Amino acid dipepetide frequency for Defluviitalea raffinosedens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.151AlaAla: 5.151 ± 0.101	0.729AlaCys: 0.729 ± 0.031	3.091AlaAsp: 3.091 ± 0.068	4.373AlaGlu: 4.373 ± 0.079	2.7AlaPhe: 2.7 ± 0.06	4.485AlaGly: 4.485 ± 0.094	1.037AlaHis: 1.037 ± 0.036	5.748AlaIle: 5.748 ± 0.084	5.147AlaLys: 5.147 ± 0.077	6.584AlaLeu: 6.584 ± 0.099	1.924AlaMet: 1.924 ± 0.05	2.528AlaAsn: 2.528 ± 0.053	1.677AlaPro: 1.677 ± 0.047	2.159AlaGln: 2.159 ± 0.052	2.354AlaArg: 2.354 ± 0.053	3.643AlaSer: 3.643 ± 0.062	2.886AlaThr: 2.886 ± 0.068	4.992AlaVal: 4.992 ± 0.096	0.499AlaTrp: 0.499 ± 0.024	2.361AlaTyr: 2.361 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.591CysAla: 0.591 ± 0.03	0.171CysCys: 0.171 ± 0.016	0.531CysAsp: 0.531 ± 0.028	0.634CysGlu: 0.634 ± 0.031	0.432CysPhe: 0.432 ± 0.021	0.942CysGly: 0.942 ± 0.035	0.196CysHis: 0.196 ± 0.015	0.947CysIle: 0.947 ± 0.033	0.685CysLys: 0.685 ± 0.029	0.824CysLeu: 0.824 ± 0.033	0.277CysMet: 0.277 ± 0.02	0.54CysAsn: 0.54 ± 0.026	0.503CysPro: 0.503 ± 0.029	0.269CysGln: 0.269 ± 0.016	0.401CysArg: 0.401 ± 0.021	0.665CysSer: 0.665 ± 0.028	0.546CysThr: 0.546 ± 0.027	0.622CysVal: 0.622 ± 0.03	0.079CysTrp: 0.079 ± 0.009	0.38CysTyr: 0.38 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.104AspAla: 3.104 ± 0.069	0.499AspCys: 0.499 ± 0.024	2.374AspAsp: 2.374 ± 0.052	4.656AspGlu: 4.656 ± 0.081	2.615AspPhe: 2.615 ± 0.057	3.458AspGly: 3.458 ± 0.068	1.151AspHis: 1.151 ± 0.036	5.478AspIle: 5.478 ± 0.074	3.635AspLys: 3.635 ± 0.064	5.212AspLeu: 5.212 ± 0.084	1.482AspMet: 1.482 ± 0.043	1.992AspAsn: 1.992 ± 0.045	1.885AspPro: 1.885 ± 0.049	1.931AspGln: 1.931 ± 0.05	2.002AspArg: 2.002 ± 0.044	2.699AspSer: 2.699 ± 0.055	2.651AspThr: 2.651 ± 0.056	3.577AspVal: 3.577 ± 0.064	0.47AspTrp: 0.47 ± 0.022	2.483AspTyr: 2.483 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.137GluAla: 5.137 ± 0.084	0.637GluCys: 0.637 ± 0.026	4.166GluAsp: 4.166 ± 0.07	7.805GluGlu: 7.805 ± 0.125	2.835GluPhe: 2.835 ± 0.052	4.453GluGly: 4.453 ± 0.084	1.243GluHis: 1.243 ± 0.035	7.537GluIle: 7.537 ± 0.103	7.296GluLys: 7.296 ± 0.117	6.901GluLeu: 6.901 ± 0.11	2.273GluMet: 2.273 ± 0.054	4.539GluAsn: 4.539 ± 0.067	1.832GluPro: 1.832 ± 0.05	2.768GluGln: 2.768 ± 0.061	2.92GluArg: 2.92 ± 0.067	3.55GluSer: 3.55 ± 0.065	3.246GluThr: 3.246 ± 0.06	4.978GluVal: 4.978 ± 0.077	0.559GluTrp: 0.559 ± 0.025	3.138GluTyr: 3.138 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	2.663PheAla: 2.663 ± 0.063	0.543PheCys: 0.543 ± 0.026	2.376PheAsp: 2.376 ± 0.054	2.899PheGlu: 2.899 ± 0.051	1.99PhePhe: 1.99 ± 0.052	2.879PheGly: 2.879 ± 0.069	0.751PheHis: 0.751 ± 0.029	4.085PheIle: 4.085 ± 0.074	2.839PheLys: 2.839 ± 0.048	3.749PheLeu: 3.749 ± 0.081	1.175PheMet: 1.175 ± 0.038	2.108PheAsn: 2.108 ± 0.057	1.371PhePro: 1.371 ± 0.045	1.174PheGln: 1.174 ± 0.034	1.451PheArg: 1.451 ± 0.038	3.012PheSer: 3.012 ± 0.057	2.273PheThr: 2.273 ± 0.054	2.662PheVal: 2.662 ± 0.057	0.359PheTrp: 0.359 ± 0.019	1.704PheTyr: 1.704 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.38GlyAla: 4.38 ± 0.086	0.89GlyCys: 0.89 ± 0.031	3.263GlyAsp: 3.263 ± 0.072	4.646GlyGlu: 4.646 ± 0.079	3.07GlyPhe: 3.07 ± 0.059	4.391GlyGly: 4.391 ± 0.085	1.102GlyHis: 1.102 ± 0.036	6.892GlyIle: 6.892 ± 0.094	5.324GlyLys: 5.324 ± 0.084	5.636GlyLeu: 5.636 ± 0.089	2.023GlyMet: 2.023 ± 0.057	3.037GlyAsn: 3.037 ± 0.068	1.441GlyPro: 1.441 ± 0.046	1.913GlyGln: 1.913 ± 0.056	2.526GlyArg: 2.526 ± 0.056	3.717GlySer: 3.717 ± 0.07	3.59GlyThr: 3.59 ± 0.063	4.453GlyVal: 4.453 ± 0.079	0.606GlyTrp: 0.606 ± 0.03	3.034GlyTyr: 3.034 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.933HisAla: 0.933 ± 0.037	0.219HisCys: 0.219 ± 0.018	0.767HisAsp: 0.767 ± 0.032	1.097HisGlu: 1.097 ± 0.04	0.857HisPhe: 0.857 ± 0.033	1.173HisGly: 1.173 ± 0.035	0.399HisHis: 0.399 ± 0.022	1.727HisIle: 1.727 ± 0.049	1.257HisLys: 1.257 ± 0.044	1.606HisLeu: 1.606 ± 0.037	0.486HisMet: 0.486 ± 0.024	0.818HisAsn: 0.818 ± 0.033	0.933HisPro: 0.933 ± 0.036	0.577HisGln: 0.577 ± 0.025	0.642HisArg: 0.642 ± 0.03	1.069HisSer: 1.069 ± 0.027	0.951HisThr: 0.951 ± 0.034	0.941HisVal: 0.941 ± 0.028	0.171HisTrp: 0.171 ± 0.016	0.781HisTyr: 0.781 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.084IleAla: 6.084 ± 0.094	0.989IleCys: 0.989 ± 0.039	5.38IleAsp: 5.38 ± 0.092	7.054IleGlu: 7.054 ± 0.096	3.815IlePhe: 3.815 ± 0.07	6.069IleGly: 6.069 ± 0.083	1.827IleHis: 1.827 ± 0.045	8.005IleIle: 8.005 ± 0.116	6.991IleLys: 6.991 ± 0.1	8.916IleLeu: 8.916 ± 0.117	2.234IleMet: 2.234 ± 0.054	4.372IleAsn: 4.372 ± 0.069	3.711IlePro: 3.711 ± 0.066	3.078IleGln: 3.078 ± 0.064	3.574IleArg: 3.574 ± 0.074	6.211IleSer: 6.211 ± 0.1	5.098IleThr: 5.098 ± 0.079	5.952IleVal: 5.952 ± 0.081	0.644IleTrp: 0.644 ± 0.029	3.368IleTyr: 3.368 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	5.214LysAla: 5.214 ± 0.077	0.559LysCys: 0.559 ± 0.027	4.959LysAsp: 4.959 ± 0.083	8.23LysGlu: 8.23 ± 0.107	2.241LysPhe: 2.241 ± 0.05	4.842LysGly: 4.842 ± 0.082	1.16LysHis: 1.16 ± 0.039	6.973LysIle: 6.973 ± 0.083	6.911LysLys: 6.911 ± 0.102	6.342LysLeu: 6.342 ± 0.085	2.355LysMet: 2.355 ± 0.053	4.71LysAsn: 4.71 ± 0.077	2.2LysPro: 2.2 ± 0.047	2.676LysGln: 2.676 ± 0.062	3.165LysArg: 3.165 ± 0.069	4.11LysSer: 4.11 ± 0.075	3.82LysThr: 3.82 ± 0.066	5.292LysVal: 5.292 ± 0.077	0.627LysTrp: 0.627 ± 0.031	3.147LysTyr: 3.147 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	5.917LeuAla: 5.917 ± 0.091	0.986LeuCys: 0.986 ± 0.033	4.938LeuAsp: 4.938 ± 0.074	6.674LeuGlu: 6.674 ± 0.102	3.934LeuPhe: 3.934 ± 0.075	6.172LeuGly: 6.172 ± 0.099	1.382LeuHis: 1.382 ± 0.043	7.945LeuIle: 7.945 ± 0.099	7.965LeuLys: 7.965 ± 0.095	8.537LeuLeu: 8.537 ± 0.115	2.44LeuMet: 2.44 ± 0.06	4.704LeuAsn: 4.704 ± 0.085	3.246LeuPro: 3.246 ± 0.062	2.722LeuGln: 2.722 ± 0.063	3.449LeuArg: 3.449 ± 0.067	6.682LeuSer: 6.682 ± 0.104	4.583LeuThr: 4.583 ± 0.077	5.164LeuVal: 5.164 ± 0.081	0.729LeuTrp: 0.729 ± 0.032	3.299LeuTyr: 3.299 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.992MetAla: 1.992 ± 0.049	0.197MetCys: 0.197 ± 0.014	1.717MetAsp: 1.717 ± 0.038	2.193MetGlu: 2.193 ± 0.048	0.881MetPhe: 0.881 ± 0.035	1.936MetGly: 1.936 ± 0.053	0.428MetHis: 0.428 ± 0.02	2.558MetIle: 2.558 ± 0.061	2.422MetLys: 2.422 ± 0.047	2.349MetLeu: 2.349 ± 0.054	0.823MetMet: 0.823 ± 0.03	1.67MetAsn: 1.67 ± 0.048	1.062MetPro: 1.062 ± 0.032	0.855MetGln: 0.855 ± 0.029	0.959MetArg: 0.959 ± 0.032	1.673MetSer: 1.673 ± 0.047	1.421MetThr: 1.421 ± 0.039	1.735MetVal: 1.735 ± 0.046	0.162MetTrp: 0.162 ± 0.013	0.884MetTyr: 0.884 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.088AsnAla: 3.088 ± 0.064	0.461AsnCys: 0.461 ± 0.026	2.364AsnAsp: 2.364 ± 0.05	3.655AsnGlu: 3.655 ± 0.066	1.915AsnPhe: 1.915 ± 0.047	3.346AsnGly: 3.346 ± 0.063	0.987AsnHis: 0.987 ± 0.034	5.106AsnIle: 5.106 ± 0.081	3.705AsnLys: 3.705 ± 0.07	4.524AsnLeu: 4.524 ± 0.071	1.47AsnMet: 1.47 ± 0.044	2.689AsnAsn: 2.689 ± 0.066	2.379AsnPro: 2.379 ± 0.061	1.889AsnGln: 1.889 ± 0.052	2.035AsnArg: 2.035 ± 0.048	2.628AsnSer: 2.628 ± 0.072	2.731AsnThr: 2.731 ± 0.058	3.067AsnVal: 3.067 ± 0.06	0.435AsnTrp: 0.435 ± 0.024	2.026AsnTyr: 2.026 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	1.846ProAla: 1.846 ± 0.05	0.319ProCys: 0.319 ± 0.018	1.907ProAsp: 1.907 ± 0.053	2.748ProGlu: 2.748 ± 0.061	1.614ProPhe: 1.614 ± 0.046	2.084ProGly: 2.084 ± 0.054	0.664ProHis: 0.664 ± 0.027	2.88ProIle: 2.88 ± 0.063	2.391ProLys: 2.391 ± 0.05	2.797ProLeu: 2.797 ± 0.058	0.828ProMet: 0.828 ± 0.033	1.635ProAsn: 1.635 ± 0.041	0.874ProPro: 0.874 ± 0.034	1.149ProGln: 1.149 ± 0.041	1.006ProArg: 1.006 ± 0.038	1.961ProSer: 1.961 ± 0.049	1.709ProThr: 1.709 ± 0.043	2.655ProVal: 2.655 ± 0.056	0.319ProTrp: 0.319 ± 0.023	1.557ProTyr: 1.557 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.01GlnAla: 2.01 ± 0.052	0.303GlnCys: 0.303 ± 0.019	1.59GlnAsp: 1.59 ± 0.042	2.516GlnGlu: 2.516 ± 0.064	1.26GlnPhe: 1.26 ± 0.038	1.917GlnGly: 1.917 ± 0.044	0.474GlnHis: 0.474 ± 0.019	3.105GlnIle: 3.105 ± 0.065	2.977GlnLys: 2.977 ± 0.058	2.932GlnLeu: 2.932 ± 0.053	1.074GlnMet: 1.074 ± 0.032	1.916GlnAsn: 1.916 ± 0.042	0.92GlnPro: 0.92 ± 0.037	1.097GlnGln: 1.097 ± 0.039	1.338GlnArg: 1.338 ± 0.035	1.754GlnSer: 1.754 ± 0.045	1.564GlnThr: 1.564 ± 0.052	1.875GlnVal: 1.875 ± 0.056	0.325GlnTrp: 0.325 ± 0.02	1.451GlnTyr: 1.451 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.147ArgAla: 2.147 ± 0.052	0.414ArgCys: 0.414 ± 0.022	1.883ArgAsp: 1.883 ± 0.044	2.987ArgGlu: 2.987 ± 0.068	1.58ArgPhe: 1.58 ± 0.046	2.192ArgGly: 2.192 ± 0.058	0.628ArgHis: 0.628 ± 0.028	3.629ArgIle: 3.629 ± 0.07	3.331ArgLys: 3.331 ± 0.067	3.496ArgLeu: 3.496 ± 0.076	1.217ArgMet: 1.217 ± 0.04	2.112ArgAsn: 2.112 ± 0.051	1.062ArgPro: 1.062 ± 0.033	1.229ArgGln: 1.229 ± 0.034	1.62ArgArg: 1.62 ± 0.047	1.929ArgSer: 1.929 ± 0.046	1.883ArgThr: 1.883 ± 0.047	2.367ArgVal: 2.367 ± 0.054	0.311ArgTrp: 0.311 ± 0.023	1.558ArgTyr: 1.558 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.463SerAla: 3.463 ± 0.06	0.531SerCys: 0.531 ± 0.025	3.014SerAsp: 3.014 ± 0.06	3.942SerGlu: 3.942 ± 0.073	2.886SerPhe: 2.886 ± 0.056	4.218SerGly: 4.218 ± 0.08	1.093SerHis: 1.093 ± 0.035	5.79SerIle: 5.79 ± 0.095	4.873SerLys: 4.873 ± 0.075	5.373SerLeu: 5.373 ± 0.079	1.668SerMet: 1.668 ± 0.046	3.027SerAsn: 3.027 ± 0.062	1.848SerPro: 1.848 ± 0.041	1.936SerGln: 1.936 ± 0.052	2.118SerArg: 2.118 ± 0.045	3.862SerSer: 3.862 ± 0.074	2.964SerThr: 2.964 ± 0.063	3.909SerVal: 3.909 ± 0.059	0.453SerTrp: 0.453 ± 0.025	2.25SerTyr: 2.25 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.539ThrAla: 3.539 ± 0.077	0.456ThrCys: 0.456 ± 0.021	2.551ThrAsp: 2.551 ± 0.058	3.382ThrGlu: 3.382 ± 0.068	2.22ThrPhe: 2.22 ± 0.053	3.942ThrGly: 3.942 ± 0.072	0.88ThrHis: 0.88 ± 0.03	4.533ThrIle: 4.533 ± 0.071	3.332ThrLys: 3.332 ± 0.076	4.961ThrLeu: 4.961 ± 0.075	1.199ThrMet: 1.199 ± 0.04	2.314ThrAsn: 2.314 ± 0.055	2.022ThrPro: 2.022 ± 0.046	1.476ThrGln: 1.476 ± 0.044	1.732ThrArg: 1.732 ± 0.045	2.961ThrSer: 2.961 ± 0.057	2.696ThrThr: 2.696 ± 0.069	3.933ThrVal: 3.933 ± 0.077	0.424ThrTrp: 0.424 ± 0.027	1.929ThrTyr: 1.929 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.088ValAla: 4.088 ± 0.081	0.733ValCys: 0.733 ± 0.034	3.636ValAsp: 3.636 ± 0.065	4.846ValGlu: 4.846 ± 0.074	2.912ValPhe: 2.912 ± 0.06	4.198ValGly: 4.198 ± 0.075	1.059ValHis: 1.059 ± 0.033	6.003ValIle: 6.003 ± 0.087	5.027ValLys: 5.027 ± 0.077	6.455ValLeu: 6.455 ± 0.099	1.698ValMet: 1.698 ± 0.042	3.173ValAsn: 3.173 ± 0.064	2.307ValPro: 2.307 ± 0.055	1.893ValGln: 1.893 ± 0.046	2.331ValArg: 2.331 ± 0.048	4.257ValSer: 4.257 ± 0.071	3.452ValThr: 3.452 ± 0.075	4.449ValVal: 4.449 ± 0.073	0.499ValTrp: 0.499 ± 0.022	2.534ValTyr: 2.534 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.48TrpAla: 0.48 ± 0.026	0.093TrpCys: 0.093 ± 0.01	0.497TrpAsp: 0.497 ± 0.027	0.603TrpGlu: 0.603 ± 0.031	0.389TrpPhe: 0.389 ± 0.022	0.56TrpGly: 0.56 ± 0.026	0.143TrpHis: 0.143 ± 0.015	0.79TrpIle: 0.79 ± 0.033	0.582TrpLys: 0.582 ± 0.025	0.7TrpLeu: 0.7 ± 0.03	0.277TrpMet: 0.277 ± 0.017	0.504TrpAsn: 0.504 ± 0.028	0.181TrpPro: 0.181 ± 0.015	0.254TrpGln: 0.254 ± 0.017	0.336TrpArg: 0.336 ± 0.019	0.437TrpSer: 0.437 ± 0.026	0.387TrpThr: 0.387 ± 0.021	0.482TrpVal: 0.482 ± 0.023	0.111TrpTrp: 0.111 ± 0.013	0.298TrpTyr: 0.298 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.052	0.508TyrCys: 0.508 ± 0.027	2.348TyrAsp: 2.348 ± 0.06	2.875TyrGlu: 2.875 ± 0.061	1.915TyrPhe: 1.915 ± 0.042	2.68TyrGly: 2.68 ± 0.055	0.8TyrHis: 0.8 ± 0.031	3.641TyrIle: 3.641 ± 0.062	2.841TyrLys: 2.841 ± 0.053	3.573TyrLeu: 3.573 ± 0.067	0.992TyrMet: 0.992 ± 0.034	2.112TyrAsn: 2.112 ± 0.051	1.488TyrPro: 1.488 ± 0.045	1.356TyrGln: 1.356 ± 0.034	1.614TyrArg: 1.614 ± 0.042	2.397TyrSer: 2.397 ± 0.05	2.033TyrThr: 2.033 ± 0.049	2.446TyrVal: 2.446 ± 0.051	0.325TyrTrp: 0.325 ± 0.025	1.891TyrTyr: 1.891 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2804 proteins (894548 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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