Amino acid dipepetide frequency for Lewinella agarilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.496AlaAla: 8.496 ± 0.109	0.831AlaCys: 0.831 ± 0.026	5.383AlaAsp: 5.383 ± 0.063	5.567AlaGlu: 5.567 ± 0.065	3.69AlaPhe: 3.69 ± 0.059	7.656AlaGly: 7.656 ± 0.077	1.233AlaHis: 1.233 ± 0.033	4.828AlaIle: 4.828 ± 0.06	3.548AlaLys: 3.548 ± 0.058	7.818AlaLeu: 7.818 ± 0.099	1.891AlaMet: 1.891 ± 0.043	3.49AlaAsn: 3.49 ± 0.047	3.626AlaPro: 3.626 ± 0.057	2.803AlaGln: 2.803 ± 0.041	4.165AlaArg: 4.165 ± 0.059	4.886AlaSer: 4.886 ± 0.061	5.173AlaThr: 5.173 ± 0.074	5.126AlaVal: 5.126 ± 0.049	0.954AlaTrp: 0.954 ± 0.022	2.879AlaTyr: 2.879 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.679CysAla: 0.679 ± 0.022	0.157CysCys: 0.157 ± 0.01	0.586CysAsp: 0.586 ± 0.035	0.527CysGlu: 0.527 ± 0.021	0.491CysPhe: 0.491 ± 0.019	0.853CysGly: 0.853 ± 0.034	0.207CysHis: 0.207 ± 0.012	0.445CysIle: 0.445 ± 0.017	0.269CysLys: 0.269 ± 0.012	0.871CysLeu: 0.871 ± 0.023	0.161CysMet: 0.161 ± 0.013	0.403CysAsn: 0.403 ± 0.022	0.547CysPro: 0.547 ± 0.029	0.33CysGln: 0.33 ± 0.017	0.462CysArg: 0.462 ± 0.019	0.693CysSer: 0.693 ± 0.028	0.665CysThr: 0.665 ± 0.037	0.568CysVal: 0.568 ± 0.023	0.121CysTrp: 0.121 ± 0.008	0.295CysTyr: 0.295 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.858AspAla: 4.858 ± 0.081	0.711AspCys: 0.711 ± 0.05	3.583AspAsp: 3.583 ± 0.085	3.893AspGlu: 3.893 ± 0.052	3.417AspPhe: 3.417 ± 0.041	5.789AspGly: 5.789 ± 0.093	1.191AspHis: 1.191 ± 0.03	3.518AspIle: 3.518 ± 0.046	2.434AspLys: 2.434 ± 0.051	6.15AspLeu: 6.15 ± 0.059	1.136AspMet: 1.136 ± 0.026	2.748AspAsn: 2.748 ± 0.06	2.914AspPro: 2.914 ± 0.046	2.147AspGln: 2.147 ± 0.036	3.418AspArg: 3.418 ± 0.047	3.064AspSer: 3.064 ± 0.055	2.83AspThr: 2.83 ± 0.053	3.722AspVal: 3.722 ± 0.051	1.026AspTrp: 1.026 ± 0.027	2.623AspTyr: 2.623 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.682GluAla: 5.682 ± 0.065	0.395GluCys: 0.395 ± 0.02	3.773GluAsp: 3.773 ± 0.048	5.026GluGlu: 5.026 ± 0.072	2.425GluPhe: 2.425 ± 0.037	4.589GluGly: 4.589 ± 0.056	1.099GluHis: 1.099 ± 0.025	3.764GluIle: 3.764 ± 0.055	3.36GluLys: 3.36 ± 0.058	6.752GluLeu: 6.752 ± 0.068	1.776GluMet: 1.776 ± 0.032	2.789GluAsn: 2.789 ± 0.046	2.145GluPro: 2.145 ± 0.039	2.457GluGln: 2.457 ± 0.04	3.727GluArg: 3.727 ± 0.056	3.169GluSer: 3.169 ± 0.038	3.473GluThr: 3.473 ± 0.045	4.811GluVal: 4.811 ± 0.074	0.834GluTrp: 0.834 ± 0.023	1.976GluTyr: 1.976 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.615PheAla: 3.615 ± 0.048	0.452PheCys: 0.452 ± 0.017	3.048PheAsp: 3.048 ± 0.045	2.502PheGlu: 2.502 ± 0.046	2.399PhePhe: 2.399 ± 0.05	3.801PheGly: 3.801 ± 0.05	0.835PheHis: 0.835 ± 0.021	2.375PheIle: 2.375 ± 0.034	1.675PheLys: 1.675 ± 0.04	4.627PheLeu: 4.627 ± 0.058	0.869PheMet: 0.869 ± 0.023	2.184PheAsn: 2.184 ± 0.035	2.032PhePro: 2.032 ± 0.033	1.517PheGln: 1.517 ± 0.03	2.685PheArg: 2.685 ± 0.042	3.623PheSer: 3.623 ± 0.049	3.249PheThr: 3.249 ± 0.052	2.814PheVal: 2.814 ± 0.043	0.6PheTrp: 0.6 ± 0.02	1.669PheTyr: 1.669 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.762GlyAla: 5.762 ± 0.064	0.943GlyCys: 0.943 ± 0.04	4.7GlyAsp: 4.7 ± 0.081	5.096GlyGlu: 5.096 ± 0.063	3.655GlyPhe: 3.655 ± 0.048	6.767GlyGly: 6.767 ± 0.104	1.388GlyHis: 1.388 ± 0.028	4.601GlyIle: 4.601 ± 0.059	4.198GlyLys: 4.198 ± 0.067	7.296GlyLeu: 7.296 ± 0.083	1.973GlyMet: 1.973 ± 0.037	3.618GlyAsn: 3.618 ± 0.063	2.59GlyPro: 2.59 ± 0.055	3.063GlyGln: 3.063 ± 0.041	4.164GlyArg: 4.164 ± 0.057	4.906GlySer: 4.906 ± 0.074	4.959GlyThr: 4.959 ± 0.101	5.035GlyVal: 5.035 ± 0.061	1.127GlyTrp: 1.127 ± 0.028	2.855GlyTyr: 2.855 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.222HisAla: 1.222 ± 0.035	0.204HisCys: 0.204 ± 0.011	0.975HisAsp: 0.975 ± 0.027	1.014HisGlu: 1.014 ± 0.028	1.072HisPhe: 1.072 ± 0.025	1.228HisGly: 1.228 ± 0.031	0.532HisHis: 0.532 ± 0.02	0.879HisIle: 0.879 ± 0.024	0.703HisLys: 0.703 ± 0.024	2.106HisLeu: 2.106 ± 0.044	0.295HisMet: 0.295 ± 0.013	0.684HisAsn: 0.684 ± 0.022	1.2HisPro: 1.2 ± 0.032	0.739HisGln: 0.739 ± 0.025	1.101HisArg: 1.101 ± 0.028	0.888HisSer: 0.888 ± 0.027	0.93HisThr: 0.93 ± 0.021	0.969HisVal: 0.969 ± 0.023	0.288HisTrp: 0.288 ± 0.012	0.874HisTyr: 0.874 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.694IleAla: 4.694 ± 0.059	0.625IleCys: 0.625 ± 0.022	4.037IleAsp: 4.037 ± 0.052	3.545IleGlu: 3.545 ± 0.051	2.403IlePhe: 2.403 ± 0.036	4.326IleGly: 4.326 ± 0.053	1.05IleHis: 1.05 ± 0.025	3.295IleIle: 3.295 ± 0.045	2.389IleLys: 2.389 ± 0.047	4.881IleLeu: 4.881 ± 0.052	1.065IleMet: 1.065 ± 0.027	2.833IleAsn: 2.833 ± 0.046	2.664IlePro: 2.664 ± 0.038	1.696IleGln: 1.696 ± 0.035	3.128IleArg: 3.128 ± 0.049	3.933IleSer: 3.933 ± 0.055	3.795IleThr: 3.795 ± 0.068	3.749IleVal: 3.749 ± 0.049	0.59IleTrp: 0.59 ± 0.018	1.907IleTyr: 1.907 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.929LysAla: 3.929 ± 0.064	0.199LysCys: 0.199 ± 0.012	2.576LysAsp: 2.576 ± 0.053	3.267LysGlu: 3.267 ± 0.059	1.48LysPhe: 1.48 ± 0.032	3.052LysGly: 3.052 ± 0.056	0.825LysHis: 0.825 ± 0.023	2.643LysIle: 2.643 ± 0.048	2.745LysLys: 2.745 ± 0.059	4.128LysLeu: 4.128 ± 0.06	1.279LysMet: 1.279 ± 0.031	1.797LysAsn: 1.797 ± 0.032	1.826LysPro: 1.826 ± 0.038	1.58LysGln: 1.58 ± 0.039	2.397LysArg: 2.397 ± 0.044	2.524LysSer: 2.524 ± 0.047	2.577LysThr: 2.577 ± 0.051	3.032LysVal: 3.032 ± 0.06	0.556LysTrp: 0.556 ± 0.017	1.458LysTyr: 1.458 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	8.708LeuAla: 8.708 ± 0.095	0.874LeuCys: 0.874 ± 0.024	5.672LeuAsp: 5.672 ± 0.057	6.091LeuGlu: 6.091 ± 0.067	4.607LeuPhe: 4.607 ± 0.063	6.722LeuGly: 6.722 ± 0.081	1.824LeuHis: 1.824 ± 0.04	5.279LeuIle: 5.279 ± 0.072	4.47LeuLys: 4.47 ± 0.065	11.221LeuLeu: 11.221 ± 0.135	2.067LeuMet: 2.067 ± 0.039	4.306LeuAsn: 4.306 ± 0.057	5.448LeuPro: 5.448 ± 0.065	3.431LeuGln: 3.431 ± 0.051	6.046LeuArg: 6.046 ± 0.082	7.175LeuSer: 7.175 ± 0.066	6.194LeuThr: 6.194 ± 0.065	5.864LeuVal: 5.864 ± 0.063	1.049LeuTrp: 1.049 ± 0.03	2.984LeuTyr: 2.984 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.045MetAla: 2.045 ± 0.036	0.131MetCys: 0.131 ± 0.009	1.269MetAsp: 1.269 ± 0.03	1.416MetGlu: 1.416 ± 0.031	0.596MetPhe: 0.596 ± 0.021	1.521MetGly: 1.521 ± 0.033	0.385MetHis: 0.385 ± 0.015	1.281MetIle: 1.281 ± 0.028	1.311MetLys: 1.311 ± 0.028	2.031MetLeu: 2.031 ± 0.04	0.566MetMet: 0.566 ± 0.02	1.003MetAsn: 1.003 ± 0.024	1.092MetPro: 1.092 ± 0.026	0.765MetGln: 0.765 ± 0.022	1.256MetArg: 1.256 ± 0.028	1.379MetSer: 1.379 ± 0.032	1.396MetThr: 1.396 ± 0.028	1.449MetVal: 1.449 ± 0.029	0.172MetTrp: 0.172 ± 0.012	0.528MetTyr: 0.528 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.231AsnAla: 3.231 ± 0.047	0.497AsnCys: 0.497 ± 0.032	2.648AsnAsp: 2.648 ± 0.055	2.512AsnGlu: 2.512 ± 0.041	2.113AsnPhe: 2.113 ± 0.047	3.995AsnGly: 3.995 ± 0.092	0.772AsnHis: 0.772 ± 0.022	2.493AsnIle: 2.493 ± 0.04	1.641AsnLys: 1.641 ± 0.036	4.217AsnLeu: 4.217 ± 0.057	0.789AsnMet: 0.789 ± 0.023	2.164AsnAsn: 2.164 ± 0.046	2.537AsnPro: 2.537 ± 0.042	1.606AsnGln: 1.606 ± 0.03	2.385AsnArg: 2.385 ± 0.043	2.505AsnSer: 2.505 ± 0.044	2.563AsnThr: 2.563 ± 0.052	2.729AsnVal: 2.729 ± 0.048	0.715AsnTrp: 0.715 ± 0.02	1.878AsnTyr: 1.878 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.62ProAla: 4.62 ± 0.059	0.331ProCys: 0.331 ± 0.032	3.439ProAsp: 3.439 ± 0.049	3.761ProGlu: 3.761 ± 0.045	2.045ProPhe: 2.045 ± 0.036	3.819ProGly: 3.819 ± 0.057	0.725ProHis: 0.725 ± 0.023	2.26ProIle: 2.26 ± 0.035	1.702ProLys: 1.702 ± 0.038	4.103ProLeu: 4.103 ± 0.051	0.863ProMet: 0.863 ± 0.023	2.079ProAsn: 2.079 ± 0.041	1.972ProPro: 1.972 ± 0.051	1.385ProGln: 1.385 ± 0.032	1.84ProArg: 1.84 ± 0.035	2.606ProSer: 2.606 ± 0.041	2.811ProThr: 2.811 ± 0.054	3.426ProVal: 3.426 ± 0.052	0.534ProTrp: 0.534 ± 0.017	1.472ProTyr: 1.472 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.822GlnAla: 2.822 ± 0.042	0.223GlnCys: 0.223 ± 0.012	1.916GlnAsp: 1.916 ± 0.036	2.363GlnGlu: 2.363 ± 0.042	1.534GlnPhe: 1.534 ± 0.029	2.297GlnGly: 2.297 ± 0.048	0.628GlnHis: 0.628 ± 0.021	1.953GlnIle: 1.953 ± 0.031	1.532GlnLys: 1.532 ± 0.039	4.289GlnLeu: 4.289 ± 0.058	0.803GlnMet: 0.803 ± 0.023	1.421GlnAsn: 1.421 ± 0.031	1.643GlnPro: 1.643 ± 0.034	1.74GlnGln: 1.74 ± 0.038	2.193GlnArg: 2.193 ± 0.044	2.04GlnSer: 2.04 ± 0.034	2.029GlnThr: 2.029 ± 0.036	2.274GlnVal: 2.274 ± 0.037	0.469GlnTrp: 0.469 ± 0.019	1.177GlnTyr: 1.177 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.192ArgAla: 4.192 ± 0.065	0.382ArgCys: 0.382 ± 0.017	2.81ArgAsp: 2.81 ± 0.04	3.7ArgGlu: 3.7 ± 0.059	2.707ArgPhe: 2.707 ± 0.044	3.483ArgGly: 3.483 ± 0.055	1.063ArgHis: 1.063 ± 0.026	3.398ArgIle: 3.398 ± 0.051	2.825ArgLys: 2.825 ± 0.053	5.786ArgLeu: 5.786 ± 0.073	1.463ArgMet: 1.463 ± 0.028	2.352ArgAsn: 2.352 ± 0.042	2.428ArgPro: 2.428 ± 0.044	2.339ArgGln: 2.339 ± 0.045	3.378ArgArg: 3.378 ± 0.055	3.12ArgSer: 3.12 ± 0.045	2.846ArgThr: 2.846 ± 0.047	3.455ArgVal: 3.455 ± 0.05	0.822ArgTrp: 0.822 ± 0.025	2.27ArgTyr: 2.27 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.979SerAla: 4.979 ± 0.056	0.756SerCys: 0.756 ± 0.031	3.424SerAsp: 3.424 ± 0.051	3.184SerGlu: 3.184 ± 0.049	3.285SerPhe: 3.285 ± 0.043	5.631SerGly: 5.631 ± 0.073	1.019SerHis: 1.019 ± 0.029	3.737SerIle: 3.737 ± 0.054	2.294SerLys: 2.294 ± 0.044	6.534SerLeu: 6.534 ± 0.082	1.164SerMet: 1.164 ± 0.029	2.449SerAsn: 2.449 ± 0.043	3.143SerPro: 3.143 ± 0.048	1.951SerGln: 1.951 ± 0.033	3.224SerArg: 3.224 ± 0.05	4.066SerSer: 4.066 ± 0.055	3.612SerThr: 3.612 ± 0.048	4.184SerVal: 4.184 ± 0.054	0.93SerTrp: 0.93 ± 0.026	2.302SerTyr: 2.302 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.198ThrAla: 5.198 ± 0.073	0.563ThrCys: 0.563 ± 0.024	4.105ThrAsp: 4.105 ± 0.074	3.579ThrGlu: 3.579 ± 0.045	3.098ThrPhe: 3.098 ± 0.055	5.049ThrGly: 5.049 ± 0.078	0.964ThrHis: 0.964 ± 0.026	3.978ThrIle: 3.978 ± 0.068	2.06ThrLys: 2.06 ± 0.043	5.865ThrLeu: 5.865 ± 0.072	1.081ThrMet: 1.081 ± 0.026	2.538ThrAsn: 2.538 ± 0.045	3.072ThrPro: 3.072 ± 0.055	1.698ThrGln: 1.698 ± 0.04	2.41ThrArg: 2.41 ± 0.045	3.618ThrSer: 3.618 ± 0.053	3.903ThrThr: 3.903 ± 0.068	4.72ThrVal: 4.72 ± 0.102	0.561ThrTrp: 0.561 ± 0.022	2.307ThrTyr: 2.307 ± 0.051	0.001ThrXaa: 0.001 ± 0.001
Val	5.581ValAla: 5.581 ± 0.062	0.64ValCys: 0.64 ± 0.025	4.118ValAsp: 4.118 ± 0.05	4.151ValGlu: 4.151 ± 0.054	3.078ValPhe: 3.078 ± 0.046	4.559ValGly: 4.559 ± 0.052	1.113ValHis: 1.113 ± 0.026	3.794ValIle: 3.794 ± 0.056	2.807ValLys: 2.807 ± 0.053	5.982ValLeu: 5.982 ± 0.06	1.463ValMet: 1.463 ± 0.027	3.041ValAsn: 3.041 ± 0.048	2.857ValPro: 2.857 ± 0.041	1.954ValGln: 1.954 ± 0.036	3.605ValArg: 3.605 ± 0.053	4.673ValSer: 4.673 ± 0.061	4.365ValThr: 4.365 ± 0.093	4.625ValVal: 4.625 ± 0.059	0.75ValTrp: 0.75 ± 0.019	2.301ValTyr: 2.301 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.967TrpAla: 0.967 ± 0.028	0.116TrpCys: 0.116 ± 0.008	0.702TrpAsp: 0.702 ± 0.018	0.756TrpGlu: 0.756 ± 0.024	0.527TrpPhe: 0.527 ± 0.018	0.871TrpGly: 0.871 ± 0.023	0.271TrpHis: 0.271 ± 0.013	0.617TrpIle: 0.617 ± 0.019	0.646TrpLys: 0.646 ± 0.02	1.433TrpLeu: 1.433 ± 0.037	0.372TrpMet: 0.372 ± 0.014	0.555TrpAsn: 0.555 ± 0.017	0.477TrpPro: 0.477 ± 0.018	0.572TrpGln: 0.572 ± 0.018	0.786TrpArg: 0.786 ± 0.025	0.891TrpSer: 0.891 ± 0.029	0.788TrpThr: 0.788 ± 0.023	0.773TrpVal: 0.773 ± 0.022	0.267TrpTrp: 0.267 ± 0.013	0.452TrpTyr: 0.452 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.764TyrAla: 2.764 ± 0.045	0.298TyrCys: 0.298 ± 0.013	2.404TyrAsp: 2.404 ± 0.039	2.072TyrGlu: 2.072 ± 0.034	1.951TyrPhe: 1.951 ± 0.031	2.69TyrGly: 2.69 ± 0.042	0.778TyrHis: 0.778 ± 0.022	1.467TyrIle: 1.467 ± 0.03	1.259TyrLys: 1.259 ± 0.027	3.941TyrLeu: 3.941 ± 0.054	0.515TyrMet: 0.515 ± 0.019	1.537TyrAsn: 1.537 ± 0.032	1.579TyrPro: 1.579 ± 0.031	1.574TyrGln: 1.574 ± 0.035	2.449TyrArg: 2.449 ± 0.041	2.111TyrSer: 2.111 ± 0.038	2.208TyrThr: 2.208 ± 0.051	2.133TyrVal: 2.133 ± 0.038	0.477TyrTrp: 0.477 ± 0.017	1.473TyrTyr: 1.473 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.008XaaXaa: 0.008 ± 0.008

Statistics based on 4889 proteins (1822202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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