Amino acid dipepetide frequency for Paraburkholderia ribeironis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.446AlaAla: 17.446 ± 0.151	1.432AlaCys: 1.432 ± 0.028	6.571AlaAsp: 6.571 ± 0.065	5.723AlaGlu: 5.723 ± 0.061	4.177AlaPhe: 4.177 ± 0.049	10.238AlaGly: 10.238 ± 0.095	3.0AlaHis: 3.0 ± 0.044	5.648AlaIle: 5.648 ± 0.052	3.622AlaLys: 3.622 ± 0.049	13.811AlaLeu: 13.811 ± 0.105	3.215AlaMet: 3.215 ± 0.04	3.395AlaAsn: 3.395 ± 0.05	5.881AlaPro: 5.881 ± 0.072	5.508AlaGln: 5.508 ± 0.061	9.05AlaArg: 9.05 ± 0.082	7.602AlaSer: 7.602 ± 0.08	6.438AlaThr: 6.438 ± 0.067	8.66AlaVal: 8.66 ± 0.071	1.617AlaTrp: 1.617 ± 0.03	2.669AlaTyr: 2.669 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.418CysAla: 1.418 ± 0.028	0.173CysCys: 0.173 ± 0.01	0.611CysAsp: 0.611 ± 0.02	0.565CysGlu: 0.565 ± 0.018	0.379CysPhe: 0.379 ± 0.014	1.102CysGly: 1.102 ± 0.027	0.294CysHis: 0.294 ± 0.013	0.489CysIle: 0.489 ± 0.015	0.267CysLys: 0.267 ± 0.012	0.842CysLeu: 0.842 ± 0.024	0.249CysMet: 0.249 ± 0.012	0.28CysAsn: 0.28 ± 0.013	0.526CysPro: 0.526 ± 0.017	0.257CysGln: 0.257 ± 0.011	0.79CysArg: 0.79 ± 0.022	0.63CysSer: 0.63 ± 0.017	0.546CysThr: 0.546 ± 0.017	0.868CysVal: 0.868 ± 0.024	0.145CysTrp: 0.145 ± 0.009	0.245CysTyr: 0.245 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.607AspAla: 7.607 ± 0.084	0.536AspCys: 0.536 ± 0.015	3.077AspAsp: 3.077 ± 0.045	3.322AspGlu: 3.322 ± 0.053	1.959AspPhe: 1.959 ± 0.03	4.486AspGly: 4.486 ± 0.047	1.214AspHis: 1.214 ± 0.026	2.452AspIle: 2.452 ± 0.037	1.537AspLys: 1.537 ± 0.031	4.975AspLeu: 4.975 ± 0.049	1.17AspMet: 1.17 ± 0.026	1.349AspAsn: 1.349 ± 0.03	2.87AspPro: 2.87 ± 0.044	1.659AspGln: 1.659 ± 0.03	3.416AspArg: 3.416 ± 0.042	2.655AspSer: 2.655 ± 0.034	2.85AspThr: 2.85 ± 0.041	4.222AspVal: 4.222 ± 0.046	0.913AspTrp: 0.913 ± 0.024	1.487AspTyr: 1.487 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.2GluAla: 6.2 ± 0.059	0.468GluCys: 0.468 ± 0.017	2.042GluAsp: 2.042 ± 0.034	2.222GluGlu: 2.222 ± 0.038	1.789GluPhe: 1.789 ± 0.034	3.182GluGly: 3.182 ± 0.046	1.47GluHis: 1.47 ± 0.03	2.698GluIle: 2.698 ± 0.04	1.793GluLys: 1.793 ± 0.034	5.429GluLeu: 5.429 ± 0.051	1.158GluMet: 1.158 ± 0.022	1.401GluAsn: 1.401 ± 0.024	2.575GluPro: 2.575 ± 0.04	2.446GluGln: 2.446 ± 0.036	4.858GluArg: 4.858 ± 0.058	2.646GluSer: 2.646 ± 0.039	2.721GluThr: 2.721 ± 0.04	3.457GluVal: 3.457 ± 0.045	0.727GluTrp: 0.727 ± 0.02	1.134GluTyr: 1.134 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.623PheAla: 4.623 ± 0.048	0.461PheCys: 0.461 ± 0.014	2.693PheAsp: 2.693 ± 0.039	2.107PheGlu: 2.107 ± 0.033	1.467PhePhe: 1.467 ± 0.034	3.641PheGly: 3.641 ± 0.046	0.797PheHis: 0.797 ± 0.021	1.626PheIle: 1.626 ± 0.026	1.034PheLys: 1.034 ± 0.025	2.856PheLeu: 2.856 ± 0.04	0.797PheMet: 0.797 ± 0.02	1.219PheAsn: 1.219 ± 0.027	1.545PhePro: 1.545 ± 0.028	0.996PheGln: 0.996 ± 0.021	2.131PheArg: 2.131 ± 0.035	2.298PheSer: 2.298 ± 0.038	1.954PheThr: 1.954 ± 0.03	3.088PheVal: 3.088 ± 0.042	0.49PheTrp: 0.49 ± 0.016	0.955PheTyr: 0.955 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.173GlyAla: 9.173 ± 0.084	0.941GlyCys: 0.941 ± 0.024	3.849GlyAsp: 3.849 ± 0.042	4.135GlyGlu: 4.135 ± 0.047	3.309GlyPhe: 3.309 ± 0.043	6.582GlyGly: 6.582 ± 0.087	1.964GlyHis: 1.964 ± 0.035	4.179GlyIle: 4.179 ± 0.047	3.16GlyLys: 3.16 ± 0.044	7.773GlyLeu: 7.773 ± 0.07	2.17GlyMet: 2.17 ± 0.035	2.386GlyAsn: 2.386 ± 0.052	2.901GlyPro: 2.901 ± 0.039	2.801GlyGln: 2.801 ± 0.04	5.246GlyArg: 5.246 ± 0.061	4.701GlySer: 4.701 ± 0.069	4.526GlyThr: 4.526 ± 0.058	6.53GlyVal: 6.53 ± 0.065	1.352GlyTrp: 1.352 ± 0.028	2.332GlyTyr: 2.332 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	3.227HisAla: 3.227 ± 0.046	0.318HisCys: 0.318 ± 0.012	1.439HisAsp: 1.439 ± 0.025	1.273HisGlu: 1.273 ± 0.024	0.966HisPhe: 0.966 ± 0.022	2.238HisGly: 2.238 ± 0.036	0.715HisHis: 0.715 ± 0.021	0.986HisIle: 0.986 ± 0.025	0.582HisLys: 0.582 ± 0.02	2.213HisLeu: 2.213 ± 0.035	0.538HisMet: 0.538 ± 0.016	0.603HisAsn: 0.603 ± 0.017	1.455HisPro: 1.455 ± 0.029	0.723HisGln: 0.723 ± 0.017	1.775HisArg: 1.775 ± 0.031	1.173HisSer: 1.173 ± 0.022	1.173HisThr: 1.173 ± 0.026	1.821HisVal: 1.821 ± 0.028	0.404HisTrp: 0.404 ± 0.015	0.681HisTyr: 0.681 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.832IleAla: 6.832 ± 0.063	0.514IleCys: 0.514 ± 0.014	3.511IleAsp: 3.511 ± 0.041	3.209IleGlu: 3.209 ± 0.043	1.487IlePhe: 1.487 ± 0.026	4.708IleGly: 4.708 ± 0.057	0.985IleHis: 0.985 ± 0.02	1.673IleIle: 1.673 ± 0.031	1.396IleLys: 1.396 ± 0.034	3.325IleLeu: 3.325 ± 0.047	0.79IleMet: 0.79 ± 0.018	1.467IleAsn: 1.467 ± 0.028	2.082IlePro: 2.082 ± 0.03	1.289IleGln: 1.289 ± 0.023	2.952IleArg: 2.952 ± 0.04	2.576IleSer: 2.576 ± 0.037	2.408IleThr: 2.408 ± 0.035	4.285IleVal: 4.285 ± 0.045	0.52IleTrp: 0.52 ± 0.017	1.097IleTyr: 1.097 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.578LysAla: 3.578 ± 0.053	0.194LysCys: 0.194 ± 0.01	1.475LysAsp: 1.475 ± 0.03	1.415LysGlu: 1.415 ± 0.032	0.927LysPhe: 0.927 ± 0.023	2.086LysGly: 2.086 ± 0.033	0.725LysHis: 0.725 ± 0.018	1.579LysIle: 1.579 ± 0.032	1.253LysLys: 1.253 ± 0.034	3.394LysLeu: 3.394 ± 0.04	0.809LysMet: 0.809 ± 0.017	0.91LysAsn: 0.91 ± 0.024	1.956LysPro: 1.956 ± 0.03	1.295LysGln: 1.295 ± 0.024	2.43LysArg: 2.43 ± 0.041	1.8LysSer: 1.8 ± 0.032	1.893LysThr: 1.893 ± 0.028	2.275LysVal: 2.275 ± 0.037	0.378LysTrp: 0.378 ± 0.013	0.712LysTyr: 0.712 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.534LeuAla: 13.534 ± 0.101	1.13LeuCys: 1.13 ± 0.025	5.824LeuAsp: 5.824 ± 0.06	4.898LeuGlu: 4.898 ± 0.051	3.612LeuPhe: 3.612 ± 0.046	7.731LeuGly: 7.731 ± 0.072	2.332LeuHis: 2.332 ± 0.031	4.642LeuIle: 4.642 ± 0.048	3.357LeuLys: 3.357 ± 0.052	9.927LeuLeu: 9.927 ± 0.095	2.241LeuMet: 2.241 ± 0.036	2.903LeuAsn: 2.903 ± 0.038	5.656LeuPro: 5.656 ± 0.055	3.484LeuGln: 3.484 ± 0.046	7.289LeuArg: 7.289 ± 0.064	6.277LeuSer: 6.277 ± 0.059	5.594LeuThr: 5.594 ± 0.052	7.184LeuVal: 7.184 ± 0.071	1.157LeuTrp: 1.157 ± 0.026	2.174LeuTyr: 2.174 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.461MetAla: 2.461 ± 0.034	0.22MetCys: 0.22 ± 0.01	0.922MetAsp: 0.922 ± 0.019	0.903MetGlu: 0.903 ± 0.022	0.76MetPhe: 0.76 ± 0.02	1.529MetGly: 1.529 ± 0.026	0.612MetHis: 0.612 ± 0.02	1.149MetIle: 1.149 ± 0.022	1.063MetLys: 1.063 ± 0.025	2.688MetLeu: 2.688 ± 0.041	0.622MetMet: 0.622 ± 0.018	0.933MetAsn: 0.933 ± 0.02	1.467MetPro: 1.467 ± 0.026	1.058MetGln: 1.058 ± 0.022	1.89MetArg: 1.89 ± 0.028	1.797MetSer: 1.797 ± 0.028	1.618MetThr: 1.618 ± 0.026	1.495MetVal: 1.495 ± 0.032	0.241MetTrp: 0.241 ± 0.012	0.417MetTyr: 0.417 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.66AsnAla: 3.66 ± 0.046	0.291AsnCys: 0.291 ± 0.012	1.546AsnAsp: 1.546 ± 0.028	1.433AsnGlu: 1.433 ± 0.026	1.033AsnPhe: 1.033 ± 0.022	2.636AsnGly: 2.636 ± 0.046	0.593AsnHis: 0.593 ± 0.019	1.292AsnIle: 1.292 ± 0.026	0.704AsnLys: 0.704 ± 0.022	2.865AsnLeu: 2.865 ± 0.045	0.592AsnMet: 0.592 ± 0.015	0.884AsnAsn: 0.884 ± 0.025	1.866AsnPro: 1.866 ± 0.031	1.008AsnGln: 1.008 ± 0.023	1.951AsnArg: 1.951 ± 0.033	1.51AsnSer: 1.51 ± 0.035	1.563AsnThr: 1.563 ± 0.033	2.267AsnVal: 2.267 ± 0.04	0.44AsnTrp: 0.44 ± 0.015	0.761AsnTyr: 0.761 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.629ProAla: 6.629 ± 0.07	0.447ProCys: 0.447 ± 0.014	3.206ProAsp: 3.206 ± 0.043	2.822ProGlu: 2.822 ± 0.043	1.931ProPhe: 1.931 ± 0.032	4.06ProGly: 4.06 ± 0.047	1.349ProHis: 1.349 ± 0.023	2.069ProIle: 2.069 ± 0.027	1.452ProLys: 1.452 ± 0.029	5.147ProLeu: 5.147 ± 0.048	1.136ProMet: 1.136 ± 0.023	1.461ProAsn: 1.461 ± 0.03	2.554ProPro: 2.554 ± 0.045	1.999ProGln: 1.999 ± 0.038	3.052ProArg: 3.052 ± 0.043	2.947ProSer: 2.947 ± 0.042	2.611ProThr: 2.611 ± 0.041	4.269ProVal: 4.269 ± 0.044	0.629ProTrp: 0.629 ± 0.016	1.213ProTyr: 1.213 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.546GlnAla: 4.546 ± 0.057	0.34GlnCys: 0.34 ± 0.012	1.392GlnAsp: 1.392 ± 0.028	1.392GlnGlu: 1.392 ± 0.027	1.376GlnPhe: 1.376 ± 0.023	2.494GlnGly: 2.494 ± 0.04	1.015GlnHis: 1.015 ± 0.022	2.029GlnIle: 2.029 ± 0.031	1.169GlnLys: 1.169 ± 0.026	3.957GlnLeu: 3.957 ± 0.049	1.083GlnMet: 1.083 ± 0.021	0.971GlnAsn: 0.971 ± 0.026	2.113GlnPro: 2.113 ± 0.039	1.994GlnGln: 1.994 ± 0.045	3.138GlnArg: 3.138 ± 0.043	2.113GlnSer: 2.113 ± 0.034	2.116GlnThr: 2.116 ± 0.034	2.51GlnVal: 2.51 ± 0.039	0.573GlnTrp: 0.573 ± 0.016	0.926GlnTyr: 0.926 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.301ArgAla: 8.301 ± 0.077	0.768ArgCys: 0.768 ± 0.022	3.837ArgAsp: 3.837 ± 0.045	4.265ArgGlu: 4.265 ± 0.048	3.078ArgPhe: 3.078 ± 0.042	4.657ArgGly: 4.657 ± 0.052	1.98ArgHis: 1.98 ± 0.03	3.727ArgIle: 3.727 ± 0.046	2.261ArgLys: 2.261 ± 0.038	7.346ArgLeu: 7.346 ± 0.07	1.909ArgMet: 1.909 ± 0.032	2.086ArgAsn: 2.086 ± 0.033	3.227ArgPro: 3.227 ± 0.043	2.693ArgGln: 2.693 ± 0.039	5.797ArgArg: 5.797 ± 0.073	3.893ArgSer: 3.893 ± 0.041	3.594ArgThr: 3.594 ± 0.048	5.297ArgVal: 5.297 ± 0.052	1.107ArgTrp: 1.107 ± 0.023	2.004ArgTyr: 2.004 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.205SerAla: 7.205 ± 0.081	0.572SerCys: 0.572 ± 0.018	2.821SerAsp: 2.821 ± 0.036	2.603SerGlu: 2.603 ± 0.036	2.268SerPhe: 2.268 ± 0.033	5.396SerGly: 5.396 ± 0.062	1.358SerHis: 1.358 ± 0.023	2.876SerIle: 2.876 ± 0.037	1.708SerLys: 1.708 ± 0.028	5.888SerLeu: 5.888 ± 0.058	1.451SerMet: 1.451 ± 0.026	1.842SerAsn: 1.842 ± 0.037	2.895SerPro: 2.895 ± 0.042	1.902SerGln: 1.902 ± 0.033	3.939SerArg: 3.939 ± 0.043	3.697SerSer: 3.697 ± 0.052	3.281SerThr: 3.281 ± 0.053	4.445SerVal: 4.445 ± 0.056	0.772SerTrp: 0.772 ± 0.022	1.366SerTyr: 1.366 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.023ThrAla: 6.023 ± 0.066	0.503ThrCys: 0.503 ± 0.017	2.761ThrAsp: 2.761 ± 0.037	2.356ThrGlu: 2.356 ± 0.031	1.909ThrPhe: 1.909 ± 0.029	4.781ThrGly: 4.781 ± 0.063	1.352ThrHis: 1.352 ± 0.026	2.623ThrIle: 2.623 ± 0.039	1.252ThrLys: 1.252 ± 0.026	6.375ThrLeu: 6.375 ± 0.063	1.215ThrMet: 1.215 ± 0.027	1.426ThrAsn: 1.426 ± 0.037	3.463ThrPro: 3.463 ± 0.039	2.014ThrGln: 2.014 ± 0.035	3.751ThrArg: 3.751 ± 0.037	3.115ThrSer: 3.115 ± 0.047	3.018ThrThr: 3.018 ± 0.049	4.36ThrVal: 4.36 ± 0.049	0.692ThrTrp: 0.692 ± 0.017	1.266ThrTyr: 1.266 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.354ValAla: 9.354 ± 0.079	0.885ValCys: 0.885 ± 0.022	4.227ValAsp: 4.227 ± 0.046	4.036ValGlu: 4.036 ± 0.049	2.809ValPhe: 2.809 ± 0.044	5.476ValGly: 5.476 ± 0.058	1.575ValHis: 1.575 ± 0.024	3.795ValIle: 3.795 ± 0.045	2.419ValLys: 2.419 ± 0.038	7.719ValLeu: 7.719 ± 0.075	1.896ValMet: 1.896 ± 0.034	2.264ValAsn: 2.264 ± 0.044	3.977ValPro: 3.977 ± 0.046	2.526ValGln: 2.526 ± 0.039	5.195ValArg: 5.195 ± 0.053	4.684ValSer: 4.684 ± 0.059	4.39ValThr: 4.39 ± 0.055	6.238ValVal: 6.238 ± 0.065	0.963ValTrp: 0.963 ± 0.022	1.645ValTyr: 1.645 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.13TrpAla: 1.13 ± 0.027	0.176TrpCys: 0.176 ± 0.009	0.62TrpAsp: 0.62 ± 0.019	0.512TrpGlu: 0.512 ± 0.016	0.541TrpPhe: 0.541 ± 0.016	0.842TrpGly: 0.842 ± 0.021	0.416TrpHis: 0.416 ± 0.015	0.688TrpIle: 0.688 ± 0.019	0.431TrpLys: 0.431 ± 0.015	1.93TrpLeu: 1.93 ± 0.031	0.353TrpMet: 0.353 ± 0.013	0.467TrpAsn: 0.467 ± 0.015	0.697TrpPro: 0.697 ± 0.017	0.705TrpGln: 0.705 ± 0.018	1.227TrpArg: 1.227 ± 0.026	0.833TrpSer: 0.833 ± 0.022	0.699TrpThr: 0.699 ± 0.021	0.923TrpVal: 0.923 ± 0.026	0.237TrpTrp: 0.237 ± 0.011	0.313TrpTyr: 0.313 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.757TyrAla: 2.757 ± 0.04	0.306TyrCys: 0.306 ± 0.013	1.332TyrAsp: 1.332 ± 0.032	1.225TyrGlu: 1.225 ± 0.024	1.002TyrPhe: 1.002 ± 0.025	2.148TyrGly: 2.148 ± 0.034	0.559TyrHis: 0.559 ± 0.016	0.883TyrIle: 0.883 ± 0.025	0.625TyrLys: 0.625 ± 0.019	2.487TyrLeu: 2.487 ± 0.035	0.448TyrMet: 0.448 ± 0.015	0.648TyrAsn: 0.648 ± 0.021	1.277TyrPro: 1.277 ± 0.028	0.889TyrGln: 0.889 ± 0.019	1.949TyrArg: 1.949 ± 0.035	1.34TyrSer: 1.34 ± 0.027	1.261TyrThr: 1.261 ± 0.028	1.879TyrVal: 1.879 ± 0.029	0.384TyrTrp: 0.384 ± 0.014	0.661TyrTyr: 0.661 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7335 proteins (2089330 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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