Amino acid dipepetide frequency for Ustilago trichophora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.68AlaAla: 13.68 ± 0.078	0.897AlaCys: 0.897 ± 0.012	5.094AlaAsp: 5.094 ± 0.032	5.773AlaGlu: 5.773 ± 0.038	3.151AlaPhe: 3.151 ± 0.025	6.801AlaGly: 6.801 ± 0.036	2.112AlaHis: 2.112 ± 0.02	3.989AlaIle: 3.989 ± 0.026	4.905AlaLys: 4.905 ± 0.034	8.294AlaLeu: 8.294 ± 0.04	1.948AlaMet: 1.948 ± 0.017	3.473AlaAsn: 3.473 ± 0.026	5.955AlaPro: 5.955 ± 0.043	4.284AlaGln: 4.284 ± 0.031	5.764AlaArg: 5.764 ± 0.031	11.634AlaSer: 11.634 ± 0.057	6.356AlaThr: 6.356 ± 0.031	5.437AlaVal: 5.437 ± 0.032	1.063AlaTrp: 1.063 ± 0.012	2.05AlaTyr: 2.05 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	0.766CysAla: 0.766 ± 0.01	0.171CysCys: 0.171 ± 0.004	0.503CysAsp: 0.503 ± 0.008	0.405CysGlu: 0.405 ± 0.007	0.453CysPhe: 0.453 ± 0.01	0.698CysGly: 0.698 ± 0.011	0.27CysHis: 0.27 ± 0.007	0.531CysIle: 0.531 ± 0.008	0.433CysLys: 0.433 ± 0.008	0.986CysLeu: 0.986 ± 0.012	0.189CysMet: 0.189 ± 0.005	0.338CysAsn: 0.338 ± 0.007	0.516CysPro: 0.516 ± 0.009	0.36CysGln: 0.36 ± 0.007	0.611CysArg: 0.611 ± 0.01	0.839CysSer: 0.839 ± 0.013	0.568CysThr: 0.568 ± 0.01	0.578CysVal: 0.578 ± 0.009	0.153CysTrp: 0.153 ± 0.004	0.262CysTyr: 0.262 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	6.068AspAla: 6.068 ± 0.031	0.465AspCys: 0.465 ± 0.007	4.948AspAsp: 4.948 ± 0.047	4.648AspGlu: 4.648 ± 0.033	1.866AspPhe: 1.866 ± 0.018	4.028AspGly: 4.028 ± 0.025	1.267AspHis: 1.267 ± 0.015	2.141AspIle: 2.141 ± 0.017	2.315AspLys: 2.315 ± 0.018	5.029AspLeu: 5.029 ± 0.029	1.08AspMet: 1.08 ± 0.011	1.635AspAsn: 1.635 ± 0.016	3.441AspPro: 3.441 ± 0.021	2.111AspGln: 2.111 ± 0.017	3.151AspArg: 3.151 ± 0.023	4.417AspSer: 4.417 ± 0.029	2.799AspThr: 2.799 ± 0.02	3.5AspVal: 3.5 ± 0.026	0.759AspTrp: 0.759 ± 0.01	1.256AspTyr: 1.256 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	6.161GluAla: 6.161 ± 0.037	0.47GluCys: 0.47 ± 0.008	4.038GluAsp: 4.038 ± 0.03	5.403GluGlu: 5.403 ± 0.045	1.495GluPhe: 1.495 ± 0.014	3.462GluGly: 3.462 ± 0.024	1.351GluHis: 1.351 ± 0.013	2.328GluIle: 2.328 ± 0.018	3.048GluLys: 3.048 ± 0.026	5.062GluLeu: 5.062 ± 0.035	1.293GluMet: 1.293 ± 0.014	1.627GluAsn: 1.627 ± 0.016	2.501GluPro: 2.501 ± 0.02	2.67GluGln: 2.67 ± 0.022	3.876GluArg: 3.876 ± 0.031	4.212GluSer: 4.212 ± 0.029	2.998GluThr: 2.998 ± 0.021	3.149GluVal: 3.149 ± 0.025	0.728GluTrp: 0.728 ± 0.01	1.232GluTyr: 1.232 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	3.151PheAla: 3.151 ± 0.023	0.429PheCys: 0.429 ± 0.008	2.194PheAsp: 2.194 ± 0.017	1.819PheGlu: 1.819 ± 0.017	1.339PhePhe: 1.339 ± 0.017	2.812PheGly: 2.812 ± 0.026	0.78PheHis: 0.78 ± 0.012	1.304PheIle: 1.304 ± 0.016	1.269PheLys: 1.269 ± 0.015	2.908PheLeu: 2.908 ± 0.022	0.601PheMet: 0.601 ± 0.01	1.199PheAsn: 1.199 ± 0.015	1.584PhePro: 1.584 ± 0.015	1.146PheGln: 1.146 ± 0.013	1.781PheArg: 1.781 ± 0.015	2.867PheSer: 2.867 ± 0.023	1.807PheThr: 1.807 ± 0.015	2.142PheVal: 2.142 ± 0.018	0.498PheTrp: 0.498 ± 0.008	0.877PheTyr: 0.877 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	6.375GlyAla: 6.375 ± 0.039	0.664GlyCys: 0.664 ± 0.01	3.388GlyAsp: 3.388 ± 0.024	3.527GlyGlu: 3.527 ± 0.029	2.459GlyPhe: 2.459 ± 0.02	6.702GlyGly: 6.702 ± 0.063	1.657GlyHis: 1.657 ± 0.017	2.937GlyIle: 2.937 ± 0.022	3.615GlyLys: 3.615 ± 0.029	5.746GlyLeu: 5.746 ± 0.036	1.505GlyMet: 1.505 ± 0.018	2.318GlyAsn: 2.318 ± 0.03	3.291GlyPro: 3.291 ± 0.029	2.617GlyGln: 2.617 ± 0.023	4.091GlyArg: 4.091 ± 0.024	6.907GlySer: 6.907 ± 0.051	3.773GlyThr: 3.773 ± 0.022	3.848GlyVal: 3.848 ± 0.025	1.01GlyTrp: 1.01 ± 0.012	1.727GlyTyr: 1.727 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.244HisAla: 2.244 ± 0.02	0.259HisCys: 0.259 ± 0.006	1.343HisAsp: 1.343 ± 0.014	1.179HisGlu: 1.179 ± 0.013	0.891HisPhe: 0.891 ± 0.011	1.601HisGly: 1.601 ± 0.015	1.163HisHis: 1.163 ± 0.019	1.085HisIle: 1.085 ± 0.012	0.891HisLys: 0.891 ± 0.01	2.495HisLeu: 2.495 ± 0.021	0.445HisMet: 0.445 ± 0.007	0.83HisAsn: 0.83 ± 0.011	1.917HisPro: 1.917 ± 0.02	1.187HisGln: 1.187 ± 0.016	1.68HisArg: 1.68 ± 0.016	2.152HisSer: 2.152 ± 0.021	1.355HisThr: 1.355 ± 0.013	1.358HisVal: 1.358 ± 0.014	0.29HisTrp: 0.29 ± 0.007	0.576HisTyr: 0.576 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.906IleAla: 3.906 ± 0.027	0.542IleCys: 0.542 ± 0.009	2.682IleAsp: 2.682 ± 0.017	2.463IleGlu: 2.463 ± 0.02	1.518IlePhe: 1.518 ± 0.016	2.7IleGly: 2.7 ± 0.023	1.068IleHis: 1.068 ± 0.012	1.744IleIle: 1.744 ± 0.019	1.984IleLys: 1.984 ± 0.018	3.677IleLeu: 3.677 ± 0.03	0.73IleMet: 0.73 ± 0.011	1.497IleAsn: 1.497 ± 0.013	2.552IlePro: 2.552 ± 0.022	1.652IleGln: 1.652 ± 0.016	2.558IleArg: 2.558 ± 0.017	3.593IleSer: 3.593 ± 0.024	2.289IleThr: 2.289 ± 0.019	2.671IleVal: 2.671 ± 0.021	0.52IleTrp: 0.52 ± 0.009	1.007IleTyr: 1.007 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.801LysAla: 4.801 ± 0.033	0.378LysCys: 0.378 ± 0.007	2.639LysAsp: 2.639 ± 0.023	2.983LysGlu: 2.983 ± 0.024	1.162LysPhe: 1.162 ± 0.015	2.975LysGly: 2.975 ± 0.025	1.091LysHis: 1.091 ± 0.013	1.849LysIle: 1.849 ± 0.019	3.232LysLys: 3.232 ± 0.03	4.082LysLeu: 4.082 ± 0.025	0.959LysMet: 0.959 ± 0.01	1.439LysAsn: 1.439 ± 0.014	2.656LysPro: 2.656 ± 0.024	2.113LysGln: 2.113 ± 0.018	3.536LysArg: 3.536 ± 0.027	3.542LysSer: 3.542 ± 0.022	2.578LysThr: 2.578 ± 0.021	2.784LysVal: 2.784 ± 0.021	0.539LysTrp: 0.539 ± 0.009	1.006LysTyr: 1.006 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.678LeuAla: 8.678 ± 0.036	1.035LeuCys: 1.035 ± 0.014	5.306LeuAsp: 5.306 ± 0.028	5.101LeuGlu: 5.101 ± 0.032	2.967LeuPhe: 2.967 ± 0.02	5.689LeuGly: 5.689 ± 0.029	2.219LeuHis: 2.219 ± 0.02	3.552LeuIle: 3.552 ± 0.027	3.74LeuLys: 3.74 ± 0.025	8.249LeuLeu: 8.249 ± 0.05	1.558LeuMet: 1.558 ± 0.015	2.963LeuAsn: 2.963 ± 0.021	5.911LeuPro: 5.911 ± 0.034	3.859LeuGln: 3.859 ± 0.027	5.719LeuArg: 5.719 ± 0.033	7.996LeuSer: 7.996 ± 0.038	4.786LeuThr: 4.786 ± 0.029	5.233LeuVal: 5.233 ± 0.029	0.952LeuTrp: 0.952 ± 0.011	1.933LeuTyr: 1.933 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.959MetAla: 1.959 ± 0.016	0.172MetCys: 0.172 ± 0.005	1.152MetAsp: 1.152 ± 0.013	1.025MetGlu: 1.025 ± 0.011	0.55MetPhe: 0.55 ± 0.009	1.319MetGly: 1.319 ± 0.017	0.477MetHis: 0.477 ± 0.009	0.798MetIle: 0.798 ± 0.01	0.717MetLys: 0.717 ± 0.01	1.822MetLeu: 1.822 ± 0.016	0.506MetMet: 0.506 ± 0.01	0.555MetAsn: 0.555 ± 0.008	1.284MetPro: 1.284 ± 0.015	0.947MetGln: 0.947 ± 0.013	1.208MetArg: 1.208 ± 0.013	1.873MetSer: 1.873 ± 0.017	1.133MetThr: 1.133 ± 0.013	1.169MetVal: 1.169 ± 0.014	0.214MetTrp: 0.214 ± 0.005	0.41MetTyr: 0.41 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	3.644AsnAla: 3.644 ± 0.023	0.31AsnCys: 0.31 ± 0.006	1.901AsnAsp: 1.901 ± 0.016	1.665AsnGlu: 1.665 ± 0.016	1.118AsnPhe: 1.118 ± 0.013	2.932AsnGly: 2.932 ± 0.032	0.805AsnHis: 0.805 ± 0.009	1.435AsnIle: 1.435 ± 0.016	1.516AsnLys: 1.516 ± 0.017	3.032AsnLeu: 3.032 ± 0.023	0.68AsnMet: 0.68 ± 0.01	1.54AsnAsn: 1.54 ± 0.024	2.243AsnPro: 2.243 ± 0.021	1.264AsnGln: 1.264 ± 0.015	1.893AsnArg: 1.893 ± 0.015	2.9AsnSer: 2.9 ± 0.025	2.067AsnThr: 2.067 ± 0.019	2.156AsnVal: 2.156 ± 0.018	0.391AsnTrp: 0.391 ± 0.007	0.775AsnTyr: 0.775 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	6.445ProAla: 6.445 ± 0.049	0.422ProCys: 0.422 ± 0.008	2.838ProAsp: 2.838 ± 0.022	3.067ProGlu: 3.067 ± 0.022	2.012ProPhe: 2.012 ± 0.015	3.671ProGly: 3.671 ± 0.03	1.519ProHis: 1.519 ± 0.017	2.49ProIle: 2.49 ± 0.018	2.468ProLys: 2.468 ± 0.022	4.968ProLeu: 4.968 ± 0.026	1.017ProMet: 1.017 ± 0.016	2.202ProAsn: 2.202 ± 0.018	5.477ProPro: 5.477 ± 0.06	2.51ProGln: 2.51 ± 0.025	3.402ProArg: 3.402 ± 0.029	8.057ProSer: 8.057 ± 0.054	4.512ProThr: 4.512 ± 0.034	3.301ProVal: 3.301 ± 0.023	0.586ProTrp: 0.586 ± 0.009	1.335ProTyr: 1.335 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	4.363GlnAla: 4.363 ± 0.029	0.347GlnCys: 0.347 ± 0.007	2.31GlnAsp: 2.31 ± 0.02	2.331GlnGlu: 2.331 ± 0.019	1.039GlnPhe: 1.039 ± 0.013	2.54GlnGly: 2.54 ± 0.02	1.456GlnHis: 1.456 ± 0.018	1.711GlnIle: 1.711 ± 0.013	1.773GlnLys: 1.773 ± 0.019	3.886GlnLeu: 3.886 ± 0.027	0.885GlnMet: 0.885 ± 0.014	1.389GlnAsn: 1.389 ± 0.014	2.964GlnPro: 2.964 ± 0.028	4.035GlnGln: 4.035 ± 0.082	3.035GlnArg: 3.035 ± 0.022	3.527GlnSer: 3.527 ± 0.025	2.273GlnThr: 2.273 ± 0.018	2.236GlnVal: 2.236 ± 0.019	0.434GlnTrp: 0.434 ± 0.008	0.916GlnTyr: 0.916 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	5.511ArgAla: 5.511 ± 0.031	0.633ArgCys: 0.633 ± 0.011	3.209ArgAsp: 3.209 ± 0.024	3.413ArgGlu: 3.413 ± 0.03	2.165ArgPhe: 2.165 ± 0.018	3.653ArgGly: 3.653 ± 0.025	1.596ArgHis: 1.596 ± 0.015	2.842ArgIle: 2.842 ± 0.02	3.508ArgLys: 3.508 ± 0.025	5.517ArgLeu: 5.517 ± 0.03	1.291ArgMet: 1.291 ± 0.013	2.209ArgAsn: 2.209 ± 0.018	3.744ArgPro: 3.744 ± 0.03	2.787ArgGln: 2.787 ± 0.021	5.457ArgArg: 5.457 ± 0.045	6.223ArgSer: 6.223 ± 0.042	3.522ArgThr: 3.522 ± 0.023	3.05ArgVal: 3.05 ± 0.022	0.774ArgTrp: 0.774 ± 0.011	1.484ArgTyr: 1.484 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	10.205SerAla: 10.205 ± 0.051	0.746SerCys: 0.746 ± 0.01	4.861SerAsp: 4.861 ± 0.031	4.199SerGlu: 4.199 ± 0.025	3.034SerPhe: 3.034 ± 0.024	6.444SerGly: 6.444 ± 0.043	2.463SerHis: 2.463 ± 0.024	4.091SerIle: 4.091 ± 0.025	4.155SerLys: 4.155 ± 0.028	7.904SerLeu: 7.904 ± 0.04	1.788SerMet: 1.788 ± 0.017	3.749SerAsn: 3.749 ± 0.028	6.457SerPro: 6.457 ± 0.054	3.871SerGln: 3.871 ± 0.026	5.968SerArg: 5.968 ± 0.041	15.134SerSer: 15.134 ± 0.11	7.644SerThr: 7.644 ± 0.047	4.817SerVal: 4.817 ± 0.025	0.941SerTrp: 0.941 ± 0.01	1.947SerTyr: 1.947 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	6.2ThrAla: 6.2 ± 0.035	0.587ThrCys: 0.587 ± 0.01	2.799ThrAsp: 2.799 ± 0.02	2.678ThrGlu: 2.678 ± 0.018	2.055ThrPhe: 2.055 ± 0.016	3.905ThrGly: 3.905 ± 0.028	1.362ThrHis: 1.362 ± 0.014	2.585ThrIle: 2.585 ± 0.02	2.509ThrLys: 2.509 ± 0.018	5.351ThrLeu: 5.351 ± 0.031	1.026ThrMet: 1.026 ± 0.012	2.081ThrAsn: 2.081 ± 0.016	4.673ThrPro: 4.673 ± 0.037	2.221ThrGln: 2.221 ± 0.018	3.236ThrArg: 3.236 ± 0.022	7.077ThrSer: 7.077 ± 0.043	4.59ThrThr: 4.59 ± 0.037	3.257ThrVal: 3.257 ± 0.02	0.679ThrTrp: 0.679 ± 0.01	1.256ThrTyr: 1.256 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	5.561ValAla: 5.561 ± 0.032	0.65ValCys: 0.65 ± 0.01	3.597ValAsp: 3.597 ± 0.025	3.672ValGlu: 3.672 ± 0.023	1.932ValPhe: 1.932 ± 0.019	3.797ValGly: 3.797 ± 0.024	1.364ValHis: 1.364 ± 0.013	2.308ValIle: 2.308 ± 0.021	2.746ValLys: 2.746 ± 0.022	5.119ValLeu: 5.119 ± 0.032	1.082ValMet: 1.082 ± 0.014	1.839ValAsn: 1.839 ± 0.018	3.393ValPro: 3.393 ± 0.024	2.414ValGln: 2.414 ± 0.018	3.412ValArg: 3.412 ± 0.026	4.631ValSer: 4.631 ± 0.024	3.033ValThr: 3.033 ± 0.021	3.816ValVal: 3.816 ± 0.024	0.72ValTrp: 0.72 ± 0.01	1.322ValTyr: 1.322 ± 0.014	0.0ValXaa: 0.0 ± 0.0
Trp	0.92TrpAla: 0.92 ± 0.01	0.156TrpCys: 0.156 ± 0.004	0.706TrpAsp: 0.706 ± 0.011	0.587TrpGlu: 0.587 ± 0.009	0.431TrpPhe: 0.431 ± 0.009	0.694TrpGly: 0.694 ± 0.011	0.297TrpHis: 0.297 ± 0.007	0.641TrpIle: 0.641 ± 0.011	0.63TrpLys: 0.63 ± 0.011	1.146TrpLeu: 1.146 ± 0.013	0.298TrpMet: 0.298 ± 0.006	0.537TrpAsn: 0.537 ± 0.008	0.515TrpPro: 0.515 ± 0.008	0.513TrpGln: 0.513 ± 0.008	0.765TrpArg: 0.765 ± 0.011	1.034TrpSer: 1.034 ± 0.01	0.757TrpThr: 0.757 ± 0.01	0.611TrpVal: 0.611 ± 0.01	0.217TrpTrp: 0.217 ± 0.005	0.309TrpTyr: 0.309 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.023TyrAla: 2.023 ± 0.018	0.298TyrCys: 0.298 ± 0.006	1.418TyrAsp: 1.418 ± 0.014	1.166TyrGlu: 1.166 ± 0.013	0.869TyrPhe: 0.869 ± 0.01	1.736TyrGly: 1.736 ± 0.019	0.622TyrHis: 0.622 ± 0.009	0.99TyrIle: 0.99 ± 0.011	0.891TyrLys: 0.891 ± 0.012	2.172TyrLeu: 2.172 ± 0.019	0.409TyrMet: 0.409 ± 0.008	0.848TyrAsn: 0.848 ± 0.012	1.224TyrPro: 1.224 ± 0.015	0.889TyrGln: 0.889 ± 0.013	1.445TyrArg: 1.445 ± 0.013	1.801TyrSer: 1.801 ± 0.016	1.288TyrThr: 1.288 ± 0.015	1.294TyrVal: 1.294 ± 0.012	0.296TyrTrp: 0.296 ± 0.006	0.65TyrTyr: 0.65 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13002 proteins (7812304 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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