Amino acid dipepetide frequency for Cereibacter changlensis JA139

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.991AlaAla: 19.991 ± 0.181	1.127AlaCys: 1.127 ± 0.031	6.768AlaAsp: 6.768 ± 0.074	9.761AlaGlu: 9.761 ± 0.107	4.405AlaPhe: 4.405 ± 0.056	11.949AlaGly: 11.949 ± 0.121	2.29AlaHis: 2.29 ± 0.048	5.637AlaIle: 5.637 ± 0.068	3.352AlaLys: 3.352 ± 0.065	16.138AlaLeu: 16.138 ± 0.163	4.017AlaMet: 4.017 ± 0.058	2.437AlaAsn: 2.437 ± 0.04	6.609AlaPro: 6.609 ± 0.095	4.405AlaGln: 4.405 ± 0.067	9.987AlaArg: 9.987 ± 0.101	6.142AlaSer: 6.142 ± 0.072	6.388AlaThr: 6.388 ± 0.076	9.327AlaVal: 9.327 ± 0.083	1.439AlaTrp: 1.439 ± 0.033	2.413AlaTyr: 2.413 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.03	0.106CysCys: 0.106 ± 0.009	0.581CysAsp: 0.581 ± 0.022	0.424CysGlu: 0.424 ± 0.018	0.316CysPhe: 0.316 ± 0.015	0.931CysGly: 0.931 ± 0.029	0.243CysHis: 0.243 ± 0.013	0.368CysIle: 0.368 ± 0.02	0.155CysLys: 0.155 ± 0.01	0.914CysLeu: 0.914 ± 0.027	0.153CysMet: 0.153 ± 0.011	0.213CysAsn: 0.213 ± 0.013	0.472CysPro: 0.472 ± 0.022	0.21CysGln: 0.21 ± 0.013	0.613CysArg: 0.613 ± 0.025	0.458CysSer: 0.458 ± 0.018	0.397CysThr: 0.397 ± 0.018	0.542CysVal: 0.542 ± 0.021	0.123CysTrp: 0.123 ± 0.009	0.169CysTyr: 0.169 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.822AspAla: 6.822 ± 0.077	0.5AspCys: 0.5 ± 0.021	2.665AspAsp: 2.665 ± 0.053	3.027AspGlu: 3.027 ± 0.053	2.076AspPhe: 2.076 ± 0.041	4.991AspGly: 4.991 ± 0.088	1.208AspHis: 1.208 ± 0.033	2.513AspIle: 2.513 ± 0.052	1.156AspLys: 1.156 ± 0.028	6.525AspLeu: 6.525 ± 0.082	1.395AspMet: 1.395 ± 0.033	1.043AspAsn: 1.043 ± 0.03	3.787AspPro: 3.787 ± 0.062	1.591AspGln: 1.591 ± 0.031	4.581AspArg: 4.581 ± 0.059	2.124AspSer: 2.124 ± 0.044	2.334AspThr: 2.334 ± 0.054	3.608AspVal: 3.608 ± 0.063	1.145AspTrp: 1.145 ± 0.031	1.415AspTyr: 1.415 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	9.705GluAla: 9.705 ± 0.123	0.288GluCys: 0.288 ± 0.014	2.992GluAsp: 2.992 ± 0.048	3.345GluGlu: 3.345 ± 0.054	1.623GluPhe: 1.623 ± 0.032	5.37GluGly: 5.37 ± 0.068	1.019GluHis: 1.019 ± 0.029	3.341GluIle: 3.341 ± 0.051	1.724GluLys: 1.724 ± 0.037	5.153GluLeu: 5.153 ± 0.075	1.623GluMet: 1.623 ± 0.036	1.311GluAsn: 1.311 ± 0.03	2.827GluPro: 2.827 ± 0.053	1.827GluGln: 1.827 ± 0.04	4.454GluArg: 4.454 ± 0.059	2.144GluSer: 2.144 ± 0.04	3.763GluThr: 3.763 ± 0.055	4.6GluVal: 4.6 ± 0.062	0.684GluTrp: 0.684 ± 0.023	0.851GluTyr: 0.851 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.591PheAla: 4.591 ± 0.066	0.422PheCys: 0.422 ± 0.017	2.582PheAsp: 2.582 ± 0.04	1.891PheGlu: 1.891 ± 0.041	1.309PhePhe: 1.309 ± 0.041	3.746PheGly: 3.746 ± 0.053	0.708PheHis: 0.708 ± 0.023	1.508PheIle: 1.508 ± 0.031	0.716PheLys: 0.716 ± 0.021	3.61PheLeu: 3.61 ± 0.064	0.724PheMet: 0.724 ± 0.022	0.882PheAsn: 0.882 ± 0.023	1.563PhePro: 1.563 ± 0.035	0.947PheGln: 0.947 ± 0.025	2.406PheArg: 2.406 ± 0.04	2.007PheSer: 2.007 ± 0.041	2.044PheThr: 2.044 ± 0.039	2.467PheVal: 2.467 ± 0.042	0.517PheTrp: 0.517 ± 0.023	0.826PheTyr: 0.826 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.983GlyAla: 10.983 ± 0.108	0.911GlyCys: 0.911 ± 0.028	4.428GlyAsp: 4.428 ± 0.08	5.0GlyGlu: 5.0 ± 0.069	3.928GlyPhe: 3.928 ± 0.054	7.88GlyGly: 7.88 ± 0.106	1.82GlyHis: 1.82 ± 0.045	4.436GlyIle: 4.436 ± 0.06	2.893GlyLys: 2.893 ± 0.05	10.421GlyLeu: 10.421 ± 0.113	2.751GlyMet: 2.751 ± 0.048	1.91GlyAsn: 1.91 ± 0.048	3.991GlyPro: 3.991 ± 0.051	3.173GlyGln: 3.173 ± 0.05	6.649GlyArg: 6.649 ± 0.079	4.718GlySer: 4.718 ± 0.078	4.23GlyThr: 4.23 ± 0.069	6.421GlyVal: 6.421 ± 0.071	1.63GlyTrp: 1.63 ± 0.037	2.218GlyTyr: 2.218 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.322HisAla: 2.322 ± 0.044	0.215HisCys: 0.215 ± 0.014	1.222HisAsp: 1.222 ± 0.027	0.994HisGlu: 0.994 ± 0.027	0.726HisPhe: 0.726 ± 0.023	1.898HisGly: 1.898 ± 0.042	0.517HisHis: 0.517 ± 0.02	0.797HisIle: 0.797 ± 0.023	0.385HisLys: 0.385 ± 0.017	2.078HisLeu: 2.078 ± 0.047	0.473HisMet: 0.473 ± 0.015	0.362HisAsn: 0.362 ± 0.018	1.384HisPro: 1.384 ± 0.033	0.53HisGln: 0.53 ± 0.022	1.495HisArg: 1.495 ± 0.038	0.845HisSer: 0.845 ± 0.029	0.655HisThr: 0.655 ± 0.02	1.495HisVal: 1.495 ± 0.035	0.331HisTrp: 0.331 ± 0.014	0.505HisTyr: 0.505 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.818IleAla: 6.818 ± 0.077	0.566IleCys: 0.566 ± 0.019	3.183IleAsp: 3.183 ± 0.055	3.036IleGlu: 3.036 ± 0.056	1.673IlePhe: 1.673 ± 0.041	4.93IleGly: 4.93 ± 0.068	0.845IleHis: 0.845 ± 0.019	1.825IleIle: 1.825 ± 0.041	0.939IleLys: 0.939 ± 0.032	4.802IleLeu: 4.802 ± 0.078	0.915IleMet: 0.915 ± 0.028	1.107IleAsn: 1.107 ± 0.031	2.157IlePro: 2.157 ± 0.041	0.973IleGln: 0.973 ± 0.029	3.294IleArg: 3.294 ± 0.051	2.709IleSer: 2.709 ± 0.049	2.613IleThr: 2.613 ± 0.049	3.571IleVal: 3.571 ± 0.055	0.654IleTrp: 0.654 ± 0.023	1.011IleTyr: 1.011 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.566LysAla: 3.566 ± 0.061	0.129LysCys: 0.129 ± 0.009	1.307LysAsp: 1.307 ± 0.036	1.149LysGlu: 1.149 ± 0.032	0.687LysPhe: 0.687 ± 0.026	2.322LysGly: 2.322 ± 0.047	0.483LysHis: 0.483 ± 0.019	1.286LysIle: 1.286 ± 0.033	0.867LysLys: 0.867 ± 0.031	2.63LysLeu: 2.63 ± 0.045	0.664LysMet: 0.664 ± 0.025	0.554LysAsn: 0.554 ± 0.023	1.66LysPro: 1.66 ± 0.04	0.764LysGln: 0.764 ± 0.028	1.88LysArg: 1.88 ± 0.042	1.317LysSer: 1.317 ± 0.03	1.655LysThr: 1.655 ± 0.037	1.988LysVal: 1.988 ± 0.042	0.284LysTrp: 0.284 ± 0.015	0.448LysTyr: 0.448 ± 0.018	0.001LysXaa: 0.001 ± 0.001
Leu	15.739LeuAla: 15.739 ± 0.159	0.996LeuCys: 0.996 ± 0.03	6.012LeuAsp: 6.012 ± 0.068	5.586LeuGlu: 5.586 ± 0.066	3.498LeuPhe: 3.498 ± 0.057	9.511LeuGly: 9.511 ± 0.122	2.051LeuHis: 2.051 ± 0.037	5.097LeuIle: 5.097 ± 0.069	2.813LeuLys: 2.813 ± 0.05	10.84LeuLeu: 10.84 ± 0.14	2.825LeuMet: 2.825 ± 0.055	2.367LeuAsn: 2.367 ± 0.052	6.503LeuPro: 6.503 ± 0.073	3.057LeuGln: 3.057 ± 0.049	8.277LeuArg: 8.277 ± 0.1	6.616LeuSer: 6.616 ± 0.073	6.567LeuThr: 6.567 ± 0.078	7.705LeuVal: 7.705 ± 0.092	1.466LeuTrp: 1.466 ± 0.039	1.879LeuTyr: 1.879 ± 0.039	0.001LeuXaa: 0.001 ± 0.001
Met	3.588MetAla: 3.588 ± 0.054	0.134MetCys: 0.134 ± 0.009	1.193MetAsp: 1.193 ± 0.027	1.235MetGlu: 1.235 ± 0.031	0.698MetPhe: 0.698 ± 0.024	2.181MetGly: 2.181 ± 0.04	0.392MetHis: 0.392 ± 0.016	1.431MetIle: 1.431 ± 0.04	0.876MetLys: 0.876 ± 0.028	2.839MetLeu: 2.839 ± 0.049	0.73MetMet: 0.73 ± 0.024	0.747MetAsn: 0.747 ± 0.021	1.484MetPro: 1.484 ± 0.032	1.029MetGln: 1.029 ± 0.028	1.96MetArg: 1.96 ± 0.038	1.553MetSer: 1.553 ± 0.035	2.18MetThr: 2.18 ± 0.039	1.877MetVal: 1.877 ± 0.044	0.201MetTrp: 0.201 ± 0.014	0.294MetTyr: 0.294 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.839AsnAla: 2.839 ± 0.046	0.203AsnCys: 0.203 ± 0.013	1.194AsnAsp: 1.194 ± 0.039	0.947AsnGlu: 0.947 ± 0.028	0.819AsnPhe: 0.819 ± 0.022	2.009AsnGly: 2.009 ± 0.04	0.411AsnHis: 0.411 ± 0.017	1.136AsnIle: 1.136 ± 0.029	0.46AsnLys: 0.46 ± 0.019	2.361AsnLeu: 2.361 ± 0.041	0.555AsnMet: 0.555 ± 0.023	0.515AsnAsn: 0.515 ± 0.02	1.663AsnPro: 1.663 ± 0.034	0.559AsnGln: 0.559 ± 0.019	1.647AsnArg: 1.647 ± 0.035	0.977AsnSer: 0.977 ± 0.03	1.087AsnThr: 1.087 ± 0.032	1.519AsnVal: 1.519 ± 0.036	0.347AsnTrp: 0.347 ± 0.016	0.522AsnTyr: 0.522 ± 0.018	0.001AsnXaa: 0.001 ± 0.001
Pro	7.025ProAla: 7.025 ± 0.088	0.353ProCys: 0.353 ± 0.016	3.436ProAsp: 3.436 ± 0.054	4.672ProGlu: 4.672 ± 0.074	1.943ProPhe: 1.943 ± 0.04	5.09ProGly: 5.09 ± 0.064	1.031ProHis: 1.031 ± 0.028	2.025ProIle: 2.025 ± 0.041	1.407ProLys: 1.407 ± 0.035	5.434ProLeu: 5.434 ± 0.063	1.304ProMet: 1.304 ± 0.034	1.098ProAsn: 1.098 ± 0.027	2.705ProPro: 2.705 ± 0.055	1.778ProGln: 1.778 ± 0.038	3.24ProArg: 3.24 ± 0.056	2.451ProSer: 2.451 ± 0.044	2.383ProThr: 2.383 ± 0.037	4.509ProVal: 4.509 ± 0.062	0.675ProTrp: 0.675 ± 0.024	1.028ProTyr: 1.028 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.21GlnAla: 4.21 ± 0.058	0.178GlnCys: 0.178 ± 0.011	1.471GlnAsp: 1.471 ± 0.031	1.495GlnGlu: 1.495 ± 0.031	0.956GlnPhe: 0.956 ± 0.024	2.771GlnGly: 2.771 ± 0.045	0.548GlnHis: 0.548 ± 0.022	1.831GlnIle: 1.831 ± 0.036	0.893GlnLys: 0.893 ± 0.026	2.913GlnLeu: 2.913 ± 0.042	0.987GlnMet: 0.987 ± 0.027	0.738GlnAsn: 0.738 ± 0.023	1.831GlnPro: 1.831 ± 0.044	1.14GlnGln: 1.14 ± 0.036	2.429GlnArg: 2.429 ± 0.047	1.655GlnSer: 1.655 ± 0.039	1.628GlnThr: 1.628 ± 0.037	2.305GlnVal: 2.305 ± 0.038	0.37GlnTrp: 0.37 ± 0.016	0.492GlnTyr: 0.492 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.044ArgAla: 9.044 ± 0.099	0.542ArgCys: 0.542 ± 0.02	4.179ArgAsp: 4.179 ± 0.059	4.036ArgGlu: 4.036 ± 0.066	2.817ArgPhe: 2.817 ± 0.046	5.287ArgGly: 5.287 ± 0.073	1.679ArgHis: 1.679 ± 0.039	4.069ArgIle: 4.069 ± 0.052	1.902ArgLys: 1.902 ± 0.041	8.923ArgLeu: 8.923 ± 0.093	2.144ArgMet: 2.144 ± 0.038	1.653ArgAsn: 1.653 ± 0.037	3.844ArgPro: 3.844 ± 0.061	2.591ArgGln: 2.591 ± 0.049	6.036ArgArg: 6.036 ± 0.085	3.694ArgSer: 3.694 ± 0.053	2.918ArgThr: 2.918 ± 0.046	5.075ArgVal: 5.075 ± 0.08	1.011ArgTrp: 1.011 ± 0.029	1.485ArgTyr: 1.485 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.061SerAla: 6.061 ± 0.08	0.418SerCys: 0.418 ± 0.017	2.779SerAsp: 2.779 ± 0.055	2.6SerGlu: 2.6 ± 0.046	2.262SerPhe: 2.262 ± 0.038	5.585SerGly: 5.585 ± 0.086	1.031SerHis: 1.031 ± 0.029	2.319SerIle: 2.319 ± 0.047	1.153SerLys: 1.153 ± 0.029	5.419SerLeu: 5.419 ± 0.067	1.232SerMet: 1.232 ± 0.033	1.141SerAsn: 1.141 ± 0.037	2.65SerPro: 2.65 ± 0.042	1.453SerGln: 1.453 ± 0.033	3.464SerArg: 3.464 ± 0.056	2.513SerSer: 2.513 ± 0.052	2.473SerThr: 2.473 ± 0.047	3.837SerVal: 3.837 ± 0.057	0.686SerTrp: 0.686 ± 0.024	1.277SerTyr: 1.277 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.613ThrAla: 6.613 ± 0.086	0.437ThrCys: 0.437 ± 0.018	2.867ThrAsp: 2.867 ± 0.047	3.1ThrGlu: 3.1 ± 0.05	1.712ThrPhe: 1.712 ± 0.037	5.522ThrGly: 5.522 ± 0.076	1.008ThrHis: 1.008 ± 0.029	2.404ThrIle: 2.404 ± 0.052	1.136ThrLys: 1.136 ± 0.026	6.338ThrLeu: 6.338 ± 0.075	1.163ThrMet: 1.163 ± 0.027	1.059ThrAsn: 1.059 ± 0.031	3.347ThrPro: 3.347 ± 0.053	1.34ThrGln: 1.34 ± 0.031	3.495ThrArg: 3.495 ± 0.055	2.602ThrSer: 2.602 ± 0.048	2.758ThrThr: 2.758 ± 0.056	4.415ThrVal: 4.415 ± 0.075	0.605ThrTrp: 0.605 ± 0.023	1.056ThrTyr: 1.056 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.727ValAla: 9.727 ± 0.082	0.601ValCys: 0.601 ± 0.024	3.627ValAsp: 3.627 ± 0.056	4.638ValGlu: 4.638 ± 0.068	2.745ValPhe: 2.745 ± 0.049	5.48ValGly: 5.48 ± 0.075	1.21ValHis: 1.21 ± 0.028	4.131ValIle: 4.131 ± 0.063	1.962ValLys: 1.962 ± 0.043	8.144ValLeu: 8.144 ± 0.094	2.167ValMet: 2.167 ± 0.042	1.766ValAsn: 1.766 ± 0.04	3.399ValPro: 3.399 ± 0.051	2.203ValGln: 2.203 ± 0.043	4.293ValArg: 4.293 ± 0.059	4.034ValSer: 4.034 ± 0.061	5.102ValThr: 5.102 ± 0.075	5.699ValVal: 5.699 ± 0.067	0.956ValTrp: 0.956 ± 0.025	1.385ValTyr: 1.385 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.368TrpAla: 1.368 ± 0.034	0.139TrpCys: 0.139 ± 0.01	0.664TrpAsp: 0.664 ± 0.024	0.631TrpGlu: 0.631 ± 0.022	0.522TrpPhe: 0.522 ± 0.018	0.999TrpGly: 0.999 ± 0.028	0.296TrpHis: 0.296 ± 0.016	0.659TrpIle: 0.659 ± 0.022	0.406TrpLys: 0.406 ± 0.017	1.803TrpLeu: 1.803 ± 0.04	0.382TrpMet: 0.382 ± 0.016	0.374TrpAsn: 0.374 ± 0.018	0.69TrpPro: 0.69 ± 0.024	0.664TrpGln: 0.664 ± 0.021	1.193TrpArg: 1.193 ± 0.032	0.773TrpSer: 0.773 ± 0.024	0.79TrpThr: 0.79 ± 0.025	0.87TrpVal: 0.87 ± 0.029	0.207TrpTrp: 0.207 ± 0.013	0.233TrpTyr: 0.233 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.49TyrAla: 2.49 ± 0.04	0.199TyrCys: 0.199 ± 0.013	1.354TyrAsp: 1.354 ± 0.033	1.077TyrGlu: 1.077 ± 0.029	0.752TyrPhe: 0.752 ± 0.024	1.939TyrGly: 1.939 ± 0.039	0.439TyrHis: 0.439 ± 0.016	0.81TyrIle: 0.81 ± 0.024	0.446TyrLys: 0.446 ± 0.017	2.119TyrLeu: 2.119 ± 0.041	0.417TyrMet: 0.417 ± 0.015	0.493TyrAsn: 0.493 ± 0.02	1.023TyrPro: 1.023 ± 0.03	0.608TyrGln: 0.608 ± 0.021	1.539TyrArg: 1.539 ± 0.037	1.02TyrSer: 1.02 ± 0.029	1.012TyrThr: 1.012 ± 0.029	1.437TyrVal: 1.437 ± 0.034	0.333TyrTrp: 0.333 ± 0.016	0.531TyrTyr: 0.531 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4709 proteins (1406964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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