Amino acid dipepetide frequency for Burkholderia virus Bcepmigl

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.134AlaAla: 22.134 ± 1.547
0.857AlaCys: 0.857 ± 0.296
6.605AlaAsp: 6.605 ± 0.598
7.764AlaGlu: 7.764 ± 0.618
3.832AlaPhe: 3.832 ± 0.342
10.134AlaGly: 10.134 ± 0.982
1.916AlaHis: 1.916 ± 0.376
5.496AlaIle: 5.496 ± 0.638
6.0AlaLys: 6.0 ± 0.836
10.739AlaLeu: 10.739 ± 0.707
3.832AlaMet: 3.832 ± 0.485
4.538AlaAsn: 4.538 ± 0.539
7.613AlaPro: 7.613 ± 1.053
6.151AlaGln: 6.151 ± 0.889
9.832AlaArg: 9.832 ± 0.744
6.252AlaSer: 6.252 ± 0.541
6.504AlaThr: 6.504 ± 0.678
6.454AlaVal: 6.454 ± 0.637
1.815AlaTrp: 1.815 ± 0.282
2.874AlaTyr: 2.874 ± 0.441
0.0AlaXaa: 0.0 ± 0.0
Cys
1.26CysAla: 1.26 ± 0.401
0.151CysCys: 0.151 ± 0.085
0.353CysAsp: 0.353 ± 0.145
0.454CysGlu: 0.454 ± 0.208
0.202CysPhe: 0.202 ± 0.103
0.555CysGly: 0.555 ± 0.219
0.101CysHis: 0.101 ± 0.082
0.555CysIle: 0.555 ± 0.215
0.151CysLys: 0.151 ± 0.094
0.403CysLeu: 0.403 ± 0.187
0.303CysMet: 0.303 ± 0.161
0.353CysAsn: 0.353 ± 0.171
0.504CysPro: 0.504 ± 0.179
0.202CysGln: 0.202 ± 0.103
0.756CysArg: 0.756 ± 0.284
0.353CysSer: 0.353 ± 0.194
0.353CysThr: 0.353 ± 0.138
0.454CysVal: 0.454 ± 0.195
0.202CysTrp: 0.202 ± 0.111
0.252CysTyr: 0.252 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
9.025AspAla: 9.025 ± 0.736
0.605AspCys: 0.605 ± 0.231
5.042AspAsp: 5.042 ± 0.831
4.891AspGlu: 4.891 ± 0.706
2.017AspPhe: 2.017 ± 0.353
6.706AspGly: 6.706 ± 0.542
1.361AspHis: 1.361 ± 0.334
2.773AspIle: 2.773 ± 0.35
2.168AspLys: 2.168 ± 0.403
3.983AspLeu: 3.983 ± 0.487
1.16AspMet: 1.16 ± 0.223
2.218AspAsn: 2.218 ± 0.309
3.479AspPro: 3.479 ± 0.357
2.42AspGln: 2.42 ± 0.366
4.891AspArg: 4.891 ± 0.556
2.672AspSer: 2.672 ± 0.462
2.874AspThr: 2.874 ± 0.376
3.933AspVal: 3.933 ± 0.41
1.462AspTrp: 1.462 ± 0.264
1.26AspTyr: 1.26 ± 0.258
0.0AspXaa: 0.0 ± 0.0
Glu
7.462GluAla: 7.462 ± 0.753
0.555GluCys: 0.555 ± 0.209
2.118GluAsp: 2.118 ± 0.278
4.185GluGlu: 4.185 ± 0.452
2.723GluPhe: 2.723 ± 0.436
4.336GluGly: 4.336 ± 0.454
1.865GluHis: 1.865 ± 0.464
3.277GluIle: 3.277 ± 0.394
2.924GluLys: 2.924 ± 0.366
6.454GluLeu: 6.454 ± 0.641
1.664GluMet: 1.664 ± 0.32
2.269GluAsn: 2.269 ± 0.373
3.529GluPro: 3.529 ± 0.382
3.529GluGln: 3.529 ± 0.633
6.05GluArg: 6.05 ± 0.693
2.269GluSer: 2.269 ± 0.306
2.874GluThr: 2.874 ± 0.313
3.58GluVal: 3.58 ± 0.399
1.008GluTrp: 1.008 ± 0.243
1.765GluTyr: 1.765 ± 0.278
0.0GluXaa: 0.0 ± 0.0
Phe
3.681PheAla: 3.681 ± 0.366
0.353PheCys: 0.353 ± 0.125
2.975PheAsp: 2.975 ± 0.414
2.42PheGlu: 2.42 ± 0.487
0.807PhePhe: 0.807 ± 0.151
2.622PheGly: 2.622 ± 0.316
0.655PheHis: 0.655 ± 0.157
1.613PheIle: 1.613 ± 0.315
1.462PheLys: 1.462 ± 0.352
1.613PheLeu: 1.613 ± 0.258
0.908PheMet: 0.908 ± 0.188
1.21PheAsn: 1.21 ± 0.22
1.462PhePro: 1.462 ± 0.228
1.059PheGln: 1.059 ± 0.168
2.118PheArg: 2.118 ± 0.533
1.513PheSer: 1.513 ± 0.228
1.865PheThr: 1.865 ± 0.34
1.765PheVal: 1.765 ± 0.261
0.555PheTrp: 0.555 ± 0.153
0.857PheTyr: 0.857 ± 0.227
0.0PheXaa: 0.0 ± 0.0
Gly
9.378GlyAla: 9.378 ± 1.03
0.655GlyCys: 0.655 ± 0.241
5.899GlyAsp: 5.899 ± 0.553
4.638GlyGlu: 4.638 ± 0.637
2.773GlyPhe: 2.773 ± 0.355
7.361GlyGly: 7.361 ± 0.646
1.563GlyHis: 1.563 ± 0.291
3.731GlyIle: 3.731 ± 0.637
4.689GlyLys: 4.689 ± 0.539
4.386GlyLeu: 4.386 ± 0.585
2.571GlyMet: 2.571 ± 0.571
4.134GlyAsn: 4.134 ± 0.616
2.471GlyPro: 2.471 ± 0.255
3.378GlyGln: 3.378 ± 0.394
5.294GlyArg: 5.294 ± 0.63
3.882GlySer: 3.882 ± 0.351
6.151GlyThr: 6.151 ± 0.61
5.647GlyVal: 5.647 ± 0.439
1.109GlyTrp: 1.109 ± 0.201
2.067GlyTyr: 2.067 ± 0.379
0.0GlyXaa: 0.0 ± 0.0
His
2.269HisAla: 2.269 ± 0.451
0.252HisCys: 0.252 ± 0.138
1.26HisAsp: 1.26 ± 0.242
1.966HisGlu: 1.966 ± 0.395
0.857HisPhe: 0.857 ± 0.25
1.26HisGly: 1.26 ± 0.335
0.504HisHis: 0.504 ± 0.159
1.16HisIle: 1.16 ± 0.241
0.706HisLys: 0.706 ± 0.208
1.16HisLeu: 1.16 ± 0.293
0.353HisMet: 0.353 ± 0.133
0.807HisAsn: 0.807 ± 0.19
0.756HisPro: 0.756 ± 0.197
0.454HisGln: 0.454 ± 0.154
1.412HisArg: 1.412 ± 0.269
1.008HisSer: 1.008 ± 0.266
1.008HisThr: 1.008 ± 0.194
0.908HisVal: 0.908 ± 0.175
0.252HisTrp: 0.252 ± 0.08
0.454HisTyr: 0.454 ± 0.133
0.0HisXaa: 0.0 ± 0.0
Ile
5.546IleAla: 5.546 ± 0.402
0.403IleCys: 0.403 ± 0.201
3.529IleAsp: 3.529 ± 0.394
4.487IleGlu: 4.487 ± 0.614
1.16IlePhe: 1.16 ± 0.244
4.185IleGly: 4.185 ± 0.527
0.504IleHis: 0.504 ± 0.165
2.017IleIle: 2.017 ± 0.277
2.017IleLys: 2.017 ± 0.324
2.168IleLeu: 2.168 ± 0.318
0.958IleMet: 0.958 ± 0.194
1.865IleAsn: 1.865 ± 0.339
1.765IlePro: 1.765 ± 0.279
1.361IleGln: 1.361 ± 0.258
2.521IleArg: 2.521 ± 0.376
1.966IleSer: 1.966 ± 0.386
3.076IleThr: 3.076 ± 0.48
3.832IleVal: 3.832 ± 0.468
0.756IleTrp: 0.756 ± 0.219
1.059IleTyr: 1.059 ± 0.213
0.0IleXaa: 0.0 ± 0.0
Lys
6.756LysAla: 6.756 ± 0.633
0.101LysCys: 0.101 ± 0.076
2.874LysAsp: 2.874 ± 0.324
2.319LysGlu: 2.319 ± 0.274
1.109LysPhe: 1.109 ± 0.213
3.025LysGly: 3.025 ± 0.412
1.059LysHis: 1.059 ± 0.27
1.966LysIle: 1.966 ± 0.423
2.823LysLys: 2.823 ± 0.398
3.025LysLeu: 3.025 ± 0.407
1.21LysMet: 1.21 ± 0.223
1.714LysAsn: 1.714 ± 0.361
2.874LysPro: 2.874 ± 0.414
2.319LysGln: 2.319 ± 0.413
3.277LysArg: 3.277 ± 0.471
2.218LysSer: 2.218 ± 0.31
2.319LysThr: 2.319 ± 0.262
3.882LysVal: 3.882 ± 0.435
0.706LysTrp: 0.706 ± 0.185
0.706LysTyr: 0.706 ± 0.165
0.0LysXaa: 0.0 ± 0.0
Leu
9.327LeuAla: 9.327 ± 0.655
0.504LeuCys: 0.504 ± 0.192
5.496LeuAsp: 5.496 ± 0.575
4.739LeuGlu: 4.739 ± 0.501
1.613LeuPhe: 1.613 ± 0.284
5.193LeuGly: 5.193 ± 0.681
1.613LeuHis: 1.613 ± 0.247
2.471LeuIle: 2.471 ± 0.381
4.235LeuLys: 4.235 ± 0.46
5.143LeuLeu: 5.143 ± 0.519
1.613LeuMet: 1.613 ± 0.283
2.975LeuAsn: 2.975 ± 0.391
3.781LeuPro: 3.781 ± 0.491
1.916LeuGln: 1.916 ± 0.303
5.546LeuArg: 5.546 ± 0.498
3.882LeuSer: 3.882 ± 0.543
5.294LeuThr: 5.294 ± 0.465
4.437LeuVal: 4.437 ± 0.456
0.655LeuTrp: 0.655 ± 0.184
1.815LeuTyr: 1.815 ± 0.286
0.0LeuXaa: 0.0 ± 0.0
Met
2.672MetAla: 2.672 ± 0.417
0.101MetCys: 0.101 ± 0.072
1.513MetAsp: 1.513 ± 0.269
0.958MetGlu: 0.958 ± 0.236
0.655MetPhe: 0.655 ± 0.171
1.916MetGly: 1.916 ± 0.341
0.403MetHis: 0.403 ± 0.116
0.908MetIle: 0.908 ± 0.173
1.664MetLys: 1.664 ± 0.368
2.218MetLeu: 2.218 ± 0.259
0.303MetMet: 0.303 ± 0.1
0.908MetAsn: 0.908 ± 0.195
1.513MetPro: 1.513 ± 0.227
1.109MetGln: 1.109 ± 0.204
2.269MetArg: 2.269 ± 0.348
1.613MetSer: 1.613 ± 0.312
1.966MetThr: 1.966 ± 0.281
1.462MetVal: 1.462 ± 0.32
0.504MetTrp: 0.504 ± 0.2
0.504MetTyr: 0.504 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
4.689AsnAla: 4.689 ± 0.604
0.151AsnCys: 0.151 ± 0.099
2.218AsnAsp: 2.218 ± 0.353
2.37AsnGlu: 2.37 ± 0.313
1.16AsnPhe: 1.16 ± 0.24
4.134AsnGly: 4.134 ± 0.472
0.605AsnHis: 0.605 ± 0.156
1.563AsnIle: 1.563 ± 0.25
1.21AsnLys: 1.21 ± 0.235
2.571AsnLeu: 2.571 ± 0.364
0.807AsnMet: 0.807 ± 0.186
1.109AsnAsn: 1.109 ± 0.22
2.622AsnPro: 2.622 ± 0.376
1.16AsnGln: 1.16 ± 0.273
2.218AsnArg: 2.218 ± 0.365
1.865AsnSer: 1.865 ± 0.357
1.613AsnThr: 1.613 ± 0.243
2.723AsnVal: 2.723 ± 0.376
0.605AsnTrp: 0.605 ± 0.171
1.26AsnTyr: 1.26 ± 0.203
0.0AsnXaa: 0.0 ± 0.0
Pro
9.983ProAla: 9.983 ± 1.272
0.504ProCys: 0.504 ± 0.181
4.235ProAsp: 4.235 ± 0.429
3.882ProGlu: 3.882 ± 0.523
1.613ProPhe: 1.613 ± 0.338
3.58ProGly: 3.58 ± 0.487
0.706ProHis: 0.706 ± 0.235
1.815ProIle: 1.815 ± 0.328
2.319ProLys: 2.319 ± 0.283
3.428ProLeu: 3.428 ± 0.39
1.059ProMet: 1.059 ± 0.282
1.966ProAsn: 1.966 ± 0.27
3.378ProPro: 3.378 ± 0.864
1.664ProGln: 1.664 ± 0.362
2.823ProArg: 2.823 ± 0.542
3.731ProSer: 3.731 ± 0.446
3.025ProThr: 3.025 ± 0.344
2.672ProVal: 2.672 ± 0.319
0.655ProTrp: 0.655 ± 0.145
1.16ProTyr: 1.16 ± 0.283
0.0ProXaa: 0.0 ± 0.0
Gln
4.991GlnAla: 4.991 ± 0.668
0.101GlnCys: 0.101 ± 0.1
1.865GlnAsp: 1.865 ± 0.313
2.874GlnGlu: 2.874 ± 0.328
1.311GlnPhe: 1.311 ± 0.18
2.471GlnGly: 2.471 ± 0.41
0.857GlnHis: 0.857 ± 0.275
2.067GlnIle: 2.067 ± 0.466
1.563GlnLys: 1.563 ± 0.281
3.378GlnLeu: 3.378 ± 0.343
1.563GlnMet: 1.563 ± 0.266
1.563GlnAsn: 1.563 ± 0.492
2.874GlnPro: 2.874 ± 0.503
3.176GlnGln: 3.176 ± 0.559
3.328GlnArg: 3.328 ± 0.551
2.521GlnSer: 2.521 ± 0.475
1.513GlnThr: 1.513 ± 0.229
1.815GlnVal: 1.815 ± 0.352
0.403GlnTrp: 0.403 ± 0.121
0.958GlnTyr: 0.958 ± 0.191
0.0GlnXaa: 0.0 ± 0.0
Arg
8.924ArgAla: 8.924 ± 0.578
0.555ArgCys: 0.555 ± 0.215
5.193ArgAsp: 5.193 ± 0.464
4.235ArgGlu: 4.235 ± 0.645
3.277ArgPhe: 3.277 ± 0.386
4.991ArgGly: 4.991 ± 0.433
1.462ArgHis: 1.462 ± 0.41
3.076ArgIle: 3.076 ± 0.36
2.823ArgLys: 2.823 ± 0.482
5.949ArgLeu: 5.949 ± 0.5
2.42ArgMet: 2.42 ± 0.374
2.067ArgAsn: 2.067 ± 0.324
2.975ArgPro: 2.975 ± 0.479
3.832ArgGln: 3.832 ± 0.562
5.042ArgArg: 5.042 ± 0.652
2.874ArgSer: 2.874 ± 0.304
3.328ArgThr: 3.328 ± 0.409
5.143ArgVal: 5.143 ± 0.527
1.361ArgTrp: 1.361 ± 0.311
2.168ArgTyr: 2.168 ± 0.396
0.0ArgXaa: 0.0 ± 0.0
Ser
5.949SerAla: 5.949 ± 0.631
0.252SerCys: 0.252 ± 0.141
3.227SerAsp: 3.227 ± 0.429
2.823SerGlu: 2.823 ± 0.418
1.613SerPhe: 1.613 ± 0.254
5.949SerGly: 5.949 ± 0.536
0.807SerHis: 0.807 ± 0.235
2.168SerIle: 2.168 ± 0.428
2.471SerLys: 2.471 ± 0.388
3.529SerLeu: 3.529 ± 0.335
1.059SerMet: 1.059 ± 0.241
1.664SerAsn: 1.664 ± 0.253
2.622SerPro: 2.622 ± 0.349
1.513SerGln: 1.513 ± 0.289
3.227SerArg: 3.227 ± 0.425
2.571SerSer: 2.571 ± 0.436
3.277SerThr: 3.277 ± 0.481
3.176SerVal: 3.176 ± 0.475
0.706SerTrp: 0.706 ± 0.157
1.109SerTyr: 1.109 ± 0.225
0.0SerXaa: 0.0 ± 0.0
Thr
6.706ThrAla: 6.706 ± 0.607
0.655ThrCys: 0.655 ± 0.266
3.076ThrAsp: 3.076 ± 0.454
3.076ThrGlu: 3.076 ± 0.383
1.815ThrPhe: 1.815 ± 0.294
5.344ThrGly: 5.344 ± 0.69
1.109ThrHis: 1.109 ± 0.229
3.227ThrIle: 3.227 ± 0.499
2.571ThrLys: 2.571 ± 0.404
3.58ThrLeu: 3.58 ± 0.392
1.21ThrMet: 1.21 ± 0.197
1.865ThrAsn: 1.865 ± 0.337
4.79ThrPro: 4.79 ± 0.558
2.319ThrGln: 2.319 ± 0.322
2.823ThrArg: 2.823 ± 0.444
2.471ThrSer: 2.471 ± 0.387
2.924ThrThr: 2.924 ± 0.334
4.134ThrVal: 4.134 ± 0.483
1.361ThrTrp: 1.361 ± 0.309
1.059ThrTyr: 1.059 ± 0.217
0.0ThrXaa: 0.0 ± 0.0
Val
6.857ValAla: 6.857 ± 0.51
0.504ValCys: 0.504 ± 0.199
4.134ValAsp: 4.134 ± 0.472
4.235ValGlu: 4.235 ± 0.378
1.513ValPhe: 1.513 ± 0.34
4.991ValGly: 4.991 ± 0.629
1.008ValHis: 1.008 ± 0.321
3.126ValIle: 3.126 ± 0.471
3.378ValLys: 3.378 ± 0.468
4.185ValLeu: 4.185 ± 0.365
1.311ValMet: 1.311 ± 0.257
2.017ValAsn: 2.017 ± 0.342
3.882ValPro: 3.882 ± 0.424
2.218ValGln: 2.218 ± 0.391
4.891ValArg: 4.891 ± 0.649
3.882ValSer: 3.882 ± 0.461
3.832ValThr: 3.832 ± 0.483
3.681ValVal: 3.681 ± 0.42
0.504ValTrp: 0.504 ± 0.182
1.714ValTyr: 1.714 ± 0.305
0.0ValXaa: 0.0 ± 0.0
Trp
1.563TrpAla: 1.563 ± 0.238
0.303TrpCys: 0.303 ± 0.157
1.008TrpAsp: 1.008 ± 0.343
0.655TrpGlu: 0.655 ± 0.164
0.655TrpPhe: 0.655 ± 0.146
0.857TrpGly: 0.857 ± 0.228
0.353TrpHis: 0.353 ± 0.147
1.059TrpIle: 1.059 ± 0.263
0.353TrpLys: 0.353 ± 0.102
1.966TrpLeu: 1.966 ± 0.354
0.403TrpMet: 0.403 ± 0.138
0.555TrpAsn: 0.555 ± 0.151
0.101TrpPro: 0.101 ± 0.078
0.756TrpGln: 0.756 ± 0.203
1.513TrpArg: 1.513 ± 0.214
0.908TrpSer: 0.908 ± 0.158
1.008TrpThr: 1.008 ± 0.18
0.555TrpVal: 0.555 ± 0.141
0.151TrpTrp: 0.151 ± 0.073
0.303TrpTyr: 0.303 ± 0.161
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.168TyrAla: 2.168 ± 0.265
0.353TyrCys: 0.353 ± 0.148
2.319TyrAsp: 2.319 ± 0.358
1.462TyrGlu: 1.462 ± 0.256
0.807TyrPhe: 0.807 ± 0.168
2.168TyrGly: 2.168 ± 0.32
0.353TyrHis: 0.353 ± 0.157
1.109TyrIle: 1.109 ± 0.172
0.807TyrLys: 0.807 ± 0.194
2.37TyrLeu: 2.37 ± 0.314
0.403TyrMet: 0.403 ± 0.118
0.857TyrAsn: 0.857 ± 0.202
1.21TyrPro: 1.21 ± 0.265
0.655TyrGln: 0.655 ± 0.172
1.865TyrArg: 1.865 ± 0.28
1.26TyrSer: 1.26 ± 0.309
1.311TyrThr: 1.311 ± 0.257
1.613TyrVal: 1.613 ± 0.283
0.252TyrTrp: 0.252 ± 0.186
0.605TyrTyr: 0.605 ± 0.147
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (19835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski