Amino acid dipepetide frequency for Halalkaliarchaeum desulfuricum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.956AlaAla: 11.956 ± 0.159
0.736AlaCys: 0.736 ± 0.033
8.835AlaAsp: 8.835 ± 0.105
8.544AlaGlu: 8.544 ± 0.109
3.874AlaPhe: 3.874 ± 0.067
9.471AlaGly: 9.471 ± 0.12
1.719AlaHis: 1.719 ± 0.043
5.436AlaIle: 5.436 ± 0.082
1.893AlaLys: 1.893 ± 0.043
9.179AlaLeu: 9.179 ± 0.115
1.886AlaMet: 1.886 ± 0.047
2.15AlaAsn: 2.15 ± 0.048
3.648AlaPro: 3.648 ± 0.057
2.077AlaGln: 2.077 ± 0.049
5.97AlaArg: 5.97 ± 0.085
4.841AlaSer: 4.841 ± 0.075
6.198AlaThr: 6.198 ± 0.082
10.021AlaVal: 10.021 ± 0.137
1.023AlaTrp: 1.023 ± 0.038
2.605AlaTyr: 2.605 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.581CysAla: 0.581 ± 0.026
0.093CysCys: 0.093 ± 0.009
0.629CysAsp: 0.629 ± 0.028
0.654CysGlu: 0.654 ± 0.026
0.207CysPhe: 0.207 ± 0.017
0.93CysGly: 0.93 ± 0.035
0.201CysHis: 0.201 ± 0.012
0.277CysIle: 0.277 ± 0.019
0.156CysLys: 0.156 ± 0.01
0.586CysLeu: 0.586 ± 0.025
0.122CysMet: 0.122 ± 0.012
0.213CysAsn: 0.213 ± 0.018
0.608CysPro: 0.608 ± 0.03
0.138CysGln: 0.138 ± 0.013
0.546CysArg: 0.546 ± 0.025
0.432CysSer: 0.432 ± 0.02
0.424CysThr: 0.424 ± 0.022
0.564CysVal: 0.564 ± 0.03
0.082CysTrp: 0.082 ± 0.01
0.173CysTyr: 0.173 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
9.073AspAla: 9.073 ± 0.106
0.692AspCys: 0.692 ± 0.033
7.416AspAsp: 7.416 ± 0.104
7.928AspGlu: 7.928 ± 0.12
1.862AspPhe: 1.862 ± 0.047
8.197AspGly: 8.197 ± 0.112
1.867AspHis: 1.867 ± 0.053
2.863AspIle: 2.863 ± 0.059
0.949AspLys: 0.949 ± 0.032
6.597AspLeu: 6.597 ± 0.082
1.087AspMet: 1.087 ± 0.033
1.304AspAsn: 1.304 ± 0.041
5.075AspPro: 5.075 ± 0.081
1.602AspGln: 1.602 ± 0.039
7.364AspArg: 7.364 ± 0.097
3.444AspSer: 3.444 ± 0.066
3.941AspThr: 3.941 ± 0.075
8.077AspVal: 8.077 ± 0.108
1.081AspTrp: 1.081 ± 0.032
1.793AspTyr: 1.793 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
8.881GluAla: 8.881 ± 0.121
0.545GluCys: 0.545 ± 0.026
5.809GluAsp: 5.809 ± 0.084
8.829GluGlu: 8.829 ± 0.15
3.319GluPhe: 3.319 ± 0.061
6.112GluGly: 6.112 ± 0.077
1.988GluHis: 1.988 ± 0.045
4.778GluIle: 4.778 ± 0.084
2.033GluLys: 2.033 ± 0.054
8.898GluLeu: 8.898 ± 0.114
1.913GluMet: 1.913 ± 0.043
2.491GluAsn: 2.491 ± 0.061
4.765GluPro: 4.765 ± 0.092
2.581GluGln: 2.581 ± 0.056
7.449GluArg: 7.449 ± 0.104
5.348GluSer: 5.348 ± 0.077
7.04GluThr: 7.04 ± 0.097
6.165GluVal: 6.165 ± 0.099
1.191GluTrp: 1.191 ± 0.032
2.965GluTyr: 2.965 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.504PheAla: 3.504 ± 0.062
0.266PheCys: 0.266 ± 0.014
3.369PheAsp: 3.369 ± 0.061
3.604PheGlu: 3.604 ± 0.067
1.125PhePhe: 1.125 ± 0.044
3.345PheGly: 3.345 ± 0.063
0.638PheHis: 0.638 ± 0.031
1.085PheIle: 1.085 ± 0.035
0.491PheLys: 0.491 ± 0.023
3.036PheLeu: 3.036 ± 0.064
0.486PheMet: 0.486 ± 0.025
0.643PheAsn: 0.643 ± 0.025
1.411PhePro: 1.411 ± 0.04
0.735PheGln: 0.735 ± 0.029
1.942PheArg: 1.942 ± 0.051
1.712PheSer: 1.712 ± 0.044
1.829PheThr: 1.829 ± 0.046
3.22PheVal: 3.22 ± 0.058
0.384PheTrp: 0.384 ± 0.019
0.851PheTyr: 0.851 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
7.755GlyAla: 7.755 ± 0.112
0.8GlyCys: 0.8 ± 0.03
6.721GlyAsp: 6.721 ± 0.103
7.811GlyGlu: 7.811 ± 0.099
3.242GlyPhe: 3.242 ± 0.064
7.436GlyGly: 7.436 ± 0.098
1.636GlyHis: 1.636 ± 0.047
4.928GlyIle: 4.928 ± 0.076
1.983GlyLys: 1.983 ± 0.047
7.004GlyLeu: 7.004 ± 0.099
1.764GlyMet: 1.764 ± 0.045
2.088GlyAsn: 2.088 ± 0.049
3.31GlyPro: 3.31 ± 0.06
1.862GlyGln: 1.862 ± 0.049
5.142GlyArg: 5.142 ± 0.076
4.87GlySer: 4.87 ± 0.078
5.938GlyThr: 5.938 ± 0.087
7.707GlyVal: 7.707 ± 0.105
1.091GlyTrp: 1.091 ± 0.035
2.713GlyTyr: 2.713 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.97HisAla: 1.97 ± 0.045
0.204HisCys: 0.204 ± 0.015
1.837HisAsp: 1.837 ± 0.046
1.796HisGlu: 1.796 ± 0.045
0.487HisPhe: 0.487 ± 0.023
1.92HisGly: 1.92 ± 0.05
0.539HisHis: 0.539 ± 0.027
0.601HisIle: 0.601 ± 0.027
0.323HisLys: 0.323 ± 0.019
1.702HisLeu: 1.702 ± 0.042
0.261HisMet: 0.261 ± 0.015
0.489HisAsn: 0.489 ± 0.024
1.307HisPro: 1.307 ± 0.038
0.463HisGln: 0.463 ± 0.023
1.441HisArg: 1.441 ± 0.041
0.897HisSer: 0.897 ± 0.033
1.074HisThr: 1.074 ± 0.033
1.955HisVal: 1.955 ± 0.044
0.234HisTrp: 0.234 ± 0.015
0.529HisTyr: 0.529 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.287IleAla: 5.287 ± 0.07
0.305IleCys: 0.305 ± 0.02
4.555IleAsp: 4.555 ± 0.066
5.02IleGlu: 5.02 ± 0.078
0.977IlePhe: 0.977 ± 0.036
4.17IleGly: 4.17 ± 0.069
0.993IleHis: 0.993 ± 0.033
1.317IleIle: 1.317 ± 0.044
0.74IleLys: 0.74 ± 0.029
3.149IleLeu: 3.149 ± 0.069
0.524IleMet: 0.524 ± 0.023
0.887IleAsn: 0.887 ± 0.028
2.267IlePro: 2.267 ± 0.051
1.228IleGln: 1.228 ± 0.039
2.848IleArg: 2.848 ± 0.052
2.183IleSer: 2.183 ± 0.046
2.463IleThr: 2.463 ± 0.056
4.218IleVal: 4.218 ± 0.077
0.371IleTrp: 0.371 ± 0.019
0.957IleTyr: 0.957 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
1.744LysAla: 1.744 ± 0.046
0.124LysCys: 0.124 ± 0.011
1.099LysAsp: 1.099 ± 0.037
1.488LysGlu: 1.488 ± 0.049
0.522LysPhe: 0.522 ± 0.028
1.386LysGly: 1.386 ± 0.043
0.485LysHis: 0.485 ± 0.025
0.839LysIle: 0.839 ± 0.035
0.623LysLys: 0.623 ± 0.032
1.832LysLeu: 1.832 ± 0.046
0.372LysMet: 0.372 ± 0.019
0.571LysAsn: 0.571 ± 0.027
1.013LysPro: 1.013 ± 0.033
0.811LysGln: 0.811 ± 0.029
1.894LysArg: 1.894 ± 0.048
1.171LysSer: 1.171 ± 0.043
1.351LysThr: 1.351 ± 0.035
1.146LysVal: 1.146 ± 0.037
0.243LysTrp: 0.243 ± 0.015
0.609LysTyr: 0.609 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
10.244LeuAla: 10.244 ± 0.147
0.619LeuCys: 0.619 ± 0.028
6.933LeuAsp: 6.933 ± 0.088
8.365LeuGlu: 8.365 ± 0.105
3.25LeuPhe: 3.25 ± 0.07
7.226LeuGly: 7.226 ± 0.097
1.547LeuHis: 1.547 ± 0.042
3.082LeuIle: 3.082 ± 0.066
1.637LeuLys: 1.637 ± 0.046
8.553LeuLeu: 8.553 ± 0.139
1.203LeuMet: 1.203 ± 0.037
1.623LeuAsn: 1.623 ± 0.05
4.234LeuPro: 4.234 ± 0.062
2.262LeuGln: 2.262 ± 0.047
5.457LeuArg: 5.457 ± 0.089
6.081LeuSer: 6.081 ± 0.096
4.782LeuThr: 4.782 ± 0.075
8.057LeuVal: 8.057 ± 0.109
0.868LeuTrp: 0.868 ± 0.033
2.242LeuTyr: 2.242 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.716MetAla: 1.716 ± 0.04
0.112MetCys: 0.112 ± 0.011
1.231MetAsp: 1.231 ± 0.033
1.221MetGlu: 1.221 ± 0.037
0.486MetPhe: 0.486 ± 0.022
1.386MetGly: 1.386 ± 0.044
0.336MetHis: 0.336 ± 0.017
0.77MetIle: 0.77 ± 0.032
0.435MetLys: 0.435 ± 0.02
1.387MetLeu: 1.387 ± 0.044
0.321MetMet: 0.321 ± 0.02
0.597MetAsn: 0.597 ± 0.027
0.794MetPro: 0.794 ± 0.03
0.474MetGln: 0.474 ± 0.022
1.047MetArg: 1.047 ± 0.033
1.437MetSer: 1.437 ± 0.043
1.473MetThr: 1.473 ± 0.041
1.25MetVal: 1.25 ± 0.035
0.18MetTrp: 0.18 ± 0.014
0.452MetTyr: 0.452 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.382AsnAla: 2.382 ± 0.051
0.236AsnCys: 0.236 ± 0.018
1.656AsnAsp: 1.656 ± 0.044
1.901AsnGlu: 1.901 ± 0.047
0.627AsnPhe: 0.627 ± 0.029
1.868AsnGly: 1.868 ± 0.048
0.498AsnHis: 0.498 ± 0.023
0.797AsnIle: 0.797 ± 0.034
0.45AsnLys: 0.45 ± 0.027
1.929AsnLeu: 1.929 ± 0.046
0.377AsnMet: 0.377 ± 0.018
0.586AsnAsn: 0.586 ± 0.028
1.576AsnPro: 1.576 ± 0.045
0.577AsnGln: 0.577 ± 0.026
1.798AsnArg: 1.798 ± 0.044
0.957AsnSer: 0.957 ± 0.036
1.23AsnThr: 1.23 ± 0.033
2.298AsnVal: 2.298 ± 0.044
0.303AsnTrp: 0.303 ± 0.019
0.682AsnTyr: 0.682 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
4.452ProAla: 4.452 ± 0.072
0.275ProCys: 0.275 ± 0.019
5.129ProAsp: 5.129 ± 0.081
5.449ProGlu: 5.449 ± 0.082
1.675ProPhe: 1.675 ± 0.044
4.321ProGly: 4.321 ± 0.068
0.937ProHis: 0.937 ± 0.029
2.256ProIle: 2.256 ± 0.047
0.906ProLys: 0.906 ± 0.033
3.582ProLeu: 3.582 ± 0.064
0.844ProMet: 0.844 ± 0.031
1.139ProAsn: 1.139 ± 0.035
2.309ProPro: 2.309 ± 0.051
0.976ProGln: 0.976 ± 0.029
2.376ProArg: 2.376 ± 0.054
2.63ProSer: 2.63 ± 0.048
3.247ProThr: 3.247 ± 0.062
4.208ProVal: 4.208 ± 0.07
0.553ProTrp: 0.553 ± 0.021
1.194ProTyr: 1.194 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.211GlnAla: 2.211 ± 0.046
0.201GlnCys: 0.201 ± 0.015
1.205GlnAsp: 1.205 ± 0.04
1.832GlnGlu: 1.832 ± 0.051
1.089GlnPhe: 1.089 ± 0.031
1.657GlnGly: 1.657 ± 0.044
0.549GlnHis: 0.549 ± 0.026
1.146GlnIle: 1.146 ± 0.035
0.591GlnLys: 0.591 ± 0.028
2.668GlnLeu: 2.668 ± 0.049
0.486GlnMet: 0.486 ± 0.025
0.631GlnAsn: 0.631 ± 0.03
1.166GlnPro: 1.166 ± 0.034
0.861GlnGln: 0.861 ± 0.037
2.005GlnArg: 2.005 ± 0.049
1.43GlnSer: 1.43 ± 0.042
1.378GlnThr: 1.378 ± 0.039
1.697GlnVal: 1.697 ± 0.04
0.333GlnTrp: 0.333 ± 0.018
0.889GlnTyr: 0.889 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
5.971ArgAla: 5.971 ± 0.088
0.513ArgCys: 0.513 ± 0.024
4.976ArgAsp: 4.976 ± 0.067
7.645ArgGlu: 7.645 ± 0.098
2.431ArgPhe: 2.431 ± 0.051
4.767ArgGly: 4.767 ± 0.089
1.287ArgHis: 1.287 ± 0.036
3.602ArgIle: 3.602 ± 0.062
1.743ArgLys: 1.743 ± 0.046
6.318ArgLeu: 6.318 ± 0.092
1.361ArgMet: 1.361 ± 0.036
1.837ArgAsn: 1.837 ± 0.041
2.694ArgPro: 2.694 ± 0.057
1.893ArgGln: 1.893 ± 0.045
5.509ArgArg: 5.509 ± 0.1
3.74ArgSer: 3.74 ± 0.065
4.168ArgThr: 4.168 ± 0.064
5.098ArgVal: 5.098 ± 0.08
0.766ArgTrp: 0.766 ± 0.031
2.026ArgTyr: 2.026 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.932SerAla: 4.932 ± 0.083
0.379SerCys: 0.379 ± 0.021
4.344SerAsp: 4.344 ± 0.073
4.386SerGlu: 4.386 ± 0.079
1.874SerPhe: 1.874 ± 0.046
5.046SerGly: 5.046 ± 0.066
1.014SerHis: 1.014 ± 0.035
2.511SerIle: 2.511 ± 0.05
1.194SerLys: 1.194 ± 0.04
4.562SerLeu: 4.562 ± 0.073
1.056SerMet: 1.056 ± 0.031
1.272SerAsn: 1.272 ± 0.04
2.779SerPro: 2.779 ± 0.06
1.316SerGln: 1.316 ± 0.036
3.58SerArg: 3.58 ± 0.069
2.802SerSer: 2.802 ± 0.057
3.401SerThr: 3.401 ± 0.062
4.773SerVal: 4.773 ± 0.064
0.65SerTrp: 0.65 ± 0.031
1.439SerTyr: 1.439 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.527ThrAla: 6.527 ± 0.087
0.448ThrCys: 0.448 ± 0.024
5.4ThrAsp: 5.4 ± 0.075
4.914ThrGlu: 4.914 ± 0.064
2.195ThrPhe: 2.195 ± 0.056
5.589ThrGly: 5.589 ± 0.085
1.23ThrHis: 1.23 ± 0.037
3.061ThrIle: 3.061 ± 0.052
1.025ThrLys: 1.025 ± 0.032
5.547ThrLeu: 5.547 ± 0.079
1.042ThrMet: 1.042 ± 0.035
1.321ThrAsn: 1.321 ± 0.039
3.319ThrPro: 3.319 ± 0.07
1.316ThrGln: 1.316 ± 0.037
3.38ThrArg: 3.38 ± 0.064
2.631ThrSer: 2.631 ± 0.063
3.808ThrThr: 3.808 ± 0.077
6.646ThrVal: 6.646 ± 0.091
0.633ThrTrp: 0.633 ± 0.026
1.743ThrTyr: 1.743 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
9.265ValAla: 9.265 ± 0.119
0.713ValCys: 0.713 ± 0.03
7.677ValAsp: 7.677 ± 0.09
8.213ValGlu: 8.213 ± 0.108
3.119ValPhe: 3.119 ± 0.069
7.763ValGly: 7.763 ± 0.107
1.681ValHis: 1.681 ± 0.042
3.742ValIle: 3.742 ± 0.073
1.447ValLys: 1.447 ± 0.037
7.802ValLeu: 7.802 ± 0.122
1.389ValMet: 1.389 ± 0.037
1.9ValAsn: 1.9 ± 0.045
4.406ValPro: 4.406 ± 0.072
1.792ValGln: 1.792 ± 0.042
5.593ValArg: 5.593 ± 0.082
4.959ValSer: 4.959 ± 0.072
5.844ValThr: 5.844 ± 0.087
8.68ValVal: 8.68 ± 0.132
0.808ValTrp: 0.808 ± 0.031
2.237ValTyr: 2.237 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.89TrpAla: 0.89 ± 0.033
0.093TrpCys: 0.093 ± 0.01
0.735TrpAsp: 0.735 ± 0.029
0.989TrpGlu: 0.989 ± 0.034
0.461TrpPhe: 0.461 ± 0.021
0.852TrpGly: 0.852 ± 0.035
0.238TrpHis: 0.238 ± 0.017
0.647TrpIle: 0.647 ± 0.027
0.284TrpLys: 0.284 ± 0.017
1.267TrpLeu: 1.267 ± 0.035
0.228TrpMet: 0.228 ± 0.015
0.357TrpAsn: 0.357 ± 0.019
0.426TrpPro: 0.426 ± 0.02
0.379TrpGln: 0.379 ± 0.019
0.827TrpArg: 0.827 ± 0.033
0.548TrpSer: 0.548 ± 0.025
0.72TrpThr: 0.72 ± 0.028
0.77TrpVal: 0.77 ± 0.028
0.189TrpTrp: 0.189 ± 0.016
0.416TrpTyr: 0.416 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.723TyrAla: 2.723 ± 0.05
0.261TyrCys: 0.261 ± 0.016
2.658TyrAsp: 2.658 ± 0.067
2.51TyrGlu: 2.51 ± 0.056
0.851TyrPhe: 0.851 ± 0.035
2.359TyrGly: 2.359 ± 0.05
0.646TyrHis: 0.646 ± 0.026
0.72TyrIle: 0.72 ± 0.025
0.421TyrLys: 0.421 ± 0.022
2.666TyrLeu: 2.666 ± 0.059
0.385TyrMet: 0.385 ± 0.019
0.629TyrAsn: 0.629 ± 0.03
1.349TyrPro: 1.349 ± 0.041
0.685TyrGln: 0.685 ± 0.027
2.175TyrArg: 2.175 ± 0.052
1.2TyrSer: 1.2 ± 0.04
1.466TyrThr: 1.466 ± 0.043
2.479TyrVal: 2.479 ± 0.054
0.332TyrTrp: 0.332 ± 0.02
0.853TyrTyr: 0.853 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3224 proteins (966158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski