Amino acid dipepetide frequency for Bacteroidetes bacterium SCGC AAA795-G10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.27AlaAla: 3.27 ± 0.095
0.487AlaCys: 0.487 ± 0.034
2.516AlaAsp: 2.516 ± 0.077
2.805AlaGlu: 2.805 ± 0.081
2.771AlaPhe: 2.771 ± 0.073
3.542AlaGly: 3.542 ± 0.102
0.926AlaHis: 0.926 ± 0.042
4.705AlaIle: 4.705 ± 0.088
3.898AlaLys: 3.898 ± 0.096
5.122AlaLeu: 5.122 ± 0.098
1.116AlaMet: 1.116 ± 0.045
2.676AlaAsn: 2.676 ± 0.083
1.64AlaPro: 1.64 ± 0.055
1.774AlaGln: 1.774 ± 0.061
1.767AlaArg: 1.767 ± 0.054
4.054AlaSer: 4.054 ± 0.085
2.886AlaThr: 2.886 ± 0.116
2.973AlaVal: 2.973 ± 0.093
0.574AlaTrp: 0.574 ± 0.036
1.887AlaTyr: 1.887 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.38CysAla: 0.38 ± 0.027
0.12CysCys: 0.12 ± 0.013
0.435CysAsp: 0.435 ± 0.035
0.45CysGlu: 0.45 ± 0.03
0.494CysPhe: 0.494 ± 0.031
0.606CysGly: 0.606 ± 0.035
0.152CysHis: 0.152 ± 0.015
0.651CysIle: 0.651 ± 0.038
0.501CysLys: 0.501 ± 0.027
0.731CysLeu: 0.731 ± 0.038
0.15CysMet: 0.15 ± 0.014
0.452CysAsn: 0.452 ± 0.031
0.355CysPro: 0.355 ± 0.029
0.275CysGln: 0.275 ± 0.021
0.235CysArg: 0.235 ± 0.021
0.677CysSer: 0.677 ± 0.036
0.355CysThr: 0.355 ± 0.024
0.449CysVal: 0.449 ± 0.027
0.077CysTrp: 0.077 ± 0.011
0.28CysTyr: 0.28 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
2.643AspAla: 2.643 ± 0.089
0.347AspCys: 0.347 ± 0.026
2.761AspAsp: 2.761 ± 0.18
3.302AspGlu: 3.302 ± 0.081
3.507AspPhe: 3.507 ± 0.079
3.951AspGly: 3.951 ± 0.314
0.919AspHis: 0.919 ± 0.044
4.348AspIle: 4.348 ± 0.092
4.185AspLys: 4.185 ± 0.085
5.624AspLeu: 5.624 ± 0.114
0.948AspMet: 0.948 ± 0.04
3.299AspAsn: 3.299 ± 0.136
2.234AspPro: 2.234 ± 0.153
1.9AspGln: 1.9 ± 0.063
1.907AspArg: 1.907 ± 0.066
3.884AspSer: 3.884 ± 0.105
2.474AspThr: 2.474 ± 0.141
2.828AspVal: 2.828 ± 0.077
0.759AspTrp: 0.759 ± 0.037
2.626AspTyr: 2.626 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
3.317GluAla: 3.317 ± 0.096
0.347GluCys: 0.347 ± 0.027
2.952GluAsp: 2.952 ± 0.086
3.904GluGlu: 3.904 ± 0.093
2.925GluPhe: 2.925 ± 0.08
3.409GluGly: 3.409 ± 0.087
0.899GluHis: 0.899 ± 0.046
6.13GluIle: 6.13 ± 0.112
6.57GluLys: 6.57 ± 0.139
5.666GluLeu: 5.666 ± 0.118
1.361GluMet: 1.361 ± 0.053
4.895GluAsn: 4.895 ± 0.108
1.463GluPro: 1.463 ± 0.05
1.667GluGln: 1.667 ± 0.064
2.249GluArg: 2.249 ± 0.074
3.754GluSer: 3.754 ± 0.077
2.935GluThr: 2.935 ± 0.07
3.464GluVal: 3.464 ± 0.088
0.637GluTrp: 0.637 ± 0.04
2.151GluTyr: 2.151 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
2.486PheAla: 2.486 ± 0.062
0.479PheCys: 0.479 ± 0.028
3.482PheAsp: 3.482 ± 0.087
3.479PheGlu: 3.479 ± 0.079
3.589PhePhe: 3.589 ± 0.114
3.656PheGly: 3.656 ± 0.094
0.836PheHis: 0.836 ± 0.04
4.582PheIle: 4.582 ± 0.104
4.139PheLys: 4.139 ± 0.1
5.397PheLeu: 5.397 ± 0.139
1.056PheMet: 1.056 ± 0.04
3.799PheAsn: 3.799 ± 0.111
1.882PhePro: 1.882 ± 0.065
1.759PheGln: 1.759 ± 0.059
1.839PheArg: 1.839 ± 0.054
4.787PheSer: 4.787 ± 0.092
2.678PheThr: 2.678 ± 0.078
2.84PheVal: 2.84 ± 0.072
0.696PheTrp: 0.696 ± 0.039
2.306PheTyr: 2.306 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
3.696GlyAla: 3.696 ± 0.106
0.622GlyCys: 0.622 ± 0.035
3.424GlyAsp: 3.424 ± 0.142
3.319GlyGlu: 3.319 ± 0.069
3.682GlyPhe: 3.682 ± 0.081
4.929GlyGly: 4.929 ± 0.184
1.15GlyHis: 1.15 ± 0.055
6.177GlyIle: 6.177 ± 0.121
5.074GlyLys: 5.074 ± 0.095
6.026GlyLeu: 6.026 ± 0.111
1.46GlyMet: 1.46 ± 0.046
3.786GlyAsn: 3.786 ± 0.118
1.653GlyPro: 1.653 ± 0.056
1.824GlyGln: 1.824 ± 0.064
2.124GlyArg: 2.124 ± 0.066
4.65GlySer: 4.65 ± 0.14
3.682GlyThr: 3.682 ± 0.137
4.211GlyVal: 4.211 ± 0.095
0.819GlyTrp: 0.819 ± 0.039
2.678GlyTyr: 2.678 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
0.741HisAla: 0.741 ± 0.039
0.135HisCys: 0.135 ± 0.016
0.722HisAsp: 0.722 ± 0.036
0.823HisGlu: 0.823 ± 0.037
1.085HisPhe: 1.085 ± 0.045
1.019HisGly: 1.019 ± 0.051
0.42HisHis: 0.42 ± 0.03
1.295HisIle: 1.295 ± 0.051
1.245HisLys: 1.245 ± 0.051
1.677HisLeu: 1.677 ± 0.061
0.309HisMet: 0.309 ± 0.023
0.941HisAsn: 0.941 ± 0.039
0.916HisPro: 0.916 ± 0.04
0.544HisGln: 0.544 ± 0.035
0.669HisArg: 0.669 ± 0.035
1.101HisSer: 1.101 ± 0.044
0.716HisThr: 0.716 ± 0.037
0.813HisVal: 0.813 ± 0.038
0.229HisTrp: 0.229 ± 0.022
0.756HisTyr: 0.756 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
4.752IleAla: 4.752 ± 0.102
0.778IleCys: 0.778 ± 0.043
5.421IleAsp: 5.421 ± 0.096
5.863IleGlu: 5.863 ± 0.112
4.797IlePhe: 4.797 ± 0.126
5.534IleGly: 5.534 ± 0.118
1.348IleHis: 1.348 ± 0.058
7.663IleIle: 7.663 ± 0.171
7.426IleLys: 7.426 ± 0.156
8.568IleLeu: 8.568 ± 0.168
1.455IleMet: 1.455 ± 0.052
5.893IleAsn: 5.893 ± 0.107
3.786IlePro: 3.786 ± 0.088
2.775IleGln: 2.775 ± 0.078
2.947IleArg: 2.947 ± 0.076
7.592IleSer: 7.592 ± 0.13
4.356IleThr: 4.356 ± 0.112
4.637IleVal: 4.637 ± 0.096
0.818IleTrp: 0.818 ± 0.039
3.145IleTyr: 3.145 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
3.961LysAla: 3.961 ± 0.094
0.439LysCys: 0.439 ± 0.028
4.104LysAsp: 4.104 ± 0.085
5.761LysGlu: 5.761 ± 0.13
3.53LysPhe: 3.53 ± 0.094
4.778LysGly: 4.778 ± 0.101
1.166LysHis: 1.166 ± 0.042
8.706LysIle: 8.706 ± 0.183
9.45LysLys: 9.45 ± 0.221
7.408LysLeu: 7.408 ± 0.147
1.915LysMet: 1.915 ± 0.062
6.976LysAsn: 6.976 ± 0.147
2.348LysPro: 2.348 ± 0.071
2.411LysGln: 2.411 ± 0.068
3.115LysArg: 3.115 ± 0.076
5.96LysSer: 5.96 ± 0.122
4.73LysThr: 4.73 ± 0.087
4.428LysVal: 4.428 ± 0.094
0.964LysTrp: 0.964 ± 0.039
3.162LysTyr: 3.162 ± 0.083
0.0LysXaa: 0.0 ± 0.0
Leu
4.885LeuAla: 4.885 ± 0.096
0.764LeuCys: 0.764 ± 0.039
5.214LeuAsp: 5.214 ± 0.116
5.92LeuGlu: 5.92 ± 0.123
5.282LeuPhe: 5.282 ± 0.128
6.12LeuGly: 6.12 ± 0.108
1.433LeuHis: 1.433 ± 0.058
8.741LeuIle: 8.741 ± 0.193
8.586LeuLys: 8.586 ± 0.191
8.276LeuLeu: 8.276 ± 0.174
2.034LeuMet: 2.034 ± 0.068
6.844LeuAsn: 6.844 ± 0.115
3.617LeuPro: 3.617 ± 0.09
2.439LeuGln: 2.439 ± 0.072
3.223LeuArg: 3.223 ± 0.079
7.598LeuSer: 7.598 ± 0.127
4.717LeuThr: 4.717 ± 0.091
4.989LeuVal: 4.989 ± 0.102
0.854LeuTrp: 0.854 ± 0.04
3.107LeuTyr: 3.107 ± 0.079
0.002LeuXaa: 0.002 ± 0.002
Met
1.251MetAla: 1.251 ± 0.047
0.137MetCys: 0.137 ± 0.017
1.023MetAsp: 1.023 ± 0.04
1.233MetGlu: 1.233 ± 0.048
0.941MetPhe: 0.941 ± 0.066
1.462MetGly: 1.462 ± 0.053
0.317MetHis: 0.317 ± 0.026
1.762MetIle: 1.762 ± 0.066
1.982MetLys: 1.982 ± 0.069
1.653MetLeu: 1.653 ± 0.059
0.492MetMet: 0.492 ± 0.027
1.281MetAsn: 1.281 ± 0.046
0.699MetPro: 0.699 ± 0.031
0.619MetGln: 0.619 ± 0.031
0.854MetArg: 0.854 ± 0.034
1.453MetSer: 1.453 ± 0.049
1.086MetThr: 1.086 ± 0.045
1.071MetVal: 1.071 ± 0.045
0.204MetTrp: 0.204 ± 0.02
0.602MetTyr: 0.602 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.053AsnAla: 3.053 ± 0.073
0.549AsnCys: 0.549 ± 0.033
3.642AsnAsp: 3.642 ± 0.127
3.963AsnGlu: 3.963 ± 0.091
3.949AsnPhe: 3.949 ± 0.101
3.889AsnGly: 3.889 ± 0.116
1.108AsnHis: 1.108 ± 0.042
5.781AsnIle: 5.781 ± 0.103
5.499AsnLys: 5.499 ± 0.11
6.579AsnLeu: 6.579 ± 0.117
1.313AsnMet: 1.313 ± 0.057
4.353AsnAsn: 4.353 ± 0.114
2.968AsnPro: 2.968 ± 0.077
2.731AsnGln: 2.731 ± 0.088
2.389AsnArg: 2.389 ± 0.065
5.134AsnSer: 5.134 ± 0.104
3.292AsnThr: 3.292 ± 0.102
3.207AsnVal: 3.207 ± 0.074
0.918AsnTrp: 0.918 ± 0.05
3.048AsnTyr: 3.048 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
1.562ProAla: 1.562 ± 0.054
0.202ProCys: 0.202 ± 0.021
2.164ProAsp: 2.164 ± 0.119
2.458ProGlu: 2.458 ± 0.069
1.99ProPhe: 1.99 ± 0.063
2.069ProGly: 2.069 ± 0.064
0.624ProHis: 0.624 ± 0.032
3.15ProIle: 3.15 ± 0.076
2.962ProLys: 2.962 ± 0.075
3.242ProLeu: 3.242 ± 0.068
0.692ProMet: 0.692 ± 0.033
2.608ProAsn: 2.608 ± 0.069
1.003ProPro: 1.003 ± 0.05
0.933ProGln: 0.933 ± 0.043
1.036ProArg: 1.036 ± 0.042
2.583ProSer: 2.583 ± 0.069
1.844ProThr: 1.844 ± 0.077
2.069ProVal: 2.069 ± 0.059
0.404ProTrp: 0.404 ± 0.032
1.54ProTyr: 1.54 ± 0.047
0.002ProXaa: 0.002 ± 0.002
Gln
1.578GlnAla: 1.578 ± 0.054
0.137GlnCys: 0.137 ± 0.016
1.495GlnAsp: 1.495 ± 0.07
1.827GlnGlu: 1.827 ± 0.062
1.632GlnPhe: 1.632 ± 0.061
1.79GlnGly: 1.79 ± 0.056
0.435GlnHis: 0.435 ± 0.028
3.04GlnIle: 3.04 ± 0.075
2.988GlnLys: 2.988 ± 0.086
2.92GlnLeu: 2.92 ± 0.064
0.803GlnMet: 0.803 ± 0.04
2.451GlnAsn: 2.451 ± 0.072
0.873GlnPro: 0.873 ± 0.038
0.993GlnGln: 0.993 ± 0.048
1.225GlnArg: 1.225 ± 0.047
1.965GlnSer: 1.965 ± 0.068
1.587GlnThr: 1.587 ± 0.052
1.692GlnVal: 1.692 ± 0.058
0.4GlnTrp: 0.4 ± 0.025
1.131GlnTyr: 1.131 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
1.875ArgAla: 1.875 ± 0.056
0.197ArgCys: 0.197 ± 0.019
1.809ArgAsp: 1.809 ± 0.068
2.099ArgGlu: 2.099 ± 0.058
1.974ArgPhe: 1.974 ± 0.058
2.161ArgGly: 2.161 ± 0.067
0.579ArgHis: 0.579 ± 0.032
3.212ArgIle: 3.212 ± 0.069
3.035ArgLys: 3.035 ± 0.082
3.41ArgLeu: 3.41 ± 0.069
0.813ArgMet: 0.813 ± 0.037
2.256ArgAsn: 2.256 ± 0.065
1.113ArgPro: 1.113 ± 0.04
0.976ArgGln: 0.976 ± 0.041
1.32ArgArg: 1.32 ± 0.045
2.338ArgSer: 2.338 ± 0.071
1.592ArgThr: 1.592 ± 0.049
2.111ArgVal: 2.111 ± 0.059
0.445ArgTrp: 0.445 ± 0.026
1.617ArgTyr: 1.617 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.532SerAla: 3.532 ± 0.09
0.761SerCys: 0.761 ± 0.037
4.046SerAsp: 4.046 ± 0.137
4.602SerGlu: 4.602 ± 0.097
4.497SerPhe: 4.497 ± 0.097
5.329SerGly: 5.329 ± 0.159
1.166SerHis: 1.166 ± 0.045
6.729SerIle: 6.729 ± 0.115
6.357SerLys: 6.357 ± 0.121
7.49SerLeu: 7.49 ± 0.142
1.373SerMet: 1.373 ± 0.055
5.072SerAsn: 5.072 ± 0.113
2.478SerPro: 2.478 ± 0.075
2.429SerGln: 2.429 ± 0.066
2.423SerArg: 2.423 ± 0.062
5.546SerSer: 5.546 ± 0.147
3.482SerThr: 3.482 ± 0.09
3.874SerVal: 3.874 ± 0.093
0.909SerTrp: 0.909 ± 0.049
2.967SerTyr: 2.967 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
2.833ThrAla: 2.833 ± 0.114
0.334ThrCys: 0.334 ± 0.022
2.896ThrAsp: 2.896 ± 0.18
2.645ThrGlu: 2.645 ± 0.076
2.893ThrPhe: 2.893 ± 0.084
3.651ThrGly: 3.651 ± 0.091
0.864ThrHis: 0.864 ± 0.041
4.502ThrIle: 4.502 ± 0.11
3.547ThrLys: 3.547 ± 0.079
4.994ThrLeu: 4.994 ± 0.105
0.784ThrMet: 0.784 ± 0.037
3.042ThrAsn: 3.042 ± 0.094
2.369ThrPro: 2.369 ± 0.069
1.612ThrGln: 1.612 ± 0.06
1.585ThrArg: 1.585 ± 0.05
3.946ThrSer: 3.946 ± 0.151
2.751ThrThr: 2.751 ± 0.102
2.821ThrVal: 2.821 ± 0.112
0.514ThrTrp: 0.514 ± 0.038
2.066ThrTyr: 2.066 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
3.09ValAla: 3.09 ± 0.083
0.521ValCys: 0.521 ± 0.029
3.122ValAsp: 3.122 ± 0.073
3.314ValGlu: 3.314 ± 0.084
3.042ValPhe: 3.042 ± 0.073
3.657ValGly: 3.657 ± 0.087
0.811ValHis: 0.811 ± 0.041
4.692ValIle: 4.692 ± 0.1
3.976ValLys: 3.976 ± 0.079
4.969ValLeu: 4.969 ± 0.122
1.069ValMet: 1.069 ± 0.046
3.349ValAsn: 3.349 ± 0.083
1.882ValPro: 1.882 ± 0.06
1.495ValGln: 1.495 ± 0.051
1.939ValArg: 1.939 ± 0.064
4.421ValSer: 4.421 ± 0.102
3.03ValThr: 3.03 ± 0.157
3.369ValVal: 3.369 ± 0.09
0.582ValTrp: 0.582 ± 0.032
2.031ValTyr: 2.031 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.602TrpAla: 0.602 ± 0.034
0.112TrpCys: 0.112 ± 0.015
0.879TrpAsp: 0.879 ± 0.059
0.722TrpGlu: 0.722 ± 0.035
0.572TrpPhe: 0.572 ± 0.035
0.767TrpGly: 0.767 ± 0.034
0.247TrpHis: 0.247 ± 0.019
0.953TrpIle: 0.953 ± 0.044
0.901TrpLys: 0.901 ± 0.042
0.959TrpLeu: 0.959 ± 0.039
0.302TrpMet: 0.302 ± 0.022
0.848TrpAsn: 0.848 ± 0.042
0.262TrpPro: 0.262 ± 0.024
0.38TrpGln: 0.38 ± 0.027
0.482TrpArg: 0.482 ± 0.029
0.669TrpSer: 0.669 ± 0.033
0.584TrpThr: 0.584 ± 0.033
0.654TrpVal: 0.654 ± 0.037
0.167TrpTrp: 0.167 ± 0.018
0.39TrpTyr: 0.39 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.882TyrAla: 1.882 ± 0.065
0.36TyrCys: 0.36 ± 0.025
2.338TyrAsp: 2.338 ± 0.07
2.207TyrGlu: 2.207 ± 0.067
2.614TyrPhe: 2.614 ± 0.077
2.666TyrGly: 2.666 ± 0.08
0.752TyrHis: 0.752 ± 0.038
2.735TyrIle: 2.735 ± 0.078
2.993TyrLys: 2.993 ± 0.074
3.934TyrLeu: 3.934 ± 0.093
0.676TyrMet: 0.676 ± 0.034
2.546TyrAsn: 2.546 ± 0.063
1.593TyrPro: 1.593 ± 0.051
1.427TyrGln: 1.427 ± 0.052
1.602TyrArg: 1.602 ± 0.049
2.948TyrSer: 2.948 ± 0.076
1.87TyrThr: 1.87 ± 0.057
1.86TyrVal: 1.86 ± 0.059
0.484TyrTrp: 0.484 ± 0.031
1.693TyrTyr: 1.693 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.002XaaGlu: 0.002 ± 0.002
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.002XaaMet: 0.002 ± 0.002
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.003
Statistics based on 1767 proteins (599355 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski