Amino acid dipepetide frequency for Melioribacter roseus (strain JCM 17771 / P3M-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.549AlaAla: 5.549 ± 0.095	0.551AlaCys: 0.551 ± 0.029	3.593AlaAsp: 3.593 ± 0.063	4.633AlaGlu: 4.633 ± 0.079	3.082AlaPhe: 3.082 ± 0.061	5.342AlaGly: 5.342 ± 0.087	0.979AlaHis: 0.979 ± 0.032	4.719AlaIle: 4.719 ± 0.083	4.105AlaLys: 4.105 ± 0.065	6.618AlaLeu: 6.618 ± 0.096	1.308AlaMet: 1.308 ± 0.044	2.712AlaAsn: 2.712 ± 0.056	2.071AlaPro: 2.071 ± 0.045	1.934AlaGln: 1.934 ± 0.05	2.829AlaArg: 2.829 ± 0.056	3.753AlaSer: 3.753 ± 0.065	2.716AlaThr: 2.716 ± 0.062	4.974AlaVal: 4.974 ± 0.084	0.601AlaTrp: 0.601 ± 0.027	2.491AlaTyr: 2.491 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.445CysAla: 0.445 ± 0.021	0.087CysCys: 0.087 ± 0.01	0.495CysAsp: 0.495 ± 0.022	0.447CysGlu: 0.447 ± 0.021	0.286CysPhe: 0.286 ± 0.017	0.742CysGly: 0.742 ± 0.032	0.241CysHis: 0.241 ± 0.034	0.485CysIle: 0.485 ± 0.027	0.462CysLys: 0.462 ± 0.022	0.484CysLeu: 0.484 ± 0.02	0.138CysMet: 0.138 ± 0.012	0.43CysAsn: 0.43 ± 0.022	0.388CysPro: 0.388 ± 0.022	0.143CysGln: 0.143 ± 0.014	0.353CysArg: 0.353 ± 0.02	0.523CysSer: 0.523 ± 0.029	0.331CysThr: 0.331 ± 0.02	0.453CysVal: 0.453 ± 0.023	0.086CysTrp: 0.086 ± 0.009	0.278CysTyr: 0.278 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.241AspAla: 3.241 ± 0.07	0.399AspCys: 0.399 ± 0.021	2.909AspAsp: 2.909 ± 0.063	4.27AspGlu: 4.27 ± 0.065	3.297AspPhe: 3.297 ± 0.059	3.758AspGly: 3.758 ± 0.081	0.638AspHis: 0.638 ± 0.027	4.944AspIle: 4.944 ± 0.076	4.589AspLys: 4.589 ± 0.071	4.988AspLeu: 4.988 ± 0.085	1.009AspMet: 1.009 ± 0.031	3.17AspAsn: 3.17 ± 0.06	2.193AspPro: 2.193 ± 0.042	1.033AspGln: 1.033 ± 0.034	2.275AspArg: 2.275 ± 0.053	3.533AspSer: 3.533 ± 0.071	2.62AspThr: 2.62 ± 0.05	3.25AspVal: 3.25 ± 0.068	0.723AspTrp: 0.723 ± 0.029	3.077AspTyr: 3.077 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.393GluAla: 4.393 ± 0.072	0.407GluCys: 0.407 ± 0.021	3.453GluAsp: 3.453 ± 0.072	5.867GluGlu: 5.867 ± 0.121	3.477GluPhe: 3.477 ± 0.059	4.055GluGly: 4.055 ± 0.071	1.008GluHis: 1.008 ± 0.03	6.973GluIle: 6.973 ± 0.092	6.81GluLys: 6.81 ± 0.114	7.27GluLeu: 7.27 ± 0.092	1.575GluMet: 1.575 ± 0.045	4.721GluAsn: 4.721 ± 0.066	2.035GluPro: 2.035 ± 0.048	1.839GluGln: 1.839 ± 0.051	3.142GluArg: 3.142 ± 0.061	3.829GluSer: 3.829 ± 0.06	3.235GluThr: 3.235 ± 0.065	3.81GluVal: 3.81 ± 0.08	0.689GluTrp: 0.689 ± 0.029	3.064GluTyr: 3.064 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	2.952PheAla: 2.952 ± 0.063	0.389PheCys: 0.389 ± 0.021	3.238PheAsp: 3.238 ± 0.051	3.433PheGlu: 3.433 ± 0.059	2.548PhePhe: 2.548 ± 0.068	3.649PheGly: 3.649 ± 0.068	0.742PheHis: 0.742 ± 0.023	4.233PheIle: 4.233 ± 0.085	3.061PheLys: 3.061 ± 0.056	4.552PheLeu: 4.552 ± 0.085	0.991PheMet: 0.991 ± 0.036	2.984PheAsn: 2.984 ± 0.068	1.742PhePro: 1.742 ± 0.041	1.121PheGln: 1.121 ± 0.034	2.068PheArg: 2.068 ± 0.046	3.514PheSer: 3.514 ± 0.068	2.73PheThr: 2.73 ± 0.054	3.307PheVal: 3.307 ± 0.062	0.567PheTrp: 0.567 ± 0.028	2.453PheTyr: 2.453 ± 0.061	0.0PheXaa: 0.0 ± 0.0
Gly	4.654GlyAla: 4.654 ± 0.084	0.577GlyCys: 0.577 ± 0.031	3.386GlyAsp: 3.386 ± 0.063	4.015GlyGlu: 4.015 ± 0.071	3.502GlyPhe: 3.502 ± 0.069	4.917GlyGly: 4.917 ± 0.1	1.031GlyHis: 1.031 ± 0.034	6.191GlyIle: 6.191 ± 0.091	5.619GlyLys: 5.619 ± 0.082	5.93GlyLeu: 5.93 ± 0.088	1.651GlyMet: 1.651 ± 0.042	3.688GlyAsn: 3.688 ± 0.072	1.414GlyPro: 1.414 ± 0.039	1.519GlyGln: 1.519 ± 0.045	2.676GlyArg: 2.676 ± 0.055	3.839GlySer: 3.839 ± 0.077	3.336GlyThr: 3.336 ± 0.083	4.327GlyVal: 4.327 ± 0.073	0.877GlyTrp: 0.877 ± 0.036	3.211GlyTyr: 3.211 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.901HisAla: 0.901 ± 0.034	0.162HisCys: 0.162 ± 0.013	0.793HisAsp: 0.793 ± 0.031	0.893HisGlu: 0.893 ± 0.028	0.887HisPhe: 0.887 ± 0.031	0.984HisGly: 0.984 ± 0.031	0.359HisHis: 0.359 ± 0.024	1.205HisIle: 1.205 ± 0.036	1.074HisLys: 1.074 ± 0.034	1.355HisLeu: 1.355 ± 0.033	0.292HisMet: 0.292 ± 0.016	0.842HisAsn: 0.842 ± 0.03	0.898HisPro: 0.898 ± 0.035	0.393HisGln: 0.393 ± 0.02	0.676HisArg: 0.676 ± 0.026	1.008HisSer: 1.008 ± 0.032	0.852HisThr: 0.852 ± 0.031	0.748HisVal: 0.748 ± 0.028	0.195HisTrp: 0.195 ± 0.014	0.723HisTyr: 0.723 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.797IleAla: 5.797 ± 0.08	0.604IleCys: 0.604 ± 0.023	5.534IleAsp: 5.534 ± 0.074	6.616IleGlu: 6.616 ± 0.104	3.933IlePhe: 3.933 ± 0.077	5.21IleGly: 5.21 ± 0.086	1.261IleHis: 1.261 ± 0.035	7.343IleIle: 7.343 ± 0.11	6.825IleLys: 6.825 ± 0.088	7.78IleLeu: 7.78 ± 0.107	1.514IleMet: 1.514 ± 0.041	5.027IleAsn: 5.027 ± 0.08	3.495IlePro: 3.495 ± 0.061	1.893IleGln: 1.893 ± 0.044	3.456IleArg: 3.456 ± 0.056	5.689IleSer: 5.689 ± 0.088	4.559IleThr: 4.559 ± 0.071	5.359IleVal: 5.359 ± 0.072	0.758IleTrp: 0.758 ± 0.03	3.528IleTyr: 3.528 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.429LysAla: 4.429 ± 0.087	0.457LysCys: 0.457 ± 0.029	3.976LysAsp: 3.976 ± 0.076	6.568LysGlu: 6.568 ± 0.092	3.47LysPhe: 3.47 ± 0.055	4.191LysGly: 4.191 ± 0.069	1.085LysHis: 1.085 ± 0.033	7.768LysIle: 7.768 ± 0.095	7.148LysLys: 7.148 ± 0.119	7.289LysLeu: 7.289 ± 0.094	1.881LysMet: 1.881 ± 0.041	5.204LysAsn: 5.204 ± 0.075	2.66LysPro: 2.66 ± 0.05	1.823LysGln: 1.823 ± 0.046	3.299LysArg: 3.299 ± 0.059	4.757LysSer: 4.757 ± 0.079	3.681LysThr: 3.681 ± 0.069	4.346LysVal: 4.346 ± 0.078	0.742LysTrp: 0.742 ± 0.027	3.714LysTyr: 3.714 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.823LeuAla: 5.823 ± 0.081	0.627LeuCys: 0.627 ± 0.029	4.676LeuAsp: 4.676 ± 0.075	5.921LeuGlu: 5.921 ± 0.086	5.058LeuPhe: 5.058 ± 0.103	5.594LeuGly: 5.594 ± 0.08	1.37LeuHis: 1.37 ± 0.04	8.547LeuIle: 8.547 ± 0.121	8.026LeuLys: 8.026 ± 0.093	8.968LeuLeu: 8.968 ± 0.139	2.116LeuMet: 2.116 ± 0.051	5.8LeuAsn: 5.8 ± 0.08	3.801LeuPro: 3.801 ± 0.065	2.353LeuGln: 2.353 ± 0.047	4.06LeuArg: 4.06 ± 0.067	6.641LeuSer: 6.641 ± 0.086	4.915LeuThr: 4.915 ± 0.082	4.935LeuVal: 4.935 ± 0.078	0.864LeuTrp: 0.864 ± 0.029	3.518LeuTyr: 3.518 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.438MetAla: 1.438 ± 0.039	0.132MetCys: 0.132 ± 0.011	0.928MetAsp: 0.928 ± 0.029	1.246MetGlu: 1.246 ± 0.034	0.829MetPhe: 0.829 ± 0.031	1.332MetGly: 1.332 ± 0.039	0.353MetHis: 0.353 ± 0.021	1.694MetIle: 1.694 ± 0.043	2.304MetLys: 2.304 ± 0.049	1.839MetLeu: 1.839 ± 0.04	0.534MetMet: 0.534 ± 0.027	1.352MetAsn: 1.352 ± 0.037	0.989MetPro: 0.989 ± 0.031	0.549MetGln: 0.549 ± 0.023	0.847MetArg: 0.847 ± 0.028	1.311MetSer: 1.311 ± 0.038	1.128MetThr: 1.128 ± 0.037	1.134MetVal: 1.134 ± 0.033	0.185MetTrp: 0.185 ± 0.012	0.554MetTyr: 0.554 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.424AsnAla: 3.424 ± 0.065	0.475AsnCys: 0.475 ± 0.024	2.99AsnAsp: 2.99 ± 0.064	3.764AsnGlu: 3.764 ± 0.069	3.007AsnPhe: 3.007 ± 0.063	3.769AsnGly: 3.769 ± 0.079	0.812AsnHis: 0.812 ± 0.029	4.922AsnIle: 4.922 ± 0.078	4.382AsnLys: 4.382 ± 0.071	5.774AsnLeu: 5.774 ± 0.08	1.128AsnMet: 1.128 ± 0.031	3.394AsnAsn: 3.394 ± 0.076	2.983AsnPro: 2.983 ± 0.062	1.494AsnGln: 1.494 ± 0.046	2.419AsnArg: 2.419 ± 0.054	3.607AsnSer: 3.607 ± 0.067	2.501AsnThr: 2.501 ± 0.058	3.282AsnVal: 3.282 ± 0.064	0.622AsnTrp: 0.622 ± 0.03	3.103AsnTyr: 3.103 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	2.552ProAla: 2.552 ± 0.05	0.228ProCys: 0.228 ± 0.013	2.826ProAsp: 2.826 ± 0.059	3.666ProGlu: 3.666 ± 0.072	1.933ProPhe: 1.933 ± 0.039	2.664ProGly: 2.664 ± 0.053	0.639ProHis: 0.639 ± 0.025	2.293ProIle: 2.293 ± 0.05	2.053ProLys: 2.053 ± 0.045	3.13ProLeu: 3.13 ± 0.062	0.626ProMet: 0.626 ± 0.026	1.767ProAsn: 1.767 ± 0.046	1.282ProPro: 1.282 ± 0.038	1.066ProGln: 1.066 ± 0.033	1.213ProArg: 1.213 ± 0.035	2.234ProSer: 2.234 ± 0.048	1.653ProThr: 1.653 ± 0.044	3.083ProVal: 3.083 ± 0.053	0.403ProTrp: 0.403 ± 0.022	1.607ProTyr: 1.607 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	1.479GlnAla: 1.479 ± 0.037	0.164GlnCys: 0.164 ± 0.012	1.015GlnAsp: 1.015 ± 0.03	1.502GlnGlu: 1.502 ± 0.042	1.232GlnPhe: 1.232 ± 0.033	1.291GlnGly: 1.291 ± 0.041	0.349GlnHis: 0.349 ± 0.019	2.301GlnIle: 2.301 ± 0.046	2.25GlnLys: 2.25 ± 0.049	2.544GlnLeu: 2.544 ± 0.056	0.644GlnMet: 0.644 ± 0.027	1.686GlnAsn: 1.686 ± 0.041	0.896GlnPro: 0.896 ± 0.033	0.748GlnGln: 0.748 ± 0.03	1.102GlnArg: 1.102 ± 0.036	1.545GlnSer: 1.545 ± 0.037	1.386GlnThr: 1.386 ± 0.038	1.353GlnVal: 1.353 ± 0.04	0.274GlnTrp: 0.274 ± 0.017	1.079GlnTyr: 1.079 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.345ArgAla: 2.345 ± 0.056	0.263ArgCys: 0.263 ± 0.019	2.158ArgAsp: 2.158 ± 0.048	3.076ArgGlu: 3.076 ± 0.056	2.242ArgPhe: 2.242 ± 0.054	2.354ArgGly: 2.354 ± 0.054	0.673ArgHis: 0.673 ± 0.025	4.009ArgIle: 4.009 ± 0.062	3.711ArgLys: 3.711 ± 0.062	4.11ArgLeu: 4.11 ± 0.069	0.997ArgMet: 0.997 ± 0.029	2.551ArgAsn: 2.551 ± 0.057	1.302ArgPro: 1.302 ± 0.042	1.188ArgGln: 1.188 ± 0.038	1.92ArgArg: 1.92 ± 0.052	2.14ArgSer: 2.14 ± 0.052	1.968ArgThr: 1.968 ± 0.048	2.285ArgVal: 2.285 ± 0.05	0.49ArgTrp: 0.49 ± 0.022	1.924ArgTyr: 1.924 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.296SerAla: 4.296 ± 0.074	0.445SerCys: 0.445 ± 0.025	3.713SerAsp: 3.713 ± 0.075	4.355SerGlu: 4.355 ± 0.081	3.18SerPhe: 3.18 ± 0.072	4.835SerGly: 4.835 ± 0.083	1.023SerHis: 1.023 ± 0.038	5.052SerIle: 5.052 ± 0.078	4.251SerLys: 4.251 ± 0.066	6.004SerLeu: 6.004 ± 0.087	1.225SerMet: 1.225 ± 0.035	3.163SerAsn: 3.163 ± 0.065	2.336SerPro: 2.336 ± 0.052	1.646SerGln: 1.646 ± 0.04	2.525SerArg: 2.525 ± 0.056	3.956SerSer: 3.956 ± 0.071	2.794SerThr: 2.794 ± 0.064	4.481SerVal: 4.481 ± 0.061	0.639SerTrp: 0.639 ± 0.028	2.718SerTyr: 2.718 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	3.745ThrAla: 3.745 ± 0.066	0.305ThrCys: 0.305 ± 0.019	2.943ThrAsp: 2.943 ± 0.054	3.207ThrGlu: 3.207 ± 0.067	2.279ThrPhe: 2.279 ± 0.056	4.135ThrGly: 4.135 ± 0.07	0.765ThrHis: 0.765 ± 0.024	4.082ThrIle: 4.082 ± 0.069	3.013ThrLys: 3.013 ± 0.056	4.663ThrLeu: 4.663 ± 0.081	0.837ThrMet: 0.837 ± 0.031	2.474ThrAsn: 2.474 ± 0.06	2.166ThrPro: 2.166 ± 0.042	1.187ThrGln: 1.187 ± 0.029	1.744ThrArg: 1.744 ± 0.049	2.865ThrSer: 2.865 ± 0.06	2.602ThrThr: 2.602 ± 0.057	3.613ThrVal: 3.613 ± 0.088	0.454ThrTrp: 0.454 ± 0.023	1.833ThrTyr: 1.833 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	3.896ValAla: 3.896 ± 0.081	0.574ValCys: 0.574 ± 0.026	3.718ValAsp: 3.718 ± 0.062	4.4ValGlu: 4.4 ± 0.076	3.019ValPhe: 3.019 ± 0.061	3.85ValGly: 3.85 ± 0.075	0.929ValHis: 0.929 ± 0.033	5.491ValIle: 5.491 ± 0.074	4.812ValLys: 4.812 ± 0.081	5.142ValLeu: 5.142 ± 0.086	1.262ValMet: 1.262 ± 0.044	3.488ValAsn: 3.488 ± 0.063	2.26ValPro: 2.26 ± 0.051	1.363ValGln: 1.363 ± 0.037	2.553ValArg: 2.553 ± 0.057	4.153ValSer: 4.153 ± 0.065	3.215ValThr: 3.215 ± 0.078	4.137ValVal: 4.137 ± 0.069	0.683ValTrp: 0.683 ± 0.027	2.851ValTyr: 2.851 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.626TrpAla: 0.626 ± 0.03	0.082TrpCys: 0.082 ± 0.009	0.62TrpAsp: 0.62 ± 0.025	0.706TrpGlu: 0.706 ± 0.029	0.475TrpPhe: 0.475 ± 0.024	0.757TrpGly: 0.757 ± 0.029	0.247TrpHis: 0.247 ± 0.017	0.887TrpIle: 0.887 ± 0.032	0.794TrpLys: 0.794 ± 0.03	0.928TrpLeu: 0.928 ± 0.03	0.224TrpMet: 0.224 ± 0.016	0.744TrpAsn: 0.744 ± 0.03	0.267TrpPro: 0.267 ± 0.016	0.382TrpGln: 0.382 ± 0.021	0.486TrpArg: 0.486 ± 0.025	0.622TrpSer: 0.622 ± 0.028	0.52TrpThr: 0.52 ± 0.025	0.536TrpVal: 0.536 ± 0.026	0.184TrpTrp: 0.184 ± 0.013	0.472TrpTyr: 0.472 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.573TyrAla: 2.573 ± 0.054	0.37TyrCys: 0.37 ± 0.019	2.948TyrAsp: 2.948 ± 0.061	3.067TyrGlu: 3.067 ± 0.065	2.537TyrPhe: 2.537 ± 0.059	2.928TyrGly: 2.928 ± 0.054	0.734TyrHis: 0.734 ± 0.028	3.041TyrIle: 3.041 ± 0.061	3.201TyrLys: 3.201 ± 0.062	4.242TyrLeu: 4.242 ± 0.077	0.726TyrMet: 0.726 ± 0.025	2.656TyrAsn: 2.656 ± 0.058	1.741TyrPro: 1.741 ± 0.05	1.166TyrGln: 1.166 ± 0.036	2.063TyrArg: 2.063 ± 0.046	3.118TyrSer: 3.118 ± 0.068	2.173TyrThr: 2.173 ± 0.056	2.384TyrVal: 2.384 ± 0.05	0.528TyrTrp: 0.528 ± 0.03	2.322TyrTyr: 2.322 ± 0.067	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2833 proteins (1007411 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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