Amino acid dipepetide frequency for Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.107AlaAla: 18.107 ± 0.235	1.127AlaCys: 1.127 ± 0.027	6.304AlaAsp: 6.304 ± 0.066	7.455AlaGlu: 7.455 ± 0.094	4.256AlaPhe: 4.256 ± 0.051	10.397AlaGly: 10.397 ± 0.114	2.447AlaHis: 2.447 ± 0.047	5.247AlaIle: 5.247 ± 0.067	3.776AlaLys: 3.776 ± 0.06	13.125AlaLeu: 13.125 ± 0.121	2.453AlaMet: 2.453 ± 0.04	3.275AlaAsn: 3.275 ± 0.06	6.337AlaPro: 6.337 ± 0.077	4.479AlaGln: 4.479 ± 0.062	9.202AlaArg: 9.202 ± 0.105	6.317AlaSer: 6.317 ± 0.104	7.265AlaThr: 7.265 ± 0.116	8.899AlaVal: 8.899 ± 0.094	1.894AlaTrp: 1.894 ± 0.04	2.35AlaTyr: 2.35 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.132CysAla: 1.132 ± 0.028	0.144CysCys: 0.144 ± 0.01	0.498CysAsp: 0.498 ± 0.017	0.457CysGlu: 0.457 ± 0.017	0.372CysPhe: 0.372 ± 0.016	0.92CysGly: 0.92 ± 0.027	0.271CysHis: 0.271 ± 0.021	0.351CysIle: 0.351 ± 0.016	0.166CysLys: 0.166 ± 0.011	0.864CysLeu: 0.864 ± 0.025	0.125CysMet: 0.125 ± 0.007	0.194CysAsn: 0.194 ± 0.012	0.467CysPro: 0.467 ± 0.019	0.223CysGln: 0.223 ± 0.011	0.671CysArg: 0.671 ± 0.021	0.509CysSer: 0.509 ± 0.016	0.456CysThr: 0.456 ± 0.017	0.737CysVal: 0.737 ± 0.021	0.156CysTrp: 0.156 ± 0.01	0.219CysTyr: 0.219 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.148AspAla: 6.148 ± 0.055	0.457AspCys: 0.457 ± 0.017	2.514AspAsp: 2.514 ± 0.044	3.072AspGlu: 3.072 ± 0.05	2.29AspPhe: 2.29 ± 0.039	4.875AspGly: 4.875 ± 0.091	1.12AspHis: 1.12 ± 0.028	1.909AspIle: 1.909 ± 0.034	1.153AspLys: 1.153 ± 0.032	5.307AspLeu: 5.307 ± 0.065	0.668AspMet: 0.668 ± 0.018	1.177AspAsn: 1.177 ± 0.031	3.351AspPro: 3.351 ± 0.05	1.667AspGln: 1.667 ± 0.032	3.763AspArg: 3.763 ± 0.053	2.204AspSer: 2.204 ± 0.039	2.369AspThr: 2.369 ± 0.044	3.839AspVal: 3.839 ± 0.053	0.945AspTrp: 0.945 ± 0.026	1.732AspTyr: 1.732 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.271GluAla: 6.271 ± 0.082	0.404GluCys: 0.404 ± 0.016	2.057GluAsp: 2.057 ± 0.039	2.763GluGlu: 2.763 ± 0.059	2.374GluPhe: 2.374 ± 0.043	3.316GluGly: 3.316 ± 0.047	1.407GluHis: 1.407 ± 0.032	3.17GluIle: 3.17 ± 0.043	2.219GluLys: 2.219 ± 0.048	6.58GluLeu: 6.58 ± 0.089	1.199GluMet: 1.199 ± 0.03	1.678GluAsn: 1.678 ± 0.035	3.082GluPro: 3.082 ± 0.05	2.534GluGln: 2.534 ± 0.047	4.813GluArg: 4.813 ± 0.068	2.798GluSer: 2.798 ± 0.039	3.031GluThr: 3.031 ± 0.047	3.791GluVal: 3.791 ± 0.053	0.931GluTrp: 0.931 ± 0.025	1.047GluTyr: 1.047 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.96PheAla: 4.96 ± 0.058	0.412PheCys: 0.412 ± 0.016	2.452PheAsp: 2.452 ± 0.041	2.175PheGlu: 2.175 ± 0.037	1.677PhePhe: 1.677 ± 0.039	3.523PheGly: 3.523 ± 0.058	0.791PheHis: 0.791 ± 0.02	1.423PheIle: 1.423 ± 0.029	1.06PheLys: 1.06 ± 0.025	3.593PheLeu: 3.593 ± 0.054	0.622PheMet: 0.622 ± 0.021	1.272PheAsn: 1.272 ± 0.03	1.817PhePro: 1.817 ± 0.033	1.178PheGln: 1.178 ± 0.026	2.68PheArg: 2.68 ± 0.037	2.453PheSer: 2.453 ± 0.046	2.595PheThr: 2.595 ± 0.046	3.192PheVal: 3.192 ± 0.044	0.673PheTrp: 0.673 ± 0.023	1.076PheTyr: 1.076 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.904GlyAla: 8.904 ± 0.107	0.885GlyCys: 0.885 ± 0.026	3.971GlyAsp: 3.971 ± 0.061	4.426GlyGlu: 4.426 ± 0.064	3.46GlyPhe: 3.46 ± 0.047	6.616GlyGly: 6.616 ± 0.104	1.756GlyHis: 1.756 ± 0.032	3.552GlyIle: 3.552 ± 0.057	2.575GlyLys: 2.575 ± 0.05	8.111GlyLeu: 8.111 ± 0.084	1.667GlyMet: 1.667 ± 0.035	2.203GlyAsn: 2.203 ± 0.058	3.219GlyPro: 3.219 ± 0.05	2.746GlyGln: 2.746 ± 0.041	6.228GlyArg: 6.228 ± 0.069	4.507GlySer: 4.507 ± 0.075	4.972GlyThr: 4.972 ± 0.119	6.401GlyVal: 6.401 ± 0.077	1.656GlyTrp: 1.656 ± 0.033	2.314GlyTyr: 2.314 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.726HisAla: 2.726 ± 0.046	0.239HisCys: 0.239 ± 0.013	1.15HisAsp: 1.15 ± 0.026	1.287HisGlu: 1.287 ± 0.029	0.966HisPhe: 0.966 ± 0.027	2.02HisGly: 2.02 ± 0.04	0.628HisHis: 0.628 ± 0.02	0.665HisIle: 0.665 ± 0.022	0.401HisLys: 0.401 ± 0.016	2.189HisLeu: 2.189 ± 0.038	0.292HisMet: 0.292 ± 0.013	0.548HisAsn: 0.548 ± 0.018	1.495HisPro: 1.495 ± 0.032	0.704HisGln: 0.704 ± 0.018	1.724HisArg: 1.724 ± 0.037	1.006HisSer: 1.006 ± 0.027	1.097HisThr: 1.097 ± 0.027	1.671HisVal: 1.671 ± 0.036	0.442HisTrp: 0.442 ± 0.016	0.659HisTyr: 0.659 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.887IleAla: 5.887 ± 0.067	0.418IleCys: 0.418 ± 0.017	2.787IleAsp: 2.787 ± 0.044	2.98IleGlu: 2.98 ± 0.054	1.474IlePhe: 1.474 ± 0.03	3.975IleGly: 3.975 ± 0.053	0.86IleHis: 0.86 ± 0.022	1.624IleIle: 1.624 ± 0.038	1.21IleLys: 1.21 ± 0.028	3.508IleLeu: 3.508 ± 0.053	0.607IleMet: 0.607 ± 0.02	1.289IleAsn: 1.289 ± 0.027	2.127IlePro: 2.127 ± 0.033	1.166IleGln: 1.166 ± 0.025	2.874IleArg: 2.874 ± 0.038	2.387IleSer: 2.387 ± 0.039	2.767IleThr: 2.767 ± 0.061	3.821IleVal: 3.821 ± 0.052	0.525IleTrp: 0.525 ± 0.019	1.11IleTyr: 1.11 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.153LysAla: 3.153 ± 0.06	0.179LysCys: 0.179 ± 0.01	1.375LysAsp: 1.375 ± 0.031	1.481LysGlu: 1.481 ± 0.033	1.139LysPhe: 1.139 ± 0.032	1.783LysGly: 1.783 ± 0.038	0.615LysHis: 0.615 ± 0.021	1.714LysIle: 1.714 ± 0.035	1.328LysLys: 1.328 ± 0.044	3.445LysLeu: 3.445 ± 0.057	0.684LysMet: 0.684 ± 0.023	0.945LysAsn: 0.945 ± 0.025	1.998LysPro: 1.998 ± 0.035	1.082LysGln: 1.082 ± 0.029	2.032LysArg: 2.032 ± 0.042	1.716LysSer: 1.716 ± 0.037	1.881LysThr: 1.881 ± 0.038	2.09LysVal: 2.09 ± 0.045	0.377LysTrp: 0.377 ± 0.015	0.643LysTyr: 0.643 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.512LeuAla: 14.512 ± 0.115	0.999LeuCys: 0.999 ± 0.029	5.169LeuAsp: 5.169 ± 0.062	5.471LeuGlu: 5.471 ± 0.072	3.774LeuPhe: 3.774 ± 0.055	8.366LeuGly: 8.366 ± 0.078	2.309LeuHis: 2.309 ± 0.043	4.197LeuIle: 4.197 ± 0.059	3.193LeuLys: 3.193 ± 0.046	11.047LeuLeu: 11.047 ± 0.106	1.672LeuMet: 1.672 ± 0.035	2.857LeuAsn: 2.857 ± 0.046	6.11LeuPro: 6.11 ± 0.062	3.606LeuGln: 3.606 ± 0.046	8.604LeuArg: 8.604 ± 0.087	5.629LeuSer: 5.629 ± 0.056	6.236LeuThr: 6.236 ± 0.085	7.902LeuVal: 7.902 ± 0.075	1.453LeuTrp: 1.453 ± 0.036	2.186LeuTyr: 2.186 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	1.969MetAla: 1.969 ± 0.037	0.124MetCys: 0.124 ± 0.008	0.799MetAsp: 0.799 ± 0.024	0.852MetGlu: 0.852 ± 0.026	0.585MetPhe: 0.585 ± 0.02	1.182MetGly: 1.182 ± 0.03	0.379MetHis: 0.379 ± 0.015	0.912MetIle: 0.912 ± 0.026	0.953MetLys: 0.953 ± 0.024	1.994MetLeu: 1.994 ± 0.037	0.404MetMet: 0.404 ± 0.016	0.76MetAsn: 0.76 ± 0.022	1.22MetPro: 1.22 ± 0.027	0.663MetGln: 0.663 ± 0.02	1.339MetArg: 1.339 ± 0.034	1.185MetSer: 1.185 ± 0.027	1.092MetThr: 1.092 ± 0.025	1.137MetVal: 1.137 ± 0.03	0.191MetTrp: 0.191 ± 0.009	0.225MetTyr: 0.225 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.326AsnAla: 3.326 ± 0.084	0.211AsnCys: 0.211 ± 0.011	1.443AsnAsp: 1.443 ± 0.031	1.393AsnGlu: 1.393 ± 0.028	1.068AsnPhe: 1.068 ± 0.028	2.544AsnGly: 2.544 ± 0.071	0.59AsnHis: 0.59 ± 0.018	1.07AsnIle: 1.07 ± 0.026	0.637AsnLys: 0.637 ± 0.019	2.983AsnLeu: 2.983 ± 0.046	0.367AsnMet: 0.367 ± 0.016	0.826AsnAsn: 0.826 ± 0.027	2.079AsnPro: 2.079 ± 0.04	0.993AsnGln: 0.993 ± 0.024	2.031AsnArg: 2.031 ± 0.032	1.417AsnSer: 1.417 ± 0.034	1.562AsnThr: 1.562 ± 0.046	2.158AsnVal: 2.158 ± 0.037	0.457AsnTrp: 0.457 ± 0.02	0.859AsnTyr: 0.859 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	8.148ProAla: 8.148 ± 0.083	0.352ProCys: 0.352 ± 0.015	3.398ProAsp: 3.398 ± 0.047	3.687ProGlu: 3.687 ± 0.055	2.001ProPhe: 2.001 ± 0.034	4.643ProGly: 4.643 ± 0.058	1.174ProHis: 1.174 ± 0.03	2.115ProIle: 2.115 ± 0.039	1.596ProLys: 1.596 ± 0.034	5.245ProLeu: 5.245 ± 0.063	1.031ProMet: 1.031 ± 0.023	1.562ProAsn: 1.562 ± 0.039	3.284ProPro: 3.284 ± 0.059	1.862ProGln: 1.862 ± 0.032	3.602ProArg: 3.602 ± 0.055	2.916ProSer: 2.916 ± 0.041	3.123ProThr: 3.123 ± 0.043	4.439ProVal: 4.439 ± 0.058	0.886ProTrp: 0.886 ± 0.025	1.123ProTyr: 1.123 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.899GlnAla: 3.899 ± 0.063	0.217GlnCys: 0.217 ± 0.011	1.277GlnAsp: 1.277 ± 0.028	1.609GlnGlu: 1.609 ± 0.034	1.334GlnPhe: 1.334 ± 0.029	2.021GlnGly: 2.021 ± 0.034	0.895GlnHis: 0.895 ± 0.023	1.784GlnIle: 1.784 ± 0.035	1.153GlnLys: 1.153 ± 0.033	4.326GlnLeu: 4.326 ± 0.065	0.679GlnMet: 0.679 ± 0.021	0.952GlnAsn: 0.952 ± 0.022	2.523GlnPro: 2.523 ± 0.042	1.668GlnGln: 1.668 ± 0.04	3.187GlnArg: 3.187 ± 0.047	1.786GlnSer: 1.786 ± 0.033	1.943GlnThr: 1.943 ± 0.033	2.512GlnVal: 2.512 ± 0.046	0.519GlnTrp: 0.519 ± 0.02	0.599GlnTyr: 0.599 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	8.672ArgAla: 8.672 ± 0.09	0.664ArgCys: 0.664 ± 0.024	4.014ArgAsp: 4.014 ± 0.052	4.901ArgGlu: 4.901 ± 0.071	3.227ArgPhe: 3.227 ± 0.05	5.296ArgGly: 5.296 ± 0.06	1.755ArgHis: 1.755 ± 0.038	3.67ArgIle: 3.67 ± 0.044	2.045ArgLys: 2.045 ± 0.036	8.266ArgLeu: 8.266 ± 0.096	1.594ArgMet: 1.594 ± 0.034	1.918ArgAsn: 1.918 ± 0.037	3.897ArgPro: 3.897 ± 0.055	2.85ArgGln: 2.85 ± 0.049	6.299ArgArg: 6.299 ± 0.075	3.916ArgSer: 3.916 ± 0.051	4.038ArgThr: 4.038 ± 0.049	5.547ArgVal: 5.547 ± 0.066	1.457ArgTrp: 1.457 ± 0.033	1.964ArgTyr: 1.964 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.498SerAla: 6.498 ± 0.083	0.45SerCys: 0.45 ± 0.018	2.686SerAsp: 2.686 ± 0.039	2.595SerGlu: 2.595 ± 0.041	2.305SerPhe: 2.305 ± 0.037	5.081SerGly: 5.081 ± 0.094	1.126SerHis: 1.126 ± 0.026	2.284SerIle: 2.284 ± 0.04	1.335SerLys: 1.335 ± 0.032	5.61SerLeu: 5.61 ± 0.06	0.964SerMet: 0.964 ± 0.028	1.447SerAsn: 1.447 ± 0.052	3.223SerPro: 3.223 ± 0.05	1.558SerGln: 1.558 ± 0.03	3.799SerArg: 3.799 ± 0.048	3.284SerSer: 3.284 ± 0.054	3.103SerThr: 3.103 ± 0.056	3.991SerVal: 3.991 ± 0.063	0.85SerTrp: 0.85 ± 0.025	1.43SerTyr: 1.43 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.096ThrAla: 7.096 ± 0.114	0.458ThrCys: 0.458 ± 0.017	2.746ThrAsp: 2.746 ± 0.044	2.784ThrGlu: 2.784 ± 0.04	2.309ThrPhe: 2.309 ± 0.045	5.131ThrGly: 5.131 ± 0.08	1.19ThrHis: 1.19 ± 0.028	2.714ThrIle: 2.714 ± 0.061	1.667ThrLys: 1.667 ± 0.037	6.538ThrLeu: 6.538 ± 0.101	0.977ThrMet: 0.977 ± 0.027	1.644ThrAsn: 1.644 ± 0.044	3.982ThrPro: 3.982 ± 0.056	1.705ThrGln: 1.705 ± 0.038	3.796ThrArg: 3.796 ± 0.048	3.151ThrSer: 3.151 ± 0.054	3.492ThrThr: 3.492 ± 0.071	4.443ThrVal: 4.443 ± 0.08	0.916ThrTrp: 0.916 ± 0.027	1.385ThrTyr: 1.385 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.262ValAla: 9.262 ± 0.102	0.782ValCys: 0.782 ± 0.023	3.725ValAsp: 3.725 ± 0.052	4.133ValGlu: 4.133 ± 0.051	3.167ValPhe: 3.167 ± 0.044	5.549ValGly: 5.549 ± 0.063	1.554ValHis: 1.554 ± 0.029	3.506ValIle: 3.506 ± 0.047	2.204ValLys: 2.204 ± 0.04	8.108ValLeu: 8.108 ± 0.084	1.309ValMet: 1.309 ± 0.032	2.21ValAsn: 2.21 ± 0.046	3.977ValPro: 3.977 ± 0.061	2.524ValGln: 2.524 ± 0.042	5.639ValArg: 5.639 ± 0.062	4.172ValSer: 4.172 ± 0.06	4.842ValThr: 4.842 ± 0.076	6.193ValVal: 6.193 ± 0.085	1.058ValTrp: 1.058 ± 0.027	1.703ValTyr: 1.703 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.412TrpAla: 1.412 ± 0.029	0.192TrpCys: 0.192 ± 0.012	0.788TrpAsp: 0.788 ± 0.021	0.706TrpGlu: 0.706 ± 0.022	0.726TrpPhe: 0.726 ± 0.021	0.996TrpGly: 0.996 ± 0.026	0.411TrpHis: 0.411 ± 0.017	0.804TrpIle: 0.804 ± 0.024	0.489TrpLys: 0.489 ± 0.018	2.018TrpLeu: 2.018 ± 0.041	0.347TrpMet: 0.347 ± 0.012	0.528TrpAsn: 0.528 ± 0.021	0.813TrpPro: 0.813 ± 0.025	0.75TrpGln: 0.75 ± 0.025	1.57TrpArg: 1.57 ± 0.038	1.0TrpSer: 1.0 ± 0.028	0.965TrpThr: 0.965 ± 0.026	0.997TrpVal: 0.997 ± 0.027	0.362TrpTrp: 0.362 ± 0.015	0.303TrpTyr: 0.303 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.63TyrAla: 2.63 ± 0.039	0.216TyrCys: 0.216 ± 0.011	1.407TyrAsp: 1.407 ± 0.033	1.238TyrGlu: 1.238 ± 0.027	1.121TyrPhe: 1.121 ± 0.022	1.934TyrGly: 1.934 ± 0.04	0.631TyrHis: 0.631 ± 0.02	0.688TyrIle: 0.688 ± 0.023	0.498TyrLys: 0.498 ± 0.019	2.436TyrLeu: 2.436 ± 0.039	0.299TyrMet: 0.299 ± 0.014	0.73TyrAsn: 0.73 ± 0.025	1.185TyrPro: 1.185 ± 0.033	0.923TyrGln: 0.923 ± 0.024	2.14TyrArg: 2.14 ± 0.037	1.268TyrSer: 1.268 ± 0.033	1.297TyrThr: 1.297 ± 0.031	1.857TyrVal: 1.857 ± 0.039	0.429TyrTrp: 0.429 ± 0.016	0.776TyrTyr: 0.776 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4588 proteins (1747334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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