114
0.423CysIle: 0.423 ± 0.229
0.635CysLys: 0.635 ± 0.258
1.164CysLeu: 1.164 ± 0.403
0.106CysMet: 0.106 ± 0.105
0.635CysAsn: 0.635 ± 0.257
0.635CysPro: 0.635 ± 0.238
0.741CysGln: 0.741 ± 0.379
0.635CysArg: 0.635 ± 0.25
0.741CysSer: 0.741 ± 0.258
0.847CysThr: 0.847 ± 0.269
0.212CysVal: 0.212 ± 0.132
0.317CysTrp: 0.317 ± 0.186
0.317CysTyr: 0.317 ± 0.34
0.0CysXaa: 0.0 ± 0.0
Asp
2.646AspAla: 2.646 ± 0.497
0.635AspCys: 0.635 ± 0.241
6.773AspAsp: 6.773 ± 1.237
2.54AspGlu: 2.54 ± 0.482
1.376AspPhe: 1.376 ± 0.331
5.397AspGly: 5.397 ± 0.642
1.164AspHis: 1.164 ± 0.33
4.233AspIle: 4.233 ± 0.673
4.127AspLys: 4.127 ± 0.695
5.503AspLeu: 5.503 ± 0.672
2.646AspMet: 2.646 ± 0.698
2.646AspAsn: 2.646 ± 0.536
2.963AspPro: 2.963 ± 0.567
1.27AspGln: 1.27 ± 0.4
3.916AspArg: 3.916 ± 0.734
6.032AspSer: 6.032 ± 0.618
4.762AspThr: 4.762 ± 0.651
3.387AspVal: 3.387 ± 0.637
1.482AspTrp: 1.482 ± 0.463
3.704AspTyr: 3.704 ± 0.776
0.0AspXaa: 0.0 ± 0.0
Glu
2.963GluAla: 2.963 ± 0.509
0.317GluCys: 0.317 ± 0.162
3.598GluAsp: 3.598 ± 0.6
1.587GluGlu: 1.587 ± 0.537
2.011GluPhe: 2.011 ± 0.52
2.117GluGly: 2.117 ± 0.494
1.27GluHis: 1.27 ± 0.36
1.799GluIle: 1.799 ± 0.365
1.905GluLys: 1.905 ± 0.444
5.397GluLeu: 5.397 ± 0.781
1.164GluMet: 1.164 ± 0.337
2.646GluAsn: 2.646 ± 0.593
2.857GluPro: 2.857 ± 0.592
2.963GluGln: 2.963 ± 0.628
2.857GluArg: 2.857 ± 0.526
4.657GluSer: 4.657 ± 0.733
2.857GluThr: 2.857 ± 0.55
1.905GluVal: 1.905 ± 0.475
0.952GluTrp: 0.952 ± 0.321
1.905GluTyr: 1.905 ± 0.474
0.0GluXaa: 0.0 ± 0.0
Phe
2.011PheAla: 2.011 ± 0.489
0.423PheCys: 0.423 ± 0.293
2.117PheAsp: 2.117 ± 0.484
1.482PheGlu: 1.482 ± 0.398
1.058PhePhe: 1.058 ± 0.397
3.175PheGly: 3.175 ± 0.57
0.106PheHis: 0.106 ± 0.112
2.328PheIle: 2.328 ± 0.611
2.222PheLys: 2.222 ± 0.644
1.587PheLeu: 1.587 ± 0.349
0.741PheMet: 0.741 ± 0.275
1.376PheAsn: 1.376 ± 0.361
0.847PhePro: 0.847 ± 0.339
0.952PheGln: 0.952 ± 0.32
1.693PheArg: 1.693 ± 0.453
1.905PheSer: 1.905 ± 0.504
2.328PheThr: 2.328 ± 0.408
2.222PheVal: 2.222 ± 0.498
0.212PheTrp: 0.212 ± 0.134
0.741PheTyr: 0.741 ± 0.292
0.0PheXaa: 0.0 ± 0.0
Gly
5.503GlyAla: 5.503 ± 1.008
0.423GlyCys: 0.423 ± 0.253
3.281GlyAsp: 3.281 ± 0.507
3.069GlyGlu: 3.069 ± 0.741
2.011GlyPhe: 2.011 ± 0.543
3.704GlyGly: 3.704 ± 0.521
1.587GlyHis: 1.587 ± 0.294
4.974GlyIle: 4.974 ± 0.985
2.963GlyLys: 2.963 ± 0.627
5.503GlyLeu: 5.503 ± 0.72
1.376GlyMet: 1.376 ± 0.408
3.281GlyAsn: 3.281 ± 0.596
2.011GlyPro: 2.011 ± 0.475
3.069GlyGln: 3.069 ± 0.524
3.281GlyArg: 3.281 ± 0.692
4.974GlySer: 4.974 ± 0.757
4.974GlyThr: 4.974 ± 0.857
5.397GlyVal: 5.397 ± 0.944
1.164GlyTrp: 1.164 ± 0.357
4.445GlyTyr: 4.445 ± 0.554
0.0GlyXaa: 0.0 ± 0.0
His
1.058HisAla: 1.058 ± 0.286
0.317HisCys: 0.317 ± 0.201
0.741HisAsp: 0.741 ± 0.263
0.529HisGlu: 0.529 ± 0.258
0.847HisPhe: 0.847 ± 0.267
0.952HisGly: 0.952 ± 0.334
0.529HisHis: 0.529 ± 0.331
1.058HisIle: 1.058 ± 0.368
0.952HisLys: 0.952 ± 0.292
1.482HisLeu: 1.482 ± 0.398
0.635HisMet: 0.635 ± 0.244
0.952HisAsn: 0.952 ± 0.268
1.376HisPro: 1.376 ± 0.376
0.317HisGln: 0.317 ± 0.19
1.376HisArg: 1.376 ± 0.425
0.317HisSer: 0.317 ± 0.159
0.952HisThr: 0.952 ± 0.313
1.376HisVal: 1.376 ± 0.379
0.317HisTrp: 0.317 ± 0.243
1.058HisTyr: 1.058 ± 0.358
0.0HisXaa: 0.0 ± 0.0
Ile
3.387IleAla: 3.387 ± 0.596
0.952IleCys: 0.952 ± 0.365
4.551IleAsp: 4.551 ± 0.878
4.445IleGlu: 4.445 ± 0.727
1.482IlePhe: 1.482 ± 0.411
4.339IleGly: 4.339 ± 0.719
0.635IleHis: 0.635 ± 0.278
4.022IleIle: 4.022 ± 0.661
2.963IleLys: 2.963 ± 0.497
4.233IleLeu: 4.233 ± 0.712
0.741IleMet: 0.741 ± 0.268
3.598IleAsn: 3.598 ± 0.608
3.069IlePro: 3.069 ± 0.515
2.963IleGln: 2.963 ± 0.618
2.963IleArg: 2.963 ± 0.479
5.397IleSer: 5.397 ± 1.031
4.657IleThr: 4.657 ± 0.716
4.339IleVal: 4.339 ± 0.771
1.27IleTrp: 1.27 ± 0.565
2.328IleTyr: 2.328 ± 0.738
0.0IleXaa: 0.0 ± 0.0
Lys
6.032LysAla: 6.032 ± 1.015
0.317LysCys: 0.317 ± 0.218
2.857LysAsp: 2.857 ± 0.553
3.598LysGlu: 3.598 ± 0.782
1.27LysPhe: 1.27 ± 0.4
2.752LysGly: 2.752 ± 0.465
1.376LysHis: 1.376 ± 0.409
2.117LysIle: 2.117 ± 0.399
0.952LysLys: 0.952 ± 0.406
4.762LysLeu: 4.762 ± 0.785
0.952LysMet: 0.952 ± 0.393
1.587LysAsn: 1.587 ± 0.407
3.598LysPro: 3.598 ± 0.739
1.905LysGln: 1.905 ± 0.425
2.752LysArg: 2.752 ± 0.621
3.281LysSer: 3.281 ± 0.657
4.339LysThr: 4.339 ± 0.79
2.222LysVal: 2.222 ± 0.765
0.952LysTrp: 0.952 ± 0.246
2.54LysTyr: 2.54 ± 0.623
0.0LysXaa: 0.0 ± 0.0
Leu
5.609LeuAla: 5.609 ± 0.638
0.847LeuCys: 0.847 ± 0.282
5.927LeuAsp: 5.927 ± 0.868
4.127LeuGlu: 4.127 ± 0.765
1.799LeuPhe: 1.799 ± 0.38
5.503LeuGly: 5.503 ± 0.721
0.741LeuHis: 0.741 ± 0.302
4.868LeuIle: 4.868 ± 0.905
4.233LeuLys: 4.233 ± 0.775
4.657LeuLeu: 4.657 ± 0.549
2.011LeuMet: 2.011 ± 0.525
4.657LeuAsn: 4.657 ± 0.752
4.551LeuPro: 4.551 ± 0.84
3.704LeuGln: 3.704 ± 0.708
3.069LeuArg: 3.069 ± 0.631
4.657LeuSer: 4.657 ± 0.793
8.149LeuThr: 8.149 ± 1.029
5.397LeuVal: 5.397 ± 0.792
1.799LeuTrp: 1.799 ± 0.441
2.222LeuTyr: 2.222 ± 0.482
0.0LeuXaa: 0.0 ± 0.0
Met
2.646MetAla: 2.646 ± 0.675
0.106MetCys: 0.106 ± 0.096
1.587MetAsp: 1.587 ± 0.399
1.164MetGlu: 1.164 ± 0.406
0.847MetPhe: 0.847 ± 0.351
0.952MetGly: 0.952 ± 0.389
0.106MetHis: 0.106 ± 0.095
1.482MetIle: 1.482 ± 0.366
1.27MetLys: 1.27 ± 0.368
2.222MetLeu: 2.222 ± 0.633
0.529MetMet: 0.529 ± 0.25
1.164MetAsn: 1.164 ± 0.305
1.587MetPro: 1.587 ± 0.482
0.635MetGln: 0.635 ± 0.229
0.741MetArg: 0.741 ± 0.317
1.693MetSer: 1.693 ± 0.417
2.646MetThr: 2.646 ± 0.576
1.587MetVal: 1.587 ± 0.419
0.106MetTrp: 0.106 ± 0.123
0.635MetTyr: 0.635 ± 0.24
0.0MetXaa: 0.0 ± 0.0
Asn
4.127AsnAla: 4.127 ± 0.838
0.212AsnCys: 0.212 ± 0.15
2.328AsnAsp: 2.328 ± 0.546
2.328AsnGlu: 2.328 ± 0.542
1.27AsnPhe: 1.27 ± 0.342
5.609AsnGly: 5.609 ± 0.942
1.376AsnHis: 1.376 ± 0.477
1.905AsnIle: 1.905 ± 0.407
2.857AsnLys: 2.857 ± 0.608
3.81AsnLeu: 3.81 ± 0.673
1.27AsnMet: 1.27 ± 0.341
2.222AsnAsn: 2.222 ± 0.522
2.963AsnPro: 2.963 ± 0.791
1.905AsnGln: 1.905 ± 0.348
2.434AsnArg: 2.434 ± 0.577
3.175AsnSer: 3.175 ± 0.493
2.963AsnThr: 2.963 ± 0.597
3.704AsnVal: 3.704 ± 0.67
1.058AsnTrp: 1.058 ± 0.352
0.741AsnTyr: 0.741 ± 0.285
0.0AsnXaa: 0.0 ± 0.0
Pro
3.598ProAla: 3.598 ± 0.761
0.212ProCys: 0.212 ± 0.147
5.397ProAsp: 5.397 ± 0.853
3.81ProGlu: 3.81 ± 0.706
1.164ProPhe: 1.164 ± 0.395
3.81ProGly: 3.81 ± 0.666
0.635ProHis: 0.635 ± 0.273
2.646ProIle: 2.646 ± 0.592
2.328ProLys: 2.328 ± 0.726
3.492ProLeu: 3.492 ± 0.667
1.376ProMet: 1.376 ± 0.383
2.752ProAsn: 2.752 ± 0.52
1.905ProPro: 1.905 ± 0.443
3.175ProGln: 3.175 ± 0.844
1.693ProArg: 1.693 ± 0.45
2.117ProSer: 2.117 ± 0.48
3.704ProThr: 3.704 ± 0.587
4.233ProVal: 4.233 ± 0.725
0.847ProTrp: 0.847 ± 0.248
2.752ProTyr: 2.752 ± 0.51
0.0ProXaa: 0.0 ± 0.0
Gln
4.974GlnAla: 4.974 ± 0.892
0.212GlnCys: 0.212 ± 0.13
2.328GlnAsp: 2.328 ± 0.444
1.164GlnGlu: 1.164 ± 0.33
1.482GlnPhe: 1.482 ± 0.334
2.54GlnGly: 2.54 ± 0.472
0.952GlnHis: 0.952 ± 0.294
1.376GlnIle: 1.376 ± 0.333
1.587GlnLys: 1.587 ± 0.371
2.222GlnLeu: 2.222 ± 0.411
1.27GlnMet: 1.27 ± 0.378
1.587GlnAsn: 1.587 ± 0.387
4.127GlnPro: 4.127 ± 0.817
2.963GlnGln: 2.963 ± 0.857
2.434GlnArg: 2.434 ± 0.506
4.127GlnSer: 4.127 ± 0.704
5.292GlnThr: 5.292 ± 0.768
2.646GlnVal: 2.646 ± 0.491
1.376GlnTrp: 1.376 ± 0.382
2.328GlnTyr: 2.328 ± 0.402
0.0GlnXaa: 0.0 ± 0.0
Arg
3.281ArgAla: 3.281 ± 0.659
1.058ArgCys: 1.058 ± 0.388
3.175ArgAsp: 3.175 ± 0.541
1.905ArgGlu: 1.905 ± 0.487
2.328ArgPhe: 2.328 ± 0.873
2.328ArgGly: 2.328 ± 0.417
0.952ArgHis: 0.952 ± 0.326
3.704ArgIle: 3.704 ± 0.618
2.963ArgLys: 2.963 ± 0.632
4.233ArgLeu: 4.233 ± 0.782
1.058ArgMet: 1.058 ± 0.331
2.434ArgAsn: 2.434 ± 0.461
2.328ArgPro: 2.328 ± 0.583
2.752ArgGln: 2.752 ± 0.511
1.587ArgArg: 1.587 ± 0.302
1.482ArgSer: 1.482 ± 0.283
4.022ArgThr: 4.022 ± 0.713
3.387ArgVal: 3.387 ± 0.794
0.423ArgTrp: 0.423 ± 0.204
2.54ArgTyr: 2.54 ± 0.634
0.0ArgXaa: 0.0 ± 0.0
Ser
5.715SerAla: 5.715 ± 0.801
0.635SerCys: 0.635 ± 0.261
4.339SerAsp: 4.339 ± 0.61
2.752SerGlu: 2.752 ± 0.444
1.799SerPhe: 1.799 ± 0.528
6.879SerGly: 6.879 ± 1.486
1.058SerHis: 1.058 ± 0.308
5.08SerIle: 5.08 ± 0.814
3.281SerLys: 3.281 ± 0.543
6.138SerLeu: 6.138 ± 0.759
1.058SerMet: 1.058 ± 0.375
2.752SerAsn: 2.752 ± 0.656
3.492SerPro: 3.492 ± 0.596
3.81SerGln: 3.81 ± 0.701
2.857SerArg: 2.857 ± 0.617
4.657SerSer: 4.657 ± 0.795
4.339SerThr: 4.339 ± 0.617
4.868SerVal: 4.868 ± 0.803
1.058SerTrp: 1.058 ± 0.379
2.328SerTyr: 2.328 ± 0.464
0.0SerXaa: 0.0 ± 0.0
Thr
5.715ThrAla: 5.715 ± 0.894
0.847ThrCys: 0.847 ± 0.305
3.387ThrAsp: 3.387 ± 0.53
3.598ThrGlu: 3.598 ± 0.668
2.328ThrPhe: 2.328 ± 0.557
5.08ThrGly: 5.08 ± 0.884
1.164ThrHis: 1.164 ± 0.294
7.937ThrIle: 7.937 ± 1.061
3.81ThrLys: 3.81 ± 0.594
5.503ThrLeu: 5.503 ± 0.78
1.693ThrMet: 1.693 ± 0.379
2.54ThrAsn: 2.54 ± 0.533
4.762ThrPro: 4.762 ± 0.6
2.434ThrGln: 2.434 ± 0.613
3.492ThrArg: 3.492 ± 0.568
4.022ThrSer: 4.022 ± 0.894
4.868ThrThr: 4.868 ± 0.982
8.043ThrVal: 8.043 ± 1.161
1.376ThrTrp: 1.376 ± 0.357
3.175ThrTyr: 3.175 ± 0.498
0.0ThrXaa: 0.0 ± 0.0
Val
5.397ValAla: 5.397 ± 0.727
0.635ValCys: 0.635 ± 0.254
4.339ValAsp: 4.339 ± 0.461
2.54ValGlu: 2.54 ± 0.734
2.646ValPhe: 2.646 ± 0.507
4.022ValGly: 4.022 ± 0.537
1.164ValHis: 1.164 ± 0.371
4.445ValIle: 4.445 ± 0.576
2.963ValLys: 2.963 ± 0.511
4.762ValLeu: 4.762 ± 0.75
1.587ValMet: 1.587 ± 0.409
3.81ValAsn: 3.81 ± 0.807
2.752ValPro: 2.752 ± 0.49
2.857ValGln: 2.857 ± 0.44
3.175ValArg: 3.175 ± 0.648
7.726ValSer: 7.726 ± 1.193
6.032ValThr: 6.032 ± 0.912
5.186ValVal: 5.186 ± 0.925
2.117ValTrp: 2.117 ± 0.47
1.905ValTyr: 1.905 ± 0.387
0.0ValXaa: 0.0 ± 0.0
Trp
2.222TrpAla: 2.222 ± 0.459
0.106TrpCys: 0.106 ± 0.111
1.482TrpAsp: 1.482 ± 0.421
0.741TrpGlu: 0.741 ± 0.225
0.741TrpPhe: 0.741 ± 0.269
1.376TrpGly: 1.376 ± 0.412
0.212TrpHis: 0.212 ± 0.148
0.423TrpIle: 0.423 ± 0.208
0.529TrpLys: 0.529 ± 0.218
1.799TrpLeu: 1.799 ± 0.516
0.0TrpMet: 0.0 ± 0.0
1.587TrpAsn: 1.587 ± 0.777
0.423TrpPro: 0.423 ± 0.267
1.799TrpGln: 1.799 ± 0.508
1.058TrpArg: 1.058 ± 0.269
1.27TrpSer: 1.27 ± 0.346
1.058TrpThr: 1.058 ± 0.423
0.952TrpVal: 0.952 ± 0.304
0.317TrpTrp: 0.317 ± 0.176
1.058TrpTyr: 1.058 ± 0.404
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.704TyrAla: 3.704 ± 0.535
0.635TyrCys: 0.635 ± 0.264
3.281TyrAsp: 3.281 ± 0.625
2.011TyrGlu: 2.011 ± 0.494
1.164TyrPhe: 1.164 ± 0.384
1.905TyrGly: 1.905 ± 0.555
0.952TyrHis: 0.952 ± 0.35
2.222TyrIle: 2.222 ± 0.522
2.222TyrLys: 2.222 ± 0.463
3.281TyrLeu: 3.281 ± 0.63
1.376TyrMet: 1.376 ± 0.436
2.117TyrAsn: 2.117 ± 0.582
2.011TyrPro: 2.011 ± 0.561
2.011TyrGln: 2.011 ± 0.456
2.328TyrArg: 2.328 ± 0.597
2.328TyrSer: 2.328 ± 0.62
2.54TyrThr: 2.54 ± 0.504
2.328TyrVal: 2.328 ± 0.47
0.741TyrTrp: 0.741 ± 0.344
1.587TyrTyr: 1.587 ± 0.507
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (9450 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski