Amino acid dipepetide frequency for Alteribacillus bidgolensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.272AlaAla: 7.272 ± 0.098
0.717AlaCys: 0.717 ± 0.026
3.737AlaAsp: 3.737 ± 0.063
5.459AlaGlu: 5.459 ± 0.114
3.464AlaPhe: 3.464 ± 0.057
6.076AlaGly: 6.076 ± 0.086
1.336AlaHis: 1.336 ± 0.031
5.122AlaIle: 5.122 ± 0.07
4.118AlaLys: 4.118 ± 0.061
7.138AlaLeu: 7.138 ± 0.08
2.023AlaMet: 2.023 ± 0.042
2.588AlaAsn: 2.588 ± 0.046
2.205AlaPro: 2.205 ± 0.044
2.107AlaGln: 2.107 ± 0.045
2.642AlaArg: 2.642 ± 0.049
4.371AlaSer: 4.371 ± 0.062
2.904AlaThr: 2.904 ± 0.046
6.134AlaVal: 6.134 ± 0.073
0.652AlaTrp: 0.652 ± 0.024
2.238AlaTyr: 2.238 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.501CysAla: 0.501 ± 0.022
0.112CysCys: 0.112 ± 0.01
0.377CysAsp: 0.377 ± 0.019
0.445CysGlu: 0.445 ± 0.018
0.37CysPhe: 0.37 ± 0.019
0.703CysGly: 0.703 ± 0.023
0.194CysHis: 0.194 ± 0.013
0.541CysIle: 0.541 ± 0.021
0.37CysLys: 0.37 ± 0.016
0.682CysLeu: 0.682 ± 0.024
0.199CysMet: 0.199 ± 0.011
0.304CysAsn: 0.304 ± 0.017
0.362CysPro: 0.362 ± 0.018
0.238CysGln: 0.238 ± 0.013
0.313CysArg: 0.313 ± 0.017
0.521CysSer: 0.521 ± 0.021
0.404CysThr: 0.404 ± 0.018
0.409CysVal: 0.409 ± 0.019
0.084CysTrp: 0.084 ± 0.009
0.254CysTyr: 0.254 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.166AspAla: 3.166 ± 0.063
0.343AspCys: 0.343 ± 0.017
2.481AspAsp: 2.481 ± 0.051
4.343AspGlu: 4.343 ± 0.082
2.238AspPhe: 2.238 ± 0.04
3.338AspGly: 3.338 ± 0.056
1.282AspHis: 1.282 ± 0.031
4.328AspIle: 4.328 ± 0.06
3.211AspLys: 3.211 ± 0.058
4.818AspLeu: 4.818 ± 0.067
1.511AspMet: 1.511 ± 0.032
2.06AspAsn: 2.06 ± 0.042
2.119AspPro: 2.119 ± 0.044
1.915AspGln: 1.915 ± 0.041
2.144AspArg: 2.144 ± 0.044
2.616AspSer: 2.616 ± 0.05
2.632AspThr: 2.632 ± 0.046
3.806AspVal: 3.806 ± 0.054
0.684AspTrp: 0.684 ± 0.02
2.061AspTyr: 2.061 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.11GluAla: 6.11 ± 0.109
0.456GluCys: 0.456 ± 0.021
4.504GluAsp: 4.504 ± 0.083
8.958GluGlu: 8.958 ± 0.144
2.41GluPhe: 2.41 ± 0.05
4.85GluGly: 4.85 ± 0.079
1.67GluHis: 1.67 ± 0.033
5.162GluIle: 5.162 ± 0.076
7.191GluLys: 7.191 ± 0.102
6.795GluLeu: 6.795 ± 0.082
2.449GluMet: 2.449 ± 0.046
4.253GluAsn: 4.253 ± 0.071
2.181GluPro: 2.181 ± 0.048
3.472GluGln: 3.472 ± 0.068
3.639GluArg: 3.639 ± 0.059
3.75GluSer: 3.75 ± 0.062
4.458GluThr: 4.458 ± 0.069
5.135GluVal: 5.135 ± 0.08
0.946GluTrp: 0.946 ± 0.027
2.23GluTyr: 2.23 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
2.957PheAla: 2.957 ± 0.062
0.366PheCys: 0.366 ± 0.016
2.299PheAsp: 2.299 ± 0.045
2.863PheGlu: 2.863 ± 0.048
2.512PhePhe: 2.512 ± 0.057
3.266PheGly: 3.266 ± 0.06
1.135PheHis: 1.135 ± 0.033
3.859PheIle: 3.859 ± 0.075
2.081PheLys: 2.081 ± 0.045
4.616PheLeu: 4.616 ± 0.084
1.271PheMet: 1.271 ± 0.035
1.78PheAsn: 1.78 ± 0.041
1.814PhePro: 1.814 ± 0.039
1.634PheGln: 1.634 ± 0.041
1.614PheArg: 1.614 ± 0.037
3.287PheSer: 3.287 ± 0.057
2.63PheThr: 2.63 ± 0.048
2.949PheVal: 2.949 ± 0.054
0.478PheTrp: 0.478 ± 0.023
1.741PheTyr: 1.741 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
5.284GlyAla: 5.284 ± 0.078
0.615GlyCys: 0.615 ± 0.023
3.202GlyAsp: 3.202 ± 0.057
5.038GlyGlu: 5.038 ± 0.076
3.378GlyPhe: 3.378 ± 0.053
5.142GlyGly: 5.142 ± 0.078
1.43GlyHis: 1.43 ± 0.033
5.792GlyIle: 5.792 ± 0.077
4.695GlyLys: 4.695 ± 0.063
6.517GlyLeu: 6.517 ± 0.087
2.323GlyMet: 2.323 ± 0.044
2.714GlyAsn: 2.714 ± 0.051
2.032GlyPro: 2.032 ± 0.043
2.2GlyGln: 2.2 ± 0.043
2.753GlyArg: 2.753 ± 0.048
4.229GlySer: 4.229 ± 0.067
4.031GlyThr: 4.031 ± 0.057
5.15GlyVal: 5.15 ± 0.065
0.836GlyTrp: 0.836 ± 0.029
2.703GlyTyr: 2.703 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.396HisAla: 1.396 ± 0.039
0.215HisCys: 0.215 ± 0.016
1.04HisAsp: 1.04 ± 0.029
1.441HisGlu: 1.441 ± 0.033
1.118HisPhe: 1.118 ± 0.03
1.543HisGly: 1.543 ± 0.034
0.714HisHis: 0.714 ± 0.024
1.614HisIle: 1.614 ± 0.032
1.102HisLys: 1.102 ± 0.03
2.315HisLeu: 2.315 ± 0.043
0.596HisMet: 0.596 ± 0.022
0.829HisAsn: 0.829 ± 0.027
1.273HisPro: 1.273 ± 0.036
0.902HisGln: 0.902 ± 0.025
0.917HisArg: 0.917 ± 0.031
1.41HisSer: 1.41 ± 0.034
1.143HisThr: 1.143 ± 0.031
1.436HisVal: 1.436 ± 0.035
0.278HisTrp: 0.278 ± 0.014
0.955HisTyr: 0.955 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.756IleAla: 5.756 ± 0.083
0.626IleCys: 0.626 ± 0.024
4.096IleAsp: 4.096 ± 0.064
5.452IleGlu: 5.452 ± 0.073
3.317IlePhe: 3.317 ± 0.069
5.881IleGly: 5.881 ± 0.077
1.658IleHis: 1.658 ± 0.04
5.643IleIle: 5.643 ± 0.087
4.217IleLys: 4.217 ± 0.068
6.546IleLeu: 6.546 ± 0.087
1.738IleMet: 1.738 ± 0.042
3.321IleAsn: 3.321 ± 0.055
3.305IlePro: 3.305 ± 0.049
2.663IleGln: 2.663 ± 0.047
2.9IleArg: 2.9 ± 0.051
4.821IleSer: 4.821 ± 0.071
4.324IleThr: 4.324 ± 0.061
5.002IleVal: 5.002 ± 0.065
0.664IleTrp: 0.664 ± 0.026
2.286IleTyr: 2.286 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.616LysAla: 4.616 ± 0.067
0.321LysCys: 0.321 ± 0.016
3.67LysAsp: 3.67 ± 0.056
7.483LysGlu: 7.483 ± 0.091
1.527LysPhe: 1.527 ± 0.037
4.374LysGly: 4.374 ± 0.06
1.462LysHis: 1.462 ± 0.035
3.961LysIle: 3.961 ± 0.056
6.205LysLys: 6.205 ± 0.086
4.951LysLeu: 4.951 ± 0.073
2.127LysMet: 2.127 ± 0.04
3.467LysAsn: 3.467 ± 0.05
2.252LysPro: 2.252 ± 0.046
3.116LysGln: 3.116 ± 0.049
3.276LysArg: 3.276 ± 0.044
3.218LysSer: 3.218 ± 0.053
3.637LysThr: 3.637 ± 0.057
4.221LysVal: 4.221 ± 0.065
0.792LysTrp: 0.792 ± 0.024
1.933LysTyr: 1.933 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
6.873LeuAla: 6.873 ± 0.086
0.667LeuCys: 0.667 ± 0.023
4.572LeuAsp: 4.572 ± 0.062
7.002LeuGlu: 7.002 ± 0.084
4.815LeuPhe: 4.815 ± 0.084
6.301LeuGly: 6.301 ± 0.073
2.173LeuHis: 2.173 ± 0.041
6.764LeuIle: 6.764 ± 0.085
6.085LeuLys: 6.085 ± 0.08
9.63LeuLeu: 9.63 ± 0.115
2.435LeuMet: 2.435 ± 0.044
4.038LeuAsn: 4.038 ± 0.049
3.999LeuPro: 3.999 ± 0.057
3.691LeuGln: 3.691 ± 0.064
3.598LeuArg: 3.598 ± 0.056
6.537LeuSer: 6.537 ± 0.078
5.47LeuThr: 5.47 ± 0.067
5.618LeuVal: 5.618 ± 0.077
0.835LeuTrp: 0.835 ± 0.028
3.031LeuTyr: 3.031 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.204MetAla: 2.204 ± 0.044
0.163MetCys: 0.163 ± 0.012
1.495MetAsp: 1.495 ± 0.033
2.313MetGlu: 2.313 ± 0.048
1.142MetPhe: 1.142 ± 0.025
1.891MetGly: 1.891 ± 0.046
0.493MetHis: 0.493 ± 0.021
2.064MetIle: 2.064 ± 0.042
2.488MetLys: 2.488 ± 0.043
2.575MetLeu: 2.575 ± 0.047
0.895MetMet: 0.895 ± 0.028
1.649MetAsn: 1.649 ± 0.036
1.04MetPro: 1.04 ± 0.03
0.931MetGln: 0.931 ± 0.028
1.006MetArg: 1.006 ± 0.029
1.726MetSer: 1.726 ± 0.035
1.706MetThr: 1.706 ± 0.039
1.829MetVal: 1.829 ± 0.042
0.217MetTrp: 0.217 ± 0.011
0.779MetTyr: 0.779 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.796AsnAla: 2.796 ± 0.046
0.281AsnCys: 0.281 ± 0.014
2.328AsnAsp: 2.328 ± 0.047
3.715AsnGlu: 3.715 ± 0.063
1.543AsnPhe: 1.543 ± 0.036
3.29AsnGly: 3.29 ± 0.061
1.123AsnHis: 1.123 ± 0.03
3.599AsnIle: 3.599 ± 0.058
3.183AsnLys: 3.183 ± 0.053
3.505AsnLeu: 3.505 ± 0.059
1.288AsnMet: 1.288 ± 0.033
2.334AsnAsn: 2.334 ± 0.043
2.031AsnPro: 2.031 ± 0.042
1.914AsnGln: 1.914 ± 0.039
1.993AsnArg: 1.993 ± 0.045
2.136AsnSer: 2.136 ± 0.039
2.313AsnThr: 2.313 ± 0.047
3.133AsnVal: 3.133 ± 0.051
0.526AsnTrp: 0.526 ± 0.023
1.482AsnTyr: 1.482 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
2.65ProAla: 2.65 ± 0.046
0.243ProCys: 0.243 ± 0.013
2.269ProAsp: 2.269 ± 0.043
3.453ProGlu: 3.453 ± 0.06
2.065ProPhe: 2.065 ± 0.039
2.66ProGly: 2.66 ± 0.048
0.876ProHis: 0.876 ± 0.029
2.61ProIle: 2.61 ± 0.044
2.008ProLys: 2.008 ± 0.04
3.718ProLeu: 3.718 ± 0.05
0.931ProMet: 0.931 ± 0.03
1.581ProAsn: 1.581 ± 0.035
1.278ProPro: 1.278 ± 0.033
1.045ProGln: 1.045 ± 0.028
1.213ProArg: 1.213 ± 0.032
2.531ProSer: 2.531 ± 0.05
1.697ProThr: 1.697 ± 0.039
3.107ProVal: 3.107 ± 0.049
0.438ProTrp: 0.438 ± 0.021
1.455ProTyr: 1.455 ± 0.034
0.001ProXaa: 0.001 ± 0.001
Gln
2.786GlnAla: 2.786 ± 0.048
0.224GlnCys: 0.224 ± 0.014
1.629GlnAsp: 1.629 ± 0.037
3.146GlnGlu: 3.146 ± 0.059
1.478GlnPhe: 1.478 ± 0.033
2.16GlnGly: 2.16 ± 0.045
0.814GlnHis: 0.814 ± 0.027
2.302GlnIle: 2.302 ± 0.043
2.732GlnLys: 2.732 ± 0.046
3.648GlnLeu: 3.648 ± 0.066
1.122GlnMet: 1.122 ± 0.031
1.618GlnAsn: 1.618 ± 0.037
1.289GlnPro: 1.289 ± 0.033
1.799GlnGln: 1.799 ± 0.052
1.512GlnArg: 1.512 ± 0.04
2.197GlnSer: 2.197 ± 0.043
2.172GlnThr: 2.172 ± 0.045
2.294GlnVal: 2.294 ± 0.043
0.505GlnTrp: 0.505 ± 0.018
1.246GlnTyr: 1.246 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
2.442ArgAla: 2.442 ± 0.049
0.274ArgCys: 0.274 ± 0.015
1.991ArgAsp: 1.991 ± 0.044
3.24ArgGlu: 3.24 ± 0.053
1.975ArgPhe: 1.975 ± 0.039
2.318ArgGly: 2.318 ± 0.043
0.868ArgHis: 0.868 ± 0.024
2.868ArgIle: 2.868 ± 0.049
3.219ArgLys: 3.219 ± 0.055
3.922ArgLeu: 3.922 ± 0.056
1.262ArgMet: 1.262 ± 0.03
1.849ArgAsn: 1.849 ± 0.036
1.403ArgPro: 1.403 ± 0.035
1.539ArgGln: 1.539 ± 0.037
1.906ArgArg: 1.906 ± 0.041
2.458ArgSer: 2.458 ± 0.042
2.119ArgThr: 2.119 ± 0.043
2.553ArgVal: 2.553 ± 0.048
0.419ArgTrp: 0.419 ± 0.018
1.567ArgTyr: 1.567 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.053SerAla: 4.053 ± 0.062
0.426SerCys: 0.426 ± 0.019
2.835SerAsp: 2.835 ± 0.049
4.13SerGlu: 4.13 ± 0.063
3.433SerPhe: 3.433 ± 0.055
4.482SerGly: 4.482 ± 0.065
1.302SerHis: 1.302 ± 0.035
4.907SerIle: 4.907 ± 0.062
3.451SerLys: 3.451 ± 0.059
6.166SerLeu: 6.166 ± 0.083
1.85SerMet: 1.85 ± 0.039
2.507SerAsn: 2.507 ± 0.044
2.324SerPro: 2.324 ± 0.043
2.0SerGln: 2.0 ± 0.045
2.403SerArg: 2.403 ± 0.043
4.413SerSer: 4.413 ± 0.068
3.128SerThr: 3.128 ± 0.056
4.129SerVal: 4.129 ± 0.062
0.707SerTrp: 0.707 ± 0.025
2.238SerTyr: 2.238 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.368ThrAla: 4.368 ± 0.059
0.361ThrCys: 0.361 ± 0.017
2.681ThrAsp: 2.681 ± 0.055
3.853ThrGlu: 3.853 ± 0.065
2.747ThrPhe: 2.747 ± 0.051
4.449ThrGly: 4.449 ± 0.061
1.069ThrHis: 1.069 ± 0.026
4.237ThrIle: 4.237 ± 0.055
3.027ThrLys: 3.027 ± 0.046
5.24ThrLeu: 5.24 ± 0.07
1.382ThrMet: 1.382 ± 0.032
2.414ThrAsn: 2.414 ± 0.045
2.353ThrPro: 2.353 ± 0.044
1.301ThrGln: 1.301 ± 0.031
1.822ThrArg: 1.822 ± 0.04
3.409ThrSer: 3.409 ± 0.053
2.823ThrThr: 2.823 ± 0.052
4.091ThrVal: 4.091 ± 0.051
0.593ThrTrp: 0.593 ± 0.023
1.809ThrTyr: 1.809 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
4.381ValAla: 4.381 ± 0.074
0.623ValCys: 0.623 ± 0.024
3.537ValAsp: 3.537 ± 0.063
4.906ValGlu: 4.906 ± 0.082
3.336ValPhe: 3.336 ± 0.057
4.152ValGly: 4.152 ± 0.061
1.533ValHis: 1.533 ± 0.034
5.573ValIle: 5.573 ± 0.073
4.34ValLys: 4.34 ± 0.063
6.926ValLeu: 6.926 ± 0.074
1.991ValMet: 1.991 ± 0.044
3.129ValAsn: 3.129 ± 0.05
2.786ValPro: 2.786 ± 0.048
2.422ValGln: 2.422 ± 0.049
2.623ValArg: 2.623 ± 0.044
4.598ValSer: 4.598 ± 0.055
4.126ValThr: 4.126 ± 0.065
4.811ValVal: 4.811 ± 0.064
0.668ValTrp: 0.668 ± 0.023
2.202ValTyr: 2.202 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.622TrpAla: 0.622 ± 0.026
0.079TrpCys: 0.079 ± 0.008
0.522TrpAsp: 0.522 ± 0.022
0.824TrpGlu: 0.824 ± 0.029
0.513TrpPhe: 0.513 ± 0.02
0.727TrpGly: 0.727 ± 0.025
0.235TrpHis: 0.235 ± 0.015
0.861TrpIle: 0.861 ± 0.029
0.884TrpLys: 0.884 ± 0.03
1.17TrpLeu: 1.17 ± 0.031
0.382TrpMet: 0.382 ± 0.019
0.595TrpAsn: 0.595 ± 0.026
0.345TrpPro: 0.345 ± 0.017
0.408TrpGln: 0.408 ± 0.017
0.393TrpArg: 0.393 ± 0.019
0.58TrpSer: 0.58 ± 0.022
0.542TrpThr: 0.542 ± 0.02
0.698TrpVal: 0.698 ± 0.025
0.149TrpTrp: 0.149 ± 0.01
0.338TrpTyr: 0.338 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.07TyrAla: 2.07 ± 0.045
0.272TyrCys: 0.272 ± 0.015
1.837TyrAsp: 1.837 ± 0.039
2.554TyrGlu: 2.554 ± 0.05
1.77TyrPhe: 1.77 ± 0.042
2.459TyrGly: 2.459 ± 0.044
0.87TyrHis: 0.87 ± 0.03
2.408TyrIle: 2.408 ± 0.05
2.0TyrLys: 2.0 ± 0.04
3.259TyrLeu: 3.259 ± 0.061
0.831TyrMet: 0.831 ± 0.022
1.482TyrAsn: 1.482 ± 0.037
1.437TyrPro: 1.437 ± 0.032
1.376TyrGln: 1.376 ± 0.036
1.522TyrArg: 1.522 ± 0.04
2.073TyrSer: 2.073 ± 0.04
1.769TyrThr: 1.769 ± 0.035
2.158TyrVal: 2.158 ± 0.04
0.399TyrTrp: 0.399 ± 0.016
1.383TyrTyr: 1.383 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.001
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.01XaaXaa: 0.01 ± 0.01
Statistics based on 4578 proteins (1244654 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski