Amino acid dipepetide frequency for Klebsiella phage ST147-VIM1phi7.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.722AlaAla: 10.722 ± 2.479
0.59AlaCys: 0.59 ± 0.242
6.886AlaAsp: 6.886 ± 0.799
4.722AlaGlu: 4.722 ± 0.916
3.443AlaPhe: 3.443 ± 0.636
8.755AlaGly: 8.755 ± 1.246
1.377AlaHis: 1.377 ± 0.413
5.509AlaIle: 5.509 ± 0.777
6.394AlaLys: 6.394 ± 0.811
8.853AlaLeu: 8.853 ± 0.932
2.853AlaMet: 2.853 ± 0.471
3.148AlaAsn: 3.148 ± 0.537
4.23AlaPro: 4.23 ± 0.57
3.935AlaGln: 3.935 ± 0.928
4.623AlaArg: 4.623 ± 0.717
5.312AlaSer: 5.312 ± 0.77
5.902AlaThr: 5.902 ± 0.912
7.476AlaVal: 7.476 ± 1.019
1.672AlaTrp: 1.672 ± 0.386
2.361AlaTyr: 2.361 ± 0.612
0.0AlaXaa: 0.0 ± 0.0
Cys
0.393CysAla: 0.393 ± 0.235
0.393CysCys: 0.393 ± 0.228
0.393CysAsp: 0.393 ± 0.204
0.295CysGlu: 0.295 ± 0.161
0.197CysPhe: 0.197 ± 0.129
0.59CysGly: 0.59 ± 0.3
0.098CysHis: 0.098 ± 0.118
0.098CysIle: 0.098 ± 0.106
0.393CysLys: 0.393 ± 0.186
1.082CysLeu: 1.082 ± 0.293
0.295CysMet: 0.295 ± 0.158
0.098CysAsn: 0.098 ± 0.097
0.393CysPro: 0.393 ± 0.164
0.787CysGln: 0.787 ± 0.325
0.492CysArg: 0.492 ± 0.188
0.492CysSer: 0.492 ± 0.209
1.18CysThr: 1.18 ± 0.414
0.393CysVal: 0.393 ± 0.195
0.197CysTrp: 0.197 ± 0.143
0.393CysTyr: 0.393 ± 0.176
0.0CysXaa: 0.0 ± 0.0
Asp
6.886AspAla: 6.886 ± 0.755
0.492AspCys: 0.492 ± 0.226
5.115AspAsp: 5.115 ± 0.8
3.935AspGlu: 3.935 ± 0.808
3.246AspPhe: 3.246 ± 0.639
4.918AspGly: 4.918 ± 0.819
0.787AspHis: 0.787 ± 0.28
5.115AspIle: 5.115 ± 0.771
4.427AspLys: 4.427 ± 0.735
4.525AspLeu: 4.525 ± 0.729
1.672AspMet: 1.672 ± 0.456
2.262AspAsn: 2.262 ± 0.412
1.967AspPro: 1.967 ± 0.455
2.558AspGln: 2.558 ± 0.403
2.361AspArg: 2.361 ± 0.343
3.049AspSer: 3.049 ± 0.384
2.853AspThr: 2.853 ± 0.424
4.328AspVal: 4.328 ± 0.671
0.59AspTrp: 0.59 ± 0.312
1.476AspTyr: 1.476 ± 0.449
0.0AspXaa: 0.0 ± 0.0
Glu
5.41GluAla: 5.41 ± 0.922
0.197GluCys: 0.197 ± 0.146
3.344GluAsp: 3.344 ± 1.221
3.148GluGlu: 3.148 ± 0.873
1.476GluPhe: 1.476 ± 0.323
4.033GluGly: 4.033 ± 0.8
0.984GluHis: 0.984 ± 0.328
2.262GluIle: 2.262 ± 0.513
3.148GluLys: 3.148 ± 0.539
7.968GluLeu: 7.968 ± 0.86
2.164GluMet: 2.164 ± 0.466
3.64GluAsn: 3.64 ± 0.547
2.853GluPro: 2.853 ± 0.504
3.836GluGln: 3.836 ± 0.57
3.541GluArg: 3.541 ± 0.505
3.738GluSer: 3.738 ± 0.652
4.525GluThr: 4.525 ± 0.641
3.344GluVal: 3.344 ± 0.72
0.59GluTrp: 0.59 ± 0.208
2.164GluTyr: 2.164 ± 0.518
0.0GluXaa: 0.0 ± 0.0
Phe
3.246PheAla: 3.246 ± 0.628
0.59PheCys: 0.59 ± 0.237
1.967PheAsp: 1.967 ± 0.45
2.262PheGlu: 2.262 ± 0.36
1.967PhePhe: 1.967 ± 0.52
1.869PheGly: 1.869 ± 0.436
1.082PheHis: 1.082 ± 0.313
1.672PheIle: 1.672 ± 0.518
1.967PheLys: 1.967 ± 0.457
2.262PheLeu: 2.262 ± 0.495
0.787PheMet: 0.787 ± 0.283
2.262PheAsn: 2.262 ± 0.455
1.574PhePro: 1.574 ± 0.414
1.082PheGln: 1.082 ± 0.324
1.967PheArg: 1.967 ± 0.394
3.541PheSer: 3.541 ± 0.729
2.066PheThr: 2.066 ± 0.372
1.279PheVal: 1.279 ± 0.27
0.885PheTrp: 0.885 ± 0.325
1.476PheTyr: 1.476 ± 0.365
0.0PheXaa: 0.0 ± 0.0
Gly
5.017GlyAla: 5.017 ± 0.654
0.59GlyCys: 0.59 ± 0.326
5.017GlyAsp: 5.017 ± 0.436
4.918GlyGlu: 4.918 ± 0.907
3.148GlyPhe: 3.148 ± 0.677
5.41GlyGly: 5.41 ± 0.815
0.787GlyHis: 0.787 ± 0.263
4.427GlyIle: 4.427 ± 0.661
4.427GlyLys: 4.427 ± 0.533
5.115GlyLeu: 5.115 ± 0.879
2.066GlyMet: 2.066 ± 0.378
3.541GlyAsn: 3.541 ± 0.417
0.984GlyPro: 0.984 ± 0.377
2.459GlyGln: 2.459 ± 0.563
5.115GlyArg: 5.115 ± 0.761
2.853GlySer: 2.853 ± 0.531
5.017GlyThr: 5.017 ± 0.738
5.705GlyVal: 5.705 ± 0.927
0.984GlyTrp: 0.984 ± 0.327
2.262GlyTyr: 2.262 ± 0.455
0.0GlyXaa: 0.0 ± 0.0
His
1.574HisAla: 1.574 ± 0.399
0.295HisCys: 0.295 ± 0.153
0.984HisAsp: 0.984 ± 0.255
0.59HisGlu: 0.59 ± 0.268
0.393HisPhe: 0.393 ± 0.177
1.279HisGly: 1.279 ± 0.354
0.393HisHis: 0.393 ± 0.181
1.18HisIle: 1.18 ± 0.422
0.59HisLys: 0.59 ± 0.254
1.18HisLeu: 1.18 ± 0.287
0.787HisMet: 0.787 ± 0.236
0.492HisAsn: 0.492 ± 0.241
1.279HisPro: 1.279 ± 0.511
1.18HisGln: 1.18 ± 0.293
0.984HisArg: 0.984 ± 0.343
0.787HisSer: 0.787 ± 0.406
0.787HisThr: 0.787 ± 0.28
0.689HisVal: 0.689 ± 0.202
0.197HisTrp: 0.197 ± 0.13
0.492HisTyr: 0.492 ± 0.221
0.0HisXaa: 0.0 ± 0.0
Ile
4.623IleAla: 4.623 ± 0.529
0.59IleCys: 0.59 ± 0.287
3.836IleAsp: 3.836 ± 0.535
3.64IleGlu: 3.64 ± 0.766
1.771IlePhe: 1.771 ± 0.453
4.525IleGly: 4.525 ± 0.623
0.492IleHis: 0.492 ± 0.202
3.049IleIle: 3.049 ± 0.565
3.246IleLys: 3.246 ± 0.555
2.558IleLeu: 2.558 ± 0.646
0.984IleMet: 0.984 ± 0.399
2.754IleAsn: 2.754 ± 0.429
2.459IlePro: 2.459 ± 0.495
2.459IleGln: 2.459 ± 0.351
3.443IleArg: 3.443 ± 0.557
4.82IleSer: 4.82 ± 0.664
4.23IleThr: 4.23 ± 0.578
3.148IleVal: 3.148 ± 0.595
0.393IleTrp: 0.393 ± 0.178
1.771IleTyr: 1.771 ± 0.435
0.0IleXaa: 0.0 ± 0.0
Lys
5.902LysAla: 5.902 ± 0.822
0.492LysCys: 0.492 ± 0.205
2.262LysAsp: 2.262 ± 0.515
2.754LysGlu: 2.754 ± 0.63
1.672LysPhe: 1.672 ± 0.329
2.853LysGly: 2.853 ± 0.471
0.59LysHis: 0.59 ± 0.246
2.754LysIle: 2.754 ± 0.554
4.23LysLys: 4.23 ± 0.963
7.082LysLeu: 7.082 ± 0.92
1.377LysMet: 1.377 ± 0.34
2.656LysAsn: 2.656 ± 0.442
3.443LysPro: 3.443 ± 0.502
1.967LysGln: 1.967 ± 0.478
3.148LysArg: 3.148 ± 0.693
3.246LysSer: 3.246 ± 0.712
3.836LysThr: 3.836 ± 0.793
3.443LysVal: 3.443 ± 0.675
1.082LysTrp: 1.082 ± 0.362
2.066LysTyr: 2.066 ± 0.543
0.0LysXaa: 0.0 ± 0.0
Leu
10.033LeuAla: 10.033 ± 0.972
0.787LeuCys: 0.787 ± 0.366
5.705LeuAsp: 5.705 ± 0.783
5.902LeuGlu: 5.902 ± 0.864
3.148LeuPhe: 3.148 ± 0.645
5.312LeuGly: 5.312 ± 0.801
1.082LeuHis: 1.082 ± 0.332
4.525LeuIle: 4.525 ± 0.672
5.115LeuLys: 5.115 ± 0.811
6.591LeuLeu: 6.591 ± 0.813
2.853LeuMet: 2.853 ± 0.557
4.918LeuAsn: 4.918 ± 0.535
4.131LeuPro: 4.131 ± 0.715
3.344LeuGln: 3.344 ± 0.469
6.099LeuArg: 6.099 ± 0.695
6.0LeuSer: 6.0 ± 0.773
6.099LeuThr: 6.099 ± 0.93
5.017LeuVal: 5.017 ± 0.552
1.377LeuTrp: 1.377 ± 0.386
2.853LeuTyr: 2.853 ± 0.48
0.0LeuXaa: 0.0 ± 0.0
Met
3.344MetAla: 3.344 ± 0.514
0.295MetCys: 0.295 ± 0.144
1.377MetAsp: 1.377 ± 0.316
1.279MetGlu: 1.279 ± 0.358
0.984MetPhe: 0.984 ± 0.315
1.18MetGly: 1.18 ± 0.334
0.492MetHis: 0.492 ± 0.187
1.476MetIle: 1.476 ± 0.373
1.672MetLys: 1.672 ± 0.41
2.558MetLeu: 2.558 ± 0.604
0.689MetMet: 0.689 ± 0.259
1.574MetAsn: 1.574 ± 0.437
1.279MetPro: 1.279 ± 0.438
1.279MetGln: 1.279 ± 0.363
1.672MetArg: 1.672 ± 0.588
1.967MetSer: 1.967 ± 0.405
2.262MetThr: 2.262 ± 0.372
1.771MetVal: 1.771 ± 0.372
0.393MetTrp: 0.393 ± 0.183
0.885MetTyr: 0.885 ± 0.264
0.0MetXaa: 0.0 ± 0.0
Asn
3.738AsnAla: 3.738 ± 0.638
0.393AsnCys: 0.393 ± 0.218
2.164AsnAsp: 2.164 ± 0.369
2.754AsnGlu: 2.754 ± 0.56
1.377AsnPhe: 1.377 ± 0.355
3.738AsnGly: 3.738 ± 0.771
0.689AsnHis: 0.689 ± 0.256
2.754AsnIle: 2.754 ± 0.623
2.361AsnLys: 2.361 ± 0.382
3.935AsnLeu: 3.935 ± 0.708
1.18AsnMet: 1.18 ± 0.374
2.066AsnAsn: 2.066 ± 0.431
2.262AsnPro: 2.262 ± 0.477
1.279AsnGln: 1.279 ± 0.411
2.558AsnArg: 2.558 ± 0.456
2.853AsnSer: 2.853 ± 0.378
2.459AsnThr: 2.459 ± 0.533
2.262AsnVal: 2.262 ± 0.475
0.0AsnTrp: 0.0 ± 0.0
1.476AsnTyr: 1.476 ± 0.408
0.0AsnXaa: 0.0 ± 0.0
Pro
4.23ProAla: 4.23 ± 0.874
0.0ProCys: 0.0 ± 0.0
3.541ProAsp: 3.541 ± 0.549
3.541ProGlu: 3.541 ± 0.699
1.869ProPhe: 1.869 ± 0.5
3.64ProGly: 3.64 ± 0.594
1.279ProHis: 1.279 ± 0.418
1.574ProIle: 1.574 ± 0.331
1.574ProLys: 1.574 ± 0.386
4.23ProLeu: 4.23 ± 0.744
0.787ProMet: 0.787 ± 0.351
1.476ProAsn: 1.476 ± 0.407
2.459ProPro: 2.459 ± 0.52
1.574ProGln: 1.574 ± 0.413
1.771ProArg: 1.771 ± 0.436
2.164ProSer: 2.164 ± 0.433
1.869ProThr: 1.869 ± 0.429
4.23ProVal: 4.23 ± 0.65
0.59ProTrp: 0.59 ± 0.245
0.885ProTyr: 0.885 ± 0.375
0.0ProXaa: 0.0 ± 0.0
Gln
5.017GlnAla: 5.017 ± 1.354
0.393GlnCys: 0.393 ± 0.239
1.574GlnAsp: 1.574 ± 0.417
3.148GlnGlu: 3.148 ± 0.631
1.476GlnPhe: 1.476 ± 0.461
1.672GlnGly: 1.672 ± 0.339
0.59GlnHis: 0.59 ± 0.274
1.574GlnIle: 1.574 ± 0.536
2.262GlnLys: 2.262 ± 0.388
4.427GlnLeu: 4.427 ± 0.903
1.18GlnMet: 1.18 ± 0.396
1.082GlnAsn: 1.082 ± 0.381
2.164GlnPro: 2.164 ± 0.511
2.164GlnGln: 2.164 ± 0.536
4.918GlnArg: 4.918 ± 0.941
2.262GlnSer: 2.262 ± 0.414
2.558GlnThr: 2.558 ± 0.539
2.853GlnVal: 2.853 ± 0.484
0.59GlnTrp: 0.59 ± 0.285
1.082GlnTyr: 1.082 ± 0.352
0.0GlnXaa: 0.0 ± 0.0
Arg
5.017ArgAla: 5.017 ± 0.802
0.59ArgCys: 0.59 ± 0.211
3.148ArgAsp: 3.148 ± 0.503
4.623ArgGlu: 4.623 ± 0.791
1.967ArgPhe: 1.967 ± 0.437
3.344ArgGly: 3.344 ± 0.865
1.18ArgHis: 1.18 ± 0.347
3.344ArgIle: 3.344 ± 0.624
4.131ArgLys: 4.131 ± 0.661
5.607ArgLeu: 5.607 ± 0.848
1.18ArgMet: 1.18 ± 0.448
1.377ArgAsn: 1.377 ± 0.367
2.262ArgPro: 2.262 ± 0.666
3.935ArgGln: 3.935 ± 1.015
3.836ArgArg: 3.836 ± 0.719
2.656ArgSer: 2.656 ± 0.478
2.951ArgThr: 2.951 ± 0.478
5.017ArgVal: 5.017 ± 0.731
0.885ArgTrp: 0.885 ± 0.271
1.771ArgTyr: 1.771 ± 0.385
0.0ArgXaa: 0.0 ± 0.0
Ser
5.312SerAla: 5.312 ± 0.945
0.492SerCys: 0.492 ± 0.198
3.935SerAsp: 3.935 ± 0.55
3.344SerGlu: 3.344 ± 0.635
1.771SerPhe: 1.771 ± 0.298
4.525SerGly: 4.525 ± 0.666
1.476SerHis: 1.476 ± 0.482
3.541SerIle: 3.541 ± 0.683
2.853SerLys: 2.853 ± 0.46
5.804SerLeu: 5.804 ± 0.885
2.164SerMet: 2.164 ± 0.552
2.558SerAsn: 2.558 ± 0.496
1.869SerPro: 1.869 ± 0.495
2.951SerGln: 2.951 ± 0.344
3.443SerArg: 3.443 ± 0.452
2.951SerSer: 2.951 ± 0.534
2.754SerThr: 2.754 ± 0.477
4.328SerVal: 4.328 ± 0.63
0.492SerTrp: 0.492 ± 0.209
1.476SerTyr: 1.476 ± 0.358
0.0SerXaa: 0.0 ± 0.0
Thr
8.263ThrAla: 8.263 ± 1.337
0.492ThrCys: 0.492 ± 0.209
4.525ThrAsp: 4.525 ± 0.693
3.148ThrGlu: 3.148 ± 0.587
1.869ThrPhe: 1.869 ± 0.388
6.394ThrGly: 6.394 ± 0.828
0.984ThrHis: 0.984 ± 0.31
2.951ThrIle: 2.951 ± 0.579
1.771ThrLys: 1.771 ± 0.415
8.066ThrLeu: 8.066 ± 0.813
1.771ThrMet: 1.771 ± 0.321
1.869ThrAsn: 1.869 ± 0.361
2.951ThrPro: 2.951 ± 0.604
1.771ThrGln: 1.771 ± 0.363
3.541ThrArg: 3.541 ± 0.559
3.049ThrSer: 3.049 ± 0.516
3.836ThrThr: 3.836 ± 0.492
3.443ThrVal: 3.443 ± 0.491
0.59ThrTrp: 0.59 ± 0.268
1.279ThrTyr: 1.279 ± 0.379
0.0ThrXaa: 0.0 ± 0.0
Val
6.492ValAla: 6.492 ± 0.781
0.787ValCys: 0.787 ± 0.256
4.328ValAsp: 4.328 ± 0.797
4.918ValGlu: 4.918 ± 0.694
2.459ValPhe: 2.459 ± 0.438
3.64ValGly: 3.64 ± 0.686
0.689ValHis: 0.689 ± 0.206
5.017ValIle: 5.017 ± 0.778
4.131ValLys: 4.131 ± 0.721
4.918ValLeu: 4.918 ± 0.696
2.361ValMet: 2.361 ± 0.443
3.049ValAsn: 3.049 ± 0.622
2.459ValPro: 2.459 ± 0.574
2.459ValGln: 2.459 ± 0.397
3.049ValArg: 3.049 ± 0.524
4.23ValSer: 4.23 ± 0.71
5.213ValThr: 5.213 ± 0.634
4.328ValVal: 4.328 ± 0.62
0.393ValTrp: 0.393 ± 0.187
0.885ValTyr: 0.885 ± 0.383
0.0ValXaa: 0.0 ± 0.0
Trp
0.885TrpAla: 0.885 ± 0.317
0.0TrpCys: 0.0 ± 0.0
0.885TrpAsp: 0.885 ± 0.345
0.984TrpGlu: 0.984 ± 0.307
0.59TrpPhe: 0.59 ± 0.161
0.393TrpGly: 0.393 ± 0.188
0.393TrpHis: 0.393 ± 0.172
0.689TrpIle: 0.689 ± 0.22
0.885TrpLys: 0.885 ± 0.359
1.279TrpLeu: 1.279 ± 0.389
0.197TrpMet: 0.197 ± 0.136
0.689TrpAsn: 0.689 ± 0.25
0.984TrpPro: 0.984 ± 0.345
0.295TrpGln: 0.295 ± 0.167
0.787TrpArg: 0.787 ± 0.299
0.885TrpSer: 0.885 ± 0.277
0.393TrpThr: 0.393 ± 0.176
0.984TrpVal: 0.984 ± 0.318
0.393TrpTrp: 0.393 ± 0.207
0.295TrpTyr: 0.295 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.656TyrAla: 2.656 ± 0.496
0.197TyrCys: 0.197 ± 0.119
1.672TyrAsp: 1.672 ± 0.404
2.459TyrGlu: 2.459 ± 0.486
0.984TyrPhe: 0.984 ± 0.468
1.771TyrGly: 1.771 ± 0.374
0.689TyrHis: 0.689 ± 0.26
1.279TyrIle: 1.279 ± 0.406
1.279TyrLys: 1.279 ± 0.379
2.853TyrLeu: 2.853 ± 0.533
0.984TyrMet: 0.984 ± 0.299
0.787TyrAsn: 0.787 ± 0.376
1.279TyrPro: 1.279 ± 0.363
1.672TyrGln: 1.672 ± 0.379
1.476TyrArg: 1.476 ± 0.292
1.18TyrSer: 1.18 ± 0.466
1.771TyrThr: 1.771 ± 0.474
1.771TyrVal: 1.771 ± 0.439
0.59TyrTrp: 0.59 ± 0.177
0.885TyrTyr: 0.885 ± 0.392
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 42 proteins (10167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski