Amino acid dipepetide frequency for Papillomaviridae sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.718AlaAla: 6.718 ± 2.075
0.0AlaCys: 0.0 ± 0.0
3.101AlaAsp: 3.101 ± 1.612
5.685AlaGlu: 5.685 ± 1.036
3.101AlaPhe: 3.101 ± 0.621
4.651AlaGly: 4.651 ± 1.832
0.0AlaHis: 0.0 ± 0.0
2.067AlaIle: 2.067 ± 1.293
7.235AlaLys: 7.235 ± 1.287
5.685AlaLeu: 5.685 ± 1.807
0.517AlaMet: 0.517 ± 0.44
1.034AlaAsn: 1.034 ± 0.591
4.134AlaPro: 4.134 ± 1.023
0.517AlaGln: 0.517 ± 0.378
1.034AlaArg: 1.034 ± 0.862
4.134AlaSer: 4.134 ± 0.705
3.101AlaThr: 3.101 ± 1.103
4.134AlaVal: 4.134 ± 1.287
1.034AlaTrp: 1.034 ± 0.756
1.034AlaTyr: 1.034 ± 0.591
0.0AlaXaa: 0.0 ± 0.0
Cys
0.517CysAla: 0.517 ± 0.378
0.517CysCys: 0.517 ± 0.378
0.0CysAsp: 0.0 ± 0.0
2.067CysGlu: 2.067 ± 1.511
0.517CysPhe: 0.517 ± 0.44
0.517CysGly: 0.517 ± 0.378
0.0CysHis: 0.0 ± 0.0
1.034CysIle: 1.034 ± 0.465
1.55CysLys: 1.55 ± 0.512
2.067CysLeu: 2.067 ± 1.195
0.517CysMet: 0.517 ± 0.378
1.55CysAsn: 1.55 ± 0.811
0.0CysPro: 0.0 ± 0.0
0.517CysGln: 0.517 ± 0.44
0.517CysArg: 0.517 ± 0.44
1.034CysSer: 1.034 ± 0.584
0.517CysThr: 0.517 ± 0.827
1.034CysVal: 1.034 ± 0.881
0.517CysTrp: 0.517 ± 0.44
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.651AspAla: 4.651 ± 0.895
1.55AspCys: 1.55 ± 0.907
4.134AspAsp: 4.134 ± 2.508
2.584AspGlu: 2.584 ± 1.387
2.584AspPhe: 2.584 ± 1.291
4.651AspGly: 4.651 ± 1.558
0.0AspHis: 0.0 ± 0.0
5.168AspIle: 5.168 ± 0.668
3.101AspLys: 3.101 ± 1.215
8.269AspLeu: 8.269 ± 1.486
0.517AspMet: 0.517 ± 0.44
4.134AspAsn: 4.134 ± 1.275
4.134AspPro: 4.134 ± 1.023
0.517AspGln: 0.517 ± 0.378
0.517AspArg: 0.517 ± 0.467
4.134AspSer: 4.134 ± 1.076
3.101AspThr: 3.101 ± 0.897
4.134AspVal: 4.134 ± 1.207
0.517AspTrp: 0.517 ± 0.44
2.067AspTyr: 2.067 ± 0.755
0.0AspXaa: 0.0 ± 0.0
Glu
5.685GluAla: 5.685 ± 0.968
1.034GluCys: 1.034 ± 0.756
3.618GluAsp: 3.618 ± 1.061
6.202GluGlu: 6.202 ± 2.455
3.101GluPhe: 3.101 ± 1.215
3.101GluGly: 3.101 ± 0.897
1.55GluHis: 1.55 ± 0.608
2.067GluIle: 2.067 ± 0.602
2.067GluLys: 2.067 ± 1.034
4.134GluLeu: 4.134 ± 0.846
2.067GluMet: 2.067 ± 0.755
2.584GluAsn: 2.584 ± 1.747
6.202GluPro: 6.202 ± 4.993
2.584GluGln: 2.584 ± 1.482
2.584GluArg: 2.584 ± 1.331
4.134GluSer: 4.134 ± 1.569
3.618GluThr: 3.618 ± 0.851
6.202GluVal: 6.202 ± 0.949
0.517GluTrp: 0.517 ± 0.576
2.067GluTyr: 2.067 ± 0.739
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.034PheCys: 1.034 ± 0.537
2.584PheAsp: 2.584 ± 1.125
1.034PheGlu: 1.034 ± 0.465
1.55PhePhe: 1.55 ± 0.895
2.584PheGly: 2.584 ± 0.868
0.517PheHis: 0.517 ± 0.827
4.651PheIle: 4.651 ± 1.111
3.618PheLys: 3.618 ± 2.159
3.101PheLeu: 3.101 ± 1.797
1.034PheMet: 1.034 ± 0.499
2.067PheAsn: 2.067 ± 1.32
1.034PhePro: 1.034 ± 0.756
1.55PheGln: 1.55 ± 0.796
3.101PheArg: 3.101 ± 1.562
3.101PheSer: 3.101 ± 1.061
2.584PheThr: 2.584 ± 1.387
1.55PheVal: 1.55 ± 0.907
0.517PheTrp: 0.517 ± 0.576
1.55PheTyr: 1.55 ± 0.934
0.0PheXaa: 0.0 ± 0.0
Gly
3.101GlyAla: 3.101 ± 1.573
0.517GlyCys: 0.517 ± 0.44
4.651GlyAsp: 4.651 ± 1.558
4.651GlyGlu: 4.651 ± 3.038
3.618GlyPhe: 3.618 ± 1.271
6.202GlyGly: 6.202 ± 0.747
2.584GlyHis: 2.584 ± 1.629
5.168GlyIle: 5.168 ± 1.458
4.134GlyLys: 4.134 ± 0.871
3.101GlyLeu: 3.101 ± 1.248
1.55GlyMet: 1.55 ± 0.818
2.067GlyAsn: 2.067 ± 0.755
2.584GlyPro: 2.584 ± 0.798
1.55GlyGln: 1.55 ± 0.446
3.101GlyArg: 3.101 ± 1.473
2.067GlySer: 2.067 ± 0.28
4.134GlyThr: 4.134 ± 1.023
4.134GlyVal: 4.134 ± 1.532
1.55GlyTrp: 1.55 ± 0.745
1.55GlyTyr: 1.55 ± 0.934
0.0GlyXaa: 0.0 ± 0.0
His
1.034HisAla: 1.034 ± 0.584
0.517HisCys: 0.517 ± 0.378
1.55HisAsp: 1.55 ± 0.895
1.034HisGlu: 1.034 ± 0.499
0.517HisPhe: 0.517 ± 0.378
1.55HisGly: 1.55 ± 0.608
4.134HisHis: 4.134 ± 1.826
1.55HisIle: 1.55 ± 0.895
3.618HisLys: 3.618 ± 1.128
2.067HisLeu: 2.067 ± 1.474
0.517HisMet: 0.517 ± 0.44
0.0HisAsn: 0.0 ± 0.0
3.101HisPro: 3.101 ± 1.564
1.034HisGln: 1.034 ± 0.862
1.55HisArg: 1.55 ± 1.048
3.101HisSer: 3.101 ± 1.015
0.0HisThr: 0.0 ± 0.0
2.584HisVal: 2.584 ± 0.978
0.517HisTrp: 0.517 ± 0.467
1.034HisTyr: 1.034 ± 0.591
0.0HisXaa: 0.0 ± 0.0
Ile
3.101IleAla: 3.101 ± 0.893
1.034IleCys: 1.034 ± 0.862
3.101IleAsp: 3.101 ± 1.328
6.202IleGlu: 6.202 ± 1.795
2.584IlePhe: 2.584 ± 0.733
2.067IleGly: 2.067 ± 1.028
0.0IleHis: 0.0 ± 0.0
3.101IleIle: 3.101 ± 2.594
5.168IleLys: 5.168 ± 2.236
4.134IleLeu: 4.134 ± 1.87
0.517IleMet: 0.517 ± 0.44
2.067IleAsn: 2.067 ± 0.93
4.134IlePro: 4.134 ± 2.464
1.55IleGln: 1.55 ± 0.811
3.101IleArg: 3.101 ± 1.709
4.134IleSer: 4.134 ± 1.261
3.618IleThr: 3.618 ± 1.38
3.618IleVal: 3.618 ± 1.128
1.034IleTrp: 1.034 ± 0.537
2.067IleTyr: 2.067 ± 0.935
0.0IleXaa: 0.0 ± 0.0
Lys
3.618LysAla: 3.618 ± 1.157
2.584LysCys: 2.584 ± 0.473
2.584LysAsp: 2.584 ± 1.588
1.034LysGlu: 1.034 ± 0.499
2.067LysPhe: 2.067 ± 0.784
5.685LysGly: 5.685 ± 2.138
1.55LysHis: 1.55 ± 0.461
4.651LysIle: 4.651 ± 0.622
8.786LysLys: 8.786 ± 2.832
4.651LysLeu: 4.651 ± 0.895
1.034LysMet: 1.034 ± 0.881
3.101LysAsn: 3.101 ± 1.283
3.101LysPro: 3.101 ± 1.024
3.618LysGln: 3.618 ± 2.117
5.168LysArg: 5.168 ± 0.8
4.651LysSer: 4.651 ± 1.666
5.168LysThr: 5.168 ± 2.28
3.618LysVal: 3.618 ± 0.823
1.034LysTrp: 1.034 ± 0.584
3.618LysTyr: 3.618 ± 1.195
0.0LysXaa: 0.0 ± 0.0
Leu
4.134LeuAla: 4.134 ± 0.647
1.55LeuCys: 1.55 ± 0.797
4.651LeuAsp: 4.651 ± 1.975
10.336LeuGlu: 10.336 ± 2.924
6.202LeuPhe: 6.202 ± 1.607
1.55LeuGly: 1.55 ± 0.707
1.55LeuHis: 1.55 ± 0.811
6.718LeuIle: 6.718 ± 2.768
4.134LeuLys: 4.134 ± 0.83
8.269LeuLeu: 8.269 ± 3.142
2.067LeuMet: 2.067 ± 1.117
2.584LeuAsn: 2.584 ± 0.992
3.618LeuPro: 3.618 ± 1.271
4.134LeuGln: 4.134 ± 2.698
5.168LeuArg: 5.168 ± 0.72
5.685LeuSer: 5.685 ± 1.886
5.685LeuThr: 5.685 ± 1.259
4.651LeuVal: 4.651 ± 1.401
0.517LeuTrp: 0.517 ± 0.467
2.067LeuTyr: 2.067 ± 1.242
0.0LeuXaa: 0.0 ± 0.0
Met
1.034MetAla: 1.034 ± 0.537
1.034MetCys: 1.034 ± 0.862
1.55MetAsp: 1.55 ± 1.631
2.067MetGlu: 2.067 ± 0.93
0.517MetPhe: 0.517 ± 0.44
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.517MetIle: 0.517 ± 0.44
2.067MetLys: 2.067 ± 0.784
1.55MetLeu: 1.55 ± 0.818
0.517MetMet: 0.517 ± 0.827
1.034MetAsn: 1.034 ± 0.465
0.517MetPro: 0.517 ± 0.44
2.067MetGln: 2.067 ± 1.028
1.034MetArg: 1.034 ± 0.465
0.517MetSer: 0.517 ± 0.576
0.0MetThr: 0.0 ± 0.0
1.55MetVal: 1.55 ± 1.091
0.517MetTrp: 0.517 ± 0.378
1.55MetTyr: 1.55 ± 1.06
0.0MetXaa: 0.0 ± 0.0
Asn
3.101AsnAla: 3.101 ± 0.805
0.517AsnCys: 0.517 ± 0.378
2.584AsnAsp: 2.584 ± 0.424
1.55AsnGlu: 1.55 ± 0.818
1.55AsnPhe: 1.55 ± 0.934
4.134AsnGly: 4.134 ± 1.357
2.584AsnHis: 2.584 ± 0.726
1.034AsnIle: 1.034 ± 0.934
1.55AsnLys: 1.55 ± 0.907
1.034AsnLeu: 1.034 ± 0.537
1.034AsnMet: 1.034 ± 0.804
1.55AsnAsn: 1.55 ± 0.512
2.067AsnPro: 2.067 ± 1.291
0.517AsnGln: 0.517 ± 0.378
4.134AsnArg: 4.134 ± 0.967
1.034AsnSer: 1.034 ± 0.591
5.685AsnThr: 5.685 ± 2.222
3.101AsnVal: 3.101 ± 1.411
0.0AsnTrp: 0.0 ± 0.0
1.55AsnTyr: 1.55 ± 0.811
0.0AsnXaa: 0.0 ± 0.0
Pro
5.168ProAla: 5.168 ± 2.33
1.034ProCys: 1.034 ± 0.537
5.168ProAsp: 5.168 ± 2.406
2.584ProGlu: 2.584 ± 0.798
1.55ProPhe: 1.55 ± 0.86
2.584ProGly: 2.584 ± 0.424
3.101ProHis: 3.101 ± 2.207
3.101ProIle: 3.101 ± 0.56
1.55ProLys: 1.55 ± 1.097
6.718ProLeu: 6.718 ± 0.445
0.517ProMet: 0.517 ± 0.467
2.584ProAsn: 2.584 ± 0.798
5.685ProPro: 5.685 ± 1.703
1.55ProGln: 1.55 ± 0.895
6.202ProArg: 6.202 ± 4.993
3.101ProSer: 3.101 ± 2.207
7.235ProThr: 7.235 ± 2.337
4.651ProVal: 4.651 ± 1.138
0.517ProTrp: 0.517 ± 0.467
1.55ProTyr: 1.55 ± 0.446
0.0ProXaa: 0.0 ± 0.0
Gln
1.55GlnAla: 1.55 ± 0.86
0.0GlnCys: 0.0 ± 0.0
1.55GlnAsp: 1.55 ± 0.934
2.067GlnGlu: 2.067 ± 0.926
1.034GlnPhe: 1.034 ± 0.584
2.584GlnGly: 2.584 ± 1.071
1.55GlnHis: 1.55 ± 1.048
0.517GlnIle: 0.517 ± 0.467
3.101GlnLys: 3.101 ± 1.015
3.101GlnLeu: 3.101 ± 1.581
1.034GlnMet: 1.034 ± 1.653
0.0GlnAsn: 0.0 ± 0.0
4.134GlnPro: 4.134 ± 0.83
1.034GlnGln: 1.034 ± 0.465
1.034GlnArg: 1.034 ± 0.537
3.101GlnSer: 3.101 ± 1.644
1.55GlnThr: 1.55 ± 0.608
2.067GlnVal: 2.067 ± 0.979
1.034GlnTrp: 1.034 ± 0.499
1.034GlnTyr: 1.034 ± 0.756
0.0GlnXaa: 0.0 ± 0.0
Arg
6.202ArgAla: 6.202 ± 2.435
0.0ArgCys: 0.0 ± 0.0
3.618ArgAsp: 3.618 ± 1.411
2.584ArgGlu: 2.584 ± 1.014
1.034ArgPhe: 1.034 ± 0.465
3.618ArgGly: 3.618 ± 2.044
3.101ArgHis: 3.101 ± 1.573
1.034ArgIle: 1.034 ± 0.465
4.651ArgLys: 4.651 ± 0.707
4.651ArgLeu: 4.651 ± 2.147
0.517ArgMet: 0.517 ± 0.374
4.134ArgAsn: 4.134 ± 2.142
7.752ArgPro: 7.752 ± 5.717
0.517ArgGln: 0.517 ± 0.44
4.134ArgArg: 4.134 ± 1.154
3.618ArgSer: 3.618 ± 1.159
2.584ArgThr: 2.584 ± 0.927
2.067ArgVal: 2.067 ± 0.635
1.034ArgTrp: 1.034 ± 0.537
1.55ArgTyr: 1.55 ± 0.461
0.0ArgXaa: 0.0 ± 0.0
Ser
2.067SerAla: 2.067 ± 0.28
0.517SerCys: 0.517 ± 0.378
4.134SerAsp: 4.134 ± 1.221
3.618SerGlu: 3.618 ± 0.651
2.067SerPhe: 2.067 ± 1.102
7.235SerGly: 7.235 ± 2.149
3.618SerHis: 3.618 ± 1.582
3.618SerIle: 3.618 ± 0.985
2.584SerLys: 2.584 ± 0.576
6.202SerLeu: 6.202 ± 1.712
2.067SerMet: 2.067 ± 0.811
2.067SerAsn: 2.067 ± 0.95
4.134SerPro: 4.134 ± 0.976
2.067SerGln: 2.067 ± 1.055
3.618SerArg: 3.618 ± 1.476
5.685SerSer: 5.685 ± 1.74
4.134SerThr: 4.134 ± 1.204
2.584SerVal: 2.584 ± 0.733
1.034SerTrp: 1.034 ± 0.537
2.584SerTyr: 2.584 ± 1.071
0.0SerXaa: 0.0 ± 0.0
Thr
4.134ThrAla: 4.134 ± 1.4
0.0ThrCys: 0.0 ± 0.0
4.651ThrAsp: 4.651 ± 0.707
3.101ThrGlu: 3.101 ± 1.211
2.584ThrPhe: 2.584 ± 0.798
3.101ThrGly: 3.101 ± 1.573
0.517ThrHis: 0.517 ± 0.576
3.618ThrIle: 3.618 ± 1.128
3.618ThrLys: 3.618 ± 1.44
5.685ThrLeu: 5.685 ± 1.503
1.55ThrMet: 1.55 ± 0.818
1.55ThrAsn: 1.55 ± 0.461
6.202ThrPro: 6.202 ± 2.435
3.101ThrGln: 3.101 ± 1.395
5.168ThrArg: 5.168 ± 2.237
4.134ThrSer: 4.134 ± 1.127
5.168ThrThr: 5.168 ± 1.458
4.651ThrVal: 4.651 ± 0.767
0.0ThrTrp: 0.0 ± 0.0
2.584ThrTyr: 2.584 ± 1.727
0.0ThrXaa: 0.0 ± 0.0
Val
2.584ValAla: 2.584 ± 1.511
0.0ValCys: 0.0 ± 0.0
2.584ValAsp: 2.584 ± 1.28
4.134ValGlu: 4.134 ± 1.62
1.034ValPhe: 1.034 ± 0.499
3.101ValGly: 3.101 ± 1.11
2.584ValHis: 2.584 ± 0.765
3.101ValIle: 3.101 ± 1.411
5.168ValLys: 5.168 ± 1.249
6.202ValLeu: 6.202 ± 1.964
0.517ValMet: 0.517 ± 0.406
3.101ValAsn: 3.101 ± 0.811
2.584ValPro: 2.584 ± 0.87
3.618ValGln: 3.618 ± 0.851
4.134ValArg: 4.134 ± 0.819
5.685ValSer: 5.685 ± 1.186
4.134ValThr: 4.134 ± 1.478
3.101ValVal: 3.101 ± 1.644
0.517ValTrp: 0.517 ± 0.378
2.584ValTyr: 2.584 ± 1.153
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.517TrpCys: 0.517 ± 0.827
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
2.067TrpGly: 2.067 ± 0.998
0.517TrpHis: 0.517 ± 0.378
0.517TrpIle: 0.517 ± 0.576
3.618TrpLys: 3.618 ± 0.851
2.584TrpLeu: 2.584 ± 0.992
0.0TrpMet: 0.0 ± 0.0
1.034TrpAsn: 1.034 ± 0.537
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.517TrpArg: 0.517 ± 0.378
1.55TrpSer: 1.55 ± 0.852
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.517TrpTyr: 0.517 ± 0.378
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.517TyrAla: 0.517 ± 0.378
1.034TyrCys: 1.034 ± 0.756
4.651TyrAsp: 4.651 ± 1.879
2.584TyrGlu: 2.584 ± 1.261
1.55TyrPhe: 1.55 ± 0.461
1.034TyrGly: 1.034 ± 0.499
1.55TyrHis: 1.55 ± 0.461
3.101TyrIle: 3.101 ± 1.622
0.0TyrLys: 0.0 ± 0.0
2.067TyrLeu: 2.067 ± 0.755
1.034TyrMet: 1.034 ± 1.406
2.067TyrAsn: 2.067 ± 0.935
1.034TyrPro: 1.034 ± 0.639
1.034TyrGln: 1.034 ± 0.537
2.584TyrArg: 2.584 ± 0.733
1.034TyrSer: 1.034 ± 1.653
3.101TyrThr: 3.101 ± 0.753
1.034TyrVal: 1.034 ± 0.591
1.034TyrTrp: 1.034 ± 0.537
1.55TyrTyr: 1.55 ± 0.797
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski